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公开(公告)号：KR1020050022251A
公开(公告)日：2005-03-07
申请号：KR1020040020401
申请日：2004-03-25
Applicant: (주)아모레퍼시픽
IPC: C07C239/14
Abstract: PURPOSE: Provided are a hydroxamic acid derivative which shows an antiaging effect and is improved in safety and stability to the skin stimulus and discoloration, its preparation method, and an antiaging skin preparation for external use and a collagenase and elastase expression inhibitor containing the derivative. CONSTITUTION: The hydroxamic acid derivative is represented by the formula 1, wherein R1 and R2 are H, a C1-C10 alkyl group or a C3-C6 cycloalkyl group; R3 is CONH, NHCO, CONR5 or NR5CO (wherein R5 is H or a C1-C10 alkyl group); and R4 is -(CH)n- (wherein n is 0 or 1). The method comprises the steps of reacting benzoic acid and methyl 4-aminobenzoate or 4-aminophenylacetic acid methyl ester or reacting aniline and monomethyl terephthalate, to prepare a benzamide compound; substituting the amino bond of the benzamide compound into an alkyl bond; hydrolyzing the methyl ester group to prepare an acid; and reacting the obtained acid with hydroxyl amine·HCl salt to prepare the hydroxamic acid derivative of the formula 1.
Abstract translation: 目的：提供一种异羟肟酸衍生物，其表现出抗衰老作用，并且改善了皮肤刺激和变色的安全性和稳定性，其制备方法和外用抗衰老皮肤制剂以及含有该衍生物的胶原酶和弹性蛋白酶表达抑制剂。 构成：异羟肟酸衍生物由式1表示，其中R 1和R 2是H，C 1 -C 10烷基或C 3 -C 6环烷基; R3是CONH，NHCO，CONR5或NR5CO（其中R5是H或C1-C10烷基）; 且R 4为 - （CH）n - （其中n为0或1）。 该方法包括使苯甲酸和4-氨基苯甲酸甲酯或4-氨基苯乙酸甲酯或苯胺与对苯二甲酸单甲酯反应制备苯甲酰胺化合物的步骤; 将苯甲酰胺化合物的氨基取代成烷基键; 水解甲基酯以制备酸; 并使所得酸与羟胺·HCl盐反应制备式1的异羟肟酸衍生物。
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公开(公告)号：KR1020040058848A
公开(公告)日：2004-07-05
申请号：KR1020020085361
申请日：2002-12-27
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/342 , A61K9/0014 , A61K2236/331 , A61K2236/51 , Y10S514/857
Abstract: PURPOSE: Provided is a composition of external application to the skin containing extract of Adenophorea radix, thereby preventing dryness of the skin, improving moisture retaining property of the skin, and preventing and treating atopic dermatitis and skin inflammation. CONSTITUTION: A composition of external application to the skin is characterized by containing, as an active ingredient, 0.0001-60 wt.% of extract of Adenophorea radix. The composition moisturizes the skin, improves atopic dermatitis or skin inflammation, facilitates the differentiation of keratinocyte and expression of filaggrin, promotes the generation of ceramide, and activates PPAR-alpha.
Abstract translation: 目的：提供外用于含有Adenophorea根的提取物的皮肤的组合物，从而防止皮肤干燥，改善皮肤的保湿性，以及预防和治疗特应性皮炎和皮肤炎症。 构成：外用于皮肤的组合物的特征在于含有0.0001-60重量％的Adenophorea根的提取物作为活性成分。 组合物润湿皮肤，改善特应性皮炎或皮肤炎症，促进角质形成细胞的分化和丝聚蛋白的表达，促进神经酰胺的产生，并激活PPAR-α。
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公开(公告)号：KR101716325B1
公开(公告)日：2017-03-15
申请号：KR1020110017894
申请日：2011-02-28
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
Abstract: 열차단지수의생성방법은, 열차단물질이도포된제1 영역및 상기열 차단물질이도포되지않은제2 영역에각각열을가하는단계; 상기제1 영역및 제2 영역각각의포화온도를측정하는단계; 상기제1 영역에가해진열에대응되는에너지를상기제1 영역의포화온도로나누어제1 에너지를산출하는단계; 상기제2 영역에가해진열에대응되는에너지를상기제2 영역의포화온도로나누어제2 에너지를산출하는단계; 및상기제1 에너지를상기제2 에너지로나누거나, 또는상기제1 에너지및 상기제2 에너지의차를상기제1 에너지로나누어상기열 차단물질의열 차단지수를산출하는단계를포함할수 있다.
