公开(公告)号：NO309146B1

公开(公告)日：2000-12-18

申请号：NO924585

申请日：1992-11-27

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MUELLER GUENTER ,  MUELLNER STEFAN ,  BREIPOHL GERHARD

IPC: A61K38/00 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/087 ,  C07K5/093 ,  C07K5/097 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00

Abstract: Peptides with insulin-like activity and the formula I where C is a hydrogen atom, amino-acid residue, substituted amino-acid residue or sugar residue, D is an amino-acid residue, phosphoamino-acid residue, sugar residue, covalent bond or hydroxyl radical, E is a hydrogen atom, hydroxyl radical, substituted sugar residues, substituted alkyldiamine or glycerol residue, R is (C1-C4)-alkyl, =O or -O-(C1-C4)-alkyl, R is a sulphur protective group, SO2, SO3, (C1-C3)-alkyl, O2 radical, O3 radical, or hydrogen atom, R or R is, independently of one another, hydrogen or methyl, and W is an integer 1 or 2, the preparation and use thereof for the treatment of diabetes mellitus or non-insulin-dependent diabetes are described.

公开(公告)号：HU9702242A2

公开(公告)日：1998-12-28

申请号：HU9702242

申请日：1997-11-26

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MUELLER GUENTER

IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00 ,  C07H15/02

Abstract: Inositol glycan derivatives of formula (I), their salts and stereoisomeric forms, are new: A-Z-R (I) A = HP(=O)(OH), HP(=S)(OH), HOP(=S)(OH), HSP(=S)(OH), (1-4C alkyl)P(=O)(OH), (1-4C alkyl)P(=S)(OH), SO2ORl, S(=O)OR1, NH2CO, NR1R2, R1R2NCONH, R1OSO2NH, (1-4C alkyl)SO2, (1-4C alkyl)S(=O) or R1S; R1, R2 = H or 1-4C alkyl; Z = 2-6 sugar residues (optionally substituted by up to 6 Me, sugar residue, di-sugar residue, SO2OH, CONR1R2, CO(1-4C alkyl), P(=O)(H)OH, P(=O)(OH)2, P(=S)(H)OH, P(=S)(OH)2, P(=S)(SH)(OH), P(=O)(OH)OCH2CH2NR1R2), or the glycosidic bridge between the 2-6 sugar residues may be 1-6 fold replaced by CH2 or S; R = inositol, inositol phosphate, inositol thiophosphate, inositol cyclo-phosphate, inositol cyclo-thiophosphate (optionally substituted by 1-2 phosphate or thiophosphate, or single substitution by cyclo-phosphate or cyclo-thiophosphate), or inositol (where two neighbouring OH groups are replaced by CH2SO2NH).

公开(公告)号：CZ9703775A3

公开(公告)日：1998-06-17

申请号：CZ377597

申请日：1997-11-27

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MULLER GUNTER

IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00

CPC classification number: C07H3/06 ,  C07H3/04 ,  Y10S514/866

公开(公告)号：HU9702242D0

公开(公告)日：1998-03-02

申请号：HU9702242

申请日：1997-11-26

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MUELLER GUENTER

IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00

Abstract: Inositol glycan derivatives of formula (I), their salts and stereoisomeric forms, are new: A-Z-R (I) A = HP(=O)(OH), HP(=S)(OH), HOP(=S)(OH), HSP(=S)(OH), (1-4C alkyl)P(=O)(OH), (1-4C alkyl)P(=S)(OH), SO2ORl, S(=O)OR1, NH2CO, NR1R2, R1R2NCONH, R1OSO2NH, (1-4C alkyl)SO2, (1-4C alkyl)S(=O) or R1S; R1, R2 = H or 1-4C alkyl; Z = 2-6 sugar residues (optionally substituted by up to 6 Me, sugar residue, di-sugar residue, SO2OH, CONR1R2, CO(1-4C alkyl), P(=O)(H)OH, P(=O)(OH)2, P(=S)(H)OH, P(=S)(OH)2, P(=S)(SH)(OH), P(=O)(OH)OCH2CH2NR1R2), or the glycosidic bridge between the 2-6 sugar residues may be 1-6 fold replaced by CH2 or S; R = inositol, inositol phosphate, inositol thiophosphate, inositol cyclo-phosphate, inositol cyclo-thiophosphate (optionally substituted by 1-2 phosphate or thiophosphate, or single substitution by cyclo-phosphate or cyclo-thiophosphate), or inositol (where two neighbouring OH groups are replaced by CH2SO2NH).

公开(公告)号：FI925370A

公开(公告)日：1993-05-30

申请号：FI925370

申请日：1992-11-26

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MUELLER GUENTER ,  MUELLNER STEFAN ,  BREIPOHL GERARD

IPC: A61K38/00 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/087 ,  C07K5/093 ,  C07K5/097 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00 ,  C07K

Abstract: Peptides with insulin-like activity and the formula I where C is a hydrogen atom, amino-acid residue, substituted amino-acid residue or sugar residue, D is an amino-acid residue, phosphoamino-acid residue, sugar residue, covalent bond or hydroxyl radical, E is a hydrogen atom, hydroxyl radical, substituted sugar residues, substituted alkyldiamine or glycerol residue, R is (C1-C4)-alkyl, =O or -O-(C1-C4)-alkyl, R is a sulphur protective group, SO2, SO3, (C1-C3)-alkyl, O2 radical, O3 radical, or hydrogen atom, R or R is, independently of one another, hydrogen or methyl, and W is an integer 1 or 2, the preparation and use thereof for the treatment of diabetes mellitus or non-insulin-dependent diabetes are described.

