公开(公告)号：AT205502T

公开(公告)日：2001-09-15

申请号：AT94925135

申请日：1994-07-26

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  SUNDELIN JOHAN

IPC: C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12P21/02 ,  C12R1/91 ,  C07H21/00 ,  C07K7/00 ,  C07K2/00

Abstract: The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.

公开(公告)号：AU720513B2

公开(公告)日：2000-06-01

申请号：AU4980997

申请日：1997-10-10

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61P7/02 ,  A61P9/10 ,  A61P43/00 ,  C07D417/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08

公开(公告)号：AU710408B2

公开(公告)日：1999-09-23

申请号：AU6590296

申请日：1996-06-05

Applicant: COR THERAPEUTICS INC

Inventor： MARLOWE CHARLES K ,  SCARBOROUGH ROBERT M ,  LAIBELMAN ALAN M ,  SINHA UMA ,  ZHU BING-YAN

IPC: A61K38/00 ,  A61P7/02 ,  C07C279/24 ,  C07C281/06 ,  C07C309/30 ,  C07C335/38 ,  C07K5/06 ,  C07K5/068 ,  C07K5/072 ,  C07K5/08 ,  A61K38/55

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：NZ302524A

公开(公告)日：1999-05-28

申请号：NZ30252496

申请日：1996-01-25

Applicant: COR THERAPEUTICS INC

Inventor： SUNDELIN JOHAN ,  SCARBOROUGH ROBERT M

IPC: C12N15/09 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  A61P43/00 ,  C07H21/04 ,  C07K7/02 ,  C07K14/72 ,  C07K16/28 ,  C12N5/10 ,  C12N15/00 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K14/705 ,  C07K16/46 ,  C07K19/00 ,  A61K38/16 ,  A61K51/00

Abstract: Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.

公开(公告)号：NO304267B1

公开(公告)日：1998-11-23

申请号：NO914962

申请日：1991-12-16

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  WOLF DAVID LAWRENCE ,  CHARO ISRAEL F

IPC: A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  C07K14/81 ,  G01N33/566

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

公开(公告)号：MX9709908A

公开(公告)日：1998-07-31

申请号：MX9709908

申请日：1997-12-08

Applicant: COR THERAPEUTICS INC

Inventor： MARLOWE CHARLES K ,  SCARBOROUGH ROBERT M ,  ZHU BING-YAN

IPC: C07D277/24 ,  A61K31/42 ,  A61K31/421 ,  A61K31/423 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  C07C311/64 ,  C07D263/14 ,  C07D263/56 ,  C07D277/68 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07K5/08 ,  C07K05/06 ,  A61K38/05

Abstract: Se describen compiestos novedosos, sus sales y composiciones relacionadas con los mismos que tienen actividad contra el factor Xade mamífero; los compuestos son utiles in vitro o in vivo para prevenir o tratar trastornos de coagulacion.

公开(公告)号：CA2233204A1

公开(公告)日：1997-04-03

申请号：CA2233204

申请日：1996-09-27

Applicant: COR THERAPEUTICS INC ,  LILLY CO ELI

Inventor： PAAL MICHAEL ,  RUEHTER GERD ,  SCHOTTEN THEO ,  MULLANEY JEFFREY T ,  RUTHERBORIES KENNETH J ,  MASTERS JOHN J ,  SCARBOROUGH ROBERT M ,  FISHER MATTHEW J ,  JAKUBOWSKI JOSEPH A ,  STENZEL WOLFGANG

IPC: A61K31/00 ,  A61K31/42 ,  A61K31/423 ,  A61K31/435 ,  A61K31/437 ,  A61K31/438 ,  A61K31/535 ,  A61K31/537 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/5383 ,  A61P7/00 ,  A61P7/02 ,  C07D221/20 ,  C07D263/52 ,  C07D471/10 ,  C07D498/10 ,  C07D519/00 ,  C07D401/06 ,  C07D487/10 ,  C07D513/10 ,  C07D491/107 ,  C07D265/12 ,  C07D223/14 ,  A61K31/395 ,  A61K31/675

Abstract: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.

公开(公告)号：ZA964754B

公开(公告)日：1997-03-11

申请号：ZA964754

申请日：1996-06-06

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  MARLOWE CHARLES K ,  ZHU BING-YAN

IPC: C07D277/24 ,  A61K31/42 ,  A61K31/421 ,  A61K31/423 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  C07C311/64 ,  C07D263/14 ,  C07D263/56 ,  C07D277/68 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07K5/08 ,  C07K ,  A61K

Abstract: Ketoheterocyclic compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are usefull in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：ZA964753B

公开(公告)日：1997-02-27

申请号：ZA964753

申请日：1996-06-06

Applicant: COR THERAPEUTICS INC

Inventor： MARLOWE CHARLES K ,  LAIBELMAN ALAN M ,  SCARBOROUGH ROBERT M ,  SINHA UMA ,  ZHU BING-YAN

IPC: A61P7/02 ,  C07C279/24 ,  C07C281/06 ,  C07C309/30 ,  A61K38/00 ,  C07C335/38 ,  C07K5/06 ,  C07K5/068 ,  C07K5/072 ,  C07K5/08 ,  A61K ,  C07D ,  C07C

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：ZA9604753B

公开(公告)日：1997-02-27

申请号：ZA9604753

申请日：1996-06-06

Applicant: COR THERAPEUTICS INC

Inventor： MARLOWE CHARLES K ,  SCARBOROUGH ROBERT M ,  LAIBELMAN ALAN M ,  SINHA UMA ,  ZHU BING-YAN

IPC: A61K38/00 ,  A61P7/02 ,  C07C279/24 ,  C07C281/06 ,  C07C309/30 ,  C07C335/38 ,  C07K5/06 ,  C07K5/068 ,  C07K5/072 ,  C07K5/08 ,  A61K ,  C07C ,  C07D

CPC classification number: C07K5/06095 ,  A61K38/00 ,  C07K5/06034 ,  C07K5/06086 ,  C07K5/06191