公开(公告)号：SI1824479T1

公开(公告)日：2009-04-30

申请号：SI200530566

申请日：2005-12-06

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  STOIT AXEL ,  TERPSTRA JAN-WILLEM ,  PRAS-RAVES MARIA L ,  MCCREARY ANDREW C ,  VAN VLIET BERNARD J ,  HESSELINK MAYKE B ,  KRUSE CORNELIS G ,  VAN SCHARRENBURG G J M

IPC: A61K31/00 ,  A61P25/00 ,  C07D263/00

公开(公告)号：PL1824479T3

公开(公告)日：2009-04-30

申请号：PL05816322

申请日：2005-12-06

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  STOIT AXEL ,  TERPSTRA JAN-WILLEM ,  PRAS-RAVES MARIA L ,  MCCREARY ANDREW C ,  VAN VLIET BERNARD J ,  HESSELINK MAYKE B ,  KRUSE CORNELIS G ,  VAN SCHARRENBURG G J M

IPC: A61K31/423 ,  A61P25/00 ,  C07D263/58

公开(公告)号：HK1120261A1

公开(公告)日：2009-03-27

申请号：HK08112134

申请日：2008-11-06

Applicant: SOLVAY PHARM BV

Inventor： KOOPMAN THEODORUS S M ,  KOSTER HENDRIK J ,  AMSTERDAM PETER H VAN ,  FEENSTRA ROELOF W ,  VERHAGE MARINUS ,  MCCREARY ANDREW C ,  HESSELINK MAYKE B ,  SCHARRENBURG GUSTAAF J M VAN

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

公开(公告)号：PT1824479E

公开(公告)日：2009-01-30

申请号：PT05816322

申请日：2005-12-06

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  STOIT AXEL ,  TERPSTRA JAN-WILLEM ,  PRAS-RAVES MARIA L ,  MCCREARY ANDREW C ,  VLIET BERNARD J VAN ,  HESSELINK MAYKE B ,  KRUSE CORNELIS G ,  SCHARRENBURG GUSTAAF J M VAN

IPC: A61K31/423 ,  A61P25/00 ,  C07D263/58

公开(公告)号：NO20090164L

公开(公告)日：2009-01-14

申请号：NO20090164

申请日：2009-01-12

Applicant: SOLVAY PHARM BV

Inventor： SCHARRENBURG GUSTAAF JOHAN MARIE VAN ,  TULP MARTINUS TH M ,  MCCREARY ANDREW C

IPC: A61K31/496 ,  A61K31/198 ,  A61P25/16

Abstract: The invention concerns the use of a combination preparation of SLV308 or its N-oxide, or pharmacologically acceptable salts of those compounds (I), (II) and L-DOPA, for simultaneous, separate or sequential use in the treatment of disorders requiring recovery of dopaminergic function, in particular Parkinson's disease and restless leg syndrome.

公开(公告)号：HRP20080538T3

公开(公告)日：2008-12-31

申请号：HRP20080538

申请日：2008-10-22

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  STOIT AXEL ,  TERPSTRA JAN-WILLEM ,  PRAS-RAVES MARIA L ,  MCCREARY ANDREW C ,  VLIET BERNARD J VAN ,  HESSELINK MAYKE B ,  KRUSE CORNELIS G ,  SCHARRENBURG GUSTAAF J M VAN

IPC: A61K31/423 ,  A61P25/00 ,  C07D263/58 ,  C07D413/12

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

公开(公告)号：AT413173T

公开(公告)日：2008-11-15

申请号：AT05816322

申请日：2005-12-06

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  STOIT AXEL ,  TERPSTRA JAN-WILLEM ,  PRAS-RAVES MARIA L ,  MCCREARY ANDREW C ,  VAN VLIET BERNARD ,  HESSELINK MAYKE ,  KRUSE CORNELIS ,  VAN SCHARRENBURG G J M

IPC: A61K31/423 ,  A61P25/00 ,  C07D263/58

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

公开(公告)号：ZA200704219B

公开(公告)日：2008-05-28

申请号：ZA200704219

申请日：2007-05-23

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  JAN-WILLEM TERPSTRA ,  MCCREARY ANDREW C ,  HESSELINK MAYKE B ,  VAN SCHARRENBURG GUSTAAF J M ,  AXEL STOIT ,  PRAS-RAVES MARIA L ,  VAN VLIET BERNARD J ,  KRUSE CORNELIS G

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

公开(公告)号：AU2007259256A1

公开(公告)日：2007-12-21

申请号：AU2007259256

申请日：2007-06-15

Applicant: SOLVAY PHARM BV

Inventor： MCCREARY ANDREW C ,  SCHARRENBURG GUSTAAF J M VAN ,  TULP MARTINUS TH M

IPC: A61K31/195 ,  A61K31/496 ,  A61K45/06 ,  A61P25/14 ,  A61P25/16

Abstract: The invention concerns the use of a combination preparation of bifeprunox or its N-oxide, or pharmacologically acceptable salts of those compounds: and L-DOPA, for simultaneous, separate or sequential use in the treatment of disorders requiring recovery of dopaminergic function, in particular Parkinson's disease and restless leg syndrome.

公开(公告)号：NO323781B1

公开(公告)日：2007-07-02

申请号：NO20025902

申请日：2002-12-09

Applicant: SOLVAY PHARM BV

Inventor： SCHARRENBURG GUSTAAF JOHAN MAR ,  FEENSTRA ROELOF W ,  KRUSE CORNELIS GERRIT ,  RONKEN ERIC ,  MCCREARY ANDREW C

IPC: C07D413/12 ,  A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D471/06

Abstract: The invention relates to novel phenylpiperazine derivatives of the formula wherein: -R represents the group (a) or (b) as indicated in the description. These compounds are (partial) D2 receptor agonists and are usefull for treating CNS disorders, in particular Parkinson's disease.