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    LIVE ATTENUATED VACCINES BASED ON cp45 HPIV-3 STRAIN AND METHOD TO ENSURE ATTENUATION IN SUCH VACCINES
    52.
    发明申请
    LIVE ATTENUATED VACCINES BASED ON cp45 HPIV-3 STRAIN AND METHOD TO ENSURE ATTENUATION IN SUCH VACCINES 审中-公开
    基于cp45 HPIV-3菌株的实际灭活疫苗和确保在这些疫苗中减轻的方法

    公开(公告)号：WO1997020468A1

    公开(公告)日：1997-06-12

    申请号：PCT/US1996019512

    申请日：1996-12-09

    Applicant: ST. LOUIS UNIVERSITY ,  BELSHE, Robert, B. ,  RAY, Ranjit

    Inventor： ST. LOUIS UNIVERSITY

    IPC: A01N63/00

    CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  C12N2760/18622 ,  C12N2760/18634

    Abstract: The present invention is based upon correlation of two attenuating lesions of the cp45 strain to specific defects in the genome of cp45. Specifically, a significant level of attenuation of cp45, resulting from its temperature-sensitive and cold-adapted phenotypes is associated with mutation of the L gene of cp45. A second mutation in the gene coding for hemagglutinin-neuraminidase (HN) in the cp45 strain has also been found to be another attenuating mutation. The correlation of these two attenuating lesions of cp45 to specific genes enables several practical applications. It is now possible to create attenuated vaccines directed at other wild-type HPIV-3 viruses and other viruses other than HPIV-3 by incorporating the mutated L and/or HN genes of cp45 in to a target virus genome or alternatively, expressing surface antigen genes from other viruses in cp45.

    Abstract translation: 本发明基于cp45菌株的两个减毒损伤与cp45基因组中特异性缺陷的相关性。 具体来说，由其温度敏感和冷适应表型引起的cp45的显着水平的衰减与cp45的L基因的突变相关。 编码cp45菌株血细胞凝集素 - 神经氨酸酶（HN）的基因中的第二个突变也被发现是另一个减毒突变。 这两个cp45的减毒病变与特定基因的相关性可以实现几个实际应用。 现在可以通过将cp45的突变的L和/或HN基因并入目标病毒基因组中来创建针对其它野生型HPIV-3病毒和除了HPIV-3之外的其它病毒的减毒疫苗，或者表达表面抗原 cp45中其他病毒的基因。

    SURGICAL NAVIGATION SYSTEMS INCLUDING REFERENCE AND LOCALIZATION FRAMES
    54.
    发明申请
    SURGICAL NAVIGATION SYSTEMS INCLUDING REFERENCE AND LOCALIZATION FRAMES 审中-公开
    手术导航系统，包括参考和本地化框架

    公开(公告)号：WO1996011624A2

    公开(公告)日：1996-04-25

    申请号：PCT/US1995012894

    申请日：1995-10-05

    Applicant: ST. LOUIS UNIVERSITY ,  SURGICAL NAVIGATION TECHNOLOGIES ,  BUCHOLZ, Richard, D. ,  FOLEY, Kevin, T. ,  SMITH, Kurt, R. ,  BASS, Daniel ,  WIEDENMAIER, Thomas ,  POPE, Todd ,  WIEDENMAIER, Udo

    Inventor： ST. LOUIS UNIVERSITY ,  SURGICAL NAVIGATION TECHNOLOGIES

    IPC: A61B00/00

    CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5235 ,  A61B8/00 ,  A61B8/0833 ,  A61B8/4227 ,  A61B8/5238 ,  A61B17/1703 ,  A61B17/1739 ,  A61B17/3403 ,  A61B34/10 ,  A61B34/20 ,  A61B90/10 ,  A61B90/11 ,  A61B90/36 ,  A61B2017/00022 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/207 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/376 ,  A61B2090/378 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3983

