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    46.
    发明专利
    未知

    公开(公告)号：DE58909692D1

    公开(公告)日：1996-07-25

    申请号：DE58909692

    申请日：1989-10-28

    Applicant: HOECHST AG

    Inventor： VERTESY LASZLO DR ,  SAUBER KLAUS DR ,  EHLERS EBERHARD DR

    IPC: C07K1/12 ,  C07K14/62 ,  C12P21/02 ,  C12P21/06

    Abstract: Polypeptides or proteins such as, for example, insulins or de-B -insulins - especially human insulin or de-B -human insulin - are prepared by enzymatic cleavage, using a trypsin-like endopeptidase, of specific fusion proteins which can be obtained by genetic manipulation and which contain the residue of a peptide-like alpha -amylase inhibitor in the molecule. The use of the specific fusion proteins results in a reaction product which can be worked up advantageously; the working-up can take place, where appropriate, by crystallisation.

    47.
    发明专利
    未知

    公开(公告)号：DE58909633D1

    公开(公告)日：1996-05-02

    申请号：DE58909633

    申请日：1989-12-21

    Applicant: HOECHST AG

    Inventor： VERTESY LASZLO DR ,  GEISEN KARL DR ,  RIESS GUENTHER JOHANNES DR ,  SAUBER KLAUS DR

    IPC: C12P21/02 ,  A61K38/00 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  C07H21/04 ,  C07K1/06 ,  C07K1/08 ,  C07K1/20 ,  C07K14/575 ,  C07K14/62 ,  C12N15/09 ,  C12R1/19 ,  C12R1/465

    Abstract: Insulin derivatives with a basic modification owing to the basic amino acid arginine in position A0 of the formula II in which a) R + R together = OH or b) R = residue of a neutral, genetically encodable L-amino acid and R = OH or a physiologically acceptable organic group which is basic in nature and has up to 50 C atoms, in whose structure 0 to 3 alpha -amino acids are involved and whose terminal carboxyl group, which is present where appropriate, can be free, as ester function, as amide function, as lactone or reduced to CH2OH, with the exception of the case in which, at the same time, R = Ala, R = OH and the A and B chain are the sequences of bovine insulin, and the physiologically tolerated salts thereof are obtained by various processes. The compounds are suitable for the treatment of diabetes mellitus, have a delayed profile of action and are very well tolerated.

    49.
    发明专利
    未知

    公开(公告)号：DE3882503D1

    公开(公告)日：1993-08-26

    申请号：DE3882503

    申请日：1988-12-15

    Applicant: HOECHST AG

    Inventor： ARETZ WERNER DR ,  SAUBER KLAUS DR

    IPC: C12N9/10 ,  C12N9/52 ,  C12P13/04 ,  C12P17/18 ,  C12P35/02 ,  C12R1/125

    Abstract: New gamma-glutamyl transpeptidase (GTP) has the following characteristics (a) mol. wt. 40,000-80,000; (b) isoelectric point at pH 4.4-5.9; (c) optimum pH 6.5-10, with Km = 9-36 micromolar at pH 8, for hydrolysis of l-gamma-glutamyl p-nitroanilide; (d) ability to hydrolyse alpha-aminoadipamic acid derivs. of formula (I), where R1 is the residue of an amino acid, dipeptide, cephem cpd. or cepham cpd. Use of GTP for hyrolysis of adipoyl or glutaryl monoamides is disclosed in EP-275901. GTP is produced by culturing a suitable Pseudomonas, Proteus, Arthrobactor or Bacillus strain, esp. B.subtilis IFO 3025, as described in EP275901. Hydrolysis of (I) is pref. effected at 28-35 deg.C and pH 6.6-8.0.

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