公开(公告)号：ES2266246T3

公开(公告)日：2007-03-01

申请号：ES01967194

申请日：2001-07-17

Applicant: BASF AG

Inventor： LOCHTMAN RENE ,  KEIL MICHAEL ,  GEBHARDT JOACHIM ,  RACK MICHAEL ,  VON DEYN WOLFGANG

IPC: C07C251/40 ,  C07B61/00 ,  C07C319/14 ,  C07C323/62 ,  C07D261/04 ,  C07D413/04 ,  C07D413/10

Abstract: Un proceso para la preparación de un derivado de 4- tioalquilbromobenceno de fórmula I en donde: R1 es alquilo C1-C6, haloalquilo C1-C6, alcoxi C1- C6, haloalcoxi C1-C6 cicloalquilo C3-C8, halógeno, R2 es ciano o un radical heterocíclico, R3 es alquilo C1-C6, que comprende la reacción de un compuesto de fórmula II, en la cual R1 y R2 son como se definió anteriormente, con un dialquil disulfuro de fórmula III R3-S-S-R3 III en presencia de un nitrito y un catalizador en un solvente adecuado y en donde la relación molar del catalizador y el compuesto de fórmula II es de 0, 005:1 a 0, 05:1.

公开(公告)号：EA007931B1

公开(公告)日：2007-02-27

申请号：EA200300100

申请日：2001-07-17

Applicant: BASF AG

Inventor： LOCHTMAN RENE ,  KEIL MICHAEL ,  GEBHARDT JOACHIM ,  RACK MICHAEL ,  VON DEYN WOLFGANG

IPC: C07C251/40 ,  C07B61/00 ,  C07C319/14 ,  C07C323/62 ,  C07D261/04 ,  C07D413/04 ,  C07D413/10

Abstract: Изобретениеотноситсяк способуполученияпроизводных 4-тиоалкилбромбензолаформулы Iгде RозначаетС-Салкил, С-Сгалогеналкил, С-Салкокси, С-Сгалогеналкокси, С-Сциклоалкил, галоген; Rозначаетизоксазольное, изоксазолиновоеилиизоксазолидиновоекольцо; RозначаетС-Салкил; включающемуваимодействиесоединенияформулы IIвкоторой Rи Rимеютвышеприведенноезначение, сдиалкилдисульфидомформулы IIIвприсутствиинитритаи катализаторав подходящемрастворителе.

公开(公告)号：AU2001269111B2

公开(公告)日：2006-12-14

申请号：AU2001269111

申请日：2001-06-29

Applicant: BASF AG

Inventor： RACK MICHAEL ,  GEBHARDT JOACHIM ,  KEIL MICHAEL ,  DEYN WOLFGANG VON ,  LOCHTMAN RENE

IPC: C07D261/04 ,  C07C209/74 ,  C07C211/52

Abstract: The invention relates to a method for producing 4-bromine-aniline derivatives of formula (I), wherein the substituents have the following meanings: R : C1-C6-alkyl, C1-C6-halogenalkyl, C1-C6-alkoxy, C1-C6-halogen-alkoxy, C3-C8-cycloalkyl, halogen; R : C1-C6-alkyl, C1-C6-alkoxy, C3-C8-cycloalkyl, C2-C6-alkenyl, cyano or a heterocyclic radical.

公开(公告)号：PL366050A1

公开(公告)日：2005-01-24

申请号：PL36605001

申请日：2001-07-17

Applicant: BASF AG

Inventor： LOCHTMAN RENE ,  KEIL MICHAEL ,  GEBHARDT JOACHIM ,  RACK MICHAEL ,  VON DEYN WOLFGANG

IPC: C07B61/00 ,  C07C319/14 ,  C07C323/62 ,  C07D261/04 ,  C07D413/04 ,  C07C251/40

Abstract: A process for preparing 4-thioalkylbromobenzene derivatives of the formula I where: R 1 is C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 3 -C 8 -cycloalkyl, halogen, R 2 is C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 3 -C 8 -cycloalkyl, C 2 -C 6 -alkenyl, cyano or a heterocyclic radical, R 3 is C 1 -C 6 -alkyl, which comprises reacting a compound of the formula II, in which R 1 and R 2 are as defined above, with a dialkyl disulfide of the formula III R 3 -S-S-R 3 III in the presence of a nitrite and a catalyst in a suitable solvent is described.

公开(公告)号：DE59910677D1

公开(公告)日：2004-11-04

申请号：DE59910677

申请日：1999-11-12

Applicant: BASF AG

Inventor： VON DEYN WOLFGANG ,  GEBHARDT JOACHIM ,  RACK MICHAEL ,  LOCHTMAN RENE ,  GOETZ NORBERT ,  KEIL MICHAEL ,  WITSCHEL MATTHIAS ,  HAGEN HELMUT ,  MISSLITZ ULF ,  BAUMANN ERNST

IPC: C07C251/40 ,  C07C251/48 ,  C07C319/14 ,  C07C323/09 ,  C07D261/04 ,  C07D261/08 ,  C07D413/10

Abstract: The present invention describes a process for preparing isoxazoles of the formula Iwhere:R is hydrogen, C1-C6-alkyl,R is hydrogen, C1-C6-alkyl,R , R , R are each hydrogen, C1-C6-alkyl or R and R together form a bond,R is a heterocyclic ring,n is 0, 1 or 2;which comprises preparing an intermediate of the formula VIwhere R , R , R and R are each as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I.Furthermore, the invention describes novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates.

