Abstract:
Disclosed herein methods for the Laser-assisted Explosion Synthesis and simultaneous Transfer (LEST) of few-layer turbostratic graphene and graphene-based nanohybrids onto any substrate. Industrially scalable laser-assisted methods of fabricating turbostratic graphene by irradiating carbon-containing compounds (e.g. polymers, organic compounds, biomass-derived products, graphitic materials and their combinations). Laser-assisted methods for preparation of turbostratic graphene/inorganic nanoparticles hybrids. The disclosed processes are versatile as they operate at ambient (atmospheric) environment and through single lasing irradiation at the cm-scale spot size. LEST is capable of producing, and simultaneously transferring, turbostratic graphene on any substrate, such as polymer, glass, carbon paper, metal, ceramic, and so on, avoiding intermediate transfer steps and chemical treatment. In some embodiments LEST graphene has been used to prepare high- performance electrodes for triboelectric nanogenerators and supercapacitors. The resulting turbostratic graphene and graphene-based nanohybrids can be used, inter alia, as electrodes in energy conversion and storage devices, in flexible electronic devices, sensors, filters, photocatalytic reactors, etc.
Abstract:
Method and apparatus for performing a real-time colorimetric nucleic acid amplification assay wherein the heating of the liquid sample comprised in a reaction tube is carried out by bringing the bottom of the tube in thermal contact with a heating element. The real-time monitoring of the content of the reaction tube is carried out visually through the side wall of the tube, preferably by using a camera.
Abstract:
2,6-bis(((lH-benzo[d]imidazol-2-yl)thio)methyl)pyridine and N2, N6-dibenzylpyridine-2, 6-dicarboxamide derivatives and related compounds as phosphoinositide 3-kinase (PI3K) inhibitors for treating cancer. The present invention relates to pharmaceutically active 2,6- bis(((lH-benzo[d]imidazol-2-yl)thio)methyl)pyridine, N2,N6- dibenzylpyridine-2, 6-dicarboxamide and N2,N6-bis(3-hydroxyphenyl) pyridine-2, 6-dicarboxamide, as well as to derivatives thereof, and to structurally related compounds. These compounds are phosphoinositide 3-kinase inhibitors (PI3K) and useful in treating or preventing cancerous diseases. The invention further relates methods of manufacturing such compounds as well as to pharmaceutical compositions and formulations comprising such compounds, optionally together with other pharmaceutically active compounds. The invention further relates to a method for determining the activity of PI3Kalpha or PI3Kalpha mutants, which method includes: a) providing a solid phase which is functionalized by immobilization of GST-GRPl-molecules onto the solid phase, b) performing a PI3Kalpha or PI3Kalpha mutant catalyzed enzyme reaction to convert PIP2 to PIP3, c) adding competitor PIP3 carrying a detectable label or reporter molecule, and d) determining enzyme activity based on the amount of PIP3 obtained in step b) which competes with competitor PIP3 for binding to the functionalized solid phase.
Abstract:
A method for producing a neutral beam of spin polarized Hydrogen isotopes by photodissociating compound molecules is provided. Each compound molecule comprises a Hydrogen isotope and a second element. A molecular beam is generated by passing the compound molecules through a nozzle. The molecular beam is introduced into a photodissociation chamber. The molecular beam is photodissociated into spin polarized Hydrogen isotopes and second elements by intersecting the molecular beam with a circularly polarized photolysis laser beam. The spin polarized Hydrogen isotopes are guided, accelerated,and neutralized.A photodissociation system for producing a neutral beam of spin polarized Hydrogen isotopes by photodissociating compound molecules and a nuclear reactor system are also provided.
Abstract:
Device and methods to restore fissured areas of vitreous surfaces are disclosed. A laser beam is generated by a laser source. A controller controls the direction of the laser beam and shapes the spot-size of the laser beam according to sizes of the fissured areas. The laser beam is directed to the fissured areas to melt the vitreous surfaces around the fissured areas and fuse the melted vitreous surfaces in the fissured areas. The proposed methods may be used for amending/restoring existing surface pathologies on vitreous surfaces, such as glasses and glazes, which may be attached to non-vitreous substrates, such as ceramics or other support materials.