Abstract translation: 本发明涉及一种计算热保护因子的方法，其中该方法包括以下步骤：将热量施加到涂覆有热保护材料的第一区域和未涂覆有热保护材料的第二区域; 测量第一区域和第二区域的各自的饱和温度; 通过将对应于第一区域的热量的能量除以第一区域的饱和温度来计算第一能量; 通过将对应于第二区域的热量的能量除以第二区域的饱和温度来计算第二能量; 以及通过将第一能量除以第二能量或将第一能量与第二能量之间的差除以第一能量来计算热保护材料的热保护因子。
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公开(公告)号：KR1020160116800A
公开(公告)日：2016-10-10
申请号：KR1020150045066
申请日：2015-03-31
Applicant: (주)아모레퍼시픽
IPC: A61K8/97 , A61K8/44 , A61K36/899 , A61K31/205 , A61Q19/00 , A23L1/30
CPC classification number: A61K36/899 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K8/44 , A61K8/97 , A61K9/0014 , A61K9/0053 , A61K9/0095 , A61K9/06 , A61K9/1652 , A61K9/2018 , A61K9/4858 , A61K31/205 , A61K47/10 , A61K47/26 , A61K47/44 , A61Q19/00 , A61Q19/007 , A61K8/442 , A61K2300/00
Abstract: 본명세서의일측면에서는, 대나무수액과베타인(Betaine)을유효성분으로포함하는피부보습용조성물이제공되며, 구체적으로상기조성물은천연보습인자(Natural Moisturizing Factors, NMFs)를조절하여피부보습효과를나타내며, 피부보습에효과가있는화장료조성물, 약학조성물또는건강식품조성물을제공하고자한다.
Abstract translation: 在一方面，本公开提供了一种用于保湿皮肤的组合物，其含有竹汁和甜菜碱作为活性成分。 具体地，该组合物通过调节天然保湿因子（NMF）表现出皮肤保湿效果，并且可用作有效保湿皮肤的化妆品组合物，药物组合物或保健食品组合物。
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Patent Agency Ranking
公开(公告)号：KR1020120098142A
公开(公告)日：2012-09-05
申请号：KR1020110017894
申请日：2011-02-28
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: G01K11/00 , A61B5/01 , A61B5/441 , A61Q17/04 , G01K13/002
Abstract: PURPOSE: A method for generating a heat protection factor is provided to generate a heat protection factor, thereby objectively evaluating an effect of a cosmetic product including heat protection materials. CONSTITUTION: A first area spread with heat protection materials and a second area which is no the heat protection materials are heated respectively(S1). Saturation temperature of the first area is measured(S3). The saturation temperature of the second area is measured. An energy corresponding to heat heated in the first area is divided into the saturation temperature of the first area for calculating a first energy(S5). The energy corresponding to heat heated in the second area is divided into the saturation temperature of the second area for calculating a second energy. A heat protection factor of the heat protection materials is calculated by dividing the first energy into the second energy(S6). [Reference numerals] (AA) Start; (BB) End; (S1) Applying heat in a first area where a heat protection material is spread and a second area where no heat protection material is spread; (S2) Periodically measuring the temperature of the first area and the second area; (S3) Determining whether the temperature of the first area and the second area reaches a saturation temperature; (S4) Calculating the minimum heating amount of the first area and the second area; (S5) Calculating first and second energy by using the minimum heating amount of the first area and the second area and the saturation temperature; (S6) Calculating a heat protection factor of a heat protection material by using the first and second energy
