公开(公告)号：ES2228322T3

公开(公告)日：2005-04-16

申请号：ES00105806

申请日：2000-03-18

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  PRECHTL FRANK ,  WUENSCH THOMAS ,  WESTENFELDER HORST ,  HAREMZA SYLKE ,  BACH THORSTEN ,  SPIEGEL ANJA

IPC: C07D295/14 ,  A61K8/00 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K31/136 ,  A61K31/196 ,  A61K31/24 ,  A61K31/40 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C225/00 ,  C07C225/22 ,  C07C229/52 ,  C07D295/10 ,  C07D295/112 ,  C09K3/00 ,  A61K7/42

Abstract: Empleo de hidroxibenzofenonas aminosubstituidas de la fórmula general Ib, en la que los substituyentes tienen, independientemente entre sí, el siguiente significado: R1 y R2 significan hidrógeno, alquilo con 1 a 12 átomos de carbono, pudiendo formar los substituyentes R1 y R2 junto con el átomo de nitrógeno, con el que están enlazados, un anillo con 5 o 6 miembros; R5 significa hidrógeno, alquilo con 1 a 12 átomos de carbono, cicloalquilo con 3 a 6 átomos de carbono, como filtros de los UV-A, fotoestables, en preparaciones cosméticas y farmacéuticas para la protección de la piel humana o del cabello humano frente a las irradiaciones solares, solos o junto con compuestos que absorben en el intervalo UV, en sí conocidos, para preparaciones cosméticas y farmacéuticas.

公开(公告)号：ES2186829T3

公开(公告)日：2003-05-16

申请号：ES97113930

申请日：1997-08-13

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  AUMUELLER ALEXANDER ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUENSCH THOMAS

IPC: A61K8/00 ,  A61K8/30 ,  A61K8/40 ,  A61K8/49 ,  A61K8/92 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C255/40 ,  C07D307/52 ,  C07D317/54 ,  C07D333/24 ,  A61K7/42

Abstract: The use of compounds of formula (I) as UV-A filters in cosmetic products (optionally in combination with standard UV absorbers) to protect the human skin against sunlight is claimed. R1-R3 = H or (cyclo)aliphatic group containing up to 18 C, or two of these groups can combine to form a 5 or 6-membered ring ; R4 = optionally substituted (hetero)aryl containing 5-12 ring atoms ; and R5 = R4 or H. Also claimed are (i) cosmetic products containing (I) for protecting the epidermis layer against UV radiation with a wavelength of 280-400 nm and (ii) compounds of formula (II) : R7-R9 = lower alkyl ; R6 = 2-thienyl (optionally substituted with lower alkyl), 4-(3,5-di-t-butyl)-1-hydroxyphenyl or 4-(3,5-di-t-butyl)-1-alkoxyphenyl.

公开(公告)号：AU755281B2

公开(公告)日：2002-12-05

申请号：AU8936798

申请日：1998-10-16

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  WUNSCH THOMAS ,  WESTENFELDER HORST ,  SCHEHLMANN VOLKER ,  HAREMZA SYLKE

IPC: A61K8/00 ,  A61K8/40 ,  A61K31/00 ,  A61P17/00 ,  A61P17/16 ,  A61Q1/04 ,  A61Q17/04 ,  A61K7/42

Abstract: Photo-stable ultraviolet (UV) filters for cosmetic or pharmaceutical use consist of substituted alpha -methyl-styrene derivatives (I). The use of substituted alpha -methyl-styrene derivatives of formula (I), optionally in combination with conventional UV absorbers, as photo-stable UV filters in cosmetic or pharmaceutical preparations for protecting human skin or hair against sunlight is new. R1 = 4-10C alkoxy, 1-12C alkylamino, 1-12C dialkylamino (sic) or a water-solublizing group selected from carboxylate, sulfonate and ammonium residues; R2 = H, 2-10C alkyl or 1-12C alkoxy; R3,R4 = COOR5, COR5, CONR5R6 or CN, R4 and R5 being the same; R5,R6 = H, 1-12C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted). Independent claims are given for: (1) the use of (I) as photostable UV-A filters; (2) the use of (I) as UV stabilizers; (3) cosmetic and pharmaceutical compositions for protecting human epidermis or skin against UV light in the 280-400 nm region, comprising a carrier containing (I) (as photostable UV filter) and optionally conventional UV absorbers; (4) (I) for use as medicaments; and (5) pharmaceutical preparations containing (I).

公开(公告)号：AU754785B2

公开(公告)日：2002-11-28

申请号：AU9718198

申请日：1998-12-17

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  HAREMZA SYLKE ,  TRAUTH HUBERT ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST

IPC: A61K8/49 ,  A61K8/00 ,  A61K31/4035 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07D209/46 ,  C08K5/3417 ,  C08L101/00 ,  C09D7/12 ,  C09K3/00 ,  C09K15/30 ,  C08K5/3447 ,  A61K47/22

Abstract: Use of isoindolinone derivatives of formula (I) as stabilizers for organic materials is new, where: R = H, COOR , COR , CONR R , CN, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted); R = COOR , COR , CONR R or CN; or R +R = 7-10C bicycloalkyl or 7-10C bicycloalkenyl; R = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted) or a water-solubilizing carboxylate, sulfonate or alkylammonium group; R and R = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted). An Independent claim is included for compounds (I) as medicaments.

