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公开(公告)号：KR1020100060310A
公开(公告)日：2010-06-07
申请号：KR1020080118863
申请日：2008-11-27
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A natural calcium compound is provided to enhance calcium absorption rate with high ionizing degree and to ensure blood glucose reduction. CONSTITUTION: A composition for controlling blood glucose contains ionized calcium as an active ingredient. The ionized calcium is a shell ionized calcium. A method for manufacturing the ionized calcium comprises: a step of pulverizing shells at 1.5-10 cm; a step of pilling the pulverized shell inside a plasticizing furnace and plasticizing by 1200°C; a step of blocking heat and cooling by 200-400°C and by 100-150°C; and a step of cooling by room temperature. A health food for controlling blood glucose contains ionized calcium as an active ingredient.
Abstract translation: 目的：提供天然的钙化合物，以提高高离子化程度的钙吸收率，并确保降低血糖。 构成：用于控制血糖的组合物含有离子钙作为活性成分。 电离钙是壳电离钙。 一种电离钙的制造方法，其特征在于，包括以下步骤：粉碎1.5-10cm的壳; 将粉碎的壳体在塑化炉内冲压并在1200℃下塑化的步骤; 在200-400℃和100-150℃下阻断热和冷却的步骤; 和室温冷却的步骤。 用于控制血糖的保健食品包含电离钙作为活性成分。
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公开(公告)号：KR100804480B1
公开(公告)日：2008-02-20
申请号：KR1020060038179
申请日：2006-04-27
Applicant: 한국과학기술연구원
IPC: A61K36/69 , A61K36/882 , A61P25/28
Abstract: 본 발명은 원지, 석창포, 인삼, 당귀, 은행잎, 오미자 및 천궁으로 이루어진 혼합 추출물을 함유하는 조성물에 관한 것으로서, 이러한 조성물은 인체에 안전하며, 상기 약재들의 상승 작용에 의하여 기억력을 향상시키는 효과가 뛰어나다.
원지, 석창포, 기억력 향상-
公开(公告)号：KR100717131B1
公开(公告)日：2007-05-11
申请号：KR1020050103572
申请日：2005-10-31
Applicant: 한국과학기술연구원
IPC: C07D487/04
Abstract: 본 발명은 1-베타메틸카바페넴 유도체 및 그 제조에 사용되는 중간체에 관한 것으로서, 상기 1-베타메틸카바페넴 유도체는 하기 화학식 1의 구조를 갖는 것을 특징으로 한다.
(상기 화학식 (I)에서, X는 O, S, N 이고, Y는 옥소, 히드록시, 옥심, 메톡시이민이다.)
본 발명에 의한 1-베타메틸카바페넴 유도체는 시클릭아민기가 포함된 티올 유도체를 치환시킴으로써 항균 활성이 우수하고, 내성균에 강한 효과가 있다. 따라서 본 발명에 의한 1-베타메틸카바페넴 유도체는 항생제로서 유용하게 사용할 수 있다.
항생제, 카바페넴, 사이클릭아민, 피롤리딘Abstract translation: 本发明的特征在于具有的1-β甲基碳青霉烯衍生物青霉烯的结构具有下式1涉及的1-β甲基碳青霉烯衍生物青霉烯和它的生产中使用的中间体。
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公开(公告)号：KR1020060117550A
公开(公告)日：2006-11-17
申请号：KR1020050039475
申请日：2005-05-11
Applicant: 한국과학기술연구원
Inventor： 조정혁
IPC: A61K36/232 , A61K36/14 , A61K36/48 , A61P25/32
Abstract: A composition for curing a hangover and a preparation method thereof are provided to restore NADH from over-consumed NAD in aldehyde production process by oxidation promotion, promote alcohol decomposition, and inhibit aldehyde concentration and reactive oxygen species produced from alcohol decomposition without side effects on human body. The composition for curing the hangover comprises 10-15 parts by weight of Angelica gigas Nakai, 10-15 parts by weight of Thuja orientalis L., 9-10 parts by weight of Astragalus membranaceus(FISCH) Bunge, 9-10 parts by weight of Atractylodes macrocephala KOIDZ, 9-10 parts by weight of Rehmannia preparata Libosch, 9-10 parts by weight of Cnidium officinale, 9-10 parts by weight of Citrus unshiu MARKOVICH., 9-10 parts by weight of Polygonatum sibiricum Redoute, 9-10 parts by weight of Polygala tenuifolia WILLD., 4-5 parts by weight of Hovenia dulcis thunb and 4-5 parts by weight of Pueraria thunbergiana BENTH.
