公开(公告)号：NL2009010C

公开(公告)日：2013-12-17

申请号：NL2009010

申请日：2012-06-15

Applicant: STICHTING VU VUMC

Inventor： KOOL JEROEN ,  HEUS FERRY ADAM HENRICUS

IPC: B01D15/08 ,  G01N30/84

CPC classification number: G01N30/84 ,  B01D15/24 ,  G01N30/30 ,  G01N30/80 ,  G01N2030/025 ,  G01N2030/065 ,  G01N2030/8435

公开(公告)号：SG193539A1

公开(公告)日：2013-10-30

申请号：SG2013070487

申请日：2012-01-16

Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG ,  STICHTING VU VUMC

Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

公开(公告)号：NL2008707C2

公开(公告)日：2013-10-29

申请号：NL2008707

申请日：2012-04-26

Applicant: STICHTING VU VUMC

Inventor： BOSCH LINDA JANNA WILLEMIEN ,  WIT MEIKE ,  PINTO MORAIS DE CARVALHO BEATRIZ ,  FIJNEMAN REMONDUS JOHANNES ADRIAAN ,  MEIJER GERRIT ALBERT ,  JIMENEZ CORNELIA RAMONA ,  PIERSMA SANDER ROGIER ,  PHAM VIET THANG ,  OUDGENOEG GIDEON

IPC: G01N33/574

公开(公告)号：NL2008608C

公开(公告)日：2013-10-09

申请号：NL2008608

申请日：2012-04-05

Applicant: STICHTING VU VUMC

Inventor： ROELOFS THEODORUS FRANK MARIA ,  STRAALEN NICOLAAS MARIA

IPC: C12Q1/68

公开(公告)号：MX2013000606A

公开(公告)日：2013-06-28

申请号：MX2013000606

申请日：2011-07-15

Applicant: STICHTING VU VUMC

Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

IPC: G01N33/48

Abstract: La presente invención se relaciona con un método para analizar una muestra de sangre de un sujeto por la presencia de un marcador de enfermedad, dicho método comprende los pasos de a) extraer ácido nucleico de las células de sangre enucleadas en la muestra de sangre, para proporcionar una fracción de ácido nucleico extraída de células de sangre enucleadas, y b) analizar la fracción de ácido nucleico extraída de células de sangre enucleadas por la presencia de un marcador de enfermedad, en donde el marcador de enfermedad es una mutación específica de la enfermedad en un gen de una célula del sujeto, o en donde el marcador de enfermedad es un perfil de expresión específico de enfermedad de genes de una célula del sujeto.

公开(公告)号：CA2805586A1

公开(公告)日：2012-01-19

申请号：CA2805586

申请日：2011-07-15

Applicant: STICHTING VU VUMC

Inventor： WURDINGER THOMAS ,  NILSSON ROLF JONAS

IPC: G01N33/48

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

公开(公告)号：WO2015194954A1

公开(公告)日：2015-12-23

申请号：PCT/NL2015/050447

申请日：2015-06-18

Applicant: STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN ,  STICHTING VU-VUMC ,  RIJKSUNIVERSITEIT GRONINGEN ,  ACADEMISCH ZIEKENHUIS GRONINGEN ,  BIOFORDRUG SRL, SPIN-OFF DELL'UNIVERSITA DEGLI STUDI DI BARI

Inventor： LUURTSEMA, Gert ,  WINDHORST, Albert Dirk ,  COLABUFO, Nicola Antonio ,  CANTORE, Mariangela ,  SAVOLAINEN, Heli

IPC: C07D217/04 ,  A61K49/00 ,  A61K51/04 ,  A61K31/472 ,  G01N33/58 ,  G01N33/60 ,  G21H5/02 ,  A61P25/28

CPC classification number: C07D217/04 ,  A61K51/0455 ,  G21H5/02

Abstract: The present invention relates to a 6,7-dioxyalkyltetrahydroisoquinoline compound, or a salt or solvate thereof according to formula I: (formula I), (I) wherein R represents hydrogen or a fluorinated alkyl group, and R 2 and R 3 independently represents hydrogen or an alkyl group.