公开(公告)号：DE59804542D1

公开(公告)日：2002-08-01

申请号：DE59804542

申请日：1998-01-13

Applicant: BASF AG

Inventor： DROEGEMUELLER MICHAEL DR ,  BOMM VOLKER DR ,  SCHEHLMANN VOLKER DR ,  WESTENFELDER HORST

IPC: C07D215/42 ,  A61K8/00 ,  A61Q17/04 ,  C07C225/14 ,  C07C229/54 ,  C07C237/30 ,  C07C309/46 ,  C07C311/39 ,  C09K3/00 ,  A61K7/42

Abstract: Arylaminomethylene-camphor derivatives of formula (I) are new: R1 = H or Me; R2 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-6C alkenyl; 3-8C cycloalkenyl or aryl (optionally substituted); R3 = H, 1-6C alkyl, 3-8C cycloalkyl, aryl (optionally substituted), 1-6C alkoxy or 1-8C acyl; and Ar = aryl or heteroaryl (both optionally substituted); NB the double bond is Z or E configuration.

公开(公告)号：DE59706311D1

公开(公告)日：2002-03-28

申请号：DE59706311

申请日：1997-03-06

Applicant: BASF AG

Inventor： KANDZIA CHRISTOF ,  WESTENFELDER HORST ,  SCHEHLMANN VOLKER

IPC: A61K8/00 ,  A61K8/35 ,  A61K31/00 ,  A61K31/125 ,  A61P17/00 ,  A61P17/16 ,  A61Q17/04 ,  C07C45/51 ,  C07C45/74 ,  C07C49/683 ,  C07C49/697 ,  C07C49/753 ,  C07C225/22 ,  C09K15/06 ,  A61K7/42

Abstract: PCT No. PCT/EP97/01122 Sec. 371 Date Sep. 3, 1998 Sec. 102(e) Date Sep. 3, 1998 PCT Filed Mar. 6, 1997 PCT Pub. No. WO97/33855 PCT Pub. Date Sep. 18, 1997The invention relates to cinnamylidenecamphor derivatives of the formula (1) where the diene system is in the Z,Z, Z,E, E,Z or E,E configuration and R1 is H, CH3, R2 is C1-C6-alkyl, C1-C6-alkoxy, halogen, NR3H, NR32, R3 is C1-C4-alkyl, R4 is H, C1-C6-alkyl, n is 1, 2, and to its use.

公开(公告)号：DE59706362D1

公开(公告)日：2002-03-21

申请号：DE59706362

申请日：1997-08-21

Applicant: BASF AG

Inventor： KELLER DR ,  SPERLING-VIETMEIER DR ,  WESTENFELDER HORST

IPC: A61K8/00 ,  A61K8/04 ,  A61K8/81 ,  A61Q17/04 ,  A61K7/42

公开(公告)号：PT858318E

公开(公告)日：2001-10-30

申请号：PT96937228

申请日：1996-10-25

Applicant: BASF AG

Inventor： AUMULLER ALEXANDER ,  WESTENFELDER HORST ,  HOLDERBAUM MARTIN ,  SPERLING KARIN ,  WUNSCH THOMAS

IPC: A61K8/00 ,  A61K8/40 ,  A61K8/92 ,  A61Q1/04 ,  A61Q17/04 ,  A61K7/42

Abstract: PCT No. PCT/EP96/04637 Sec. 371 Date Apr. 29, 1998 Sec. 102(e) Date Apr. 29, 1998 PCT Filed Oct. 25, 1996 PCT Pub. No. WO97/17054 PCT Pub. Date May 15, 1997A sunscreen-containing cosmetic formulation to protect the human epidermis from UV light in the range from 280 to 400 nm, which formulation includes a cosmetically suitable carrier, together with compounds which absorb in the UV-B region and as photostable UV-A filters effective amounts of compounds of the formula I as defined in the specification.

公开(公告)号：ES2158358T3

公开(公告)日：2001-09-01

申请号：ES96937228

申请日：1996-10-25

Applicant: BASF AG

Inventor： HOLDERBAUM MARTIN ,  AUMULLER ALEXANDER ,  SPERLING KARIN ,  WESTENFELDER HORST ,  WUNSCH THOMAS

IPC: A61K8/00 ,  A61K8/40 ,  A61K8/92 ,  A61Q1/04 ,  A61Q17/04 ,  A61K7/42

Abstract: PCT No. PCT/EP96/04637 Sec. 371 Date Apr. 29, 1998 Sec. 102(e) Date Apr. 29, 1998 PCT Filed Oct. 25, 1996 PCT Pub. No. WO97/17054 PCT Pub. Date May 15, 1997A sunscreen-containing cosmetic formulation to protect the human epidermis from UV light in the range from 280 to 400 nm, which formulation includes a cosmetically suitable carrier, together with compounds which absorb in the UV-B region and as photostable UV-A filters effective amounts of compounds of the formula I as defined in the specification.

公开(公告)号：DE10057353A1

公开(公告)日：2001-06-07

申请号：DE10057353

申请日：2000-11-18

Applicant: BASF AG

Inventor： TIEFENSEE KRISTIN ,  WESTENFELDER HORST ,  GOTSCHE MICHAEL

IPC: A61K7/00 ,  A61K7/42

Abstract: A cosmetic or dermatological composition comprises (A) a water-in-oil (W/O) emulsion with a polymeric thickener in the aqueous phase; (B) a UV-filter; and optionally (C) further active ingredients.