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    PROCESS FOR PREPARING SUBSTITUTED 0-PROPYLOXIMES
    1.
    发明授权
    PROCESS FOR PREPARING SUBSTITUTED 0-PROPYLOXIMES 失效

    公开(公告)号：KR810000559B1

    公开(公告)日：1981-06-01

    申请号：KR770003022

    申请日：1977-12-24

    Applicant: HOECHST AG

    Inventor： GREVE H ,  KOMAREK J ,  GEBERT U ,  THORWART W ,  POPENDIKER K ,  CARTHEUSER C

    IPC: C07D211/14 ,  C07D295/08

    Abstract: Substituted O-propyloximes(I; R1 = H, carboxyl, C1-6 alkyl or alkenyl; R2 = H, C1-3 alkyl, R3 = H, hydroxy, acyloxy; R4 = H, C1-3 alkyl, phenyl group; R5 = H, halogen, C1-2 alkoxy, hydroxy group; X = N, methyl; M = H, alkaline metal, alkali earth metal cation; n = 1 or valence of cation; Y = halogen, active sulfonic ester; Z = halogen, active sulfonic ester), useful for treatment of catatonia, were prepd. by reaction of O-alkylated oxime(II) and compd.(III). The carbonyl compd.(IV) or its active derivs. were reacted with hydroxylamine derivs.(V) to give intermediate(II).

    ALKYLATED HYDROXYLAMINES
    2.
    发明专利
    ALKYLATED HYDROXYLAMINES 未知

    公开(公告)号：ZA776670B

    公开(公告)日：1978-08-30

    申请号：ZA776670

    申请日：1977-11-08

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  KOMAREK J ,  THORWART W ,  CARTHEUSER C

    IPC: A61K31/395 ,  A61K31/13 ,  A61K31/24 ,  A61P9/12 ,  C07C215/30 ,  C07C239/12 ,  C07C239/20 ,  C07C255/53 ,  C07C255/54 ,  C07C319/14 ,  C07C323/12 ,  C07D207/06 ,  C07D211/00 ,  C07D211/14 ,  C07D233/60 ,  C07D233/74 ,  C07D235/06 ,  C07D295/06 ,  C07D295/08 ,  C07D295/088 ,  C07D295/12 ,  C07D473/08 ,  C07D521/00 ,  C07C83/02

    Abstract: A compound of general formula (I) wherein X represents a radical selected from the group consisting of one of the formulae in which R1 represents a radical selected from the group (a) a hydrogen atom, (b) an amino group, when X represents an -OR1 moiety, (c) an alkyl group having from 1 to 6 carbon atoms (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents of the group halogen atoms, alkyl, alkoxy, halogenalkyl groups each having up to 4 carbon atoms, cycloalkyl groups having 3 to 6 carbon atoms, nitro and cyano groups; and R2 and R3, which may be the same or different, each represents a radical selected from the group (a) a hydrogen atom, (b) an alkyl group having from 1 to 6 carbon atoms, an unsubstituted cycloalkyl group having from 3 to 7 carbon atoms, such cycloalkyl group substituted by at most 3 substituents of the group hydroxy groups and alkoxycarbonyl groups having 1 to 4 carbon atoms, (c) an aralkyl group, a diaralkyl group each having 1 to 4 carbon atoms in the alkyl moiety and being unsubstituted or substituted in at least one of the radicals in the alkyl moiety by hydroxy groups, and in the aryl moieties by at most 3 substituents selected from the group consisting of alkoxy groups having from 1 to 4 carbon atoms and halogen atoms, (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy, halogenoalkyl groups each having up to 4 carbon atoms and halogen atoms, (e) a hydroxy group when the other of R2 and R3 is hydrogen, (f) R2 and R3, together with the nitrogen atom to which they are attached, represent a 5- to 7-membered ring selected from the group consisting of an unsubstituted ring, a ring being substituted by an alkyl group having from 1 to 4 carbon atoms, and a ring being interrupted by a heteroatom selected from the group consisting of oxygen, sulphur and further nitrogen atom, and (g) R2 and R3 together with the nitrogen atom to which they are attached, represent a ring from the group a 5-membered heteroaromatic ring containing up to 4 nitrogen atoms and such a ring being anelled to a benzene- or uracil-ring, and physiologically acceptable acid addition salts thereof, a process for their preparation and a pharmaceutical composition containing them.

