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公开(公告)号:US12247029B2
公开(公告)日:2025-03-11
申请号:US16972501
申请日:2019-06-07
Applicant: Forschungsverbund Berlin e.V.
Inventor: Wen-Ting Lo , Hassane Belabed , Volker Haucke , Marc Nazare , Murat Kucukdisli
IPC: C07D487/04 , C07D519/00
Abstract: Compounds of the following formula: having defined substituents. The compounds can inhibit class II phosphoinositide 3-kinase (PI3K) signaling and are useful for the treatment of a medical condition associated with defective PI3K signaling, such as myopathy, cancer, diabetes, thrombosis or cardiovascular disease.
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公开(公告)号:US11746124B2
公开(公告)日:2023-09-05
申请号:US17460791
申请日:2021-08-30
Inventor: Christian Hackenberger , Marc André Kasper , Maria Glanz , Tom Sauer , Dominik Schumacher , Jonas Helma-Smets , Heinrich Leonhardt , Andreas Stengl
CPC classification number: C07K1/1077 , A61K38/07 , A61K47/64 , A61K47/6803 , A61K47/6849 , A61K47/6855 , A61K47/6889 , C07F9/448 , C07F9/4461 , C07F9/4473
Abstract: Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of
(I) reacting a compound of formula (III)
with an azide of formula (IV)
to prepare a compound of formula (V)
(II) reacting a compound of formula (V) with a thiol-containing molecule of formula (VI)
resulting in a compound of formula (VII)-
公开(公告)号:US11591712B2
公开(公告)日:2023-02-28
申请号:US16424987
申请日:2019-05-29
Applicant: Forschungsverbund Berlin e.V. , Cornell University
Inventor: Christo Guguschev , Mario Brutzam , Darrell Schlom , Hanjong Paik
Abstract: The invention relates to a method for growing a bulk single crystal, wherein the method comprises the steps of inserting a starting material into a crucible, melting the starting material in the crucible by heating the starting material, arranging a thermal insulation lid at a distance above a melt surface of said melt such that at least a central part of the melt surface is covered by the lid, and growing the bulk single crystal from the melt by controllably cooling the melt with the thermal insulation lid arranged above the melt surface.
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公开(公告)号:US11152760B2
公开(公告)日:2021-10-19
申请号:US16469484
申请日:2017-12-05
Applicant: Forschungsverbund Berlin e.V.
Inventor: Oliver Brandt , Lutz Geelhaar , Ivano Giuntoni
IPC: H01S5/0625 , H01S5/12 , H01S5/187 , H01S5/042 , H01S5/34 , H01S5/11 , H01S5/02 , H01S5/04 , H01S5/10
Abstract: A light emitter device (100) comprises a substrate (10) and a photonic crystal (20), which is arranged on the substrate (10) and comprises pillar- and/or wall-shaped semiconductor elements (21), which are arranged periodically standing out from the substrate (10), wherein the photonic crystal (20) forms a resonator, in which the semiconductor elements (21) are arranged in a first resonator section (22) with a first period (d1), in a second resonator section (23) with a second period (d2) and in a third resonator section (24) with a third period (d3), wherein on the substrate (10) the second resonator section (23) and the third resonator section (24) are arranged on two mutually opposing sides of the first resonator section (22) and the second period (d2) and the third period (d3) differ from the first period (d1), the first resonator section (22) forms a light-emitting medium and the third resonator section (24) forms a coupling-out region, through which a part of the light field in the first resonator section (22) can be coupled out of the resonator in a light outcoupling direction parallel to a substrate surface (11) of the substrate (10). Methods for operating and producing the light emitter device (100) are also described.
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公开(公告)号:US11127863B2
公开(公告)日:2021-09-21
申请号:US16462650
申请日:2017-11-20
Applicant: FORSCHUNGSVERBUND BERLIN E.V.
Inventor: Konstantin Osipov , Richard Lossy , Hans-Joachim Würfl
IPC: H01L29/812 , H01L29/66
Abstract: This invention concerns a gate structure and a process for its manufacturing. In particular, the present invention concerns the gate structuring of a field effect transistor with reduced thermo-mechanical stress and increased reliability (lower electromigration or diffusion of the gate metal). The gate structure according to the invention comprises a substrate; an active layer disposed on the substrate; an intermediate layer disposed on the active layer, the intermediate layer-having a recess extending through the entire intermediate layer towards the active layer; and a contact element which is arranged within the recess, the contact element completely filling the recess and extending to above the intermediate layer, the contact element resting at least in sections directly on the intermediate layer; the contact element being made of a Schottky metal and the contact element having an interior cavity completely enclosed by the Schottky metal.
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公开(公告)号:US11028084B2
公开(公告)日:2021-06-08
申请号:US16349580
申请日:2017-11-14
Applicant: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft , Forschungsverbund Berlin e.V.
