公开(公告)号：WO1994024933A1

公开(公告)日：1994-11-10

申请号：PCT/US1994004530

申请日：1994-04-25

Applicant: ST. LOUIS UNIVERSITY

Inventor： ST. LOUIS UNIVERSITY ,  BUCHOLZ, Richard, D.

IPC: A61B05/05

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/061 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2063 ,  A61B2034/2065 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/061 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/373 ,  A61B2090/378 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3979 ,  A61B2090/3983 ,  A61B2090/3995

Abstract: This is a system for determining a position of a probe (302) relative to an object such as a head of a body of a patient. The head includes a surface such as a forehead having a contour. Cross-sectional images of the head are scanned and stored as a function of the forehead contour. If the forehead contour does not appear in the scan images, then the position of the forehead contour relative to the scan images is determined with an optical scanner (380) and ring (590). During surgery, the optical scanner (380) also determines the position of the tip of the forehead relative to the ring (590). An array (300) for receiving radiation emitted from the probe and from the ring generates signals indicating the position of the tip (301) of the probe (302) relative to the ring (590). A stereo-tactic imaging system (324) generates and displays an image of the head corresponding to the measured position of the tip (301) of the probe (302).

Abstract translation: 这是用于确定探针（302）相对于物体（例如患者的身体的头部）的位置的系统。 头部包括具有轮廓的诸如前额的表面。 作为前额轮廓的函数扫描和存储头部的横截面图像。 如果前额轮廓没有出现在扫描图像中，则用光学扫描器（380）和环（590）确定前额轮廓相对于扫描图像的位置。 在手术期间，光学扫描器（380）还确定前额相对于环（590）的尖端的位置。 用于接收从探针和环产生的辐射的阵列（300）产生指示探针（302）相对于环（590）的尖端（301）的位置的信号。 立体战术成像系统（324）产生并显示对应于探针（302）的尖端（301）的测量位置的头部的图像。

公开(公告)号：WO1989012461A1

公开(公告)日：1989-12-28

申请号：PCT/US1989002404

申请日：1989-06-01

Applicant: ST. LOUIS UNIVERSITY

Inventor： ST. LOUIS UNIVERSITY ,  GREEN, Maurice ,  LOEWENSTEIN, Paul, M.

IPC: A61K39/12

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N2710/10322 ,  C12N2710/20022 ,  C12N2740/16322

Abstract: A method for preparing antagonists of viral transactivating proteins is disclosed. In one aspect the method involves the preparation of antagonists from active domains of the viral transactivating protein. Pharmaceutical compositions comprising the antagonists which compositions are useful in treating an individual suffering from viral infection are also disclosed.

Abstract translation: 公开了一种制备病毒反式激活蛋白质的拮抗剂的方法。 在一个方面，该方法涉及从病毒反式激活蛋白的活性结构域制备拮抗剂。 还公开了包含该组合物可用于治疗患有病毒感染的个体的拮抗剂的药物组合物。

公开(公告)号：WO1997020468A1

公开(公告)日：1997-06-12

申请号：PCT/US1996019512

申请日：1996-12-09

Applicant: ST. LOUIS UNIVERSITY ,  BELSHE, Robert, B. ,  RAY, Ranjit

Inventor： ST. LOUIS UNIVERSITY

IPC: A01N63/00

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  C12N2760/18622 ,  C12N2760/18634

Abstract: The present invention is based upon correlation of two attenuating lesions of the cp45 strain to specific defects in the genome of cp45. Specifically, a significant level of attenuation of cp45, resulting from its temperature-sensitive and cold-adapted phenotypes is associated with mutation of the L gene of cp45. A second mutation in the gene coding for hemagglutinin-neuraminidase (HN) in the cp45 strain has also been found to be another attenuating mutation. The correlation of these two attenuating lesions of cp45 to specific genes enables several practical applications. It is now possible to create attenuated vaccines directed at other wild-type HPIV-3 viruses and other viruses other than HPIV-3 by incorporating the mutated L and/or HN genes of cp45 in to a target virus genome or alternatively, expressing surface antigen genes from other viruses in cp45.

Abstract translation: 本发明基于cp45菌株的两个减毒损伤与cp45基因组中特异性缺陷的相关性。 具体来说，由其温度敏感和冷适应表型引起的cp45的显着水平的衰减与cp45的L基因的突变相关。 编码cp45菌株血细胞凝集素 - 神经氨酸酶（HN）的基因中的第二个突变也被发现是另一个减毒突变。 这两个cp45的减毒病变与特定基因的相关性可以实现几个实际应用。 现在可以通过将cp45的突变的L和/或HN基因并入目标病毒基因组中来创建针对其它野生型HPIV-3病毒和除了HPIV-3之外的其它病毒的减毒疫苗，或者表达表面抗原 cp45中其他病毒的基因。

公开(公告)号：WO1996030519A1

公开(公告)日：1996-10-03

申请号：PCT/US1996004031

申请日：1996-03-22

Applicant: WASHINGTON UNIVERSITY ,  ST. LOUIS UNIVERSITY ,  ST. GEME, Joseph, W., III ,  BARENKAMP, Stephen, J.

Inventor： WASHINGTON UNIVERSITY ,  ST. LOUIS UNIVERSITY

IPC: C12N15/31

CPC classification number: C07K14/285 ,  A61K38/00 ,  A61K39/00

Abstract: The invention relates to novel Haemophilus adhesion proteins, nucleic acids, and antibodies.

