公开(公告)号：WO2008054205A3

公开(公告)日：2008-06-05

申请号：PCT/NL2007050522

申请日：2007-10-31

Applicant: UNIV MAASTRICHT ,  STICHTING TECH WETENSCHAPP ,  KOOLE LEVINUS HENDRIK ,  VAN HOOY-CORSTJENS CATHARINA S

Inventor： KOOLE LEVINUS HENDRIK ,  VAN HOOY-CORSTJENS CATHARINA S

IPC: A61L31/18

CPC classification number: A61L24/001 ,  A61L24/04 ,  A61L2430/36

Abstract: The invention is directed to embolic material comprising spherical, homogeneous and substantially non-porous radiopaque polymer particles based on at least one hydrophilic monomer and at least one radiopaque monomer according to general formula (I): wherein R is H, methyl or ethyl, and R 1 is I, Br or formula (II): wherein R 2 is O, NH, 0-[CH 2 -CH 2 -O] P -C(O)-, O- [CH 2 ] m -O-C(O)-, O-[CH 2 ] p -, NH-[CH 2 -CH 2 -O] p -C(O)-, NH-[CH 2 ] m -O-C(O)- or NH-[CH 2 ] p - wherein m>l and p=l, R 3 is I or Br and n is 1, 2 or 3, the iodine and/or bromine content being at least 5 wt.% based on the dry weight of the particle, the said particles having an average particle diameter of at least 10 µm and being able to imbibe water up to a volume increase of the particle of at least 10 %.

Abstract translation: 本发明涉及包含基于至少一种亲水性单体和至少一种根据通式（I）的不透射线单体的球形，均匀和基本上无孔的不透射线聚合物颗粒的栓塞材料：其中R是H，甲基或乙基，和 R 1是I，Br或式（II）：其中R 2是O，NH，O- [CH 2 SUB-CH _{1且p = 1，R 3是I或Br，并且n是1,2或3，碘和/ 或溴含量基于颗粒干重为至少5重量％，所述颗粒具有至少10μm的平均颗粒直径，并且能够吸收水直到颗粒的体积增加至少10 ％。}

公开(公告)号：WO2007136250A2

公开(公告)日：2007-11-29

申请号：PCT/NL2007000135

申请日：2007-05-24

Applicant: STICHTING TECH WETENSCHAPP ,  PEPPELENBOSCH MAIKEL PETRUS ,  BIJLSMA MAARTEN FOKKE ,  SPEK CHRISTOFFEL AMOLDUS

Inventor： PEPPELENBOSCH MAIKEL PETRUS ,  BIJLSMA MAARTEN FOKKE ,  SPEK CHRISTOFFEL AMOLDUS

CPC classification number: A61K31/136 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition com- prising an inhibitor of the enzyme 7-dehydrocholesterol reductase (DHCR 7 ) together with a pharmaceutically acceptable carrier or ex- cipient. This pharmaceutical composition is active against various types of cancer, in particular but not limited to adenocarcinomas of the upper gastro-intestinal tract. The invention also relates to a method of preparing a pharmaceutical composition suitable for the treatment of an adenocarcinoma.

Abstract translation: 本发明涉及包含7-脱氢胆甾醇还原酶（DHCR 7）的抑制剂以及药学上可接受的载体或外用剂的药物组合物。 该药物组合物对各种类型的癌症具有活性，特别是但不限于上胃肠道的腺癌。 本发明还涉及制备适于治疗腺癌的药物组合物的方法。

公开(公告)号：WO2006107206A3

公开(公告)日：2007-05-03

申请号：PCT/NL2006050074

申请日：2006-04-06

Applicant: STICHTING TECH WETENSCHAPP ,  MIES MARTIJN JACOBUS MARINUS ,  REBROV EVGUENI VICTOROVICH ,  DE CROON MARTIEN HENDRIK JOZEF ,  SCHOUTEN JACOB CORNELIS ,  ISMAGILOV ILYAS ZINFEROVICH

