公开(公告)号：JP2007117189A

公开(公告)日：2007-05-17

申请号：JP2005310218

申请日：2005-10-25

Applicant: Hamamatsu Photonics Kk ,  Hamamatsu Univ School Of Medicine ,  Teiji Nakayama ,  禎司 中山 ,  国立大学法人浜松医科大学 ,  浜松ホトニクス株式会社

Inventor： OKADA HIROYUKI ,  NAKAYAMA TEIJI ,  UMEMURA KAZUO ,  YAMASHITA DAISUKE ,  YAMASHITA YUTAKA ,  KOBAYASHI KATSUHIRO

IPC: A61M39/00 ,  A61B18/20

CPC classification number: A61B18/24 ,  A61B90/39 ,  A61M5/007 ,  A61M2025/0037

Abstract: PROBLEM TO BE SOLVED: To provide a catheter which can effectively irradiate an object with a laser beam and an examination system which can effectively dissolve a thrombus as the object. SOLUTION: The location relation of a metal marker 5 and an optical fiber 6 is fixed and the metal marker 5 can be moved to the nearness of a target place such as the thrombus. In addition, a longitudinal position of the optical fiber at the end surface of the optical fiber 6 is in agreement with the longitudinal position of the optical fiber at the end surface of the metal marker 5. That is, since the distance between the target place and the leading edge of the optical fiber 6 becomes clear by roentgenography, it is unnecessary to employ a large quantity of a contrast medium and to irradiate it with the laser beam depending on a skill or intuition and therefore the effective irradiation with the laser beam is possible. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供一种可以有效地用激光照射物体的导管和能够有效地溶解血栓作为对象的检查系统。 解决方案：金属标记5和光纤6的位置关系是固定的，并且金属标记5可以移动到诸如血栓的目标位置的接近度。 此外，在光纤6的端面处的光纤的纵向位置与金属标记5的端面处的光纤的纵向位置一致。也就是说，由于目标位置之间的距离 并且光纤6的前端通过扫描成像而变得清晰，不需要使用大量的造影剂并根据技术或直觉用激光照射它，因此激光束的有效照射是 可能。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2005087405A

公开(公告)日：2005-04-07

申请号：JP2003323494

申请日：2003-09-16

Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

Inventor： OMAE ETSUKO ,  YAMASHITA YUTAKA ,  ODA MOTOKI ,  SUZUKI TOSHIHIKO ,  WATANABE YUJI

IPC: A61B5/145 ,  A61B5/1455 ,  G01N21/35

Abstract: PROBLEM TO BE SOLVED: To provide an optical organism measuring instrument which determines whether or not an organism measuring object section is appropriately selected. SOLUTION: When the organism measuring object section is near the great blood vessel, the oxygen saturation degree is largely fluctuated in vein avascularization. This instrument can determine whether the organism measuring object section is appropriately selected or not by specifying the same situation from the oxygen saturation degree or parameters related thereto. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种确定生物体测量对象部分是否被适当选择的光学生物测量仪器。

解决方案：当生物体测量对象部分靠近大血管时，血氧饱和度在静脉血管形成中很大程度上波动。 该仪器可以通过从氧饱和度或与其相关的参数指定相同的情况来确定生物体测量对象部分是否被适当地选择。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2005049238A

公开(公告)日：2005-02-24

申请号：JP2003282067

申请日：2003-07-29

Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

Inventor： YAMANAKA TAKESHI ,  UEDA YUKIO ,  YAMASHITA YUTAKA

IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/359 ,  G01N21/49

CPC classification number: G01N21/4795 ,  A61B5/14553 ,  A61B2562/0233 ,  A61B2562/046 ,  G01N21/49

