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    MEASUREMENT OF ANALYTE WITH AN ACOUSTIC WAVE SENSOR
    1.
    发明申请
    MEASUREMENT OF ANALYTE WITH AN ACOUSTIC WAVE SENSOR 审中-公开
    用声波传感器测量分析仪

    公开(公告)号：WO2017005663A1

    公开(公告)日：2017-01-12

    申请号：PCT/EP2016/065612

    申请日：2016-07-01

    Applicant: FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS

    Inventor： PAPADAKIS, George ,  GIZELI, Electra

    IPC: G01N29/02 ,  G01N29/032 ,  C12Q1/68 ,  G01N29/036 ,  G01N33/543

    CPC classification number: G01N29/022 ,  C12Q1/6825 ,  C12Q2565/634 ,  G01N29/032 ,  G01N29/036 ,  G01N33/54373 ,  G01N33/586 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0257 ,  G01N2291/0426 ,  C12Q2525/197

    Abstract: A sensitive assay for an analyte employing an acoustic wave sensor. A label which has a higher dissipative capacity than the analyte is adhered to the sensing surface of an acoustic wave sensor through the analyte such that the body of the label is spaced apart from and anchored to the surface of the acoustic wave sensor by a distance of 15 to 250nm. The change in the energy losses or the frequency or phase of the acoustic wave when the label binds to the sensing surface is used to measure the presence or amount of the label. A substantial improvement in the detection limit of the label is obtained. The analyte may for example be a nucleic acid and the label may for example comprise liposomes.

    Abstract translation: 使用声波传感器的分析物的敏感测定。 具有比分析物更高的耗散能力的标签通过分析物粘附到声波传感器的感测表面，使得标签的主体与声波传感器的表面间隔开并锚定在声波传感器的表面上 15至250nm。 当标签与感测表面结合时，能量损失或声波频率或相位的变化用于测量标签的存在或数量。 获得标签检测限的实质性改进。 分析物可以例如是核酸，并且标记可以例如包括脂质体。

    MOLECULAR CONFORMATION BIOSENSING
    2.
    发明申请
    MOLECULAR CONFORMATION BIOSENSING 审中-公开

    公开(公告)号：WO2008155692A3

    公开(公告)日：2008-12-24

    申请号：PCT/IB2008/052323

    申请日：2008-06-12

    Applicant: FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS ,  TSORTOS, Achilleas ,  PAPADAKIS, Georgios ,  GIZELI, Electra

    Inventor： TSORTOS, Achilleas ,  PAPADAKIS, Georgios ,  GIZELI, Electra

    IPC: C12Q1/68 ,  G01N29/00 ,  G01N33/00

    Abstract: Disclosed is a method of investigating the conformation of biomolecules or changes in the conformation of biomolecules as a result of an interaction, in which biomolecules from a sample of biomolecules are adhered discretely to the sensing surface of an acoustic wave sensor operating in a liquid, and a conformation parameter which is related to the conformation of the biomolecules from the said sample which are adhered discretely to the sensing surface, but substantially independent of the resulting change in mass loading of the sensing surface, is calculated from the resulting change in the output signals of the acoustic wave sensor. The conformation parameter may the acoustic ratio or a parameter which is directly related to the acoustic ratio. There is also disclosed a method of investigating changes in the conformation of biomolecules which are adhered discretely to the sensing surface of an acoustic wave sensor operating in a liquid, in response to an interaction with an agent, by calculating a conformation parameter which is related to the change in conformation of biomolecules adhered discretely to the sensing surface as a result of an interaction with the agent, but which is substantially independent of any resulting change in mass loading of the sensing surface.

    MOLECULAR CONFORMATION BIOSENSING
    8.
    发明公开
    MOLECULAR CONFORMATION BIOSENSING 有权
    生物传感器分子构象

    公开(公告)号：EP2171083A2

    公开(公告)日：2010-04-07

    申请号：EP08763311.1

    申请日：2008-06-12

    Applicant: Foundation For Research And Technology Hellas

    Inventor： TSORTOS, Achilleas ,  PAPADAKIS, Georgios ,  GIZELI, Electra

    IPC: C12Q1/68 ,  G01N29/00 ,  G01N33/00

    CPC classification number: G01N33/54373 ,  C12Q1/6811 ,  G01N29/022 ,  G01N29/4427 ,  G01N2291/014 ,  G01N2291/015 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2500/00 ,  C12Q2565/634

    Abstract: Disclosed is a method of investigating the conformation of biomolecules or changes in the conformation of biomolecules as a result of an interaction, in which biomolecules from a sample of biomolecules are adhered discretely to the sensing surface of an acoustic wave sensor operating in a liquid, and a conformation parameter which is related to the conformation of the biomolecules from the said sample which are adhered discretely to the sensing surface, but substantially independent of the resulting change in mass loading of the sensing surface, is calculated from the resulting change in the output signals of the acoustic wave sensor. The conformation parameter may the acoustic ratio or a parameter which is directly related to the acoustic ratio. There is also disclosed a method of investigating changes in the conformation of biomolecules which are adhered discretely to the sensing surface of an acoustic wave sensor operating in a liquid, in response to an interaction with an agent, by calculating a conformation parameter which is related to the change in conformation of biomolecules adhered discretely to the sensing surface as a result of an interaction with the agent, but which is substantially independent of any resulting change in mass loading of the sensing surface.

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