Inventor： MIES MARTIJN JACOBUS MARINUS ,  REBROV EVGUENI VICTOROVICH ,  DE CROON MARTIEN HENDRIK JOZEF ,  SCHOUTEN JACOB CORNELIS ,  ISMAGILOV ILYAS ZINFEROVICH

IPC: B01J19/00 ,  B01J4/00

CPC classification number: B01J4/001 ,  B01J2219/00286 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00747 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00995

Abstract: Inlet section for providing a uniform flow distribution in a downstream reactor (14) which is connectable to the inlet section (10). The inlet section has an inlet diffuser (11) for receiving a fluid flow, an upstream passage (12) positioned downstream from the inlet diffuser (11), and a downstream passage (13) positioned downstream of the upstream passage (12). The upstream passage and downstream passage each comprise thick wall screens (12, 13). The upstream passage (12) has a first plurality (m) of elongated parallel upstream channels (15), and the downstream passage (13) has a second plurality (n) of elongated parallel downstream channels (16). The elongated upstream channels (15) are positioned at an angle of substantially 90 degrees with respect to the elongated downstream channels (16).

Abstract translation: 用于在可连接到入口部分（10）的下游反应器（14）中提供均匀流动分布的入口段。 入口部分具有用于接收流体流的入口扩散器（11），位于入口扩散器（11）下游的上游通道（12）和位于上游通道（12）下游的下游通道（13）。 上游通道和下游通道各自包括厚壁筛网（12,13）。 上游通道（12）具有第一多个（m）细长的平行上游通道（15），并且下游通道（13）具有第二多个（n）个细长的平行的下游通道（16）。 细长的上游通道（15）相对于细长的下游通道（16）以大致90度的角度定位。

公开(公告)号：WO2006031104A9

公开(公告)日：2006-10-19

申请号：PCT/NL2005000662

申请日：2005-09-12

Applicant: UNIV DELFT TECH ,  STICHTING TECH WETENSCHAPP ,  CREEMER JAN FREDRIK ,  ZANDBERGEN HENDRIK WILLEM ,  SARRO PASQUALINA MARIA

Inventor： CREEMER JAN FREDRIK ,  ZANDBERGEN HENDRIK WILLEM ,  SARRO PASQUALINA MARIA

IPC: H01J37/20 ,  H01J37/26

CPC classification number: H01J37/26 ,  H01J37/20 ,  H01J2237/2002 ,  H01J2237/206

Abstract: A microreactor for use in a microscope, comprising a first and second cove layer (13) , which cover layers are both at least partly transparent to an electron beam (14) of an electron microscope, and extend next to each other at a mutual distance from each other and between which a chamber (15) is enclosed, wherein an inlet (4) and an outlet (5) are provided for feeding fluid through the chamber and wherein heating means (8) are provided for heating the chamber and/or elements present therein.

Abstract translation: 一种用于显微镜的微反应器，包括第一和第二凹入层（13），所述覆盖层对于电子显微镜的电子束（14）至少部分透明，并且以相互距离彼此相邻地延伸 （15）被封闭在其之间，其中提供入口（4）和出口（5）用于将流体供给通过腔室，并且其中设置用于加热腔室的加热装置（8）和/或 其中存在的元件。

公开(公告)号：WO2005068585A8

公开(公告)日：2006-09-28

申请号：PCT/EP2005000098

申请日：2005-01-10

Applicant: STICHTING TECH WETENSCHAPP ,  UNIV BERNE ,  KRAMER KARL WILHELM ,  GUEDEL HANS-ULRICH ,  BESSIERE AURELIE ,  DORENBOS PIETER ,  VAN EIJK CAREL WILHELM EDUARD

Inventor： KRAMER KARL WILHELM ,  GUEDEL HANS-ULRICH ,  BESSIERE AURELIE ,  DORENBOS PIETER ,  VAN EIJK CAREL WILHELM EDUARD

IPC: C09K11/77 ,  G01T3/00

CPC classification number: C09K11/7772 ,  C30B11/00 ,  C30B29/12

Abstract: The invention pertains to a neutron detector comprising a scintillating material of the generic formula Cs ( 2-z ) Rb Z LiLn(1- X )X 6 : xCe 3+ , where X is either Br or I, Ln is Y or Gd or Lu or Sc or La, where z is greater or equal to 0 and less or equal to 2, and x is above 0.0005, generally under the form of monocristal. The scintillating material has a remarkably low decay time.

