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公开(公告)号：KR1020090056311A
公开(公告)日：2009-06-03
申请号：KR1020070123407
申请日：2007-11-30
Applicant: (주)아모레퍼시픽 , 재단법인서울대학교산학협력재단
CPC classification number: C12N15/1086 , A61Q19/08
Abstract: A skin external composition improving anti-aging through the regulation of caveolin productivity is provided to promote the collagen biosynthesis, prevent skin aging and enhance skin elasticity. A skin external composition comprises 0.001-10% by weight of caveolin or a material which increases the caveolin biosynthesis as a efficient ingredient. The material which increases the caveolin biosynthesis is the cholesterol. The skin external composition is used in a form of skin, lotion, massage cream, pack, gel, ointment, gel, cream, patch, or transdermal administration of spray. A screening process is performed by selecting materials which increase the caveolin productivity in dermis from candidate materials in vitro.
Abstract translation: 提供通过调节窖蛋白生产力来改善抗衰老的皮肤外用组合物，以促进胶原蛋白生物合成，防止皮肤老化和增强皮肤弹性。 皮肤外用组合物包含0.001-10重量％的小窝蛋白或增加窖蛋白生物合成作为有效成分的材料。 增加窖蛋白生物合成的物质是胆固醇。 皮肤外用组合物以皮肤，洗剂，按摩霜，包装，凝胶，软膏，凝胶，霜剂，补片或透皮给药的形式使用。 通过选择在体外从候选材料增加真皮中的小窝蛋白生产力的材料进行筛选过程。
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公开(公告)号：KR1020090036299A
公开(公告)日：2009-04-14
申请号：KR1020070101391
申请日：2007-10-09
Applicant: (주)아모레퍼시픽
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/6893 , G01N2500/04 , G01N2800/20 , C12Q1/6876
Abstract: A method for diagnosing degree of aging and a kit thereof are provided to rapidly diagnose degree of aging caused by female hormone deficiency using a marker gene and induce development of a skin aging inhibitor. A kit for diagnosing degree of aging caused by female hormone deficiency comprises one or more polynucleotides and polynucleotide containing ten or more continuous nucleotide as the fraction of the polynucleotides or complementary polynucleotide thereof. The kit for diagnosing degree of aging caused by female hormone deficiency contains a solid support whose surface is coupled with the polynucleotides. If the quantify of transcriptome mixed to the polynucleotides among transcriptomes of keratinocyte is less than standard value, the skin is diagnosed as geroderma.
Abstract translation: 提供了一种诊断老化程度的方法及其试剂盒，以使用标记基因快速诊断由雌激素缺乏引起的老化程度并诱导皮肤老化抑制剂的发生。 用于诊断由雌性激素缺乏引起的老化程度的试剂盒包含一种或多种多核苷酸和含有多个连续核苷酸的多核苷酸或多核苷酸作为多核苷酸或其互补多核苷酸的部分。 用于诊断由雌激素缺乏引起的老化程度的试剂盒含有表面与多核苷酸偶联的固体支持物。 如果在角质形成细胞转录组中与多核苷酸混合的转录组的定量小于标准值，则将皮肤诊断为皮病。
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公开(公告)号：KR1020090027537A
公开(公告)日：2009-03-17
申请号：KR1020070092824
申请日：2007-09-12
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/6876 , C12Q1/6834 , G06F19/20
Abstract: An abnormal keratinization skin disease diagnosis kit is provided to diagnose rapidly abnormal keratinization skin disease and to screen a keratinocyte allotypic differentiation antisagging agent. An abnormal keratinization skin disease diagnosis kit comprises specific polynucleotide or polynucleotide thereof and a solid support. The specific polynucleotide is one or more selected from a group consisting of SEC24D, WASF1, MTFR1, STT3A, CDKN3, EIF2B3, PTPRZ1, TRIM37, GTF2H2, ATM, FST, G3BP2, TETRAN, MDFIC, ALG14, RPS7, OLFM1, RCN2, IGSF3, HS3ST1, ERLIN1, IL1A, SST, FHL1, PTGS2, BCAT1, DNAJC10, IBTK, ODC1, OR7E38P, TIMM17A, PLDN, TBPL1, PFAS, TTTY15, FAM91A1, SNRPG, SNRPB2, SLMO2, SCFD1, ATP11C, CYCS, CD9, CKS1B, DPM1, UQCRQ, CPSF2, RNF41, PDE4D, HLA-DOB, CSNK1G3, LYSMD3, DORA2B, SSR1, GALK2, GTF2H3, ZNF410, TXNL2, NUS1, MEF2B, GPD2, AMMECR1L, SLC3A2, MAD2L2, MGAT1, ATP5E, FXN, TAF7, DCK, NCOA1, AKAP8L, CA14, CRSP8, C7orf30, FAM126A, SEC23B, CTBS, BBS12, TRIM32, RAE1, PBEF1, TNFAIP8, C10orf104, PPP2R1B, RNF139, PRDX6, CBX5, ARG2, HOXD8 and C10orf11.
