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公开(公告)号：KR1020140122490A
公开(公告)日：2014-10-20
申请号：KR1020130039240
申请日：2013-04-10
Applicant: 재단법인 제주테크노파크 , 주식회사 아이지에스
IPC: A61K36/896 , A61P3/04 , A61P3/06
Abstract: 본 발명은 문주란 추출물을 이용한 항비만 조성물 및 항고지혈증 조성물을 개시한다. 본 발명에서 문주란 추출물은 지방세포로의 분화 억제 활성과 중성지방 축적 억제 활성을 갖고, 또한 PPARγ, C/EBRα, C/EBRβ 등의 전사인자, aP2 등의 지방세포 특이적 단백질의 발현 억제 활성을 가지며, 고지방식이가 급여된 비만 유도 실험동물에 투여될 때도 실험동물의 체중을 감소시키고 혈중 지질 농도를 낮추는 활성을 갖는다.
Abstract translation: 本发明公开了一种利用积雪草提取物改善肥胖和高脂血症的组合物。 本发明的积雪草提取物对脂肪形成分化，中性脂肪蓄积以及脂肪细胞特异性蛋白质如转录因子（包括PPARγ，C /EBRα和C /EBRβ和aP2）的表达具有抑制作用。 当用高脂肪饮食诱导的肥胖的实验动物给药时，Crinum asiaticum的提取物会减轻体重并降低血液中的脂质水平。
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公开(公告)号：KR1020140090584A
公开(公告)日：2014-07-17
申请号：KR1020140070905
申请日：2014-06-11
Applicant: 재단법인 제주테크노파크
IPC: A61K31/343 , A61K31/045 , A61P29/00
Abstract: The present invention discloses an anti-infammatory composition using vladinol F which is an active substance isolated from Ficus erecta var. sieboldii King. The vladinol F which is an active substance has inhibitory activities against the generation of NO, the generation of PGE2, and the generation of inflammatory cytokines (TNF-α, IL-1β and IL-6).
Abstract translation: 本发明公开了一种抗炎组合物，其使用vladinol F，其是从Ficus erecta var。分离的活性物质。 sieboldii国王。 作为活性物质的vladinol F具有对NO的产生，PGE2的产生和炎性细胞因子（TNF-α，IL-1β和IL-6）的产生的抑制活性。
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公开(公告)号：KR1020140046200A
公开(公告)日：2014-04-18
申请号：KR1020120112367
申请日：2012-10-10
Applicant: 재단법인 제주테크노파크
Abstract: Disclosed is a functional natural fragrance composition using an essential oil extract of Torreya nucifera. Specifically, disclosed is a functional natural fragrance composition using an essential oil extract of Torreya nucifera with antibacterial activity and anti-stress activity as an effective component. The functional natural fragrance composition has the antibacterial activity against Propionibacterium acne, which is an acne germ.
Abstract translation: 本发明公开了一种功能性天然香料组合物，其使用了Torreya nucifera的精油提取物。 具体地说，公开了一种功能性天然香料组合物，其使用具有抗菌活性和抗应激活性的Torreya nucifera精油提取物作为有效成分。 功能性天然香料组合物对痤疮丙酸杆菌具有抗菌活性，这是痤疮细菌。
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Patent Agency Ranking
公开(公告)号：KR101300845B1
公开(公告)日：2013-08-29
申请号：KR1020110109104
申请日：2011-10-25
Applicant: 재단법인 제주테크노파크
Abstract: 본 발명은 백수오 및 이엽우피소의 감별 방법 및 그 키트에 관한 것이다. 본 발명의 백수오 및 이엽우피소의 감별 방법 및 그 키트는 백수오의 ITS에 존재하는
Xcm I 제한효소 인식 부위와 이에 대한 이엽우피소의 대립 서열을 이용하거나 백수오와 이엽우피소의 ITS 서열을 이용함을 특징으로 한다.-
公开(公告)号：KR1020130073179A
公开(公告)日：2013-07-03
申请号：KR1020110140888
申请日：2011-12-23
Applicant: 재단법인 제주테크노파크
IPC: A61K36/18 , A61K36/185 , A61P29/00 , A61P17/00
Abstract: PURPOSE: An anti-inflammatory composition and a skin whitening composition using a kiwi fruit fermentation are provided to suppress NO, PGE2, and inflammatory cytokine generation, and melanogenesis. CONSTITUTION: An anti-inflammatory composition contains a kiwi fruit fermentation which is prepared by inoculating lactic acid bacteria and yeast to a crushed kiwi fruit and fermenting. Sugar is added to the crushed kiwi fruit as an energy source. The lactic acid bacteria and the yeast are Lactobacillus plantarum and Saccharomyces cerevisiae. The composition is a pharmaceutical composition, a food composition, or a cosmetic composition.