Abstract translation: 提供了一种用于固化宿醉的组合物及其制备方法，用于通过氧化促进，促进醇分解和抑制醛浓度和抑制醛分解产生的活性氧，从而在醛生产过程中从过度消耗的NAD中恢复NADH，而对人体没有副作用 身体。 用于固化宿醉的组合物包含10-15重量份天竺葵Nakai，10-15重量份Thuja orientalis L.，9-10重量份黄芪（FISCH）Bunge，9-10重量份 的Atractylodes macrocephala KOIDZ，9-10重量份的地黄熟料，9-10重量份的Cnidium officinale，9-10重量份的Citrus unshiu MARKOVICH。，9-10重量份的Polygonatum sibiricum Redoute，9 -10重量份Polygala tenuifolia WILLD，4-5重量份Hovenia dulcis thunb和4-5重量份Pueraria thunbergiana BENTH。
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公开(公告)号：KR100522532B1
公开(公告)日：2005-10-20
申请号：KR1020030042835
申请日：2003-06-27
Applicant: 주식회사 엔에스케이텍 , 한국과학기술연구원
IPC: A61K36/066 , A61P3/10
Abstract: 본 발명은 동충하초와 여주를 함유하는 혈당강하용 조성물에 관한 것으로, 보다 상세하게는 누에동충하초, 여주 및 마그네슘을 함유하는 혈당강하용 조성물에 관한 것이다. 본 발명에 따른 혈당강하용 조성물은 동물 실험에서 평균 60 % 이상의 혈당강하효과를 나타내었으며, 이는 각 개별성분으로는 달성할 수 없는 우수한 혈당 강하 효능이라 할 것이다.
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Patent Agency Ranking
公开(公告)号：KR100510587B1
公开(公告)日：2005-08-30
申请号：KR1020010088951
申请日：2001-12-31
Applicant: 한국과학기술연구원
IPC: C07C41/52
Abstract: 본 발명은 할로겐이 치환된 디페닐에테르 유도체의 제조방법에 관한 것으로, 더욱 구체적으로 디페닐에테르 화합물을 출발물질로 하여 산용액하에서 할로겐산나트륨을 혼합하여 할로겐화하는 단계; 프리델-크래프트 아실화 반응을 수행하는 단계; 과산화 수소와 무수말린산을 이용하여 산화시키는 단계; 및 가수분해 단계로 이루어진 할로겐이 치환된 디페닐에테르 유도체의 제조방법에 관한 것으로, 종래 염소화 반응에서 사용되는 염소기체 대신 할로겐산나트륨 및 산용액을 사용하므로, 대규모 생산하는데 있어서 비용 및 제조시간이 절약되며, 정량적인 반응에 의해 부생성물을 줄일 수 있으며, 이로 인해 수율을 더욱 높일 수 있으며, 또한 전 과정에서 단일 용매를 사용할 수 있어 공정상의 조작을 단순히 하여 경제성 있는 제조방법이다.
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公开(公告)号：KR100441764B1
公开(公告)日：2004-07-27
申请号：KR1020000087303
申请日：2000-12-30
Applicant: 한국과학기술연구원
IPC: C07C247/08
Abstract: PURPOSE: Provided is a vinyl carbamoyl azide derivative, which is more stable than a conventional carbamoyl azide derivative and has an effective sterilizing power against mold harmful to the crops. CONSTITUTION: The vinyl carbamoyl azide derivative represented by the formula 1 is produced by reacting an isocyanate compound(R1NCO) and hydrazoic acid(NH3) or sodium azide(NaN3). In the formula, R1 is at least one C1-C6 alkyl, or furyl or phenyl capable of being substituted by at least one substituent selected from the group consisting of halogen, C1-C6 alkoxy, and nitro.