Abstract translation: 提供异常角质化皮肤病诊断试剂盒，用于诊断快速异常角质化皮肤病，并筛选角质形成细胞异构化分化抗凝剂。 异常角质化皮肤病诊断试剂盒包括其特异性多核苷酸或多核苷酸和固体支持物。 特异性多核苷酸是选自由SEC24D，WASF1，MTFR1，STT3A，CDKN3，EIF2B3，PTPRZ1，TRIM37，GTF2H2，ATM，FST，G3BP2，TETRAN，MDFIC，ALG14，RPS7，OLFM1，RCN2，IGSF3组成的组中的一种或多种 ，HS3ST1，ERLIN1，IL1A，SST，FHL1，PTGS2，BCAT1，DNAJC10，IBTK，ODC1，OR7E38P，TIMM17A，PLDN，TBPL1，PFAS，TTTY15，FAM91A1，SNRPG，SNRPB2，SLMO2，SCFD1，ATP11C，CYCS，CD9，CKS1B ，DPM1，UQCRQ，CPSF2，RNF41，PDE4D，HLA-DOB，CSNK1G3，LYSMD3，DORA2B，SSR1，GALK2，GTF2H3，ZNF410，TXNL2，NUS1，MEF2B，GPD2，AMMECR1L，SLC3A2，MAD2L2，MGAT1，ATP5E，FXN，TAF7 ，DCK，NCOA1，AKAP8L，CA14，CRSP8，C7orf30，FAM126A，SEC23B，CTBS，BBS12，TRIM32，RAE1，PBEF1，TNFAIP8，C10orf104，PPP2R1B，RNF139，PRDX6，CBX5，ARG2，HOXD8和C10orf11。
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公开(公告)号：KR100881143B1
公开(公告)日：2009-02-02
申请号：KR1020070048493
申请日：2007-05-18
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 녹차꽃 추출물을 유효성분으로 함유하는 피부 외용제에 관한 것으로서, 보다 상세하게는 주름 개선, 탄력 개선의 효과가 있으며, 자외선에 의한 피부의 미세염증 상태를 조절하고 환경 유해요소에 의한 독성을 제거하여 피부를 보호하며, 색소 침착을 줄여 주고, 부작용이 없는 녹차꽃의 고유 향취를 유지하면서 뛰어난 피부 효능을 갖는 녹차꽃 추출물을 함유하는 피부 외용제 조성물에 관한 것이다.
녹차꽃 향취, 녹차꽃 추출물, 주름 개선, 피부 탄력 개선, 미세염증 조절, 해독작용 세포손상 보호, 색소 침착 조절-
公开(公告)号：KR1020080105591A
公开(公告)日：2008-12-04
申请号：KR1020070053362
申请日：2007-05-31
Applicant: (주)아모레퍼시픽
Abstract: A cosmetic composition is provided to prevent the damage of hair by reducing the loss of labile proteins inside hair. A cosmetic composition for preventing the damage of hair contains 0.01-10 wt% of a lime oil, a lemon oil, or their mixture. Preferably the lime oil is an oil extracted by distilling Citrus aurantifolia, and the lemon oil is an oil extracted by compressing the shell of Citrus limon.
