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公开(公告)号：KR1020050022251A
公开(公告)日：2005-03-07
申请号：KR1020040020401
申请日：2004-03-25
Applicant: (주)아모레퍼시픽
IPC: C07C239/14
Abstract: PURPOSE: Provided are a hydroxamic acid derivative which shows an antiaging effect and is improved in safety and stability to the skin stimulus and discoloration, its preparation method, and an antiaging skin preparation for external use and a collagenase and elastase expression inhibitor containing the derivative. CONSTITUTION: The hydroxamic acid derivative is represented by the formula 1, wherein R1 and R2 are H, a C1-C10 alkyl group or a C3-C6 cycloalkyl group; R3 is CONH, NHCO, CONR5 or NR5CO (wherein R5 is H or a C1-C10 alkyl group); and R4 is -(CH)n- (wherein n is 0 or 1). The method comprises the steps of reacting benzoic acid and methyl 4-aminobenzoate or 4-aminophenylacetic acid methyl ester or reacting aniline and monomethyl terephthalate, to prepare a benzamide compound; substituting the amino bond of the benzamide compound into an alkyl bond; hydrolyzing the methyl ester group to prepare an acid; and reacting the obtained acid with hydroxyl amine·HCl salt to prepare the hydroxamic acid derivative of the formula 1.
Abstract translation: 目的：提供一种异羟肟酸衍生物，其表现出抗衰老作用，并且改善了皮肤刺激和变色的安全性和稳定性，其制备方法和外用抗衰老皮肤制剂以及含有该衍生物的胶原酶和弹性蛋白酶表达抑制剂。 构成：异羟肟酸衍生物由式1表示，其中R 1和R 2是H，C 1 -C 10烷基或C 3 -C 6环烷基; R3是CONH，NHCO，CONR5或NR5CO（其中R5是H或C1-C10烷基）; 且R 4为 - （CH）n - （其中n为0或1）。 该方法包括使苯甲酸和4-氨基苯甲酸甲酯或4-氨基苯乙酸甲酯或苯胺与对苯二甲酸单甲酯反应制备苯甲酰胺化合物的步骤; 将苯甲酰胺化合物的氨基取代成烷基键; 水解甲基酯以制备酸; 并使所得酸与羟胺·HCl盐反应制备式1的异羟肟酸衍生物。
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公开(公告)号：KR101723481B1
公开(公告)日：2017-04-07
申请号：KR1020100078282
申请日：2010-08-13
Applicant: (주)아모레퍼시픽
Inventor： 백흥수
IPC: A61K31/352 , A61K31/355 , A61K8/49 , A61Q5/00 , A61Q19/00
Abstract: 본발명은백모방지용및 백반증치료용조성물에관한것으로서, 보다상세하게는플라보노이드유도체를유효성분으로함유함으로써 MITF 발현을증가시켜멜라노사이트를활성화시키고멜라닌합성을촉진함으로써백모의유발을사전에예방하고흑모유발을촉진하며, 또한백반증치료에효과적인백모방지용및 백반증치료용조성물에관한것이다.
Abstract translation: 本发明涉及一种组合物用于预防阿姨和白癜风治疗，更具体地涉及通过增加MITF表达由含有类黄酮衍生物作为活性成分的预防姨的诱导活化黑素细胞并促进黑色素合成提前和日本黑 这对于治疗白癜风是有效的。背景技术
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公开(公告)号：KR101695002B1
公开(公告)日：2017-01-12
申请号：KR1020100078279
申请日：2010-08-13
Applicant: (주)아모레퍼시픽
Inventor： 백흥수
IPC: A61K31/047 , A61K31/05 , A61K8/33 , A61K8/34 , A61K8/97 , A61K36/60 , A61Q19/08 , A61Q19/00 , A61Q19/02 , A61Q17/04
Abstract: 본발명은프로판노이드유도체를함유하는피부외용제조성물에관한것으로서, 보다상세하게는프레닐기로치환된프로판노이드유도체를함유함으로써피부노화방지효과, 피부보습력개선효과, 항염효과, 여드름및 피부트러블개선효과, 미백효과등 전반적인피부상태개선효과를제공할수 있는조성물에관한것이다.