Abstract translation: 目的：提供一种产生热保护因子的方法以产生热保护因子，从而客观地评估包括耐热材料的化妆品的效果。 构成：分散加热保护材料的第一个区域和不是热保护材料的第二个区域（S1）。 测量第一区域的饱和温度（S3）。 测量第二区域的饱和温度。 对应于在第一区域中加热的热量的能量被划分为用于计算第一能量的第一区域的饱和温度（S5）。 对应于在第二区域中加热的热量的能量被分成用于计算第二能量的第二区域的饱和温度。 通过将第一能量除以第二能量来计算热保护材料的热保护系数（S6）。 （附图标记）（AA）开始; （BB）结束; （S1）在散热保护材料的第一区域和没有热保护材料扩散的第二区域施加热量; （S2）周期性地测量第一区域和第二区域的温度; （S3）确定第一区域和第二区域的温度是否达到饱和温度; （S4）计算第一区域和第二区域的最小加热量; （S5）通过使用第一区域和第二区域的最小加热量和饱和温度来计算第一和第二能量; （S6）通过使用第一和第二能量来计算热保护材料的热保护系数
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公开(公告)号：KR1020120006945A
公开(公告)日：2012-01-19
申请号：KR1020110069383
申请日：2011-07-13
Applicant: (주)아모레퍼시픽
CPC classification number: A61B10/02 , G01N33/6893 , G01N2800/20
Abstract: PURPOSE: A method for diagnosing skin condition is provide to ensure simply and quick diagnosis of skin condition and to receive proper skin care. CONSTITUTION: A method for diagnosing skin condition comprises: a step of collecting skin or skin secretion; and a step of measuring a biomarker of the skin or skin secretion. The skin condition includes skin aging, moisture degree, oxidation degree. The biomarker for diagnosing skin aging contains gelatinase or stratum corneum carbonylated protein(SCCP). The biomarker for diagnosing skin moisture degree contains SCCP, lactate, pH, SC tryptase-like enzyme, plasmin, trypsin-like kallikreins(KLK5), chymotrypsin-like kallikreins(KLK7), or transglutaminase(TGase). The biomarker for measuring oxidation degree contains catalase, glutathione, or cathepsin L.
Abstract translation: 目的：提供一种诊断皮肤状况的方法，以确保简单快速地诊断皮肤状况并获得适当的皮肤护理。 构成：用于诊断皮肤状况的方法包括：收集皮肤或皮肤分泌物的步骤; 以及测量皮肤或皮肤分泌物的生物标志物的步骤。 皮肤状况包括皮肤老化，潮湿程度，氧化度。 用于诊断皮肤老化的生物标志物包含明胶酶或角质层羰基化蛋白（SCCP）。 用于诊断皮肤湿度的生物标志物包含SCCP，乳酸盐，pH，SC类胰蛋白酶样酶，纤溶酶，胰蛋白酶样激肽释放酶（KLK5），胰凝乳蛋白酶样激肽释放酶（KLK7）或转谷氨酰胺酶（TGase）。 用于测量氧化度的生物标志物包含过氧化氢酶，谷胱甘肽或组织蛋白酶L.
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公开(公告)号：KR1020100120585A
公开(公告)日：2010-11-16
申请号：KR1020090039462
申请日：2009-05-06
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
IPC: A61K31/202 , A61P17/16 , A61K8/36 , A61Q19/08
Abstract: PURPOSE: A composition of external use skin formulation for anti-aging and moisturizing is provided to suppress MMP(matrix metalloprotease) increase. CONSTITUTION: A composition of external use skin formulation contains 0.001-10 weight% of 11,14,17-Eicosatrienoic acid(ETA) as an active ingredient. ETA is contained in oil phase. The composition is used for preventing aging through reduction of collagenase expression. The composition is also used for skin moisturizing by suppressing skin barrier damage.
Abstract translation: 目的：提供抗老化和保湿的外用皮肤制剂组合物，以抑制MMP（基质金属蛋白酶）增加。 构成：外用皮肤制剂的组合物含有作为活性成分的11,14,17-二十碳三烯酸（ETA）的0.001-10重量％。 ETA含在油相中。 该组合物用于通过降低胶原酶表达来预防老化。 该组合物还可用于通过抑制皮肤屏障损伤来进行皮肤保湿。
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59.发明授权대두배아 이소플라본 어글리콘, 석류추출물 및 세코이소라리시레시놀로 이루어진 ＩＢ ｃｏｍｐｌｅｘ를 함유하는 피부 주름 개선 및 탄력 증진용 외용제 조성물 有权皮肤外用组合物，含有构成大豆胚芽异黄酮骨架，石榴提取物和双异吲哚林醇的IB复合物，用于改善皮肤皱纹和增强弹性
公开(公告)号：KR100868904B1
公开(公告)日：2008-11-14
申请号：KR1020030019195
申请日：2003-03-27
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 갱년기 이후 여성에서 유발되는 피부의 주름, 탄력 및 피부 보습을 개선시킬 수 있는 외용제 조성물에 관한 것으로, 보다 상세하게는 여성호르몬과 유사작용을 하는 피토에스트로젠(phytoestrogen) 성분을 다량 함유하고 있는 대두배아 이소플라본 어글리콘(Soybean Germ Isoflavone Agylcone), 석류 추출물 (Pomegranate Extract), 및 세코이소라리시레시놀(Secoisolariciresinol)을 혼합하여 제조한 'IB complex(Inner Balance Complex)'를 함유하여 피부 주름의 개선 및 피부 탄력 증진에 효과가 우수한 외용제 조성물에 관한 것이다.
