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51.发明授权
公开(公告)号：KR100125129B1
公开(公告)日：1997-11-28
申请号：KR1019940019984
申请日：1994-08-13
Applicant: 한국과학기술연구원
IPC: C12P1/02
Abstract: The present invention is related to new compounds, GERI-BP001 (C27H33NO5) which is acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor separated from fungus Aspergillus fumigatus FM-F-37 isolated from the earth and its derivatives and to the method for preparation therof. The GERI-BP001 and its derivatives, GERI-BP001-A and GERI-BP001-B are useful for the treatment of hyperlipemia by inhibiting cholesterol trasferase in blood. The GERI-BP001 together its derivatives, GERI-BP001-A and GERI-BP001-B are separated and purified from cultures of Aspergillus sp. strains including Aspergillus fumigatus FM-F-37, GERI-BP001-C can be prepared chemically from GERI-BP001-A by means of nucleophilic substitution reactions.
Abstract translation: 本发明涉及从分离自地球及其衍生物的真菌烟曲霉FM-F-37分离的酰基辅酶A：胆固醇酰基转移酶（ACAT）抑制剂GERI-BP001（C27H33NO5）和制备方法的新化合物 therof。 GERI-BP001及其衍生物GERI-BP001-A和GERI-BP001-B可用于通过抑制血液中的胆固醇trasferase来治疗高脂血症。 将GERI-BP001及其衍生物GERI-BP001-A和GERI-BP001-B从曲霉菌培养物中分离和纯化。 包括烟曲霉FM-F-37，GERI-BP001-C的菌株可以通过亲核取代反应由GERI-BP001-A化学制备。
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公开(公告)号：KR1019960030789A
公开(公告)日：1996-09-17
申请号：KR1019950002058
申请日：1995-02-06
Applicant: 한국과학기술연구원
IPC: A01N63/00
Abstract: 본 발명은 미생물이 이용할 수 있는 생체 고분자를 포함하는 천연 물질, 그로부터 추출된 미생물이 이용할 수 있는 생체 고분자 및 그들의 유도체를 물과 혼합하여 고온에서 겔 상태로 만들고; 상기 겔을 저온으로 냉각시키고; 하나 이상의 길항, 미생물을 상기 겔과 혼합하는 단계들을 포함하는 액상 생체고분자 겔내에 캡슐화된 미생물 농약의 제조 방법 및 그에 의해 제조된 미생물 농약에 관한 것이다.
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Patent Agency Ranking
公开(公告)号：KR100362940B1
公开(公告)日：2002-11-30
申请号：KR1020020027396
申请日：2002-05-17
Applicant: 한국과학기술연구원
IPC: A61K31/335
Abstract: 본발명은유효량의헤마테인을함유하는고지혈증및 동맥경화증예방및 치료용조성물에관한것으로, 본발명의조성물은의약용및 식품용조성물을포함한다. 헤마테인은 LDL-항산화제활성을나타내며, 혈중콜레스테롤을현저하게감소시키고, 간마이크로좀 ACAT 활성을강력하게저해하므로, 헤마테인을함유하는본 발명의조성물은고지혈증및 동맥경화증의치료및 예방을위해유용하게사용될수 있다.
Abstract translation: 本发明涉及含有有效量的伴侣H.的高脂血症和动脉硬化的预防和治疗组合物，包括本发明和医疗食物组合物为的组合物。 H.伴侣-在LDL-抗氧化剂是指活性，显著降低血液中的胆固醇，将含有微粒体肝ACAT本发明的组合物中，H.配合，从而强烈地抑制高脂血症和动脉粥样硬化的治疗和预防的活性 可以有用地用于。
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公开(公告)号：KR100291141B1
公开(公告)日：2001-07-12
申请号：KR1019980037962
申请日：1998-09-15
Applicant: 한국과학기술연구원
IPC: A61K31/70
Abstract: 본 발명은 디오스민(diosmin)을 포함하는 동맥경화증 및 고지혈증의 예방 및 치료용 조성물에 관한 것으로, 디오스민은 동물에게 투여되었을 때 동맥내피에 대식세포-지질 복합체가 침착되는 것을 강력히 억제할 뿐만 아니라, ACAT 및 HMG-CoA 환원효소의 활성을 억제하고, 혈중 콜레스테롤 및 중성지질의 농도를 감소시키므로, 동맥경화증 및 고지혈증의 예방 및 치료제로서 유용하게 사용될 수 있다.