Abstract:
A storage system for organizing and maintaining metadata in a distributed network. The system includes: a network; a plurality of distributed nodes configured to communicate through the network; a plurality of block devices configured to communicate with the plurality of distributed nodes through the network; and a management server configured to communicate with each of the plurality of distributed nodes and block devices and further configured to arbitrarily associate metadata and data to any of the plurality of distributed nodes such that a global copy of the metadata does not exist in one or more fixed locations known to all distributed nodes.
Abstract:
The invention proposes a manufacturing method for enhancement of the luminosity of SiC-based LED devices using double exposure of the light-emitting surface of a LED device or LED component or SiC wafer to linearly polarized radiation of a femtosecond laser beam of a proper fluence. The first exposure results in the formation of a pattern of parallel periodic grooves onto SiC surface. Then the LED device, or LED component, or SiC wafer is rotated by 90 degrees and subsequently irradiated for a second time. The double exposure results in the formation of an array of regular depressions and nanogrooves onto SiC surface. These depressions act as an anti- reflecting coating due to smooth variation of the refractive index from its value in the crystal to air and lead to the increase of internal quantum efficiency of LED. The manufacturing method can be performed during the LED device fabrication or as a pre- or post- fabrication step. The manufacturing process can be performed in air or after immersion of a LED device, or LED component, or SiC wafer in liquid.
Abstract:
The present invention relates to a catalyst comprising (a) a polymer, which has a weight-average molecular weight in the range of from 1000 g/mol –100000 g/mol and which polymer comprises 50 wt-% -99.9 wt-% ofunits derived from one or more non-functionalized monomeric units A, 0.1 wt-% -50 wt-% of units derived from one or more monomeric units B, 0wt-% - 30 wt-% of units derived from one or more cross-linking monomeric units C; wherein monomeric units A are selected from (meth) acrylates and monomers co-polymerizable with (meth) acrylates; wherein monomeric units B are selected from hydroxyl-functionalized (meth) acrylates and monomers copolymerizable with (meth) acrylates,which are esterified with one or more suitable precursors of phosphorousand/or nitrogen containing uncharged electron donors as coordinative groups; and wherein cross-linking monomeric units C are selected from compounds which compriseat least two olefinically unsaturated double bondsco-polymerizable with A and/or B, and (b) a catalytically-active metal compound that is bound to one or more phosphorous and/or nitrogen containing uncharged electron donors of said polymer. Furthermore, the invention relates to corresponding polymers to afore-mentioned catalyst, a process for producing the catalyst and the polymer as well as the use of the catalyst in homogeneous and/or heterogeneous catalysis.
Abstract:
A method for managing data and corresponding computer program are provided. The method includes providing a plurality of buckets, each associated with a corresponding scope of similarity metric, processing a first data container of a plurality of data containers to determine a corresponding similarity metric, comparing the similarity metric of the first data container with the scope of similarity metric of the plurality of buckets, assigning, if the similarity metric of the first data container matches the scope of similarity metric of any of the plurality of buckets and the corresponding bucket has sufficient available space, the first data container with the corresponding one of the plurality of buckets, creating, if either the similarity metric of the first data container does not match the scope of similarity metric of any of the plurality of buckets or a match is present but any of the corresponding buckets do not have sufficient available space, a new bucket for the plurality of buckets, and subsequently associating the first data container with the bucket; and compressing as a unit, when at least one condition is met, any of the plurality of data containers assigned by the assigning to a particular one of the plurality of buckets.
Abstract:
A computer readable storage medium includes executable instructions to construct a delay element to replicate the timing of critical gates and paths within a segment of an asynchronous circuit. The rise and fall delay mismatch of the delay element is minimized without obeying timing constraints. The position of each output of the delay element is determined to include a globally shared node within the segment and a non-shared local node in the segment.