UN METODO PARA ANALIZAR UNA MUESTRA DE SANGRE DE UN SUJETO POR LA PRESENCIA DE UN MARCADOR DE ENFERMEDAD.

    公开(公告)号:MX2013000606A

    公开(公告)日:2013-06-28

    申请号:MX2013000606

    申请日:2011-07-15

    Abstract: La presente invención se relaciona con un método para analizar una muestra de sangre de un sujeto por la presencia de un marcador de enfermedad, dicho método comprende los pasos de a) extraer ácido nucleico de las células de sangre enucleadas en la muestra de sangre, para proporcionar una fracción de ácido nucleico extraída de células de sangre enucleadas, y b) analizar la fracción de ácido nucleico extraída de células de sangre enucleadas por la presencia de un marcador de enfermedad, en donde el marcador de enfermedad es una mutación específica de la enfermedad en un gen de una célula del sujeto, o en donde el marcador de enfermedad es un perfil de expresión específico de enfermedad de genes de una célula del sujeto.

    A METHOD OF ANALYSING A BLOOD SAMPLE OF A SUBJECT FOR THE PRESENCE OF A DISEASE MARKER

    公开(公告)号:CA2805586A1

    公开(公告)日:2012-01-19

    申请号:CA2805586

    申请日:2011-07-15

    Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

    MEMS SENSOR STRUCTURE COMPRISING MECHANICALLY PRELOADED SUSPENSION SPRINGS
    58.
    发明申请
    MEMS SENSOR STRUCTURE COMPRISING MECHANICALLY PRELOADED SUSPENSION SPRINGS 审中-公开
    MEMS传感器结构包含机械预先悬挂弹簧

    公开(公告)号:WO2015185222A1

    公开(公告)日:2015-12-10

    申请号:PCT/EP2015/001150

    申请日:2015-06-08

    Abstract: A MEMS sensor comprising preloaded suspension springs and a method for mechanically preloading suspension springs of a MEMS sensor are described. The MEMS sensor comprises a MEMS support structure; a plurality of suspension springs connected to said support structure; and, a proof mass flexibly suspended by said suspension springs; wherein at least one of said suspension springs is mechanically preloaded with a compressive force for reducing the natural frequency of said proof mass.

    Abstract translation: 描述了包括预加载悬架弹簧的MEMS传感器和用于机械预加载MEMS传感器的悬架弹簧的方法。 MEMS传感器包括MEMS支撑结构; 连接到所述支撑结构的多个悬架弹簧; 以及由所述悬架弹簧柔性地悬挂的证明质量块; 其中所述悬架弹簧中的至少一个机械地预加载有用于减小所述证明物质的固有频率的压缩力。

    LEUKEMIC STEM CELL MARKERS
    60.
    发明申请

    公开(公告)号:WO2015084166A1

    公开(公告)日:2015-06-11

    申请号:PCT/NL2014/050821

    申请日:2014-12-02

    Abstract: The present invention relates to a method for identifying Leukemic stem cells (LSC), based on measurement of the presence of a specific set of markers. The invention further relates to a container for use in performing the method. Also provided is application of the method for predicting response to therapy and/or chance of relapse of Acute Myeloid Leukemia, and application of the method in the context of screening for compounds that specifically eradicate Leukemic cells and not benign cells.

    Abstract translation: 本发明涉及一种用于鉴别白血病干细胞(LSC)的方法,该方法是基于特定标记物组的存在的测量。 本发明还涉及一种用于执行该方法的容器。 还提供了预测对急性骨髓性白血病的治疗反应和/或复发机率的方法的应用,以及在筛选特异性根除白血病细胞而不是良性细胞的化合物的上下文中应用该方法。

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