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59.发明公开
公开(公告)号：KR1020010015512A
公开(公告)日：2001-02-26
申请号：KR1020000063394
申请日：2000-10-27
Applicant: 한국과학기술연구원
IPC: A61K36/725 , A61K36/752 , A61P3/06 , A61P9/12
Abstract: PURPOSE: A composition containing the extract of jujube and the extract of citrus rind is provided for improving lipid metabolism and lowering blood pressure, so that it can prevent liver diseases, hypertension, arteriosclerosis, hyperlipemia and cancer. CONSTITUTION: The composition contains 0.1 to 5g/weight kg/day of the extract of jujube and 0.1 to 10g/weight kg/day of the extract of citrus rind in a weight ratio of 1:1 to 100:1, in which the extract of jujube is produced by adding 2 to 5 liter of 70 to 95% ethanol into 1 kg of jujube, and extracting them at 50 to 60deg.C for 1 to 24 hours, or by adding 2 to 5 liter of water into 1 kg of citrus rind, and extracting them at 70 to 121deg.C for 30 minutes to 12 hours; the extract of citrus rind is produced by drying citrus rind, adding 3 to 30 liter of 20 to 95% ethanol into 1kg of dried rind, extracting them at 25 to 80deg.C for 1 to 12 hours, filtering the extract, and condensing it under reduced pressure, wherein citrus includes orange, lemon, tangerine, grapefruit or citron.
Abstract translation: 目的：提供含有枣提取物和柑橘皮提取物的组合物，用于改善脂质代谢和降低血压，从而可以预防肝脏疾病，高血压，动脉硬化，高脂血症和癌症。 构成：组合物以1：1〜100：1的重量比含有0.1〜5g / kg的枣提取物和0.1〜10g / kg的柑橘皮提取物，其中提取物 通过向1kg的枣中加入2〜5升的70〜95％的乙醇，在50〜60℃下提取1〜24小时，或者将2〜5升的水加入1kg的 柑橘皮，70〜121℃，30分钟〜12小时提取; 柑橘皮提取物是通过干燥柑橘皮制成的，将3〜30升20〜95％乙醇加入1kg干燥的皮中，在25〜80℃下提取1〜12小时，过滤提取物，冷凝 在减压下，其中柑橘包括橙，柠檬，橘子，葡萄柚或柚子。
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公开(公告)号：KR1020010015494A
公开(公告)日：2001-02-26
申请号：KR1020000058704
申请日：2000-10-06
Applicant: 한국과학기술연구원
IPC: A23L1/29
Abstract: PURPOSE: A hypotensive composition containing a bioflavonoid compound is provided to use itself as a therapeutic agent for glycosemia or as a health food. CONSTITUTION: A hypotensive composition comprises an effective amount, preferably, 0.01-50 wt.% of bioflavonoid of formula (1) and a pharmaceutical acceptable carrier thereof. The flavonoids consist in citrus fruits such as orange, lemon, citron, grapefruit and the like. The composition containing the flavonoid compounds is useful to treat glycosemia. To drop the blood sugar level, the flavonoid compound of formula (1) can be added to foods, for example meats, beverages, snacks, chocolates etc. In the formula (1), R1 is OH, rutinosyl or rhaminosyl group; R2 is H, OH or rutinosyl group; R3 is H or OH group; R4 is OH or methoxy group; X is single bond or double bond.
Abstract translation: 目的：提供含有生物类黄酮化合物的低血压组合物作为糖血症的治疗剂或作为保健食品。 构成：低血压组合物包含有效量，优选0.01-50重量％的式（1）的生物类黄酮及其药学上可接受的载体。 黄酮类化合物包括橙子，柠檬，柚子，葡萄柚等柑橘类水果。 含有类黄酮化合物的组合物可用于治疗糖血症。 为了降低血糖水平，式（1）的类黄酮化合物可以加入到食品中，例如肉类，饮料，小吃，巧克力等。在式（1）中，R 1是OH，芸香酰基或脱氨基糖基; R2是H，OH或芸香糖基; R3是H或OH基; R4是OH或甲氧基; X是单键或双键。
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