Abstract: PROBLEM TO BE SOLVED: To provide a scattering absorber measuring device and a measuring method for suppressing crosstalk between channels without spacial restriction. SOLUTION: This scattering absorber measuring device is constituted of a measuring module 1 having an irradiation probe 11 and detection probes 61, 71, and a measuring module 2 having an irradiation probe 21 and detection probes 81, 91. A light delaying unit 22 is provided between a light source 30 and the irradiation probe 21 relative to the pulse light source 30 which is a common light source to the irradiation probes 11, 21, and thereby pulsed light is irradiated successively from the irradiation probes 11, 21. A trigger circuit 50 indicates irradiation timing of the pulsed light to the light source 30, and indicates each light detection timing synchronized with the irradiation timing to signal processing circuits 62-92. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种散射吸收器测量装置和用于抑制通道之间的串扰的测量方法，而不受空间限制。 解决方案：该散射吸收器测量装置由具有照射探针11和检测探针61,71的测量模块1和具有照射探针21和检测探针81,91的测量模块2构成。光延迟单元 22相对于作为照射探头11,21的共同光源的脉冲光源30在光源30和照射探测器21之间设置，从而从照射探测器11,21依次照射脉冲光。 触发电路50表示对光源30的脉冲光的照射定时，并且将与照射定时同步的每个光检测定时指示给信号处理电路62-92。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JPH11173976A

公开(公告)日：1999-07-02

申请号：JP34298597

申请日：1997-12-12

Applicant: HAMAMATSU PHOTONICS KK

Inventor： OMAE ETSUKO ,  UEDA YUKIO ,  YAMASHITA YUTAKA

IPC: G01N21/17 ,  A61B5/145 ,  A61B10/00 ,  A61B5/14

Abstract: PROBLEM TO BE SOLVED: To provide an optical CT apparatus and an image reconstruction method in which the image of the distribution of absorption coefficients can be reconstructed with good accuracy and at a high speed. SOLUTION: The optical CT apparatus is constituted mainly of a container 12 whose inside is filled with an optical interface material 20, a light projection part which is composed of a light source 22 and an optical switch 24 and which projects light to the inside of the container 12, a light detection part which is composed of photodetectors 30 and shutters 32 and which detects light from the inside of the container 12 and of a computing/control part 14 which computes the spatial distribution of an absorption coefficient. The computing/ control part 14 has a function to find the spatial distribution of the absorption coefficient of a part to be measured on the basis of the comparison of an optical intensity signal measured by every photodetector 30 in a state that the optical interface material 20 is filled into the inside of the container 12 with a light signal measured by every photodetector 30 in a state that a part of the optical interface material 20 is replaced by the part to be measured.

公开(公告)号：JPH1080415A

公开(公告)日：1998-03-31

申请号：JP23927296

申请日：1996-09-10

Applicant: HAMAMATSU PHOTONICS KK ,  NOZUE MICHIHIKO ,  YASUHARA AKIO

Inventor： SHINODA KAZUNORI ,  YAMASHITA YUTAKA ,  SUZUKI YOSHIJI ,  YASUHARA AKIO ,  NOZUE MICHIHIKO

IPC: A61B5/08

Abstract: PROBLEM TO BE SOLVED: To surely observe the change in the lapse of time of a snort image by forming the snort image of a testee on the flat surface of a light transmission means and, after that irradiating light from the other surface side of the light transmission means so as to pickup the image of the snort image. SOLUTION: The snort is blown from the nose N of the testee onto the flat surface 70 of transparent glass G which is fixed to a measurement box 7. Then, the snort image is formed on the flat surface 70 by a drop of water W which is stuck by the due condensation of the snort. The shape and the area of the snort image change every moment in accordance with breath. Then, uniform light is irradiated from the other surface 71 of transparent glass G on the flat surface 70 by a light source 16, its reflection light is received by translucent mirror 17 so as to be made incident on a CCD camera 18 and the snort image is picked-up. It is processed by an image processor 19 and the shape and the area of the snort image, change in the lapse of time of the change or the position coordinate of an end point in terms of a feature are calculated. Thus, the snort image is observed with the lapse of time.

