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    METABOLICALLY ACTIVE DERIVATIVES OF BIS-(4-HYDROXY-PHENYL)ALKANOIC ACID AND PROCESS FOR THEIR MANUFACTURE
    52.
    发明专利
    METABOLICALLY ACTIVE DERIVATIVES OF BIS-(4-HYDROXY-PHENYL)ALKANOIC ACID AND PROCESS FOR THEIR MANUFACTURE 未知

    公开(公告)号：ZA733891B

    公开(公告)日：1974-05-29

    申请号：ZA733891

    申请日：1973-06-08

    Applicant: HOECHST AG

    Inventor： MAUZ O ,  GRANZER E

    IPC: C07C59/52 ,  C07C

    Abstract: Pharmaceutical compositions acting on the metabolism which contain as active substance bis(4-hydroxy-phenyl)alkanoic acids corresponding to the formulae I and II wherein R1 and R2 wich may be identical or different, each stands for a hydrogen or halogen atom or an alkyl group having 1 to 4 carbon atoms, R3 stands for a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R4 stands for hydroxy, alkoxy having 1 to 18 carbon atoms, phenyl-alkoxy having 1 to 4 alkyl carbon atoms, cycloalkoxy having 5 to 8 carbon atoms or a group of the formula in which Z and Z', which may be identical or different, each stands for hydrogen, alkyl of 1 to 18 carbon atoms, phenyl or cycloalkyl of 5 to 8 carbon atoms, or both together with the nitrogen atom may form a heterocyclic ring, R6 stands for an alkylene radical having 2 to 12 atoms and n stands for zero or an integer of 1 to 6, and process for preparing them.

    54.
    发明专利
    未知

    公开(公告)号：SE433493B

    公开(公告)日：1984-05-28

    申请号：SE7714684

    申请日：1977-12-22

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  GRANZER E ,  GREVE H-G ,  THORWART W

    IPC: C07D295/08 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06 ,  C07D209/14 ,  C07D211/14 ,  C07D213/53 ,  C07D213/80 ,  C07D295/088 ,  C07D303/12 ,  C07D303/36 ,  C07D333/22 ,  C07D409/12 ,  C07D295/12

    Abstract: Compounds of general formula (I) wherein R1 represents a member selected from the group consisting of (a) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms, such groups substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen phenyl, carboxyl, cyano, nitro and hydroxy groups, (b) a 5- to 6-membered heteroaromatic ring wherein the heteroatom is selected from nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms; R3 represents hydrogen, hydroxy or acyloxy; R4 and R5 are the same or different and each represents a member selected from the group consisting of halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and X represents nitrogen or methine and physiologically acceptable acid addition salts thereof and a pharmaceutical composition containing said compounds.

    58.
    发明专利
    未知

    公开(公告)号：SE412388B

    公开(公告)日：1980-03-03

    申请号：SE1699972

    申请日：1972-12-27

    Applicant: HOECHST AG

    Inventor： GRANZER E ,  GEBERT U

    IPC: C07D233/54 ,  C07D233/64 ,  C07D235/12 ,  C07D235/18 ,  C07D235/20 ,  C07D403/06 ,  C07D235/06

    Abstract: Pharmaceutical preparations having hypolipidemic activity, which contain in addition to a pharmaceutically acceptable carrier an effective amount of an imidazolyl-(2)-carbinol of the general formula I (I) in which R represents hydrogen, lower alkyl, phenyl or benzyl, R1 and R2 each represent hydrogen or together the group -CH=CH-CH=CH-, R3 and R4 represent hydrogen, lower alkyl, phenyl, lower haloalkyl, lower alkylphenyl, lower alkoxyphenyl, lower haloalkoxyphenyl, mono- or dihalophenyl, imidazolyl or benzylimidazolyl or R3 and R4 are together fluoryl of the formula or of a physiologically tolerable acid addition salt thereof, and process for preparing them.

    60.
    发明专利
    未知

    公开(公告)号：DK139428C

    公开(公告)日：1979-07-30

    申请号：DK271474

    申请日：1974-05-17

    Applicant: HOECHST AG

    Inventor： KUNSTMANN R ,  GRANZER E

    IPC: C07D221/16

    Abstract: Partially hydrogenated 1H-indeno[1,2-b]-pyridine derivatives of the general formula I in which R1 and R2, which may be identical or different, represent hydrogen, halogen or alkoxy of 1 to 4 carbon atoms, R3 represents pyridyl, phenyl, or phenyl mono- or di-substituted by halogen, nitro, amino, acylamino, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or amino substituted by 1 or 2 aliphatic or aromatic hydrocarbon groups having 2 to 18 carbon atoms or substituted amino wherein the amino-nitrogen is included in a heterocycle, A represents a single or double bond, and X represents oxygen or sulfur, AND THEIR PHYSIOLOGICALLY TOLERATED SALTS, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.

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