公开(公告)号：EP0449900A1

公开(公告)日：1991-10-09

申请号：EP90900766.0

申请日：1989-12-21

Applicant: RADIOMETER A/S

Inventor： LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

IPC: G01N33 ,  G01N21 ,  G01N35

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: On fait passer l'échantillon de sang directement d'un emplacement in vivo à un récipient d'échantillon au moins partiellement transparent, puis on coupe la communication entre le récipient d'échantillon contenant l'échantillon et l'appareil circulatoire. On met ensuite le récipient d'échantillon contenant l'échantillon de sang en communication optique avec un système optique, qui comprend une source de radiation coopérant avec un détecteur de radiation, de préférence en plaçant le récipient d'échantillon dans un système de récipient d'échantillon à l'intérieur d'un analyseur. On détermine le paramètre gazeux du sang sur la base de la radiation détectée par le détecteur de radiation. Est également décrit un système pour déterminer par photométrie in vitro un paramètre gazeux dans un échantillon de sang.

公开(公告)号：EP0389545A1

公开(公告)日：1990-10-03

申请号：EP89900194.0

申请日：1988-11-24

Applicant: RADIOMETER A/S

Inventor： PETERSSON, Bo, Arne

IPC: C12Q1

CPC classification number: C12Q1/006 ,  C12Q1/005 ,  C12Q1/58

Abstract: Le procédé et l'appareil décrit servent à l'analyse chimique d'échantillons à matrice variable. Les échantillons sont transportés en série par un fluide porteur. En un point au moins est amené un élément fluide dont la composition chimique est maintenue sensiblement constante à la suite de l'exposition de l'élément fluide au fluide porteur avant et après l'exposition de l'élément fluide à chaque échantillon.

公开(公告)号：EP0077073B1

公开(公告)日：1989-08-09

申请号：EP82109436.4

申请日：1982-10-12

Applicant: RADIOMETER A/S

Inventor： Baumbach, Per Lennart ,  Poulsen, Jorgen

IPC: A61B5/00

CPC classification number: G01K1/16 ,  A61B5/14542 ,  A61B5/1477 ,  A61B5/1491 ,  G01K1/165 ,  G01K1/20

公开(公告)号：EP0210417A1

公开(公告)日：1987-02-04

申请号：EP86108426.7

申请日：1986-06-20

Applicant: RADIOMETER A/S

Inventor： Lundsgaard, Finn Chresten

IPC: G01N21/31

CPC classification number: G01N21/31 ,  G01N2021/3129 ,  Y10T436/113332

Abstract: Method and apparatus for spectrophotometrically determining the concentration of a number of hemoglobin derivatives comprising at least deoxyhemoglobin and oxyhemoglobin or parameters derived from the concentration of individual hemoglobin derivatives, in particular the oxygen saturation fraction, in whole blood, in which light is transmitted to the blood undertest, the modification on the lig httrans- mitted to the blood which the blood causes is determined at a number of individual wavelengths, and the concentrations (or the derived parameters) are determined on the basis of the light modification at the individual wavelengths and on the basis of predetermined coefficients representing the light absorption characteristics of each of the hemoglobin derivatives at each of the individual wavelengths, any error on the determination values due to turbidity being substantially compensated for by utilizing predetermined coefficients representing an absorption characteristic of turbidity at each of the wavelengths. The measurement is normally performed at a number of wavelengths which is at least equal to the number of hemoglobin derivatives to be determined plus one. Although the turbidity-caused contribution to the total reduction in the light transmission is not based on any direct proportionality between the reduction in light transmission and the concentration of the turbidity-causing components (such as is the case with the hemoglobin derivatives), the "absorbances" caused by the turbidity at each particular wavelength may simply be eliminated from the equation set from which the concentrations of the hemoglobin derivatives are calculated.