Abstract translation: 目的：提供含有丙酸衍生物的外用皮肤组合物，以增强皮肤的抗衰老，保湿和抗炎，并治疗痤疮和皮肤问题。 构成：外用皮肤组合物含有0.001-50重量％的以化学式1的异戊烯基作为活性成分取代的类异构体衍生物。衍生物包括二羟色胺A，broxonin B，broxonin C，broxonin D，broxonin E，broxonin F， 卡西诺醇C，卡西诺醇D，卡西诺醇F，卡西诺醇G，卡西醇J，卡辛醇K，卡西醇L，卡西醇M或卡西诺醇N.衍生物从布鲁氏菌（Broussonetia kazinokii）中分离。
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公开(公告)号：KR101684671B1
公开(公告)日：2016-12-09
申请号：KR1020100088083
申请日：2010-09-08
Applicant: (주)아모레퍼시픽
IPC: C07D241/44 , A61K9/00 , A61K47/06 , A61L31/16
Abstract: 본발명은신규한퀴녹살린계화합물, 그의이성질체, 그의전구약물, 또는그의약학적으로허용가능한염, 수화물또는용매화물을제공한다. 상기퀴녹살린계화합물은 UVA 및 UVC 영역의자외선을흡수할수 있어서, 자외선흡수제나, 노화방지용약학조성물또는노화방지용화장료조성물로유용하게사용할수 있다.
Abstract translation: 目的：提供一种新的喹喔啉化合物，其异构体，其前体药物或其药学上可接受的盐以吸收UVA和UVB。 构成：喹喔啉化合物由化学式1表示。用于抗衰老的紫外线吸收剂或药物或化妆品组合物含有喹喔啉化合物，其异构体，其前体药物或其药学上可接受的盐，水合物或溶剂化物作为活性成分。
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公开(公告)号：KR1020160105646A
公开(公告)日：2016-09-07
申请号：KR1020150028474
申请日：2015-02-27
Applicant: (주)아모레퍼시픽
IPC: G01N33/50
CPC classification number: G01N33/50 , G01N33/5044 , C12N2502/091
Abstract: 본명세서의일측면에서는미백성분의부작용을예측하는방법으로서, 상기방법은, ⅰ) 미백성분의장시간사용에따른독성증가폭ⅱ) 미백효능농도와세포독성농도의차이ⅲ) 자외선전처리에따른미백성분에대한민감도증가폭중 하나이상을측정하는것을포함하는방법을제공하며, 상기방법은미백성분을장시간사용할경우의부작용발생여부를효과적으로예측하는효과가있다.
Abstract translation: 本发明的一个方面涉及一种预测增白组分的副作用的方法。 该方法包括以下步骤中的至少一个：i）相对于长期使用美白组分的毒性增加量; ii）表现出增白效果的美白组分浓度与表现出细胞毒性的浓度之间的差异; 和iii）增白组分相对于紫外线处理作为预处理的灵敏度的增加量。 该方法有效地预测当美白组分长时间使用时是否发生副作用。
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Patent Agency Ranking
公开(公告)号：KR1020160046639A
公开(公告)日：2016-04-29
申请号：KR1020140142818
申请日：2014-10-21
Applicant: (주)아모레퍼시픽
Abstract: 본발명은 2,3-부탄디올의이성질체인하기화학식 1로표현되는메조(meso)-2,3-부탄디올을함유함으로써화학방부제를포함하지않으면서도방부력이우수하고피부에대한자극이적어사용감이뛰어난피부외용제조성물에관한것이다. [화학식 1]
Abstract translation: 本发明涉及一种外用组合物，其含有由化学式1表示的2,3-丁二醇异构体的内消旋-2,3-丁二醇，即使没有化学防腐剂也具有优异的防腐活性， 并通过刺激性较差而对皮肤有良好的感觉。
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公开(公告)号：KR101367057B1
公开(公告)日：2014-02-25
申请号：KR1020090022704
申请日：2009-03-17
Applicant: (주)아모레퍼시픽
IPC: A61K31/353 , A61K8/49 , A61P17/10 , A61Q19/08
Abstract: 본 발명은 하기 화학식 1의 화합물, 그것의 이성질체 또는 약제학적으로 허용 가능한 염을 유효 성분으로 포함하는 피부 자극 완화용 조성물에 관한 것이다.
(화학식 1)
본 발명에 따른 조성물에 포함되는 화학식 1의 화합물, 그것의 이성질체 또는 약제학적으로 허용 가능한 염은 예를 들어, 레티노이드(retinoid) 또는 계면활성제 등에 의한 염증성 매개인자의 발현을 억제함으로써, 피부 자극 완화에 우수한 효과를 발휘하는 바, 피부 자극 완화용 조성물의 유효 성분으로 적합하게 사용될 수 있다.