IB complex * 대두배아 이소플라본 어글리콘 * 석류 추출물 * 세코이소라리시레시놀 * 피부 주름 개선 * 피부 탄력 증진 * 피부 보습 증진-
60.发明公开카텝신 Ｇ 저해제를 함유하는 피부노화 방지용 피부외용제조성물 및 항노화용 물질을 스크리닝하는 방법 有权用于外用于含皮肤抑制剂G抑制剂以防止皮肤老化的筛选组合物和用于开发抗病材料的筛选方法
公开(公告)号：KR1020080040612A
公开(公告)日：2008-05-08
申请号：KR1020070111803
申请日：2007-11-02
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K8/44 , A61K8/34 , A61Q19/08
CPC classification number: A61K8/42 , A61K2800/522 , A61Q19/08
Abstract: A skin external composition comprising a cathepsin G inhibitor is provided to prevent an adhesion protein from being degraded by intrinsic aging and photo-aging, reduce the production of metalloproteinase and inhibit the activity of metalloproteinase, thereby being more potent anti-aging substance than existing anti-aging substances. A method for screening anti-aging materials is provided to develop the anti-aging materials which effectively inhibit the quantitative and qualitative increase of metalloproteinase, resulting from the degradation of an adhesion protein by cathepsin G in skin cells without direct UV irradiation. A skin external composition for preventing skin aging comprises 0.01-10 wt% a cathepsin G inhibitor as an effective ingredient, wherein the cathepsin G inhibitor is at least one selected from the group consisting of compounds represented by formulae(1) to (4). The composition is formulated into skin lotion, astringent lotion, milk lotion, nourishing cream, essence, massage cream, eye cream, pack, body lotion, body cream, body oil or body essence. A method for screening an anti-aging material comprises the steps of: (a) adding an anti-aging candidate material to a substrate in the presence of cathepsin G enzyme; and (b) measuring the inhibition of activity of the cathepsin G enzyme. Further, the measure of the inhibition of activity of the cathepsin G enzyme is performed by measuring a concentration of a produced metalloprotease.
Abstract translation: 提供包含组织蛋白酶G抑制剂的皮肤外用组合物，以防止粘附蛋白由于内在老化和光老化而降解，减少金属蛋白酶的产生并抑制金属蛋白酶的活性，从而比现有的抗老化物质更有效的抗衰老物质 化学物质。 提供了一种筛选抗衰老材料的方法，以开发有效抑制金属蛋白酶定量和定性增加的抗衰老材料，这是由皮肤细胞中组织蛋白酶G在组织蛋白酶G中的降解引起的，而不需要直接的紫外线照射。 用于防止皮肤老化的皮肤外用组合物包含0.01-10重量％的组织蛋白酶G抑制剂作为有效成分，其中组织蛋白酶G抑制剂是选自由式（1）至（4）表示的化合物中的至少一种。 该组合物配制成皮肤洗剂，收敛剂，乳液，滋养霜，精华液，按摩霜，眼霜，包装，身体乳液，身体霜，身体油或身体精华。 用于筛选抗衰老材料的方法包括以下步骤：（a）在组织蛋白酶G酶存在下将抗老化候选材料加入到底物中; 和（b）测量组织蛋白酶G酶的活性的抑制。 此外，组织蛋白酶G酶的活性的抑制的测量是通过测量产生的金属蛋白酶的浓度进行的。
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