公开(公告)号：EP0061190B1

公开(公告)日：1986-09-03

申请号：EP82102365.2

申请日：1982-03-22

Applicant: RADIOMETER A/S

Inventor： Jensen, Ole Jörgen ,  Melberg, Steen Gyldendaal

IPC: A61B5/00 ,  G01N27/28

CPC classification number: A61B5/14539 ,  A61B5/1491

公开(公告)号：EP0127148A1

公开(公告)日：1984-12-05

申请号：EP84105955.3

申请日：1984-05-24

Applicant: RADIOMETER A/S

Inventor： Klitgaard, Peter Christian ,  Pedersen, Knud Gronlund

IPC: G01N27/416 ,  A61B5/00

CPC classification number: A61B5/1477 ,  A61B5/04004 ,  A61B5/0448 ,  A61B5/14542 ,  A61B5/4362 ,  A61B2562/0215 ,  A61B2562/0217

Abstract: An electrode assemblyfortranscutaneously measuring a blood gas parameter and for measuring a bioelectrical signal comprises two separate electrode devices (10, 40), one of which (10) further comprises an electrochemical measuring electrode system. The electrochemical measuring electrode system comprises a reference electrode of a potentiometric electrode system and an anode of a polarographic electrode system constituted by a single metallic body (13), a pH-electrode (31,32) of the potentiometric electrode system, and a noble metal cathode (33 34) of the polarographic electrode system. The biolectrical signal sensing electrode of the electrode device (10) is further constituted by the metallic body (13). A first part of the metallic body (13) is covered by an electrolyte solution (28) which communicates electrolytically therewith and further with the pH-glass electrode and the noble metal cathode, and a second part of which is not covered by the electrolyte solution but adapted to electrically conductively communicate with a skin surface part of a test person or a patient through an electrically conductive contact liquid (19). The membrane separates the first and the second part of the metallic body from one another. The second electrode (40) comprises a bioelectrical signal sensing electrode (41), which is adapted to electrically conductively communicate with a skin surface part of a test person or patient through an electrically conductive contact liquid (20). By means of the electrode assembly coincident measuring results of the blood gas partial pressures of oxygen and carbon dioxide and of a bioelectrical signal such as the ECG (Electrocardiography), the RR (Respiration rate) or the heart rate of the test person or patient is obtainable (Fig. 3).

Abstract translation: 单独的电极组件，用于经皮测量血液气体参数和用于测量生物电信号由两个电极装置（10，40），其中一个（10）电化学测量电极系统进一步包括。电化学测量电极系统包括一个参考电极 一个电位电极系统和由单个金属体（13），所述电位电极系统的pH电极（31，32），和极谱的贵金属阴极（33 34）构成的极谱电极系统的阳极 电极系统。该电极装置（10）的biolectrical信号感测电极是由另外的金属本体（13）构成。 金属体（13）的第一部分是通过在电解质溶液（28）有连通电解那里与并进一步用pH玻璃电极和贵金属阴极，并且其不包括在电解质溶液中的所有的第二部分覆盖 但angepasst到导电与测试人的皮肤表面部分或通过在导电接触液体（19）的患者进行通信。 膜分离第一和金属体的彼此的第二部分。 所述第二电极（40）包括一个生物电信号的感测电极（41），所有这些是angepasst到导电与测试人或患者的皮肤表面部分通过在导电的接触液体（20）进行通信。 ... 由电极组件重合测量氧气和二氧化碳的和生物电信号的血液气体分压的结果的方式：如ECG（心电图），则RR（呼吸率）或的的心脏速率 测试者或病人得到A.

公开(公告)号：EP0049509A3

公开(公告)日：1984-09-26

申请号：EP81107938

申请日：1981-10-05

Applicant: RADIOMETER A/S

Inventor： Lundsgaard, Finn Chresten ,  Andersen, Willy

IPC: G01N33/48 ,  G01N37/00

CPC classification number: G01N35/00

Abstract: An apparatus for analyzing biological liquids comprises a measuring block (10) including measuring means (11- 13) for measuring characteristics of said liquids. The measuring block is mounted within a thermal shield or housing (19) by means of a base member (21) interconnecting a minor part of the inner wall of the housing and the measuring block so as to define a space between the inner walls of the housing and the measuring block, said space being filled with air or another medium having a poor thermal conductivity. The thermal shield or housing (19) and the base member (21) are made of a material with good thermal conductivity, and heating and/or cooling means (25) are arranged in heat conductive contact with the said shield. The function of the heating and or cooling means is controlled by a temperature sensor (26) arranged in heat conductive contact with the measuring block (19), so as to maintain the temperature of said block at a substantially constant predetermined value.