Abstract translation: 目的：提供使用猕猴桃发酵的抗炎组合物和皮肤美白组合物，以抑制NO，PGE2和炎性细胞因子的产生以及黑素生成。 构成：抗炎组合物含有猕猴桃发酵，其通过将乳酸菌和酵母接种到破碎的猕猴桃中并发酵而制备。 糖被添加到被碾碎的猕猴桃作为能源。 乳酸菌和酵母是植物乳杆菌（Lactobacillus plantarum）和酿酒酵母（Saccharomyces cerevisiae）。 组合物是药物组合物，食品组合物或化妆品组合物。
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公开(公告)号：KR1020130071666A
公开(公告)日：2013-07-01
申请号：KR1020110139005
申请日：2011-12-21
Applicant: 재단법인 제주테크노파크
IPC: A61K31/343 , A61K31/045 , A61P29/00
Abstract: PURPOSE: An anti-inflammatory composition using vladinol F isolated from F. erecta var. sieboldii is provided to suppress generation of NO, PGE2 (prostaglandin), and inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6). CONSTITUTION: An anti-inflammatory composition contains vladinol F as an active ingredient. A method for isolating vladinol F from F. erecta var. sieboldii comprises the steps of: dipping F. erecta var. sieboldii leaves, stems, or a mixture thereof in a mixture solvent of ethanol and water and preparing a power extract; suspending the extract in distilled water, and sequentially fractioning to obtain a dichloromethane fraction; coating a celite surface with the fraction and performing column chromatography using hexane, dichloromethane, ethyl acetate, and methanol to obtain 4 purified materials; performing normal phase column chromatography of a second purified material using hexane:ethyl acetate:methanol (1:2:0.2, v/v) to obtain total 20 purified materials; performing normal phase silicagel column chromatography of 16th purified material among 20 purified materials using chloroform:methanol (10:1, v/v) and preparing total 18 purified materials; and collecting 9th purified material among 18 purified materials. [Reference numerals] (AA) MC fraction of a F. erecta var. sieboldii extract (11.2g); (BB) Column chromatography; (CC) Normal phase silica gel (5cm×60cm); (DD) Normal phase silica gel (2.0cm×50cm)
Abstract translation: 目的：使用从F. erecta var。分离的vladinol F的抗炎组合物。 提供sieboldii以抑制NO，PGE2（前列腺素）和炎性细胞因子（TNF-α，IL-1β和IL-6）的产生。 构成：抗炎组合物含有vladinol F作为活性成分。 一种从F. erecta var。中分离vladinol F的方法。 sieboldii包括以下步骤：浸渍F.frecta var。 sieboldii叶，茎或其在乙醇和水的混合溶剂中的混合物，并制备动力提取物; 将提取物悬浮在蒸馏水中，并依次分级得到二氯甲烷馏分; 用级分涂覆硅藻土表面，并使用己烷，二氯甲烷，乙酸乙酯和甲醇进行柱层析，得到4种纯化物; 使用己烷：乙酸乙酯：甲醇（1:2:0.2，v / v）进行第二纯化物质的正相柱色谱，得到总共20种纯化物质; 使用氯仿：甲醇（10:1，v / v）在20个纯化物中进行第16次纯化物质的正相硅胶柱色谱，并制备总共18种纯化物质; 并在18种纯化材料中收集第9种纯化材料。 （参考数字）（AA）MC分数F.frecta var。 sieboldii提取物（11.2g）; （BB）柱色谱; （CC）正相硅胶（5cm×60cm）; （DD）正相硅胶（2.0cm×50cm）
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公开(公告)号：KR1020120100859A
公开(公告)日：2012-09-12
申请号：KR1020120082039
申请日：2012-07-26
Applicant: 재단법인 제주테크노파크
CPC classification number: A61K36/60 , A23L33/105 , A23V2002/00 , A23V2200/324
Abstract: PURPOSE: An anti-inflammatory composition using Ficus erecta leaf extract is provided to suppress IL-1beta generation and iNOS and COX-2 expression. CONSTITUTION: An anti-inflammatory composition contains Ficus erecta leaf extract as an active ingredient. The extract is selected from: extract prepared with alcohol of 1-5 carbon atoms, acetone, hexane, ethyl acetate, dichloromethane, water or a mixture thereof; extract of a fraction solvent layer prepared by fractioning solid extract with water and hexane, water and dichloromethane, or water and ethyl acetate; and extract prepared by suspending the solid extract in the water and fractioning with hexane, dichloromethane, and ethyl acetate in order. The composition is a pharmaceutical composition and food composition.
