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公开(公告)号：WO2011059329A3
公开(公告)日：2011-09-01
申请号：PCT/NL2010050755
申请日：2010-11-12
Applicant: UNIV UTRECHT HOLDING BV , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG , STICHTING TECH WETENSCHAPP , UNIV LEIDEN , VANKUYK PATRICIA ANN , DE VRIES RONALD PETER , VISSER JACOB , RAM ARTHUR FRANCISCUS JOHANNES , VAN DEN HONDEL CORNELIS ANTONIUS MARIA JACOBUS JOH , BATTAGLIA EVY , VIVAS DUARTE DIANA ALEXANDRA
Inventor： VANKUYK PATRICIA ANN , DE VRIES RONALD PETER , VISSER JACOB , RAM ARTHUR FRANCISCUS JOHANNES , VAN DEN HONDEL CORNELIS ANTONIUS MARIA JACOBUS JOH , BATTAGLIA EVY , VIVAS DUARTE DIANA ALEXANDRA
IPC: C07K14/38
Abstract: The invention relates to the production of biofuels, proteins, peptides and other value-added compounds from crude carbon sources. The inventors identified genes encoding novel pentose transporters, in particular transporters of L-arabinose and/or D-xylose. Regulation of the Aspergillus niger genes by xlnR and araR was instrumental in the identification of these genes and their substrate specificities. Provided are novel pentose transporters and their encoding nucleic acids. Also provided are host cells (over)expressing a transporter, and industrial applications thereof, for instance in biofuel production.
Abstract translation: 本发明涉及从粗碳源生产生物燃料，蛋白质，肽和其他增值化合物。 发明人确定了编码新戊糖转运蛋白的基因，特别是L-阿拉伯糖和/或D-木糖的转运蛋白。 通过xlnR和araR调节黑曲霉基因有助于鉴定这些基因及其底物特异性。 提供新的戊糖转运蛋白及其编码核酸。 还提供了表达转运蛋白的宿主细胞（以上）及其工业应用，例如在生物燃料生产中。
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公开(公告)号：WO2006071118A2
公开(公告)日：2006-07-06
申请号：PCT/NL2005050094
申请日：2005-12-23
Applicant: STICHTING TECH WETENSCHAPP , UNIV LEIDEN , RAM ARTHUR FRANCISCUS JOHANNES , DAMVELD ROBBERT ANTONIUS , ARENTSHORST MARK , VAN KUYK PATRICIA ANN , VAN DEN HONDEL CORNELIS ANTONI
Inventor： RAM ARTHUR FRANCISCUS JOHANNES , DAMVELD ROBBERT ANTONIUS , ARENTSHORST MARK , VAN KUYK PATRICIA ANN , VAN DEN HONDEL CORNELIS ANTONI
CPC classification number: C12Q1/18 , G01N2333/37
Abstract: The present invention relates to a fungus which produces substantially no functional protein with regulating activity on the transcription of genes which are involved in cell wall stress response. It also relates to a method for screening for antifungal agents, in particular to antifungal agents which target the cell wall. It also relates to a kit for screening for antifungal agents which disturb cell wall biogenesis.
Abstract translation: 本发明涉及一种真菌，其基本上不产生对参与细胞壁应激反应的基因的转录具有调节活性的功能性蛋白质。 它还涉及用于筛选抗真菌剂的方法，特别是靶向细胞壁的抗真菌剂。 它还涉及用于筛选干扰细胞壁生物发生的抗真菌剂的试剂盒。
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公开(公告)号：WO2011059329A2
公开(公告)日：2011-05-19
申请号：PCT/NL2010/050755
申请日：2010-11-12
Applicant: UNIVERSITEIT UTRECHT HOLDING B.V. , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORG , STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN , UNIVERSITEIT LEIDEN , VANKUYK, Patricia, Ann , DE VRIES, Ronald, Peter , VISSER, Jacob , RAM, Arthur, Franciscus, Johannes , VAN DEN HONDEL, Cornelis, Antonius, Maria, Jacobus, Johannes , BATTAGLIA, Evy , VIVAS DUARTE, Diana, Alexandra
Inventor： VANKUYK, Patricia, Ann , DE VRIES, Ronald, Peter , VISSER, Jacob , RAM, Arthur, Franciscus, Johannes , VAN DEN HONDEL, Cornelis, Antonius, Maria, Jacobus, Johannes , BATTAGLIA, Evy , VIVAS DUARTE, Diana, Alexandra
IPC: C07K14/38
Abstract: The invention relates to the production of biofuels, proteins, peptides and other value-added compounds from crude carbon sources. The inventors identified genes encoding novel pentose transporters, in particular transporters of L-arabinose and/or D-xylose. Regulation of the Aspergillus niger genes by xlnR and araR was instrumental in the identification of these genes and their substrate specificities. Provided are novel pentose transporters and their encoding nucleic acids. Also provided are host cells (over)expressing a transporter, and industrial applications thereof, for instance in biofuel production.
Abstract translation: 本发明涉及从粗碳源生产生物燃料，蛋白质，肽和其他增值化合物。 发明人确定了编码新戊糖转运蛋白的基因，特别是L-阿拉伯糖和/或D-木糖的转运蛋白。 通过xlnR和araR调节黑曲霉基因有助于鉴定这些基因及其底物特异性。 提供新的戊糖转运体及其编码核酸。 还提供了表达转运蛋白的宿主细胞（以上）及其工业应用，例如在生物燃料生产中。
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公开(公告)号：WO2006071118A3
公开(公告)日：2006-07-06
申请号：PCT/NL2005/050094
申请日：2005-12-23
Applicant: STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN , UNIVERSITEIT LEIDEN , RAM, Arthur, Franciscus, Johannes , DAMVELD, Robbert, Antonius , ARENTSHORST, Mark , VAN KUYK, Patricia, Ann , VAN DEN HONDEL, Cornelis, Antonius, Maria, Jacobus, Johannes
Inventor： RAM, Arthur, Franciscus, Johannes , DAMVELD, Robbert, Antonius , ARENTSHORST, Mark , VAN KUYK, Patricia, Ann , VAN DEN HONDEL, Cornelis, Antonius, Maria, Jacobus, Johannes
Abstract: The present invention relates to a fungus which produces substantially no functional protein with regulating activity on the transcription of genes which are involved in cell wall stress response. It also relates to a method for screening for antifungal agents, in particular to antifungal agents which target the cell wall. It also relates to a kit for screening for antifungal agents which disturb cell wall biogenesis.
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