    Abstract: A system for use during a medical or surgical procedure on a body. The system generates an image representing the position of one or more body elements during the procedure using scans generated by a scanner prior or during the procedure. The image data set has reference points for each of the body elements, the reference points of a particular body element having a fixed spatial relation to the particular body element. The system includes an apparatus for identifying, during the procedure, the relative position of each of the reference points of each of the body elements to be displayed. The system also includes a processor for modifying the image data set according to the identified relative position of each of the reference points during the procedure, as identified by the identifying apparatus, said processor generating a displaced image data set representing the position of the body elements during the procedure. The system also includes a display utilizing the displaced image data set generated by the processor, illustrating the relative position of the body elements during the procedure. Methods relating to the system are also disclosed. Also disclosed are devices for use with a surgical navigation system having a sensor array which is in communication with the device to identify its position. The device may be a reference frame for attachment of a body part of the patient, such as a cranial reference arc frame for attachment to the head or a spine reference arc frame for attachment to the spine. The device may also be a localization frame for positioning an instrument relative to a body part, such as a localization biopsy guide frame for positioning a biopsy needle, a localization drill guide assembly for positioning a drill bit, a localization drill yoke assembly for positioning a drill, or a ventriculostomy probe for positioning a catheter.

    Abstract translation: 在身体的医疗或外科手术过程中使用的系统。 在该过程期间，该系统使用由扫描仪生成的扫描器在过程之前或过程期间生成表示一个或多个身体元件的位置的图像。 图像数据集具有每个身体元素的参考点，特定身体元件的参考点与特定身体元件具有固定的空间关系。 该系统包括用于在过程期间识别要显示的每个身体元素的每个参考点的相对位置的装置。 该系统还包括处理器，用于根据识别装置识别的过程期间根据所识别的每个参考点的相对位置修改图像数据集，所述处理器生成表示身体元件的位置的位移图像数据集 在程序中。 该系统还包括使用由处理器生成的移位的图像数据集的显示器，示出了在该过程期间主体元件的相对位置。 还公开了与系统有关的方法。 还公开了一种与外科导航系统一起使用的装置，该外科导航系统具有与装置通信以识别其位置的传感器阵列。 该装置可以是用于附接患者的身体部分的参考框架，例如用于附接到头部的颅骨参考弧形框架或用于附接到脊柱的脊柱参考弧形框架。 该装置还可以是用于相对于身体部位定位器械的定位框架，例如用于定位活检针的定位活检引导框架，用于定位钻头的定位钻子引导器组件，用于定位钻头的定位钻杆组件 钻孔或用于定位导管的脑室造口术探针。

    SURGICAL PROBE LOCATING SYSTEM FOR HEAD USE
    55.
    发明申请
    SURGICAL PROBE LOCATING SYSTEM FOR HEAD USE 审中-公开
    头部使用的外科探头定位系统

    公开(公告)号：WO1992006645A1

    公开(公告)日：1992-04-30

    申请号：PCT/US1991007755

    申请日：1991-10-17

    Applicant: ST. LOUIS UNIVERSITY ,  BUCHOLZ, Richard, D.

    Inventor： ST. LOUIS UNIVERSITY

    IPC: A61B19/00

    CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2017/00738 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/378 ,  A61B2090/3788 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3983 ,  B82Y15/00

    Abstract: A system for determining a position of a probe (302) relative to an object such as a head (390) of a body of a patient. The head includes a surface such as a forehead (394) having a contour. The head is placed in a cradle (392) equipped with an arc (393). The cross-sectional images of the head are determined relative to the arc. A hand-held unit (380) optically scans the forehead and the arc. During scanning to generate the cross-sectional images, the optical scanner (380) is used to determine the position of the forehead (394) relative to the cradle (392). During surgery, the optical scanner (380) also determines the position of the forehead (394) relative to a base ring (306). An array (300) for receiving radiation emitted from the probe (302) and from the base ring (306) generates signals indicating the position of the tip of the probe (302) relative to the base ring (306). A stereotactic imaging system selects and displays the image of the head closest to the measured position of the tip of the probe (302).