Abstract translation: 本发明涉及新型嗜血杆菌粘附蛋白，核酸和抗体。

公开(公告)号：WO1996011624A2

公开(公告)日：1996-04-25

申请号：PCT/US1995012894

申请日：1995-10-05

Applicant: ST. LOUIS UNIVERSITY ,  SURGICAL NAVIGATION TECHNOLOGIES ,  BUCHOLZ, Richard, D. ,  FOLEY, Kevin, T. ,  SMITH, Kurt, R. ,  BASS, Daniel ,  WIEDENMAIER, Thomas ,  POPE, Todd ,  WIEDENMAIER, Udo

Inventor： ST. LOUIS UNIVERSITY ,  SURGICAL NAVIGATION TECHNOLOGIES

IPC: A61B00/00

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5235 ,  A61B8/00 ,  A61B8/0833 ,  A61B8/4227 ,  A61B8/5238 ,  A61B17/1703 ,  A61B17/1739 ,  A61B17/3403 ,  A61B34/10 ,  A61B34/20 ,  A61B90/10 ,  A61B90/11 ,  A61B90/36 ,  A61B2017/00022 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/207 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/376 ,  A61B2090/378 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3983

Abstract: A system for use during a medical or surgical procedure on a body. The system generates an image representing the position of one or more body elements during the procedure using scans generated by a scanner prior or during the procedure. The image data set has reference points for each of the body elements, the reference points of a particular body element having a fixed spatial relation to the particular body element. The system includes an apparatus for identifying, during the procedure, the relative position of each of the reference points of each of the body elements to be displayed. The system also includes a processor for modifying the image data set according to the identified relative position of each of the reference points during the procedure, as identified by the identifying apparatus, said processor generating a displaced image data set representing the position of the body elements during the procedure. The system also includes a display utilizing the displaced image data set generated by the processor, illustrating the relative position of the body elements during the procedure. Methods relating to the system are also disclosed. Also disclosed are devices for use with a surgical navigation system having a sensor array which is in communication with the device to identify its position. The device may be a reference frame for attachment of a body part of the patient, such as a cranial reference arc frame for attachment to the head or a spine reference arc frame for attachment to the spine. The device may also be a localization frame for positioning an instrument relative to a body part, such as a localization biopsy guide frame for positioning a biopsy needle, a localization drill guide assembly for positioning a drill bit, a localization drill yoke assembly for positioning a drill, or a ventriculostomy probe for positioning a catheter.

Abstract translation: 在身体的医疗或外科手术过程中使用的系统。 在该过程期间，该系统使用由扫描仪生成的扫描器在过程之前或过程期间生成表示一个或多个身体元件的位置的图像。 图像数据集具有每个身体元素的参考点，特定身体元件的参考点与特定身体元件具有固定的空间关系。 该系统包括用于在过程期间识别要显示的每个身体元素的每个参考点的相对位置的装置。 该系统还包括处理器，用于根据识别装置识别的过程期间根据所识别的每个参考点的相对位置修改图像数据集，所述处理器生成表示身体元件的位置的位移图像数据集 在程序中。 该系统还包括使用由处理器生成的移位的图像数据集的显示器，示出了在该过程期间主体元件的相对位置。 还公开了与系统有关的方法。 还公开了一种与外科导航系统一起使用的装置，该外科导航系统具有与装置通信以识别其位置的传感器阵列。 该装置可以是用于附接患者的身体部分的参考框架，例如用于附接到头部的颅骨参考弧形框架或用于附接到脊柱的脊柱参考弧形框架。 该装置还可以是用于相对于身体部位定位器械的定位框架，例如用于定位活检针的定位活检引导框架，用于定位钻头的定位钻子引导器组件，用于定位钻头的定位钻杆组件 钻孔或用于定位导管的脑室造口术探针。

公开(公告)号：WO1992006645A1

公开(公告)日：1992-04-30

申请号：PCT/US1991007755

申请日：1991-10-17

Applicant: ST. LOUIS UNIVERSITY ,  BUCHOLZ, Richard, D.

Inventor： ST. LOUIS UNIVERSITY

IPC: A61B19/00

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2017/00738 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/378 ,  A61B2090/3788 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3983 ,  B82Y15/00

Abstract: A system for determining a position of a probe (302) relative to an object such as a head (390) of a body of a patient. The head includes a surface such as a forehead (394) having a contour. The head is placed in a cradle (392) equipped with an arc (393). The cross-sectional images of the head are determined relative to the arc. A hand-held unit (380) optically scans the forehead and the arc. During scanning to generate the cross-sectional images, the optical scanner (380) is used to determine the position of the forehead (394) relative to the cradle (392). During surgery, the optical scanner (380) also determines the position of the forehead (394) relative to a base ring (306). An array (300) for receiving radiation emitted from the probe (302) and from the base ring (306) generates signals indicating the position of the tip of the probe (302) relative to the base ring (306). A stereotactic imaging system selects and displays the image of the head closest to the measured position of the tip of the probe (302).

Abstract translation: 一种用于确定探针（302）相对于诸如患者身体的头部（390）的物体的位置的系统。 头包括具有轮廓的诸如前额（394）的表面。 头部放置在配备有电弧（393）的支架（392）中。 头部的横截面图像相对于电弧确定。 手持单元（380）光学扫描前额和弧。 在扫描期间产生横截面图像时，光学扫描器（380）用于确定前额（394）相对于托架（392）的位置。 在手术期间，光学扫描器（380）还确定前额（394）相对于基环（306）的位置。 用于接收从探针（302）和基座（306）发射的辐射的阵列（300）产生指示探针（302）的尖端相对于基环（306）的位置的信号。 立体摄影系统选择并显示最靠近探头（302）的尖端的测量位置的头部的图像。