Abstract translation: 本发明涉及一种中子检测器，其包括通式为Cs（2-z）R b R z LiLn（1-Sub）的闪烁材料 其中X为Br或I，Ln为Y或Gd或Lu或Sc或La，其中z为X或X， 大于或等于0且小于或等于2，并且x大于0.0005，通常为单晶形式。 闪烁材料具有非常低的衰减时间。

公开(公告)号：WO2006071118A2

公开(公告)日：2006-07-06

申请号：PCT/NL2005050094

申请日：2005-12-23

Applicant: STICHTING TECH WETENSCHAPP ,  UNIV LEIDEN ,  RAM ARTHUR FRANCISCUS JOHANNES ,  DAMVELD ROBBERT ANTONIUS ,  ARENTSHORST MARK ,  VAN KUYK PATRICIA ANN ,  VAN DEN HONDEL CORNELIS ANTONI

Inventor： RAM ARTHUR FRANCISCUS JOHANNES ,  DAMVELD ROBBERT ANTONIUS ,  ARENTSHORST MARK ,  VAN KUYK PATRICIA ANN ,  VAN DEN HONDEL CORNELIS ANTONI

CPC classification number: C12Q1/18 ,  G01N2333/37

Abstract: The present invention relates to a fungus which produces substantially no functional protein with regulating activity on the transcription of genes which are involved in cell wall stress response. It also relates to a method for screening for antifungal agents, in particular to antifungal agents which target the cell wall. It also relates to a kit for screening for antifungal agents which disturb cell wall biogenesis.

Abstract translation: 本发明涉及一种真菌，其基本上不产生对参与细胞壁应激反应的基因的转录具有调节活性的功能性蛋白质。 它还涉及用于筛选抗真菌剂的方法，特别是靶向细胞壁的抗真菌剂。 它还涉及用于筛选干扰细胞壁生物发生的抗真菌剂的试剂盒。

公开(公告)号：WO2005049679A3

公开(公告)日：2006-02-02

申请号：PCT/NL2004000807

申请日：2004-11-18

Applicant: STICHTING TECH WETENSCHAPP ,  KEURENTJES JOHANNES THEODORUS ,  CUSTERS JOHANNES PETRUS ALDEGO ,  KELEMEN PETER ,  TIMMER JOHANNES MARTINUS KOEN ,  VAN DEN BROEKE LEO JACQUES PIE ,  COHEN STUART MARTINUS ABRAHAM ,  LEERMAKERS FRANCISCUS ADRIANUS

Inventor： KEURENTJES JOHANNES THEODORUS ,  CUSTERS JOHANNES PETRUS ALDEGO ,  KELEMEN PETER ,  TIMMER JOHANNES MARTINUS KOEN ,  VAN DEN BROEKE LEO JACQUES PIE ,  COHEN STUART MARTINUS ABRAHAM ,  LEERMAKERS FRANCISCUS ADRIANUS

IPC: C02F5/10 ,  C02F5/12 ,  C02F5/14 ,  C08G65/332 ,  C11D1/00 ,  C11D3/37

CPC classification number: C02F5/14 ,  C02F5/10 ,  C02F5/12 ,  C02F2103/002 ,  C02F2209/02 ,  C02F2305/04 ,  C08G65/3322 ,  C08G65/3346 ,  C08L71/02

Abstract: The present invention relates to high molecular weight non-ionic surfactants comprising terminal anionic end groups or salts thereof, a process for the preparation of such surfactants and the use of such surfactants in decreasing the hardness of aqueous systems, desalination or softening of water, removal of heavy metals from aqueous systems contaminated with such metals, and in industrial and domestic wash processes and products used for such processes.