    5.
    发明专利
    未知

    公开(公告)号：DK496977A

    公开(公告)日：1978-05-10

    申请号：DK496977

    申请日：1977-11-08

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  THORWART W ,  KOMAREK J ,  CARTHEUSER C

    IPC: A61K31/395 ,  A61K31/13 ,  A61K31/24 ,  A61P9/12 ,  C07C215/30 ,  C07C239/12 ,  C07C239/20 ,  C07C255/53 ,  C07C255/54 ,  C07C319/14 ,  C07C323/12 ,  C07D207/06 ,  C07D211/00 ,  C07D211/14 ,  C07D233/60 ,  C07D233/74 ,  C07D235/06 ,  C07D295/06 ,  C07D295/08 ,  C07D295/088 ,  C07D295/12 ,  C07D473/08 ,  C07D521/00 ,  C07C

    Abstract: A compound of general formula (I) wherein X represents a radical selected from the group consisting of one of the formulae in which R1 represents a radical selected from the group (a) a hydrogen atom, (b) an amino group, when X represents an -OR1 moiety, (c) an alkyl group having from 1 to 6 carbon atoms (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents of the group halogen atoms, alkyl, alkoxy, halogenalkyl groups each having up to 4 carbon atoms, cycloalkyl groups having 3 to 6 carbon atoms, nitro and cyano groups; and R2 and R3, which may be the same or different, each represents a radical selected from the group (a) a hydrogen atom, (b) an alkyl group having from 1 to 6 carbon atoms, an unsubstituted cycloalkyl group having from 3 to 7 carbon atoms, such cycloalkyl group substituted by at most 3 substituents of the group hydroxy groups and alkoxycarbonyl groups having 1 to 4 carbon atoms, (c) an aralkyl group, a diaralkyl group each having 1 to 4 carbon atoms in the alkyl moiety and being unsubstituted or substituted in at least one of the radicals in the alkyl moiety by hydroxy groups, and in the aryl moieties by at most 3 substituents selected from the group consisting of alkoxy groups having from 1 to 4 carbon atoms and halogen atoms, (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy, halogenoalkyl groups each having up to 4 carbon atoms and halogen atoms, (e) a hydroxy group when the other of R2 and R3 is hydrogen, (f) R2 and R3, together with the nitrogen atom to which they are attached, represent a 5- to 7-membered ring selected from the group consisting of an unsubstituted ring, a ring being substituted by an alkyl group having from 1 to 4 carbon atoms, and a ring being interrupted by a heteroatom selected from the group consisting of oxygen, sulphur and further nitrogen atom, and (g) R2 and R3 together with the nitrogen atom to which they are attached, represent a ring from the group a 5-membered heteroaromatic ring containing up to 4 nitrogen atoms and such a ring being anelled to a benzene- or uracil-ring, and physiologically acceptable acid addition salts thereof, a process for their preparation and a pharmaceutical composition containing them.

    NOVEL O-PROPYLOXIMES
    7.
    发明专利
    NOVEL O-PROPYLOXIMES 未知

    公开(公告)号：ZA777586B

    公开(公告)日：1978-11-29

    申请号：ZA777586

    申请日：1977-12-21

    Applicant: HOECHST AG

    Inventor： CARTHEUSER C ,  THORWART W ,  GEBERT U ,  POPENDIKER K ,  KOMAREK J ,  GREVE H

    IPC: C07D295/08 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/451 ,  A61K31/455 ,  A61K31/495 ,  A61K31/52 ,  A61K31/522 ,  A61P7/10 ,  A61P9/08 ,  A61P9/12 ,  A61P25/02 ,  A61P25/20 ,  C07D209/14 ,  C07D211/22 ,  C07D213/53 ,  C07D213/80 ,  C07D231/16 ,  C07D231/38 ,  C07D233/54 ,  C07D233/64 ,  C07D295/088 ,  C07D303/12 ,  C07D311/22 ,  C07D317/58 ,  C07D317/62 ,  C07D317/64 ,  C07D333/22 ,  C07D473/12 ,  A61K31/51 ,  C07D295/18 ,  C07C131/00

    Abstract: Compounds of general formula (I) wherein R1 represents a radical selected from the group consisting of (a) hydrogen, carboxyl; (b) alkyl, alkenyl each having up to 6 carbon atoms and their phenyl substituted derivatives; (c) at most binuclear unsubstituted aryl, at most binuclear aryl substituted by from 1 to 3 substituents selected from the group consisting of alkyl and alkoxy each having up to 6 carbon atoms, benzloxy, haloalkyl having up to 2 carbon atoms, halogen, cyano and nitro; amino, carboxyl and hydroxy; amino, carboxyl and hydroxy each being substituted by alkyl having at most 2 carbon atoms, methylenedioxy groups and O- -hydroximinom ethyl groups; (d) at most bicyclic unsubstituted heteroaromatic group having 1 to 4 heteroatoms selected from the group consisting of nitrogen, one sulphur and one oxygen in the ring system and such a heteroaromatic group being substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy each having up to 2 carbon atoms, phenylalkyl having up to 3 carbon atoms in the alkyl moiety, halogen, methylamino and dimethylamino; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, cycloalkyl having up to 6 carbon atoms and phenyl; and R1 and R2, together with the carbon atom to which they are attached, form a radical selected from the group consisting of fluorene-9-ylidene and a cycloaliphatic group having up to 10 carbon atoms and such a cycloaliphatic group containing a hydrocarbon bridging group; R3 represents a member selected from the group consisting of hydrogen hydroxy and acyloxy; R4 represents a member selected from the group consisting of hydrogen alkyl having up to 3 carbon atoms and phenyl; R5 represents a member selected from the group consisting of halogen, alkoxy having up to 2 carbon atoms and hydroxy; and X represents a member selected from the group consisting of nitrogen and methine and physiologically acceptable acid addition salts thereof; a pharmaceutical composition containing said compounds.