Abstract translation: 提供化妆品组合物以通过减少毛发内不稳定蛋白质的损失来防止毛发的损伤。 用于防止头发损伤的化妆品组合物含有0.01-10重量％的石灰油，柠檬油或它们的混合物。 优选地，石灰油是通过蒸馏柑橘柠檬提取的油，柠檬油是通过压缩柑橘柠檬的壳提取的油。
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Patent Agency Ranking56.发明公开카텝신 Ｇ 저해제를 함유하는 피부노화 방지용 피부외용제조성물 및 항노화용 물질을 스크리닝하는 방법 有权用于外用于含皮肤抑制剂G抑制剂以防止皮肤老化的筛选组合物和用于开发抗病材料的筛选方法
公开(公告)号：KR1020080040612A
公开(公告)日：2008-05-08
申请号：KR1020070111803
申请日：2007-11-02
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K8/44 , A61K8/34 , A61Q19/08
CPC classification number: A61K8/42 , A61K2800/522 , A61Q19/08
Abstract: A skin external composition comprising a cathepsin G inhibitor is provided to prevent an adhesion protein from being degraded by intrinsic aging and photo-aging, reduce the production of metalloproteinase and inhibit the activity of metalloproteinase, thereby being more potent anti-aging substance than existing anti-aging substances. A method for screening anti-aging materials is provided to develop the anti-aging materials which effectively inhibit the quantitative and qualitative increase of metalloproteinase, resulting from the degradation of an adhesion protein by cathepsin G in skin cells without direct UV irradiation. A skin external composition for preventing skin aging comprises 0.01-10 wt% a cathepsin G inhibitor as an effective ingredient, wherein the cathepsin G inhibitor is at least one selected from the group consisting of compounds represented by formulae(1) to (4). The composition is formulated into skin lotion, astringent lotion, milk lotion, nourishing cream, essence, massage cream, eye cream, pack, body lotion, body cream, body oil or body essence. A method for screening an anti-aging material comprises the steps of: (a) adding an anti-aging candidate material to a substrate in the presence of cathepsin G enzyme; and (b) measuring the inhibition of activity of the cathepsin G enzyme. Further, the measure of the inhibition of activity of the cathepsin G enzyme is performed by measuring a concentration of a produced metalloprotease.
Abstract translation: 提供包含组织蛋白酶G抑制剂的皮肤外用组合物，以防止粘附蛋白由于内在老化和光老化而降解，减少金属蛋白酶的产生并抑制金属蛋白酶的活性，从而比现有的抗老化物质更有效的抗衰老物质 化学物质。 提供了一种筛选抗衰老材料的方法，以开发有效抑制金属蛋白酶定量和定性增加的抗衰老材料，这是由皮肤细胞中组织蛋白酶G在组织蛋白酶G中的降解引起的，而不需要直接的紫外线照射。 用于防止皮肤老化的皮肤外用组合物包含0.01-10重量％的组织蛋白酶G抑制剂作为有效成分，其中组织蛋白酶G抑制剂是选自由式（1）至（4）表示的化合物中的至少一种。 该组合物配制成皮肤洗剂，收敛剂，乳液，滋养霜，精华液，按摩霜，眼霜，包装，身体乳液，身体霜，身体油或身体精华。 用于筛选抗衰老材料的方法包括以下步骤：（a）在组织蛋白酶G酶存在下将抗老化候选材料加入到底物中; 和（b）测量组织蛋白酶G酶的活性的抑制。 此外，组织蛋白酶G酶的活性的抑制的测量是通过测量产生的金属蛋白酶的浓度进行的。
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公开(公告)号：KR1020080038811A
公开(公告)日：2008-05-07
申请号：KR1020060106236
申请日：2006-10-31
Applicant: (주)아모레퍼시픽
IPC: A61K31/352 , A61K31/4439 , A61K8/49 , A61Q19/08
Abstract: An anti-aging composition is provided to promote activity of proteasome of fibroblast and keratinocyte, thereby inhibiting accumulation of oxidation proteins and blocking increase of aging markers. An anti-aging cosmetic or pharmaceutical composition comprises 0.001-5 wt.% of at least one selected from the group consisting of epicatechins, caffeine, naringenin, ellagic acid, sanguinarine, eupomatenoid 6, mahanimbine, tanshinone IIA, theobromine, and gallic acid as an effective ingredient. Further, a 0.001 to 5 wt.% of effective ingredient is comprised based on the 100 wt.% of composition.
Abstract translation: 提供抗衰老组合物以促进成纤维细胞和角质形成细胞的蛋白酶体的活性，从而抑制氧化蛋白的积累并阻止老化标记物的增加。 抗衰老化妆品或药物组合物包含0.001-5重量％的选自表儿茶素，咖啡因，柚皮素，鞣花酸，血根碱，顺铂6，马哈芬精，丹参酮IIA，可可碱和没食子酸的至少一种作为 有效成分。 此外，基于100重量％的组合物，包含0.001至5重量％的有效成分。
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公开(公告)号：KR1020080027526A
公开(公告)日：2008-03-28
申请号：KR1020060092676
申请日：2006-09-25
Applicant: (주)아모레퍼시픽
IPC: A61K31/506 , A61K31/19 , A61P17/14
CPC classification number: A61K8/4953 , A61K8/34 , A61K8/92 , A61Q7/00 , Y10S514/88 , Y10S514/969
Abstract: A composition comprising minoxidil, tretinoin(all-trans retinoic acid), a solvent and glycerine is provided to promote permeation of the minoxidil without stimulus of the tretinoin, thereby inducing hair growth and alleviating alopecia. An external composition for preventing hair loss and promoting hair growth comprises 0.5-7.5 weight/volume% of minoxidil as a hair growth ingredient, 0.007-0.015 weight/volume% of tretinoin, 72-83 weight/volume% of ethanol, and 15-20 weight/volume% of glycerine.