Inventor: Claus Scheidereit , Michael Willenbrock , Peter Lindemann , Silke Radetzki , Jens-Peter Von Kries , Marc Nazare
IPC: C07D471/04 , A61P35/00 , C07D209/56 , C07D221/06 , C07D471/14 , C07D487/04 , C07D471/16
Abstract: A method is for treatment of a disease associated with genotoxic stress-induced inhibitor of nuclear factor-κB kinase/nuclear factor kappa-light chain enhancer of activated B cells (IKK/NF-κB) signaling. The method can include administering a compound to a subject having a cancer exhibiting genotoxic stress induced IKK/NF-κB activation.
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公开(公告)号:US10344053B2
公开(公告)日:2019-07-09
申请号:US15535002
申请日:2015-12-11
Applicant: Forschungsverbund Berlin e.V. , Universität zu Köln
Inventor: Ronald Kühne , Hans-Günther Schmalz , Matthias Müller , Cedric Reuter , Arne Soicke , Robert Opitz , Matthias Barone , Hartmut Oschkinat
IPC: A61K31/55 , C07D471/10 , C07K7/06 , C07D519/00 , A61K38/00
Abstract: The present invention relates to chemical compounds that can in particular be used as structural mimetics of proline-rich peptides. The compounds of the present invention are capable of selectively inhibiting ena/VASP-EVH1-mediated protein-protein interactions. The invention further relates to the use of said compounds as pharmaceutical agents and to the use of the pharmaceutical agents to treat tumor diseases. The chemical compounds of the present invention can significantly inhibit the chemotaxis and motility of invasive tumor cells and can therefore be used in the treatment and/or prevention of tumor metastases.
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公开(公告)号:US20180145481A1
公开(公告)日:2018-05-24
申请号:US15736631
申请日:2016-03-09
Applicant: FORSCHUNGSVERBUND BERLIN E.V.
Inventor: Jörg FRICKE , Götz ERBERT , Paul CRUMP , Jonathan DECKER
CPC classification number: H01S5/1225 , H01S5/026 , H01S5/1221 , H01S5/1231 , H01S5/2086
Abstract: Laser diode comprises an active layer; a waveguiding region at least partially surrounding the active layer; a rear facet; a front facet designed for decoupling laser radiation, wherein the active layer extends at least partially along a first axis (X) between the rear facet and the front facet; and a grid operatively connected to the waveguiding region, wherein the grid comprises a plurality of webs and trenches designed such that an average increase of a coupling parameter P for the plurality of trenches along the grid is non-zero, wherein the coupling parameter P of a trench is defined by the formula, wherein dres is a distance of the trench to the active layer, w is a width of the trench and Δn is the refractive index difference between a refractive index of the trench and a refractive index of a material surrounding the trench.
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59.
公开(公告)号:US20160093475A1
公开(公告)日:2016-03-31
申请号:US14962680
申请日:2015-12-08
Applicant: Forschungsverbund Berlin E.V.
Inventor: Roland GESCHE
IPC: H01J37/32
CPC classification number: H01J37/32293 , H01J37/3222 , H01J2237/327 , H05H1/46 , H05H1/48
Abstract: A method and apparatus generates pulses that can be used for high-precision three-dimensional plasma treatment. At least two sources are furnished with at least one time function, wherein each of the at least two sources radiates an electromagnetic field generated by one of the time functions, and the at least one time function. In a method, the at least two sources cooperate in such a manner that at least one predetermined field strength is realized sequentially in a temporal succession in at least two predetermined space-time points. An alternative method uses at least one source and at least one reflection element. An apparatus with at least two sources and at least one data processing device or at least one source, at least one reflection element and at least one data processing device is configured such that one of the methods can be executed.
Abstract translation: 一种方法和装置产生可用于高精度三维等离子体处理的脉冲。 至少两个源具有至少一个时间功能,其中至少两个源中的每一个辐射由时间函数之一产生的电磁场和至少一个时间函数。 在一种方法中,所述至少两个源以这样的方式协作,使得至少一个预定的场强在至少两个预定的时空点中以时间依次顺序地实现。 替代方法使用至少一个源和至少一个反射元件。 具有至少两个源和至少一个数据处理设备或至少一个源,至少一个反射元件和至少一个数据处理设备的设备被配置为使得可以执行其中一个方法。
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公开(公告)号:US09296729B2
公开(公告)日:2016-03-29
申请号:US14243821
申请日:2014-04-02
Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services , Forschungsverbund Berlin E.V.
Inventor: Marvin C. Gershengorn , Susanne Neumann , Bruce M. Raaka , Craig J. Thomas , James Inglese , Noel T. Southall , Steven Titus , Wenwei Huang , Gerd Krause , Gunnar Kleinau , Wei Zheng
IPC: C07D405/06 , C07D239/91 , A61K49/00 , A61K51/00 , C07D401/06 , C07D405/14 , C07D487/04 , A61K31/517
CPC classification number: C07D405/06 , A61K31/517 , A61K49/0004 , A61K51/00 , C07D239/91 , C07D401/06 , C07D405/14 , C07D487/04
Abstract: Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
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