公开(公告)号：USRE25937E

公开(公告)日：1965-12-07

申请号：US25937D

IPC: C07D201/10

CPC classification number: C07D201/10

公开(公告)号：US09624242B2

公开(公告)日：2017-04-18

申请号：US14621726

申请日：2015-02-13

Applicant: CTI BIOPHARMA CORP.

Inventor： Brian Dymock ,  Cheng Hsia Angeline Lee ,  Anthony Deodaunia William

IPC: C07D498/08 ,  C07C55/22 ,  C07D201/10 ,  C07D498/04

CPC classification number: C07D498/08 ,  C07B2200/13 ,  C07C55/22 ,  C07D201/10 ,  C07D498/04

Abstract: The present invention relates to certain salts of a 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (Compound I) which have been found to have improved properties. In particular the present invention relates to the citrate salt of this compound. The invention also relates to pharmaceutical compositions containing the citrate salt and methods of use of the citrate salt in the treatment of certain medical conditions.

公开(公告)号：US4349473A

公开(公告)日：1982-09-14

申请号：US199218

申请日：1980-10-21

Applicant: Pier P. Rossi ,  Mario Catoni

Inventor： Pier P. Rossi ,  Mario Catoni

IPC: C07D201/16 ,  B01J19/18 ,  C07D201/08 ,  C07D201/10

CPC classification number: C07D201/10 ,  B01J19/1862 ,  C07D201/08 ,  B01J2219/00058 ,  B01J2219/00094 ,  B01J2219/00128

Abstract: Process for the preparation of .omega.-lactams (in particular caprolactam)ith improved yields, by reaction of cycloaliphatic derivatives having the general formula: ##STR1## wherein n=3-13 with nitrosating agents in the presence of dehydrating agents, characterized by the fact that the reaction is carried out a low temperature which is constant between stages, and in all the zones of a stage and with particular concentrations of the dehydrating agent.

Abstract translation: 通过在脱水剂存在下，通过使具有以下通式的脂环族衍生物（其中n = 3-13）与亚硝化剂反应制备具有改善产率的ω-内酰胺（特别是己内酰胺）的方法，其特征在于： 反应进行阶段之间恒定的低温，在一个阶段的所有区域和特定浓度的脱水剂中进行。

公开(公告)号：US3816404A

公开(公告)日：1974-06-11

申请号：US20619771

申请日：1971-12-08

Applicant: TEXACO INC

Inventor： KABLAOUI M ,  LOVE R ,  DURANLEAU R

IPC: C07C205/51 ,  C07D201/02 ,  C07D201/10 ,  C07D41/06

CPC classification number: C07D201/02 ,  C07C201/12 ,  C07C201/14 ,  C07D201/10 ,  Y02P20/582 ,  C07C205/45 ,  C07C205/51

Abstract: A METHOD FOR PREPARING CAPROLACTAM BY THE STEPS OF (1) NITRO-OXIDIZING CYCLOHEXENE TO 2-NITROCYCOLHEXANONE, (2) CLEAVING AND ESTERIFYING 2-NITROCYCLOHEXANONE WITH AN ALCOHOL TO FORM AN ALKYL 6-NITROHEXANOATE AND (3) CATALYTICALLY HYDROGENATING AND CYCLIZING THE NITROESTER TO CAPROLACTAM.

公开(公告)号：US3733317A

公开(公告)日：1973-05-15

申请号：US3733317D

申请日：1970-06-30

Applicant: SNIA VISCOSA

Inventor： GIUFFRE L ,  SIOLI G

IPC: C07D201/10 ,  C07D41/06

CPC classification number: C07D201/10

Abstract: THERE IS DESCRIBED A PROCESS FOR THE PREPARATION OF OMEGA-LACTAMS HAVING THE GENERAL FORMULA:

O=C
WHEREIN N= FROM 2 TO 13, AND/OR OF THEIR LACTAMIZABLE PRECURSORS, WHICH MAY BE CYCLOALIPHATIC OXIMES OR CYCLOALIPHATIC NITROSO DERIVATIVES, MONOMERS OR DIMERS CHARACTERIZED BY THE FACT THAT THE CORRESPONDING CYCLOMETHYLENE KETENE, HAVING THE GENERAL FORMULA

O=C=C
WHERE N HAS THE AFOREMENTIONED VALUE, IS SUBJECTED TO NITROSATION WITH A NITROSATING AGENT OF THE FORMULLA NOX, WHERE X CAN BE -HSOBJ4, -CL, -NO2, -OR (IN WHICH R INDICATES AN ALKYL OR ARYL ORGANIC SUBSTITUENT), AT A TEMPERATURE COMPRISED BETWEEN -60*C. AND + 100*C.