Abstract translation: 本发明涉及包含末端阴离子末端基团或其盐的高分子量非离子表面活性剂，制备这种表面活性剂的方法以及这种表面活性剂在降低水性体系硬度，脱盐或软化水中的用途 来自被这些金属污染的水性体系的重金属，以及用于这些工艺的工业和家庭洗涤方法和产品。

公开(公告)号：WO03050542A2

公开(公告)日：2003-06-19

申请号：PCT/NL0200815

申请日：2002-12-11

Applicant: STICHTING TECH WETENSCHAPP ,  VAN VENROOIJ WALTHERUS JACOBUS ,  DRIJFHOUT JAN WOUTER ,  VAN BOEKEL MARTINUS ADRIANUS M ,  PRUIJN GERARDUS JOZEF MARIA

Inventor： VAN VENROOIJ WALTHERUS JACOBUS ,  DRIJFHOUT JAN WOUTER ,  VAN BOEKEL MARTINUS ADRIANUS M ,  PRUIJN GERARDUS JOZEF MARIA

IPC: C07K7/06 ,  C07K7/08 ,  C07K7/54 ,  C07K14/47 ,  G01N33/53 ,  G01N33/564 ,  G01N33/68

CPC classification number: G01N33/564 ,  C07K7/08 ,  C07K7/52 ,  C07K7/64 ,  C07K14/4713 ,  G01N2410/00 ,  G01N2800/102 ,  Y10S435/973 ,  Y10S435/975 ,  Y10S530/806

Abstract: The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, and which peptide unit comprises the motif XG, and a peptide unit comprising the motif XnonG, wherein X is a citrullin or an analogue thereof, and nonG is an amino acid other than glycine.

Abstract translation: 本发明涉及从患有类风湿性关节炎的患者中检测自身抗体的方法。 为此，根据本发明，使用至少两个肽单元，其中至少一个肽单元包含不衍生自（pro）填充蛋白，纤维蛋白，纤维蛋白原，波形蛋白，细胞角蛋白1和细胞角蛋白9的部分，哪个肽单元 包含基序XG和包含基序XnonG的肽单元，其中X是瓜氨酸或其类似物，而nonG是除甘氨酸以外的氨基酸。

公开(公告)号：WO9822503A3

公开(公告)日：1998-08-27

申请号：PCT/NL9700624

申请日：1997-11-14

Applicant: STICHTING SCHEIKUNDIG ONDERZOE ,  STICHTING TECH WETENSCHAPP ,  VENROOIJ WALTHERUS JACOBUS WIL ,  SCHELLEKENS GERARDUS ANTONIUS ,  RAATS JOZEF MARIA HENDRIK ,  HOET RENE MICHAEL ANTONIUS

Inventor： VAN VENROOIJ WALTHERUS JACOBUS ,  SCHELLEKENS GERARDUS ANTONIUS ,  RAATS JOZEF MARIA HENDRIK ,  HOET RENE MICHAEL ANTONIUS

IPC: C07K7/08 ,  C07K14/47 ,  C07K16/18 ,  C12P21/08 ,  G01N33/564

CPC classification number: G01N33/6893 ,  C07K14/47 ,  C07K14/4713 ,  C07K16/18 ,  G01N33/564 ,  G01N2333/46 ,  G01N2800/10 ,  G01N2800/102 ,  G01N2800/24

Abstract: The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine residue. The invention also relates to antibodies against the peptide and a method of detecting autoimmune antibodies.

公开(公告)号：EP2424984A4

公开(公告)日：2013-03-13

申请号：EP10769158

申请日：2010-04-30

Applicant: STICHTING TECH WETENSCHAPP ,  VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Inventor： QUATTROCCHIO FRANCESCA ,  KOES RONALD ,  SPELT KEES

IPC: C12N15/05 ,  A01H1/00 ,  A01H5/00

CPC classification number: C12N15/825 ,  A01H5/02 ,  A01H5/08 ,  C07K14/415 ,  C12N9/14 ,  C12N15/8243 ,  C12N15/8249 ,  C12N15/827