PROCESS FOR THE PREPARATION OF SUBSTITUTED 2,3-DIFLUOROPYRIDINES

    公开(公告)号:CA2089938A1

    公开(公告)日:1993-08-21

    申请号:CA2089938

    申请日:1993-02-19

    Applicant: HOECHST AG

    Abstract: Process for the preparation of substituted 2,3-difluoro-pyridines The invention relates to a novel process for the preparation of substituted 2,3-difluoropyridines by reaction of substituted 2,3-halopyridines with fluoride salts in the presence of phase transfer catalysts, preferably in polar aprotic solvents, without removing the resulting substituted 2,3-difluoropyridines continuously from the reaction mixture. The substituted 2,3-difluoropyridines which can be prepared according to the invention are, inter alia, starting materials for the preparation of plant protection agents or pharmaceuticals.

    PROCESS FOR THE PREPARATION OF 2,3-DIFLUORO-6-NITROPHENOL

    公开(公告)号:CA2092407C

    公开(公告)日:1997-03-18

    申请号:CA2092407

    申请日:1991-09-25

    Applicant: HOECHST AG

    Abstract: According to a process for producing isomer-free 2,3-difluor-6-nitrophenol, 2,3,4-trifluornitrobenzol is reacted with an aqueous solution of alkali metal or alkaline earth metal hydroxide in the absence of organic solvent, at temperatures between about 20.degree.C and 100.degree.C, the pH value of the reaction mixture is set at about 1 to 6 by acid addition, the resulting product is steam distilled and the 2,3-difluor-6-nitrophenol is isolated after cooling. No organic solvents are used during any of the steps of the process.

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