公开(公告)号：FI925370A

公开(公告)日：1993-05-30

申请号：FI925370

申请日：1992-11-26

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MUELLER GUENTER ,  MUELLNER STEFAN ,  BREIPOHL GERARD

IPC: A61K38/00 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/087 ,  C07K5/093 ,  C07K5/097 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00 ,  C07K

Abstract: Peptides with insulin-like activity and the formula I where C is a hydrogen atom, amino-acid residue, substituted amino-acid residue or sugar residue, D is an amino-acid residue, phosphoamino-acid residue, sugar residue, covalent bond or hydroxyl radical, E is a hydrogen atom, hydroxyl radical, substituted sugar residues, substituted alkyldiamine or glycerol residue, R is (C1-C4)-alkyl, =O or -O-(C1-C4)-alkyl, R is a sulphur protective group, SO2, SO3, (C1-C3)-alkyl, O2 radical, O3 radical, or hydrogen atom, R or R is, independently of one another, hydrogen or methyl, and W is an integer 1 or 2, the preparation and use thereof for the treatment of diabetes mellitus or non-insulin-dependent diabetes are described.

公开(公告)号：NO923252L

公开(公告)日：1993-02-22

申请号：NO923252

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  TRIPIER DOMINIQUE ,  MUELLNER STEFAN

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865 ,  C07K15/24 ,  C07K15/14 ,  C07K7/40 ,  A61K37/16

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：FI923702A

公开(公告)日：1993-02-21

申请号：FI923702

申请日：1992-08-18

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  TRIPIER DOMINIQUE ,  MUELLNER STEFAN

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：NO923252D0

公开(公告)日：1992-08-19

申请号：NO923252

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  TRIPIER DOMINIQUE ,  MUELLNER STEFAN

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865 ,  C07K15/00

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：HUT59697A

公开(公告)日：1992-06-29

申请号：HU400991

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MUELLNER STEFAN ,  KOENIG WOLFGANG ,  MUELLER GUENTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  A61K37/02

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：CA2058020A1

公开(公告)日：1992-06-20

申请号：CA2058020

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MUELLNER STEFAN ,  KOENIG WOLFGANG ,  MUELLER GUENTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  A61K38/04 ,  C07K5/04

Abstract: HOE 90/F 374 of the disclosure Short peptides with insulin activity Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I) where A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerization component, the stereoisomeric forms thereof where appropriate, or the physiologically tolerated salts thereof, the preparation thereof and the use thereof for the treatment of diabetes mellitus are described.

公开(公告)号：PL188604B1

公开(公告)日：2005-03-31

申请号：PL32340797

申请日：1997-11-28

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MUELLER GUENTER

IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00 ,  A61K31/702

Abstract: Inositol glycan derivatives of formula (I), their salts and stereoisomeric forms, are new: A-Z-R (I) A = HP(=O)(OH), HP(=S)(OH), HOP(=S)(OH), HSP(=S)(OH), (1-4C alkyl)P(=O)(OH), (1-4C alkyl)P(=S)(OH), SO2ORl, S(=O)OR1, NH2CO, NR1R2, R1R2NCONH, R1OSO2NH, (1-4C alkyl)SO2, (1-4C alkyl)S(=O) or R1S; R1, R2 = H or 1-4C alkyl; Z = 2-6 sugar residues (optionally substituted by up to 6 Me, sugar residue, di-sugar residue, SO2OH, CONR1R2, CO(1-4C alkyl), P(=O)(H)OH, P(=O)(OH)2, P(=S)(H)OH, P(=S)(OH)2, P(=S)(SH)(OH), P(=O)(OH)OCH2CH2NR1R2), or the glycosidic bridge between the 2-6 sugar residues may be 1-6 fold replaced by CH2 or S; R = inositol, inositol phosphate, inositol thiophosphate, inositol cyclo-phosphate, inositol cyclo-thiophosphate (optionally substituted by 1-2 phosphate or thiophosphate, or single substitution by cyclo-phosphate or cyclo-thiophosphate), or inositol (where two neighbouring OH groups are replaced by CH2SO2NH).

公开(公告)号：SK281333B6

公开(公告)日：2001-02-12

申请号：SK255392

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  TRIPIER DOMINIQUE ,  MUELLNER STEFAN

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：NO308951B1

公开(公告)日：2000-11-20

申请号：NO914999

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MUELLNER STEFAN ,  KOENIG WOLFGANG ,  MUELLER GUENTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：HRP940839B1

公开(公告)日：2000-02-29

申请号：HRP940839

申请日：1994-10-26

Applicant: HOECHST AG

Inventor： MUELLNER STEFAN ,  KOENIG WOLFGANG ,  MUELLER GUENTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.