公开(公告)号：JPH06343625A

公开(公告)日：1994-12-20

申请号：JP13873693

申请日：1993-06-10

Applicant: HAMAMATSU PHOTONICS KK

Inventor： ODA MOTOKI ,  YAMASHITA YUTAKA ,  OTA KAZUYOSHI ,  TAMURA MAMORU ,  NISHIMURA GORO

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  G01N21/17 ,  G01N21/27 ,  G01N21/49 ,  A61B5/14

Abstract: PURPOSE:To provide a method and device for measuring the concentration of the light absorptive substance in a diffusing medium simply and accurately using a simple device configuration. CONSTITUTION:A light pulse emitted by a light pulse source 21 is put incident to a vital organism structure 23 through an optical fiber 22 and entered into a light sapling part 25 through another optical fiber 24. The sampling part 25 senses the intensity (f) of each light pulse sensed at each trigger signal input timing from a delay device 26. The first cumulation part 27 calculates the product t.f of the sensed photo-intensity (f) and the delay time (t) given by the delay device 26, while the second cumulation part 28 cumulates the photo- intensity (f). A mean light, path length calculation part 29 calculates the mean light path length using the cumulative results of the product t.f and photo- intensity (f). An SO2 value calculation part 30 determines the concentration ratio of VHbO2 to VHb from the mean light path length obtained, and the SO2 value is calculated. A display part 31 displays the SO2 value.

公开(公告)号：JPH06281566A

公开(公告)日：1994-10-07

申请号：JP24445691

申请日：1991-08-29

Applicant: AGENCY IND SCIENCE TECHN ,  HAMAMATSU PHOTONICS KK

Inventor： YAMADA YUKIO ,  HASEGAWA HIROO ,  YAMASHITA YUTAKA

IPC: A61B10/00 ,  A61B5/00 ,  G01N21/17 ,  G01N21/27

Abstract: PURPOSE:To obtain an optical CT image in a short time by arranging so that the change of absorption of light within a to-be-measured object is extracted from the light penetrating the object, effectively utilizing the scattering of light in the object, and extracting/processing the change of absorption at one time in a wide range. CONSTITUTION:Pulse lights of a minute time width are cast to one point of an object 1 to be measured from a pulse light source 2. The pulse lights scattered and penetrating the object are detected at many points in the neighborhood of the object. The penetrating light can be detected by a photodetector 6 with a super-high time resolution. The time distribution of the difference of the optical thickness is obtained by an operating/controlling device 8 based on the measuring data of the penetrating light for the object and the measuring data of a penetrating light with a different wavelength, etc. Data of a CT algorithm is extracted from the distribution, thereby to reconstruct the image.

公开(公告)号：JPH02298838A

公开(公告)日：1990-12-11

申请号：JP11999589

申请日：1989-05-12

Applicant: HAMAMATSU PHOTONICS KK

Inventor： YAMASHITA YUTAKA ,  TSUCHIYA KOJI ,  OTA KAZUYOSHI

IPC: G01N21/27 ,  G01N21/39

Abstract: PURPOSE:To measure the molar concentration of a non-transparent substance accurately by applying a laser of wavelengths lambda1 and lambda2 of the non-transparent substance, by measuring absorbances A1 and A2 and the optical path l of the non-transparent sub stance and by executing computation by using a specific formula. CONSTITUTION:A laser generating device 1 applies onto a sample a picosecond oscilla tion laser of wavelengths lambda1 and lambda2 generated. Integration circuits 16a and 16b of a pulse-height analyzing circuit 11 output emission luminous intensities for lambda1 and lambda2, which are passed through a division circuit 19, and absorbances A1 and A2 are outputted from a log amplifier 20 to a molar concentration computing circuit 22. Meanwhile, a time for running through a non-transparent substance is determined from a difference between peak voltages of pulse counting circuits 14a and 14b and a voltage at the time when the laser is not transmitted through the non-transparent substance, and it is converted into an optical path l by a voltage-distance conversion circuit 21 and inputted to the circuit 22. The circuit computes a molar concentration C according to the formula I by using the absorbances A1 and A2, the optical path and an absorption constant. Thereby the molar concentration of the non-transparent substance can be measured accurately.