公开(公告)号：US3541080A

公开(公告)日：1970-11-17

申请号：US3541080D

申请日：1967-07-24

Applicant: TORAY INDUSTRIES

Inventor： WAKAMATSU SHIGERU ,  KONDO RYOZO ,  SHINOMIYA MASAYASU ,  OKAMOTO MASARU

IPC: B23K9/12 ,  C07D201/04 ,  C07D201/10 ,  C07D41/06

CPC classification number: C07D201/10 ,  B23K9/125 ,  C07D201/04

公开(公告)号：US3265685A

公开(公告)日：1966-08-09

申请号：US32128663

申请日：1963-11-04

Applicant: INVENTA AG

Inventor： HANS-JOACHIM SCHULTZE ,  JOHANN GIESEN ,  CLAU BERTHER

IPC: C07D201/10

CPC classification number: C07D201/10

公开(公告)号：US2719116A

公开(公告)日：1955-09-27

申请号：US41749054

申请日：1954-03-19

Applicant: OLIN MATHIESON

Inventor： BROWN BERNARD B

IPC: C07D201/10

CPC classification number: C07D201/10 ,  Y10S204/903 ,  Y10S204/912

公开(公告)号：KR101729918B1

公开(公告)日：2017-04-25

申请号：KR1020117015738

申请日：2009-12-09

Applicant: 씨티아이 바이오파마 코포레이션

Inventor： 다이막크,브라이언 ,  리,쳉샤엔젤린 ,  윌리엄,안토니디오다우니아

IPC: C07D498/04 ,  A61K31/519

CPC classification number: C07D498/08 ,  C07B2200/13 ,  C07C55/22 ,  C07D201/10 ,  C07D498/04

Abstract: 본발명은향상된특성을갖는것으로발견된 11-(2-피롤리딘-1-일-에톡시)-14,19-디옥사-5,7,26-트리아자-테트라사이클로[19.3.1.1(2,6).1(8,12)]헵타코사-1(25),2(26),3,5,8,10,12(27),16,21,23-데카엔{11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene}의특정염(화학식 1)에관한것이다. 특히본 발명은이 화합물의시트르산염에관한것이다. 또한, 본발명은상기시트르산염을포함하는약학적조성물및 특정의학적질병의치료에서상기시트르산염의사용방법에관한것이다. [화학식 1]

公开(公告)号：KR1020000062223A

公开(公告)日：2000-10-25

申请号：KR1019990060171

申请日：1999-12-22

Applicant: 프랙스에어 테크놀로지, 인코포레이티드

Inventor： 에체가레이,디에고페르난데스 ,  벨로소,안토니오오구스토엠. ,  와그너,매튜링컨

IPC: C07D227/087

CPC classification number: C07D201/06 ,  C07D201/10

Abstract: 본발명은 (a) 산화질소를제조하기위해암모니아변환영역내의암모니아가스와공기를반응시키는단계와, (b) NO-부화공정가스스트림을발생시키도록산화질소의일부분을이산화질소로산화시키는단계와, (c) 질산암모늄을제조하기위해 NO-부화스트림을아질산염영역내의탄산암모늄과반응시키는단계와, (d) 질산암모늄을히드록실아민디암모늄설페이트로환원시키는단계와, (e) 히드록실아민디암모늄설페이트를히드록실아민설페이트로가수분해시키는단계와, (f) 시클로헥산온옥심을발생시키기위해히드록실아민설페이트를시클로헥산온으로옥심화시키는단계와, 그리고 (g) 시클로헥산온옥심을카프로락탐으로변환시키는단계를포함하는종래의카프로락탐의제조방법을개선한것으로서, NO-부화공정가스스트림내의이산화질소의형성량 및속도를증가시키기위해암모니아변환영역의하류에보충산소를부가함으로써개선된다.