公开(公告)号：CA2222103C

公开(公告)日：2007-08-28

申请号：CA2222103

申请日：1997-11-25

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MULLER GUNTER

IPC: C07H11/00 ,  C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  A61P5/50 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H13/00 ,  C07H15/203 ,  C08B37/00

Abstract: Inositolglycans having insulin-like action Compounds of the formula I A-Z-R (I) are described, where A is the radical H - P(O)(OH) -, H - P(S)(OH) -, HO-- P(S)(OH) -, HS-P(S)(OH) -, (C1-C4) - alkyl - P(O)(OH) -, (C1-C4) - alkyl - P(S)(OH)-, S(O)2(OR1) -, S(O)(OR1)-, NH2 - C(O) -, R1R2N -, R1R2N - C(O) - NH -, R1O - SO2 - NH -, (C1-C4) - alkyl - SO2 -, (C1-C4) - alkyl - S(O) - or R1 - S -, Z is 2 to 6 substituted or unsubstituted sugar radicals and R is substituted or unsubstituted inositol. The compounds of the formula I are suitable for the treatment of diabetes mellitus or noninsulin-dependent diabetes.

公开(公告)号：CZ294886B6

公开(公告)日：2005-04-13

申请号：CZ377597

申请日：1997-11-27

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MULLER GUNTER

IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00

Abstract: In the present invention, there is disclosed inositol glycans exhibiting insulin like activity of the general formula A - Z - R, in which A represents the groups HP(O)(OH)-, S(O)i2(ORe1)-, NHi2C(O)-, Z denotes 2 to 6 sugar radicals and R represents inositol and phosphates thereof. The invented inositol glycans are suitable for the treatment of diabetes mellitus or noninsulin-dependent diabetes. There is also described process of their preparation, their use as well as pharmaceutical compositions in which the above-indicated substances are comprised.

公开(公告)号：AU4538297A

公开(公告)日：1998-06-04

申请号：AU4538297

申请日：1997-11-26

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MULLER GUNTER

IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00 ,  C07H13/00

Abstract: Inositol glycan derivatives of formula (I), their salts and stereoisomeric forms, are new: A-Z-R (I) A = HP(=O)(OH), HP(=S)(OH), HOP(=S)(OH), HSP(=S)(OH), (1-4C alkyl)P(=O)(OH), (1-4C alkyl)P(=S)(OH), SO2ORl, S(=O)OR1, NH2CO, NR1R2, R1R2NCONH, R1OSO2NH, (1-4C alkyl)SO2, (1-4C alkyl)S(=O) or R1S; R1, R2 = H or 1-4C alkyl; Z = 2-6 sugar residues (optionally substituted by up to 6 Me, sugar residue, di-sugar residue, SO2OH, CONR1R2, CO(1-4C alkyl), P(=O)(H)OH, P(=O)(OH)2, P(=S)(H)OH, P(=S)(OH)2, P(=S)(SH)(OH), P(=O)(OH)OCH2CH2NR1R2), or the glycosidic bridge between the 2-6 sugar residues may be 1-6 fold replaced by CH2 or S; R = inositol, inositol phosphate, inositol thiophosphate, inositol cyclo-phosphate, inositol cyclo-thiophosphate (optionally substituted by 1-2 phosphate or thiophosphate, or single substitution by cyclo-phosphate or cyclo-thiophosphate), or inositol (where two neighbouring OH groups are replaced by CH2SO2NH).

公开(公告)号：SG46640A1

公开(公告)日：1998-02-20

申请号：SG1996006947

申请日：1992-11-23

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MULLER GUNTER ,  MULLNER STEFAN ,  BREIPOHL GERHARD

IPC: A61K38/00 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/087 ,  C07K5/093 ,  C07K5/097 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00 ,  C07K

Abstract: Peptides with insulin-like activity and the formula I where C is a hydrogen atom, amino-acid residue, substituted amino-acid residue or sugar residue, D is an amino-acid residue, phosphoamino-acid residue, sugar residue, covalent bond or hydroxyl radical, E is a hydrogen atom, hydroxyl radical, substituted sugar residues, substituted alkyldiamine or glycerol residue, R is (C1-C4)-alkyl, =O or -O-(C1-C4)-alkyl, R is a sulphur protective group, SO2, SO3, (C1-C3)-alkyl, O2 radical, O3 radical, or hydrogen atom, R or R is, independently of one another, hydrogen or methyl, and W is an integer 1 or 2, the preparation and use thereof for the treatment of diabetes mellitus or non-insulin-dependent diabetes are described.

公开(公告)号：NO924585L

公开(公告)日：1993-06-01

申请号：NO924585

申请日：1992-11-27

Applicant: HOECHST AG

Inventor： FRICK WENDELIN ,  MUELLER GUENTER ,  MUELLNER STEFAN ,  BREIPOHL GERHARD

IPC: A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  A61K38/28 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/087 ,  C07K5/093 ,  C07K5/097 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00

Abstract: Peptides with insulin-like activity and the formula I where C is a hydrogen atom, amino-acid residue, substituted amino-acid residue or sugar residue, D is an amino-acid residue, phosphoamino-acid residue, sugar residue, covalent bond or hydroxyl radical, E is a hydrogen atom, hydroxyl radical, substituted sugar residues, substituted alkyldiamine or glycerol residue, R is (C1-C4)-alkyl, =O or -O-(C1-C4)-alkyl, R is a sulphur protective group, SO2, SO3, (C1-C3)-alkyl, O2 radical, O3 radical, or hydrogen atom, R or R is, independently of one another, hydrogen or methyl, and W is an integer 1 or 2, the preparation and use thereof for the treatment of diabetes mellitus or non-insulin-dependent diabetes are described.