    Abstract translation: 一种用于确定探针（302）相对于诸如患者身体的头部（390）的物体的位置的系统。 头包括具有轮廓的诸如前额（394）的表面。 头部放置在配备有电弧（393）的支架（392）中。 头部的横截面图像相对于电弧确定。 手持单元（380）光学扫描前额和弧。 在扫描期间产生横截面图像时，光学扫描器（380）用于确定前额（394）相对于托架（392）的位置。 在手术期间，光学扫描器（380）还确定前额（394）相对于基环（306）的位置。 用于接收从探针（302）和基座（306）发射的辐射的阵列（300）产生指示探针（302）的尖端相对于基环（306）的位置的信号。 立体摄影系统选择并显示最靠近探头（302）的尖端的测量位置的头部的图像。

    METHODS AND COMPOSITIONS FOR DECOMPOSITION OF BIOMASS
    57.
    发明申请
    METHODS AND COMPOSITIONS FOR DECOMPOSITION OF BIOMASS 审中-公开
    生物量分解的方法和组合物

    公开(公告)号：WO2013020022A2

    公开(公告)日：2013-02-07

    申请号：PCT/US2012/049464

    申请日：2012-08-03

    Applicant: ST. LOUIS UNIVERSITY ,  AURORA, Rajeev ,  MINTEER, Shelley, D.

    Inventor： AURORA, Rajeev ,  MINTEER, Shelley, D.

    IPC: C12P7/16 ,  C12P7/40 ,  G01N21/64

    CPC classification number: G01N21/6428 ,  C12P7/16 ,  C12P7/40 ,  Y02E50/10 ,  Y02E50/16 ,  Y10T436/143333

    Abstract: Disclosed are methods for detecting cellulose in cellulosic materials and producing alcohol using cellulosic materials. More particularly, disclosed are methods for producing alcohol in a cell-free system by contacting pyruvate with enzymes from a minimal enzymatic pathway. Also disclosed are methods of producing pyruvate by culturing a microorganism under hypoxic conditions. Disclosed are methods for detecting cellulose in a sample using Congo red dye.

    Abstract translation: 公开了在纤维素材料中检测纤维素并使用纤维素材料生产醇的方法。 更具体地，公开了通过使丙酮酸与最小酶途径的酶接触而在无细胞系统中产生醇的方法。 还公开了通过在缺氧条件下培养微生物来生产丙酮酸的方法。 公开了使用刚果红染料检测样品中的纤维素的方法。

    METHODS FOR INHIBITING TGF-β
    59.
    发明申请
    METHODS FOR INHIBITING TGF-β 审中-公开
    抑制TGF-β的方法

    公开(公告)号：WO2009029656A1

    公开(公告)日：2009-03-05

    申请号：PCT/US2008/074446

    申请日：2008-08-27

    Applicant: AUXAGEN, INC. ,  ST. LOUIS UNIVERSITY ,  HUANG, Shuan, Shian ,  HUANG, Jung, San

    Inventor： HUANG, Shuan, Shian ,  HUANG, Jung, San

    IPC: A61K31/56 ,  C07J9/00

    CPC classification number: A61K31/56

    Abstract: The present invention provides methods for inhibiting or blocking TGF-β activity in cells and/or tissues expressing TGF-β comprising, contacting cells and/or tissues expressing TGF-β with an amount of cholesterol or cholesterol derivative effective to inhibit the activity of TGF-β. The present invention further provides a method for treating a condition associated with overactivity of TGF-β or negative regulation in normal physiology by TGF-β in a subject in need of treatment, comprising contacting cells and/or tissue overexpressing TGF-β in the subject with an amount of cholesterol or cholesterol derivative effective to inhibit activity of TGF-β thereby treating the condition. In a preferred embodiment, the cholesterol derivative is oxidized 7-DHC.

    Abstract translation: 本发明提供了在表达TGF-β的细胞和/或组织中抑制或阻断TGF-β活性的方法，其包括：将表达TGF-β的细胞和/或组织与一定量的有效抑制TGFβ活性的胆固醇或胆固醇衍生物接触 -ss。 本发明还提供了在需要治疗的受试者中通过TGF-β处理与TGF-β的过度活性或正常生理学负调节相关的病症的方法，包括使受试者中过表达TGF-β的细胞和/或组织接触 与一定量的胆固醇或胆固醇衍生物有效抑制TGF-β的活性，从而治疗病症。 在优选的实施方案中，胆固醇衍生物被氧化为7-DHC。

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