피부 자극 완화, 레티노이드, 계면활성제-
公开(公告)号：KR1020130055114A
公开(公告)日：2013-05-28
申请号：KR1020110120662
申请日：2011-11-18
Applicant: (주)아모레퍼시픽
IPC: A61K31/05 , A61K31/192 , A61K31/185 , A61P17/00
Abstract: PURPOSE: Carnosic acid, a derivative thereof, or a pharmaceutically acceptable salt thereof is provided to suppress c-kit activation and signal transduction in melanocytes, and to improve skin whitening. CONSTITUTION: A c-kit activity inhibitor contains carnosic acid of chemical formula 1, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. The derivative is carnosic acid methyl ester or carnosic acid ethyl alcohol. The carnosic acid, a derivative thereof, or a pharmaceutically acceptable salt thereof is derived from rosemary and/or sage. The inhibitor contains 0.0001-10 wt% of the active ingredient. A composition for skin whitening contains the derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof. The composition further contains one or more selected from a group consisting of a Gycyrrhiza extract, arbutin, ascorbic acid, and kojic acid.
Abstract translation: 目的：提供鼠尾草酸，其衍生物或其药学上可接受的盐以抑制黑素细胞中的c-kit活化和信号转导，并改善皮肤美白。 构成：c-kit活性抑制剂含有化学式1的鼠尾草酸，其衍生物或其药学上可接受的盐作为活性成分。 衍生物为卡诺卡因酸甲酯或鼠尾草醇乙醇。 鼠尾草酸，其衍生物或其药学上可接受的盐衍生自迷迭香和/或鼠尾草。 抑制剂含有0.0001-10重量％的活性成分。 用于皮肤美白的组合物含有化学式1的衍生物或其药学上可接受的盐。 组合物还含有选自由甘草提取物，熊果苷，抗坏血酸和曲酸组成的组中的一种或多种。
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公开(公告)号：KR1020130045452A
公开(公告)日：2013-05-06
申请号：KR1020110109656
申请日：2011-10-26
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A makeup cosmetic composition containing a cholesteric liquid crystal containing a useful pigment is provided to implement an optical property such as hologram when applied on skin or lip. CONSTITUTION: A makeup cosmetic composition contains 50.0-99.999 wt% of a cholesteric liquid crystal containing a useful pigment. The composition contains 0.001-10.0 wt% of the useful pigment. The cholesteric liquid crystal is a liquid crystal mixture containing a nematic liquid crystal(NLC) with chiral dopant which induces a periodic helical structure. The cholesteric liquid crystal selectively reflects light according to the pitch of a repetitive structure and the twisting direction of the helix. [Reference numerals] (AA) Optical characteristic from external appearances; (BB) Optical characteristic after being applied on lips; (CC) Comparative example 1; (DD) Comparative example 2; (EE) Comparative example 3; (FF) Example 1; (GG) Example 2
Abstract translation: 目的：提供一种含有含有有用颜料的胆甾型液晶的化妆品组合物，以在施用于皮肤或唇部时实现全息图等光学性质。 构成：化妆组合物含有50.0-99.999重量％的含有有用颜料的胆固醇液晶。 该组合物含有0.001-10.0重量％的有用颜料。 胆甾型液晶是含有引发周期性螺旋结构的手性掺杂剂的向列型液晶（NLC）的液晶混合物。 胆甾型液晶根据重复结构的螺距和螺旋的扭转方向选择性地反射光。 （附图标记）（AA）外观的光学特性; （BB）应用于唇部后的光学特性; （CC）比较例1; （DD）比较例2; （EE）比较例3 （FF）实施例1; （GG）实施例2
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公开(公告)号：KR1020130037405A
公开(公告)日：2013-04-16
申请号：KR1020110101797
申请日：2011-10-06
Applicant: (주)아모레퍼시픽
IPC: C07C233/43 , A61K8/42 , A61K31/165 , A61Q7/00
CPC classification number: C07C233/65 , C07C233/59 , C07C255/57
Abstract: PURPOSE: A novel adamantane derivative compound is provided to decrease androgen, thereby obtaining hair growth and sebum secretion inhibiting effects. CONSTITUTION: A novel adamantane derivative compound is represented by chemical formula 1. In chemical formula 1, X is -NHCO- or -CONH-; R1 is C0-C5 alkyl or C1-C5 alkoxy; R2 is selected from NO2, CN, and NH2; and R3 is C1-C5 haloalkyl. The anti-androgen composition comprises the compound, isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, anhydride thereof, or a solvent thereof.
Abstract translation: 目的：提供一种新的金刚烷衍生物，以减少雄激素，从而获得毛发生长和皮脂分泌抑制作用。 组成：一种新颖的金刚烷衍生化合物由化学式1表示。在化学式1中，X是-NHCO-或-CONH-; R1是C0-C5烷基或C1-C5烷氧基; R2选自NO2，CN和NH2; 并且R 3是C 1 -C 5卤代烷基。 抗雄激素组合物包含化合物，其异构体，其药学上可接受的盐，其前药，其酸酐或其溶剂。
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