公开(公告)号：JPS62127669A

公开(公告)日：1987-06-09

申请号：JP26869385

申请日：1985-11-29

Applicant: HAMAMATSU PHOTONICS KK

Inventor： NAKAMURA TATSU ,  SUZUKI SHIYOUHACHI ,  SAKAGUCHI SHUKICHI ,  OOTA KAZUYOSHI ,  YAMASHITA YUTAKA ,  FUJIWAKE HIDEJI ,  HAYAKAWA TAKESHI

IPC: G01N33/49

Abstract: PURPOSE:To make thorough analysis in a sort period so as not to give a large burden to a patient by temporarily taking the blood out of the body for the purpose of inspection and returning the blood into the patient' body upon ending of the inspection. CONSTITUTION:The blood is introduced from the artery into a transparent vessel 3 via a catheter 1 by drawing out a piston of a piston cylinder 4. Light is conducted via an optical fiber 6 for projection from a light source 5 into the vessel 3 and the light transmitted through the blood in the vessel 3 is taken out by an optical fiber 7 for detection. The light is conducted to a spectroscope consisting of a slit 9, a plane mirror 10 and a diffraction grating 11. The spectrally divided light is detected by a photodiode array 12 and the output thereof is processed by a data processor 13. The diagnosis information such as biochemical inspection data is displayed by a display device 14. The blood is returned through the catheter 1 into the body by the piston cylinder 4 after the inspection.

公开(公告)号：JP2013019696A

公开(公告)日：2013-01-31

申请号：JP2011151086

申请日：2011-07-07

Applicant: Univ Of Tsukuba ,  国立大学法人 筑波大学 ,  Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

Inventor： KUDO HIROYUKI ,  SAITO NAOYA ,  UEDA YUKIO ,  YOSHIMOTO KENJI ,  YAMASHITA YUTAKA

IPC: G01N21/17 ,  A61B6/03 ,  A61B8/00 ,  G01N22/02 ,  G01N29/00 ,  G01N29/44

CPC classification number: A61B5/7203 ,  A61B5/0073 ,  A61B5/0082 ,  A61B6/5247 ,  A61B8/15 ,  A61B8/5207 ,  A61B10/0041 ,  G01N21/4795 ,  G06T11/006

Abstract: PROBLEM TO BE SOLVED: To provide a biological measurement apparatus and an image formation method that can form an image which is as uniform as possible by suppressing differences in spatial resolution and noise characteristic with positions in a region to be measured.SOLUTION: A biological measurement apparatus 10 includes a light irradiation part which irradiates a region B to be measured with light, an optical detection part which detects diffused light from the region to be measured, and an arithmetic part 14 which forms a reconstructed image associated with the interior of the region to be measured. The operation part 14 forms the reconstructed image by calculating J coefficients w(J is the number of pixels of the reconstructed image) which are set by the pixels of the reconstructed image, and larger than 0 and equal to or less than 1, and performing a sequential approximation operation using an iterative expression (where (k) is an integer of 1 to N, N is the number of times of iterative operation, xis a pixel value in a (k)th iterative operation of a (j)th pixel, and dis an update quantity in the (k)th iterative operation of the (j)th pixel).

Abstract translation: 解决的问题：提供一种可以通过抑制在待测区域中的位置的空间分辨率和噪声特性的差异来形成尽可能均匀的图像的生物测量装置和图像形成方法。 解决方案：生物测量装置10包括用光照射待测区域B的光照射部分，检测来自待测区域的漫射光的光检测部分和形成重建的运算部分14的运算部分14。 与要测量的区域的内部相关联的图像。 操作部分14通过计算由重构图像的像素设置的J个系数，从而形成重构图像，并且 大于0且等于或小于1，并且使用迭代表达式（其中（k）是1到N的整数）执行顺序近似运算，N是迭代操作的次数，x 是第（j）个像素的（k）次迭代运算中的像素值，d 是第（j）个像素的（k）次迭代运算中的更新量。 版权所有（C）2013，JPO＆INPIT