Abstract translation: 本发明涉及式I的6,7-二氧烷基四氢异喹啉化合物或其盐或溶剂合物：（Ⅰ）式（Ⅰ）其中R代表氢或氟化烷基，R2和R3独立地代表氢或 烷基。

公开(公告)号：WO2015185222A1

公开(公告)日：2015-12-10

申请号：PCT/EP2015/001150

申请日：2015-06-08

Applicant: STICHTING VU-VUMC ,  FOM-NIKHEF

Inventor： HENNES, Eric ,  BERTOLINI, Alessandro ,  VAN DEN BRAND, Johannes, Franciscus

IPC: B81B3/00 ,  B81B7/00

CPC classification number: B81B3/0078 ,  B81B2201/0235 ,  B81B2201/0285 ,  B81B2203/0163 ,  G01P15/125

Abstract: A MEMS sensor comprising preloaded suspension springs and a method for mechanically preloading suspension springs of a MEMS sensor are described. The MEMS sensor comprises a MEMS support structure; a plurality of suspension springs connected to said support structure; and, a proof mass flexibly suspended by said suspension springs; wherein at least one of said suspension springs is mechanically preloaded with a compressive force for reducing the natural frequency of said proof mass.

Abstract translation: 描述了包括预加载悬架弹簧的MEMS传感器和用于机械预加载MEMS传感器的悬架弹簧的方法。 MEMS传感器包括MEMS支撑结构; 连接到所述支撑结构的多个悬架弹簧; 以及由所述悬架弹簧柔性地悬挂的证明质量块; 其中所述悬架弹簧中的至少一个机械地预加载有用于减小所述证明物质的固有频率的压缩力。

公开(公告)号：WO2015156673A1

公开(公告)日：2015-10-15

申请号：PCT/NL2015/050235

申请日：2015-04-10

Applicant: STICHTING VU-VUMC

Inventor： VAN DER VLIET, Johannes Jelle ,  DE BRUIN, Renée Cornelia Gerarda ,  DE GRUIJL, Tanja Denise ,  VERHEUL, Hendrik Marinus Willem

IPC: C07K16/28

CPC classification number: C07K16/2809 ,  C07K2317/21 ,  C07K2317/22 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/70 ,  C07K2317/75 ,  C07K2317/76

Abstract: The invention is in the field of medicine and relates to immunology, and relates in particular to human Vγ9Vδ2 T cell receptor bindingimmunoglobulin molecules. Human Vγ9Vδ2 T cell receptor binding immunoglobulin molecules are in particular for use in medical treatment and/or useful in assays with human Vγ9Vδ2 T cells, wherein human Vγ9Vδ2 T cells may be modulated.

Abstract translation: 本发明涉及医学领域，涉及免疫学，特别涉及人Vγ9Vδ2T细胞受体结合免疫球蛋白分子。 人Vγ9Vδ2T细胞受体结合免疫球蛋白分子特别用于医学治疗和/或可用于与人Vγ9Vδ2T细胞的测定中，其中可以调节人Vγ9Vδ2T细胞。

公开(公告)号：WO2015084166A1

公开(公告)日：2015-06-11

申请号：PCT/NL2014/050821

申请日：2014-12-02

Applicant: STICHTING VU-VUMC

Inventor： OSSENKOPPELE, Gerrit Johan ,  SCHUURHUIS, Gerrit Jan ,  ZEIJLEMAKER, Wendelien

IPC: G01N33/574

CPC classification number: G01N33/57426 ,  G01N15/14 ,  G01N33/5011 ,  G01N33/5073 ,  G01N33/57492 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2800/52

Abstract: The present invention relates to a method for identifying Leukemic stem cells (LSC), based on measurement of the presence of a specific set of markers. The invention further relates to a container for use in performing the method. Also provided is application of the method for predicting response to therapy and/or chance of relapse of Acute Myeloid Leukemia, and application of the method in the context of screening for compounds that specifically eradicate Leukemic cells and not benign cells.

Abstract translation: 本发明涉及一种用于鉴别白血病干细胞（LSC）的方法，该方法是基于特定标记物组的存在的测量。 本发明还涉及一种用于执行该方法的容器。 还提供了预测对急性骨髓性白血病的治疗反应和/或复发机率的方法的应用，以及在筛选特异性根除白血病细胞而不是良性细胞的化合物的上下文中应用该方法。