Abstract translation: 用途：提供一种比常规氨基甲酰叠氮衍生物更稳定的乙烯基氨基甲酰基叠氮化物衍生物，并且具有对作物有害的霉菌有效的杀菌力。 构成：由式1表示的乙烯基氨基甲酰基叠氮化物衍生物通过使异氰酸酯化合物（R1NCO）和叠氮酸（NH3）或叠氮化钠（NaN3）反应来制备。 在该式中，R1是至少一个C1-C6烷基，或者能被至少一个选自卤素，C1-C6烷氧基和硝基的取代基取代的呋喃基或苯基。
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公开(公告)号：KR1020030058496A
公开(公告)日：2003-07-07
申请号：KR1020010088951
申请日：2001-12-31
Applicant: 한국과학기술연구원
IPC: C07C41/52
Abstract: PURPOSE: A method for preparing a diphenyl ether derivative substituted with halogen is provided, to reduce the cost and the preparation time by employing a sodium salt of halogen acid and an acid solution instead of chlorine gas, to reduce the amount of by-product and to improve the yield. CONSTITUTION: The method comprises the steps of reacting diphenyl ether represented by the formula 2 with sodium salt of halogen acid in the presence of an acid solution to prepare 2,4,4'-trihalogen diphenyl ether represented by the formula 3; reacting the obtained compound of the formula 3 with acetyl chloride in the presence of an aluminium catalyst to prepare 2,4,4'-trihalogen-2'-acetyldiphenyl ether represented by the formula 4; reacting the obtained compound of the formula 4 with maleic anhydride in the presence of hydrogen peroxide to prepare 2,4,4'-trihalogen-2'-acetoxydiphenyl ether represented by the formula 5; and reacting the obtained compound of the formula 5 with a strong base to prepare 2,4,4'-trihalogen-2'-hydroxydiphenyl ether represented by the formula 1, wherein X is Cl or Br.
Abstract translation: 目的：提供一种制备被卤素取代的二苯基醚衍生物的方法，通过使用卤酸钠和酸溶液代替氯气来降低成本和制备时间，以减少副产物的量和 提高产量。 方案：该方法包括在酸溶液存在下使由式2表示的二苯醚与卤酸钠盐反应制备由式3表示的2,4,4'-三卤代二苯醚; 在铝催化剂存在下，使所得到的式3化合物与乙酰氯反应，制得式4表示的2,4,4'-三卤代-2'-乙酰基二苯基醚; 所得到的式4化合物与过氧化氢存在下的马来酸酐反应制备式5表示的2,4,4'-三卤素-2'-乙酰氧基二苯醚; 并使所得式5的化合物与强碱反应，制备由式1表示的2,4,4'-三卤代-2'-羟基二苯醚，其中X为Cl或Br。
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公开(公告)号：KR100388432B1
公开(公告)日：2003-06-25
申请号：KR1020000087302
申请日：2000-12-30
Applicant: 한국과학기술연구원
IPC: C07F9/38
Abstract: PURPOSE: Provided is a manufacturing method for dialkyl(4-hydroxy-3,5-di(t-butyl)benzyl)phosphonate(DAP) in high yield , thereby mass-producing DAP without generating carcinogens not by using a strong base. CONSTITUTION: Dialkyl(4-hydroxy-3,5-di(t-butyl)benzyl)phosphonate is manufactured by reacting N, N-dialkyl-(4-hydroxy-3,5-di(t-butyl)benzyl)amine or its salt with dialkyl phosphate or trialkyl phosphate in the presence of an alkylating agent, at 60-120 deg.C.
Abstract translation: 目的：提供高收率地制备（4-羟基-3,5-二（叔丁基）苄基）膦酸二烷基酯（DAP）的方法，由此不用强碱就可以大量生产DAP而不产生致癌物质。 构成：通过N，N-二烷基 - （4-羟基-3,5-二（叔丁基）苄基）胺或 其在烷基化试剂存在下与磷酸二烷基酯或磷酸三烷基酯在60-120℃下进行反应。
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公开(公告)号：KR1020030015551A
公开(公告)日：2003-02-25
申请号：KR1020010049334
申请日：2001-08-16
Applicant: 한국과학기술연구원
IPC: C07D487/06
Abstract: PURPOSE: Provided are antibiotic 1-β-methyl-carbapenem derivatives of the formula(2) substituted with novel bicyclic thiol derivatives represented by the formula(1) which have stability against DHP-1 enzyme and are effective against resistant bacteria. CONSTITUTION: The method for preparing thiols and carbapenem derivatives comprises the steps of: carrying on the reaction scheme(1) to make thiols and combining them with carbapenem derivatives to make the final product of the formula(2). In the formula(1) and the formula(2), R1 is methyl or ethyl group and R2 is C1-6 alkyl such as methyl, ethyl, propyl, C1-6 cycloalkyl or alkyl substituted with phenyl, vinyl and hydroxyl group.
Abstract translation: 目的：提供式（2）的抗生素1-β-甲基 - 碳青霉烯衍生物，其由式（1）表示的新型双环硫醇衍生物取代，其具有对DHP-1酶的稳定性并且对抗细菌有效。 构成：制备硫醇和碳青霉烯衍生物的方法包括以下步骤：进行反应方案（1）制备硫醇并与碳青霉烯衍生物结合，制得式（2）的最终产物。 在式（1）和式（2）中，R 1是甲基或乙基，R 2是C 1-6烷基，例如甲基，乙基，丙基，C 1-6环烷基或被苯基，乙烯基和羟基取代的烷基。
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