Abstract translation: 提供包含米诺地尔，维A酸（全反式视黄酸），溶剂和甘油的组合物，以促进米诺地尔的渗透，而不刺激维甲酸，从而诱导毛发生长和减轻脱发。 用于防止脱发和促进毛发生长的外用组合物包含0.5-7.5重量/体积％的作为毛发生长成分的米诺地尔，0.007-0.015重量/体积％的维甲酸，72-83重量/体积％的乙醇和15- 20重量/体积％的甘油。
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公开(公告)号：KR100775333B1
公开(公告)日：2007-11-08
申请号：KR1020060114331
申请日：2006-11-20
Applicant: (주)아모레퍼시픽
IPC: G01N33/48
Abstract: A screening method of pigmentation regulatory agents by using zebrafish(Danio rerio) is provided to screen a large quantity of materials capable of increasing or inhibiting melanin formation as pigmentation regulatory agents easily and rapidly by determining various biological parameters from zebrafish. A screening method of pigmentation regulatory agents by using zebrafish comprises the steps of: administering a candidate pigmentation regulatory agent into an embryo of zebrafish; and detecting the reactions of zebrafish including expression amount of melanin formation, and in vivo activity, expression amount or transition amount of proteins associated with melanin formation, wherein the screening method optionally comprises a detecting step of toxicity of the candidate material by measuring morphological change or heartbeat number.
Abstract translation: 提供通过使用斑马鱼（Danio rerio）的色素调节剂的筛选方法，通过确定斑马鱼的各种生物参数，可以容易且快速地筛选大量能够增加或抑制黑色素形成的物质，作为色素调节剂。 通过使用斑马鱼的色素调节剂的筛选方法包括以下步骤：将候选色素调节剂施用于斑马鱼的胚胎; 检测斑马鱼的反应，包括黑色素形成的表达量以及与黑色素形成相关的蛋白质的体内活性，表达量或转化量，其中所述筛选方法任选地包括通过测量形态学变化或候选物质的毒性检测步骤， 心跳数
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公开(公告)号：KR100774437B1
公开(公告)日：2007-11-08
申请号：KR1020060113662
申请日：2006-11-17
Applicant: (주)아모레퍼시픽
IPC: A61K31/343 , A61K8/49 , A61Q19/02
CPC classification number: A61K8/4973 , A61K31/343 , A61Q19/02
Abstract: A skin external composition for skin-whitening containing manassantin B is provided to inhibit mobility of melanin by inhibiting binding of melanophilin as a carrier of melanosome in a melanocyte with myosin 5a, thereby forming melanosome aggregation and whitening the skin. A skin external composition for skin-whitening contains 0.001-10% of manassantin B which is extracted from Saururus chinensis Baill by extracting Saururus chinensis Baill with water or organic solvent selected from ethanol, methanol, butanol, ether, ethylacetate, chloroform and methylene chloride, filtering the extract, concentrating the filtered solution under reduced pressure, extracting the concentrate with methylene chloride and concentrating the extract under reduced pressure, and is formulated as solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray.
Abstract translation: 提供含有马桑丁汀B的皮肤外用组合物，用于通过抑制作为黑素细胞的黑素体的载体的黑色素细胞与肌球蛋白5a的结合来抑制黑色素的迁移，从而形成黑素体聚集并使皮肤变白。 用于皮肤美白的皮肤外用组合物含有0.001-10％的苦参碱B，其通过用水或选自乙醇，甲醇，丁醇，乙醚，乙酸乙酯，氯仿和二氯甲烷的有机溶剂萃取中华白菜， 过滤浓缩滤液，减压浓缩萃取液，减压浓缩，配制成溶液，悬浮液，乳液，糊剂，凝胶，乳液，乳液，粉末，皂，表面活性剂， 含有清洁，油，粉底，乳液粉底，蜡基或喷雾剂。
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