公开(公告)号：MX2007016401A

公开(公告)日：2008-02-20

申请号：MX2007016401

申请日：2006-06-29

Applicant: ABBOTT LAB

Inventor： HINTON PAUL R ,  ROGUSKA MICHAEL ,  DIXON RICHARD W ,  LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  KUMAR SHANKAR

IPC: C07K14/715

Abstract: La presente invencion se refiere a proteinas de union IL-12p40, particularmente anticuerpos que unen interleucina-12 humana (hlL-12) y/o IL-23 humana (hlL-23). Especificamente, la invencion se refiere a anticuerpos que son quimericos, anticuerpos CDR-injertados y humanizados. Los anticuerpos preferidos tienen alta afinidad para hlL-12 y/o hlL-23 y neutralizar la actividad de hlL-12 y/o hlL-23 in vitro e in vivo. Un anticuerpo de la invencion puede ser un anticuerpo de longitud completa o una porcion de union de antigeno del mismo. Tambien se proporcionan metodos para hacer y utilizar los anticuerpos de la invencion. Los anticuerpos, o porciones de anticuerpos de la invencion, son utiles para detectar hlL-12 y/o hlL-23 y para inhibir la actividad de hlL-12 y/o hlL-23, por ejemplo, en un sujeto ser humano que sufre de un trastorno en donde la actividad de hlL-12 y/o hlL-23 es danina.

公开(公告)号：CA2612239A1

公开(公告)日：2007-01-11

申请号：CA2612239

申请日：2006-06-29

Applicant: ABBOTT LAB

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  KUMAR SHANKAR ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  DIXON RICHARD W

IPC: C12N15/13 ,  A61K35/12 ,  A61K39/395 ,  A61P37/02 ,  C07K14/54 ,  C07K14/715 ,  C07K16/24 ,  C07K17/02 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/63 ,  C12P21/00

Abstract: The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL- 23). Specifically, the invention relates to antibodies that are chimeric, CD R grafted and humanized antibodies. Preferred antibodies have high affinity fo r hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or a n antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.

公开(公告)号：AU2006252098A1

公开(公告)日：2007-01-11

申请号：AU2006252098

申请日：2006-12-18

Applicant: ABBOTT LAB

Inventor： MANKOVICH JOHN ,  GHAYUR TARIQ ,  SHORROCK CELIA ELIZABETH ,  BROCKLEHURST SIMON MARK ,  DUNCAN ALEXANDER ROBERT ,  LENNARD SIMON NICHOLAS ,  THOMPSON JULIA ELIZABETH ,  SALFELD JOCHEN ,  WHITE MICHAEL ,  LABKOVSKY BORIS ,  ROGUSKA MIKE ,  DIXON RICHARD W

IPC: C12N15/02 ,  A61K39/395 ,  A61K45/00 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/00 ,  A61P39/02 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08

Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

公开(公告)号：BG107045A

公开(公告)日：2003-05-30

申请号：BG10704502

申请日：2002-09-02

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  WHITE MICHAEL ,  LABKOVSKY BORIS ,  SALFELD JOCHEN G ,  DUNCAN ALEXANDER R ,  BROCKLEHURST SIMON M ,  MANKOVICH JOHN ,  SHORROCK CELIA P ,  THOMPSON JULIA E ,  LENNARD SIMON N

IPC: C12N15/02 ,  A61K39/395 ,  A61K45/00 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/00 ,  A61P39/02 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  C07K16/00

Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof., Methods of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g. in a human subject suffering from a disorder in which hIL-18 activity is detrimental. 60 claims, 5 figures

公开(公告)号：BR0108188A

公开(公告)日：2003-02-25

申请号：BR0108188

申请日：2001-02-09

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  DIXON RICHARD W ,  ROGUSKA MIKE ,  WHITE MICHAEL ,  LABKOVSKY BORIS ,  SALFELD JOCHEN ,  DUNCAN ALEXANDER ROBERT ,  BROCKLEHURST SIMON MARK ,  MANKOVICH JOHN ,  SHORROCK CELIA PATRICIA ,  THOMPSON JULIA ELISABETH ,  LENNARD SIMON NICHOLAS

IPC: C12N15/02 ,  A61K39/395 ,  A61K45/00 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/00 ,  A61P39/02 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  C07K16/00

Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

公开(公告)号：ZA200901526B

公开(公告)日：2018-11-28

申请号：ZA200901526

申请日：2009-03-03

Applicant: ABBOTT LAB

Inventor： MELIM TERRY L ,  CUFF CAROLYN A ,  ARGIRIADI MARIA A ,  WU CHENGBIN ,  HINTON PAUL R ,  DIXON RICHARD W ,  KUMAR SHANKAR ,  BELK JONATHAN P ,  CHEN YAN ,  YING HUANG

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

公开(公告)号：CA2662701C

公开(公告)日：2015-12-08

申请号：CA2662701

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  DIXON RICHARD W ,  BELK JONATHAN P ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  HINTON PAUL R ,  KUMAR SHANKAR ,  MELIM TERRY L ,  CHEN YAN

IPC: C07K16/24 ,  A61K39/395 ,  A61K47/48 ,  A61K49/00 ,  A61K51/10 ,  C07K16/46 ,  C12N15/13 ,  C12N15/63 ,  C12P21/08

Abstract: The present invention encompasses IL- 13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hlL-13 activity, e.g., in a human subject suffering from a disorder in which hTL-13 activity is detrimental.

公开(公告)号：ZA201306105B

公开(公告)日：2014-05-28

申请号：ZA201306105

申请日：2013-08-14

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  DIXON RICHARD W ,  GHAYUR TARIQ ,  SALFELD JOCHEN G

IPC: A61K20060101

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

公开(公告)号：CR20130153A

公开(公告)日：2013-05-23

申请号：CR20130153

申请日：2013-04-03

Applicant: ABBOTT LAB

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

IPC: C07K16/00

Abstract: Proteínas de unión a IL-12 p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Específicamente, la invención se relaciona con anticuerpos que son quiméricos, con injertos de CDR y anticuerpos humanizados.

公开(公告)号：CR20130150A

公开(公告)日：2013-05-23

申请号：CR20130150

申请日：2013-04-03

Applicant: ABBOTT LAB

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

IPC: C07K16/00

Abstract: Proteínas de unión a IL-12 p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Específicamente, la invención se relaciona con anticuerpos que son quiméricos, con injertos de CDR y anticuerpos humanizados. Los anticuerpos preferidos tienen gran afinidad por hIL-12 y/o hIL-23 y neutralizan la actividad de hIL-12 y/o hIL-23 in vitro y in vivo. Un anticuerpo de la invención puede ser un anticuerpo de longitud completa o una porción de unión al antígeno del mismo. También se provee un método de elaboración y un método de uso de los anticuerpos de la invención.