    8.
    发明专利
    未知

    公开(公告)号：SE7712630L

    公开(公告)日：1978-05-10

    申请号：SE7712630

    申请日：1977-11-08

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  THORWART W ,  KOMAREK J ,  CARTHEUSER C

    IPC: A61K31/395 ,  A61K31/13 ,  A61K31/24 ,  A61P9/12 ,  C07C215/30 ,  C07C239/12 ,  C07C239/20 ,  C07C255/53 ,  C07C255/54 ,  C07C319/14 ,  C07C323/12 ,  C07D207/06 ,  C07D211/00 ,  C07D211/14 ,  C07D233/60 ,  C07D233/74 ,  C07D235/06 ,  C07D295/06 ,  C07D295/08 ,  C07D295/088 ,  C07D295/12 ,  C07D473/08 ,  C07D521/00 ,  C07C83/00 ,  C07C83/04 ,  C07C149/00 ,  C07C93/02 ,  C07D233/54 ,  C07D235/04 ,  C07D249/02

    Abstract: A compound of general formula (I) wherein X represents a radical selected from the group consisting of one of the formulae in which R1 represents a radical selected from the group (a) a hydrogen atom, (b) an amino group, when X represents an -OR1 moiety, (c) an alkyl group having from 1 to 6 carbon atoms (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents of the group halogen atoms, alkyl, alkoxy, halogenalkyl groups each having up to 4 carbon atoms, cycloalkyl groups having 3 to 6 carbon atoms, nitro and cyano groups; and R2 and R3, which may be the same or different, each represents a radical selected from the group (a) a hydrogen atom, (b) an alkyl group having from 1 to 6 carbon atoms, an unsubstituted cycloalkyl group having from 3 to 7 carbon atoms, such cycloalkyl group substituted by at most 3 substituents of the group hydroxy groups and alkoxycarbonyl groups having 1 to 4 carbon atoms, (c) an aralkyl group, a diaralkyl group each having 1 to 4 carbon atoms in the alkyl moiety and being unsubstituted or substituted in at least one of the radicals in the alkyl moiety by hydroxy groups, and in the aryl moieties by at most 3 substituents selected from the group consisting of alkoxy groups having from 1 to 4 carbon atoms and halogen atoms, (d) an at most binuclear aryl group being unsubstituted or substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy, halogenoalkyl groups each having up to 4 carbon atoms and halogen atoms, (e) a hydroxy group when the other of R2 and R3 is hydrogen, (f) R2 and R3, together with the nitrogen atom to which they are attached, represent a 5- to 7-membered ring selected from the group consisting of an unsubstituted ring, a ring being substituted by an alkyl group having from 1 to 4 carbon atoms, and a ring being interrupted by a heteroatom selected from the group consisting of oxygen, sulphur and further nitrogen atom, and (g) R2 and R3 together with the nitrogen atom to which they are attached, represent a ring from the group a 5-membered heteroaromatic ring containing up to 4 nitrogen atoms and such a ring being anelled to a benzene- or uracil-ring, and physiologically acceptable acid addition salts thereof, a process for their preparation and a pharmaceutical composition containing them.

    O-ALKYLATED OXIMES
    9.
    发明专利
    O-ALKYLATED OXIMES 未知

    公开(公告)号：AU514855B2

    公开(公告)日：1981-03-05

    申请号：AU3181477

    申请日：1977-12-21

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  GRANZER E ,  GREVE H-G ,  THORWART W

    IPC: C07D295/08 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06 ,  C07D209/14 ,  C07D211/14 ,  C07D213/53 ,  C07D213/80 ,  C07D295/088 ,  C07D303/12 ,  C07D303/36 ,  C07D333/22 ,  C07D409/12 ,  C07D211/28 ,  C07D211/18 ,  C07D401/12 ,  C07D403/12

    Abstract: Compounds of general formula (I) wherein R1 represents a member selected from the group consisting of (a) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms, such groups substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen phenyl, carboxyl, cyano, nitro and hydroxy groups, (b) a 5- to 6-membered heteroaromatic ring wherein the heteroatom is selected from nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms; R3 represents hydrogen, hydroxy or acyloxy; R4 and R5 are the same or different and each represents a member selected from the group consisting of halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and X represents nitrogen or methine and physiologically acceptable acid addition salts thereof and a pharmaceutical composition containing said compounds.

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