公开(公告)号：AU6658181A

公开(公告)日：1982-11-04

申请号：AU6658181

申请日：1981-01-23

Applicant: CIBA GEIGY AG

Inventor： TARCSAY LAJOS ,  BASCHANG GERHARD ,  HARTMANN ALBERT ,  STANEK JAROSLAV

IPC: C07H13/00 ,  A61K38/00 ,  A61K38/14 ,  A61K39/39 ,  A61P37/04 ,  C07K1/06 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  A23K1/16 ,  A23K1/17 ,  A61K31/43 ,  A61K31/545 ,  A61K31/70

Abstract: The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for increasing the antibiotic effectiveness of antibiotics. (I) In the formula I, X represents carbonyl or carbonyloxy, R1 represents optionally substituted alkyl or aryl, R2, R3, R4 and R6 represent hydrogen or lower alkyl, R5 represents hydrogen, optionally substituted lower alkyl, cycloalkyl, aryl or nitrogen-containing heterocyclyl, or R4 and R5 together represent also C3-C4 alkylene, R7 represents hydrogen or free, esterified or amidated carboxyl, one of the radicals A1 and A2 represents a radical of the formula II and the other of the radicals A1 and A2 represents optionally substituted or functionally modified hydroxy or amino. (II) In the formula II, T represents NH or O, Y represents an optionally substituted alkylene group that can also be interrupted by oxycarbonyl or iminocarbonyl, W represents hydrogen and Z represents an optionally esterified or etherified 1,2-dihydroxyethyl or 2-hydroxyethyl group, or W and Z represent an optionally esterified or etherified hydroxymethyl group.

公开(公告)号：FI820178L

公开(公告)日：1982-07-24

申请号：FI820178

申请日：1982-01-20

Applicant: CIBA GEIGY AG

Inventor： BASCHANG GERHARD ,  HARTMANN ALBERT ,  WACKER OSKAR ,  TARCSAY LAJOS

IPC: A61K39/39 ,  A61P31/04 ,  A61P37/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07H

Abstract: There are described hexopyranose compounds of the formula I and salts thereof having immunomodulatory action, which can be used, for example, in the form of pharmaceutical preparations, and also together with antibiotics, and processes for their manufacture. (I) The variables are as described in the disclosure. The invention relates to the above-mentioned compounds as immunomodulators, especially as immunostimulants, their use as pharmacologically active substances, especially their use as immunomodulators, particularly as immunostimulants, and their use for the manufacture of pharmaceutical preparations, and to pharmaceutical preparations containing these compounds.

公开(公告)号：DD155984A5

公开(公告)日：1982-07-21

申请号：DD22454680

申请日：1980-10-13

Applicant: CIBA GEIGY AG

Inventor： BASCHANG GERHARD ,  TARCSAY LAJOS ,  HARTMANN ALBERT ,  STANCK JAROSLAV

IPC: A61K31/70 ,  A61P37/04 ,  C07H15/04 ,  C07J17/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07C103/52

公开(公告)号：NO802200A

公开(公告)日：1981-01-26

申请号：NO802200

申请日：1980-07-22

Applicant: CIBA GEIGY AG

Inventor： TARCSAY LAJOS ,  HARTMANN ALBERT ,  BASCHANG GERHARD ,  STANEK JAROSLAV

IPC: C07H13/00 ,  A61K38/00 ,  A61K38/14 ,  A61K39/39 ,  A61P37/04 ,  C07K1/06 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07C

CPC classification number: C07K9/005

公开(公告)号：DD141616A5

公开(公告)日：1980-05-14

申请号：DD21120479

申请日：1979-02-23

Applicant: CIBA GEIGY AG

Inventor： BASCHANG GERHARD ,  DIETRICH FELIX M ,  GISLER ROLAND ,  HARTMANN ALBERT ,  STANEK JAROSLAV ,  TARCSAY LAJOS

IPC: G01N33/531 ,  A61K38/14 ,  A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  C07H9/04 ,  C07H15/04 ,  C07H23/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/76 ,  C07K16/00 ,  C07K19/00

公开(公告)号：FI790584A

公开(公告)日：1979-08-25

申请号：FI790584

申请日：1979-02-21

Applicant: CIBA GEIGY AG

Inventor： BASCHANG GERHARD ,  DIETRICH FELIX M ,  GISLER ROLAND ,  HARTMANN ALBERT ,  STANEK JAROSLAV ,  TARCSAY LAJOS

IPC: G01N33/531 ,  A61K38/14 ,  A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  C07H9/04 ,  C07H15/04 ,  C07H23/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/76 ,  C07K16/00 ,  C07K19/00 ,  C07G

公开(公告)号：DK171646B1

公开(公告)日：1997-03-03

申请号：DK229985

申请日：1985-05-23

Applicant: CIBA GEIGY AG

Inventor： SORG CLEMENS PROF ,  BURMEISTER GERD ,  TARCSAY LAJOS ,  WIESENDANGER WALTER

IPC: A61K38/00 ,  A61K38/16 ,  A61K39/00 ,  A61K39/395 ,  A61P29/00 ,  A61P37/00 ,  C07K1/20 ,  C07K1/22 ,  C07K14/00 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K19/00 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  C07K14/47 ,  C07K1/36

公开(公告)号：PT94575B

公开(公告)日：1997-02-28

申请号：PT9457590

申请日：1990-07-03

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  TARCSAY LAJOS ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K38/19 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：IE70519B1

公开(公告)日：1996-12-11

申请号：IE242690

申请日：1990-07-04

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  TARCSAY LAJOS ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：DE69024279T2

公开(公告)日：1996-10-17

申请号：DE69024279

申请日：1990-06-26

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  TARCSAY LAJOS ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K38/19 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.