Abstract translation: 目的：提供使用Ficus erecta叶提取物的抗炎组合物，以抑制IL-1beta的产生和iNOS和COX-2的表达。 构成：抗炎组合物含有榕叶提取物作为活性成分。 提取物选自：用1-5个碳原子的醇制备的提取物，丙酮，己烷，乙酸乙酯，二氯甲烷，水或其混合物; 通过用水和己烷，水和二氯甲烷或水和乙酸乙酯分离固体提取物制备的级分溶剂层的提取物; 和通过将固体提取物悬浮在水中制备的提取物，并依次用己烷，二氯甲烷和乙酸乙酯分馏。 组合物是药物组合物和食物组合物。
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公开(公告)号：KR1020080020738A
公开(公告)日：2008-03-06
申请号：KR1020060083944
申请日：2006-09-01
Applicant: 재단법인 제주테크노파크
CPC classification number: A61K36/54 , A23V2200/304 , A61K2236/33 , Y10S514/825
Abstract: A composition comprising the extract of Litsea japonica is provided to prevent and treat inflammatory disease and metabolic bone disease including osteoporosis and osteopetrosis by inhibiting inflammation and bone metabolic factors including IL-6(interleukin-6), COX-2(cyclooxygenase-2) and PGE2(prostaglandin E2) without side effects. A composition for preventing and treating inflammatory disease and metabolic bone disease comprises the extract of Litsea japonica which is prepared by drying leaf, stem or fruit of Litsea japonica juss in the shade, pulverizing the dried Litsea japonica juss, dipping the pulverized Litsea japonica juss in 80% ethanol, sonicating the Litsea japonica juss solution for 1 hour, repeating the sonication in three times to prepare the ethanol extract of Litsea japonica juss, collecting the supernatant and concentrating the supernatant under reduced pressure, suspending the concentrate in distilled water, and extracting the suspension with hexane, dichloromethane, ethyl acetate and butanol sequentially, and is formulated as food additives or drink.
Abstract translation: 提供包含日本蓟马提取物的组合物，通过抑制炎症和包括IL-6（白细胞介素-6），COX-2（环氧合酶-2）和骨质疏松素-2）在内的骨代谢因子来预防和治疗包括骨质疏松和骨质疏松的炎性疾病和代谢性骨病， PGE2（前列腺素E2）无副作用。 用于预防和治疗炎性疾病和代谢性骨疾病的组合物包括通过在树荫下干燥荔枝枣的叶，茎或果实制备的荔枝提取物，粉碎干燥的枸杞，将粉碎的荔枝粳稻 80％乙醇，将Litsea japonica juss溶液超声处理1小时，三次重复超声处理，制备日本it杷的乙醇提取物，收集上清液，减压浓缩上清液，将浓缩物悬浮于蒸馏水中，萃取 依次用己烷，二氯甲烷，乙酸乙酯和丁醇悬浮，配制成食品添加剂或饮料。
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