公开(公告)号：NZ524049A

公开(公告)日：2004-09-24

申请号：NZ52404901

申请日：2001-07-17

Applicant: BASF AG

Inventor： LOCHTMAN RENE ,  KEIL MCIHAEL ,  GEBHARDT JOACHIM ,  RACK MICHAEL ,  VON DEYN WOLFGANG

IPC: C07B61/00 ,  C07C319/14 ,  C07C323/62 ,  C07D261/04 ,  C07D413/04 ,  C07C251/40 ,  C07D413/10

Abstract: A process for preparing 4-thioalkylbromobenzene derivatives such as 4-methylthio-3-(4,5-dihydroisoxazol-3-yl)-2-methylbromobenzene of the formula (I) is disclosed, wherein: R1 is C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl or a halogen; R2 is C1-C6-alkyl, C1-C6-alkoxy, C3-C8-cycloalkyl, C2-C6-alkenyl, cyano or a heterocyclic radical; R3 is C1-C6-alkyl; which comprises reacting a compound of the formula (II), in which R1 and R2 are as defined above, with a dialkyl disulfide of the formula (III) in the presence of a nitrite such as sodium nitrite and a catalyst such as copper powder in a suitable solvent. The reaction may be carried out at temperatures between 30-100 degree C

公开(公告)号：ZA200300816B

公开(公告)日：2004-03-10

申请号：ZA200300816

申请日：2003-01-29

Applicant: BASF AG

Inventor： GERHARDT JOACHIM ,  KEIL MICHAEL ,  LOCHTMAN RENE ,  RACK MICHAEL ,  DEYN WOLFGANG VON

IPC: C07C209/74 ,  C07C211/52 ,  C07D261/04 ,  C07D ,  C07C

Abstract: The invention relates to a method for producing 4-bromine-aniline derivatives of formula (I), wherein the substituents have the following meanings: R : C1-C6-alkyl, C1-C6-halogenalkyl, C1-C6-alkoxy, C1-C6-halogen-alkoxy, C3-C8-cycloalkyl, halogen; R : C1-C6-alkyl, C1-C6-alkoxy, C3-C8-cycloalkyl, C2-C6-alkenyl, cyano or a heterocyclic radical.

公开(公告)号：HU0302540A2

公开(公告)日：2003-11-28

申请号：HU0302540

申请日：2002-01-15

Applicant: BASF AG

Inventor： GOETZ NORBERT ,  HAMPRECHT GERHARD ,  LOCHTMAN RENE ,  PUHL MICHAEL ,  VOLK THORSTEN ,  ZAGAR CYRILL

IPC: C07D231/20

Abstract: The invention relates to a method of preparing 1-alkyl-3-aryl-5-difluoromethoxy-1H-pyrazoles of the formula (I), wherein aryl represents a mono- or polysubstituted phenyl ring, and R 1 represents C 1 -C 4 alkyl. The inventive method is characterized by reacting, in a first reaction step, a beta-ketoester of the general formula (II) with hydrazine and by successively reacting the reaction product obtained with chlorodifluoromethane and a compound R 1 -L, wherein R 1 has the meanings indicated above and L represents the leaving group of a nucleophilic displacement reaction.

公开(公告)号：SK462003A3

公开(公告)日：2003-07-01

申请号：SK462003

申请日：2001-07-17

Applicant: BASF AG

Inventor： LOCHTMAN RENE ,  KEIL MICHAEL ,  GEBHARDT JOACHIM ,  RACK MICHAEL ,  VON DEYN WOLFGANG

IPC: C07B61/00 ,  C07C319/14 ,  C07C323/62 ,  C07D261/04 ,  C07D413/04 ,  C07C251/40 ,  C07D413/10

Abstract: A process for preparing 4-thioalkylbromobenzene derivatives of the formula I where: R 1 is C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 3 -C 8 -cycloalkyl, halogen, R 2 is C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 3 -C 8 -cycloalkyl, C 2 -C 6 -alkenyl, cyano or a heterocyclic radical, R 3 is C 1 -C 6 -alkyl, which comprises reacting a compound of the formula II, in which R 1 and R 2 are as defined above, with a dialkyl disulfide of the formula III R 3 -S-S-R 3 III in the presence of a nitrite and a catalyst in a suitable solvent is described.

公开(公告)号：NO20030212L

公开(公告)日：2003-01-16

申请号：NO20030212

申请日：2003-01-16

Applicant: BASF AG

Inventor： LOCHTMAN RENE ,  KEIL MICHAEL ,  GEBHARDT JOACHIM ,  RACK MICHAEL ,  DEYN WOLFGANG VON

IPC: C07B61/00 ,  C07C319/14 ,  C07C323/62 ,  C07D261/04 ,  C07D413/04

Abstract: A process for preparing 4-thioalkylbromobenzene derivatives of the formula I where: R 1 is C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 3 -C 8 -cycloalkyl, halogen, R 2 is C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 3 -C 8 -cycloalkyl, C 2 -C 6 -alkenyl, cyano or a heterocyclic radical, R 3 is C 1 -C 6 -alkyl, which comprises reacting a compound of the formula II, in which R 1 and R 2 are as defined above, with a dialkyl disulfide of the formula III R 3 -S-S-R 3 III in the presence of a nitrite and a catalyst in a suitable solvent is described.