Abstract translation: 用于分析生物液体的装置包括测量块，其包括用于测量所述液体的特性的测量装置。 测量块通过将壳体的内壁的小部分和测量块互相连接的基座构件安装在热屏蔽或壳体内，以便在壳体的内壁和测量块之间限定空间， 所述空间填充有空气或导热性差的介质。 热屏蔽或壳体和基座构件由具有良好导热性的材料制成，并且加热和/或冷却装置布置成与所述屏蔽件导热接触。 加热和/或冷却装置的功能由布置成与测量块导热接触的温度传感器控制，以便将所述块的温度保持在基本恒定的预定值。

公开(公告)号：EP0103599A1

公开(公告)日：1984-03-28

申请号：EP83900917.0

申请日：1983-03-15

Applicant: RADIOMETER A/S

Inventor： FOG, Agner ,  ATLUNG, Sven Helge Knud

IPC: G01N27

CPC classification number: G01N27/36

Abstract: Un dispositif à électrode sélective d'ions, notamment un dispositif à électrode sensible au pH, utilise une électrode intercalaire (3) comme matériau de contact entre un élément sélectif d'ions (2) et une connexion électrique (9). Une électrode intercalaire comprend un mélange équilibré de deux phases, dont au moins une agit comme une électrode intercalaire. Le dispositif à électrode peut être fabriqué comme un dispositif à électrode à l'état solide présentant des propriétés avantageuses d'électrode.

公开(公告)号：EP0103224A2

公开(公告)日：1984-03-21

申请号：EP83108434.8

申请日：1983-08-26

Applicant: RADIOMETER A/S

Inventor： Andersen, Jorgen

IPC: A61B5/14

CPC classification number: A61B5/150213 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150259 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/153

Abstract: @ A syringe for collecting a sample of blood or another liquid comprises a syringe cylinder and a piston arranged displaceably therein. One or more axially extending recesses are formed in the inner wall of the syringe cylinder axially spaced from the inner end thereof. The recess or recesses contain a material which is pervious to gas and impervious to liquid, such as a hydrofobic material, a hydrophilic material with capillary effect, or a material which swells when contacted by liquid. The sample collecting chamber within the cylinder may be vented to the atmosphere by placing the piston in the recessed area of the cylinder. Arterial blood may then pass into the syringe under arterial blood pressure, and the flow of blood into the syringe is automatically stopped when the sample collecting chamber of the syringe has been filled, because blood cannot pass the liquid impervious material arranged in the recesses. The axial innermost portion of the inner cylinder wall, which is not recessed, may co-operate with the piston in a conventional manner so as to provide a suction effect within the blood collecting chamber, if desired.

公开(公告)号：EP0102070A2

公开(公告)日：1984-03-07

申请号：EP83108433.0

申请日：1983-08-26

Applicant: RADIOMETER A/S

Inventor： Andersen, Jorgen

IPC: A61B5/14

CPC classification number: A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150259 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/153

Abstract: A liquid sampler which may be used for collecting samples of arterial blood is preferably in the form of a syringe. A venting passage (25, 31) is defined in the syringe piston (12) so that gas may escape through the venting passage when arterial blood flows into the cylinder space (17) under the influence of the arterial blood pressure. The venting passage is controlled by valve means (19,21), which automatically close the venting passage when the cylinder space has been filled with blood and the blood starts flowing into the venting passage. The venting passage is closed by liquid resistant valve surface parts, and movement of these surface parts to their closing position is caused by a liquid reacting substance (22) which is exposed to the liquid sample flowing into the venting passage. This liquid reacting substance may, for example, be a material which swells, expands, or is softened when contacted by liquid. Alternatively, the liquid reacting substance may be a liquid soluble material.

Abstract translation: 可以用于收集动脉血样本的液体采样器优选为注射器的形式。 通气通道（25,31）被限定在注射器活塞（12）中，使得当动脉血液在动脉血压的影响下流入气缸空间（17）时气体可以通过通气通道逸出。 通气通道由阀装置（19,21）控制，当气缸空间充满血液并且血液开始流入通气通道时，阀装置自动关闭通气通道。 通气通道由防液体的阀表面部分关闭，并且这些表面部分向其关闭位置的移动是由暴露于流入通气通道的液体样品的液体反应物质（22）引起的。 该液体反应物质例如可以是当与液体接触时膨胀，膨胀或软化的材料。 或者，液体反应物质可以是液体可溶性材​​料。