公开(公告)号：WO2009108021A2

公开(公告)日：2009-09-03

申请号：PCT/KR2009/000979

申请日：2009-02-27

Applicant: (주)아모레퍼시픽 ,  경상대학교산학협력단 ,  장희경 ,  김수정 ,  안수미 ,  황재성 ,  윤태진 ,  이증훈 ,  김진화

Inventor： 장희경 ,  김수정 ,  안수미 ,  황재성 ,  윤태진 ,  이증훈 ,  김진화

IPC: C12N15/12

CPC classification number: C07K14/47

Abstract: 본 발명에 따른 과색소침착성 피부 진단용 바이오 마커는 본원 명세서 표 1에 기재된 유전자들로 구성된 군으로부터 선택된 유전자 또는 본원 명세서 표 1에 기재된 단백질들로 구성된 군으로부터 선택된 단백질을 포함하는 것을 특징으로 한다.

Abstract translation: 本发明涉及用于诊断皮肤色素沉着过度的生物标志物，其包含选自表1所列基因的基因或选自表1所列蛋白质的蛋白质。

公开(公告)号：KR100775333B1

公开(公告)日：2007-11-08

申请号：KR1020060114331

申请日：2006-11-20

Applicant: (주)아모레퍼시픽

Inventor： 안수미 ,  황재성 ,  이증훈 ,  윤태진

IPC: G01N33/48

Abstract: A screening method of pigmentation regulatory agents by using zebrafish(Danio rerio) is provided to screen a large quantity of materials capable of increasing or inhibiting melanin formation as pigmentation regulatory agents easily and rapidly by determining various biological parameters from zebrafish. A screening method of pigmentation regulatory agents by using zebrafish comprises the steps of: administering a candidate pigmentation regulatory agent into an embryo of zebrafish; and detecting the reactions of zebrafish including expression amount of melanin formation, and in vivo activity, expression amount or transition amount of proteins associated with melanin formation, wherein the screening method optionally comprises a detecting step of toxicity of the candidate material by measuring morphological change or heartbeat number.

Abstract translation: 提供通过使用斑马鱼（Danio rerio）的色素调节剂的筛选方法，通过确定斑马鱼的各种生物参数，可以容易且快速地筛选大量能够增加或抑制黑色素形成的物质，作为色素调节剂。 通过使用斑马鱼的色素调节剂的筛选方法包括以下步骤：将候选色素调节剂施用于斑马鱼的胚胎; 检测斑马鱼的反应，包括黑色素形成的表达量以及与黑色素形成相关的蛋白质的体内活性，表达量或转化量，其中所述筛选方法任选地包括通过测量形态学变化或候选物质的毒性检测步骤， 心跳数

公开(公告)号：KR1020090093245A

公开(公告)日：2009-09-02

申请号：KR1020080018672

申请日：2008-02-29

Applicant: (주)아모레퍼시픽 ,  경상대학교산학협력단

Inventor： 장희경 ,  김수정 ,  안수미 ,  황재성 ,  윤태진 ,  이증훈 ,  김진화

IPC: C12N15/12 ,  C12Q1/68

CPC classification number: C07K14/47 ,  C12Q1/6876 ,  C12Q2600/136 ,  G01N33/5008 ,  G01N33/68

Abstract: A bio marker for diagnosing hyperpigmentation disposition of skin is provided to rapidly and sensitively predict the possibility of pigmentation. A bio marker for diagnosing skin of hyperpigmentation disposition comprises a gene of which expression is increased or decreased by UV irradiation. A kit for diagnosing hyperpigmentation disposition comprises a polynucleotide of the bio marker gene or its fragment and solid support in which one or more polynucleotide is conjugated on the surface. A method for screening an inhibitor of hyperpigmentation disposition comprises: a step of treating test material in the bio marker gene; and a step of confirming whether the test material suppresses or inhibits the expression of the gene.

Abstract translation: 提供用于诊断皮肤色素沉着过度的生物标记，以快速和敏感地预测色素沉着的可能性。 用于诊断色素沉着过度皮肤的生物标志物包括通过UV照射增加或减少表达的基因。 用于诊断色素沉着过度的试剂盒包括生物标记基因的多核苷酸或其片段和固体支持物，其中一个或多个多核苷酸在表面上缀合。 一种筛选色素沉着过度抑制剂的方法，包括：在生物标记基因中处理试验材料的步骤; 以及确认测试材料是否抑制或抑制基因表达的步骤。

公开(公告)号：KR100981816B1

公开(公告)日：2010-09-13

申请号：KR1020080018672

申请日：2008-02-29

Applicant: (주)아모레퍼시픽 ,  경상대학교산학협력단

Inventor： 장희경 ,  김수정 ,  안수미 ,  황재성 ,  윤태진 ,  이증훈 ,  김진화

IPC: C12N15/12 ,  C12Q1/68

CPC classification number: C07K14/47

Abstract: 본 발명에 따른 과색소침착성 피부 진단용 바이오 마커는 본원 명세서 표 1에 기재된 유전자들로 구성된 군으로부터 선택된 유전자 또는 본원 명세서 표 1에 기재된 단백질들로 구성된 군으로부터 선택된 단백질을 포함하는 것을 특징으로 한다.
과색소침착성, 마커, 유전자, 단백질, 네트워크, 미백제, 스크리닝, 멜라닌

公开(公告)号：KR1020100058439A

公开(公告)日：2010-06-03

申请号：KR1020100038994

申请日：2010-04-27

Applicant: (주)아모레퍼시픽 ,  경상대학교산학협력단

Inventor： 장희경 ,  김수정 ,  안수미 ,  황재성 ,  윤태진 ,  이증훈 ,  김진화

IPC: C12Q1/68 ,  C12N15/12 ,  G01N33/53

CPC classification number: C12Q1/6883 ,  C12Q2600/148 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5302 ,  G01N33/5308

Abstract: PURPOSE: A kit for diagnosing hyperpigmentation is provided to sensitively and quickly predict pigmentation using a marker gene for pigmentation. CONSTITUTION: A kit for diagnosing hyperpigmentation contains a gene selected from gene. The gene expression is enhanced by UV irradiation. A marker for diagnosing hyperpigmentation contains a protein selected from proteins of table 1. The protein expression is also enhanced by UV irradiation. A diagnosis kit contains a polynucleotide having 10 polynucleotides or conplementary polynucleotide thereof, and a solid phase support coupled on the surface. A method for screening a hyperpigmentation inhibitor comprises: a step of treating a test material to the protein and a step of confirming promotion or suppression of protein activation.

Abstract translation: 目的：提供一种用于诊断色素沉着过度的试剂盒，以便使用色素沉着标记基因敏感和快速地预测色素沉着。 构成：用于诊断色素沉着过度的试剂盒含有选自基因的基因。 通过UV照射增强基因表达。 用于诊断色素沉着过度的标记物含有选自表1蛋白质的蛋白质。蛋白质表达也通过UV照射增强。 诊断试剂盒含有具有10个多核苷酸或其互补多核苷酸的多核苷酸，以及耦合在该表面上的固相载体。 用于筛选色素沉着过度抑制剂的方法包括：将测试材料处理到蛋白质的步骤和确认促进或抑制蛋白质活化的步骤。