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    PROCESS FOR PREPARING SUBSTITUTED 0-PROPYLOXIMES
    2.
    发明授权
    PROCESS FOR PREPARING SUBSTITUTED 0-PROPYLOXIMES 失效

    公开(公告)号：KR810000559B1

    公开(公告)日：1981-06-01

    申请号：KR770003022

    申请日：1977-12-24

    Applicant: HOECHST AG

    Inventor： GREVE H ,  KOMAREK J ,  GEBERT U ,  THORWART W ,  POPENDIKER K ,  CARTHEUSER C

    IPC: C07D211/14 ,  C07D295/08

    Abstract: Substituted O-propyloximes(I; R1 = H, carboxyl, C1-6 alkyl or alkenyl; R2 = H, C1-3 alkyl, R3 = H, hydroxy, acyloxy; R4 = H, C1-3 alkyl, phenyl group; R5 = H, halogen, C1-2 alkoxy, hydroxy group; X = N, methyl; M = H, alkaline metal, alkali earth metal cation; n = 1 or valence of cation; Y = halogen, active sulfonic ester; Z = halogen, active sulfonic ester), useful for treatment of catatonia, were prepd. by reaction of O-alkylated oxime(II) and compd.(III). The carbonyl compd.(IV) or its active derivs. were reacted with hydroxylamine derivs.(V) to give intermediate(II).

    PROCESS FOR PREPARING HEXAHYDRO-PYRIMIDINE COMPOUNDS
    3.
    发明授权
    PROCESS FOR PREPARING HEXAHYDRO-PYRIMIDINE COMPOUNDS 失效

    公开(公告)号：KR810000804B1

    公开(公告)日：1981-07-08

    申请号：KR780001786

    申请日：1978-06-12

    Applicant: HOECHST AG

    Inventor： ANAGNOSTOPULOS H ,  WEBER R ,  GEBERT U

    IPC: A61K31/505 ,  C07D401/06

    Abstract: Title compds. [I; R1 = H, C1-2 alkyl, Ph, tolly1; R2-R5 = H, C1-2 alkyl; R6 = H, C1-3 substituent with O-position-condensed benzene or C1-3 alkoxy or halo-substituted alkyl having halo, NO2 or OH; A = single bond or C6H5-CH; Q = single bond or alkylene group of formula -CnH2n-(n = 2-6); X = O, S; Z = N or -CH having anti-coagulation or anti-serotonin activity were prepd. by eliminating R7(that is OH) in compds. II or by reacting compds. III with halogen compds. IV(3-isocyanato- or 3-isocyanato-alkano carboxylic acid; Hal = halo) or dihalogen compds. (IVa).

    O-ALKYLATED OXIMES
    5.
    发明专利
    O-ALKYLATED OXIMES 未知

    公开(公告)号：AU514855B2

    公开(公告)日：1981-03-05

    申请号：AU3181477

    申请日：1977-12-21

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  GRANZER E ,  GREVE H-G ,  THORWART W

    IPC: C07D295/08 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06 ,  C07D209/14 ,  C07D211/14 ,  C07D213/53 ,  C07D213/80 ,  C07D295/088 ,  C07D303/12 ,  C07D303/36 ,  C07D333/22 ,  C07D409/12 ,  C07D211/28 ,  C07D211/18 ,  C07D401/12 ,  C07D403/12

    Abstract: Compounds of general formula (I) wherein R1 represents a member selected from the group consisting of (a) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms, such groups substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen phenyl, carboxyl, cyano, nitro and hydroxy groups, (b) a 5- to 6-membered heteroaromatic ring wherein the heteroatom is selected from nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms; R3 represents hydrogen, hydroxy or acyloxy; R4 and R5 are the same or different and each represents a member selected from the group consisting of halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and X represents nitrogen or methine and physiologically acceptable acid addition salts thereof and a pharmaceutical composition containing said compounds.

    8.
    发明专利
    未知

    公开(公告)号：SE7714684L

    公开(公告)日：1978-06-25

    申请号：SE7714684

    申请日：1977-12-22

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  GRANZER E ,  GREVE H-G ,  THORWART W

    IPC: C07D295/08 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06 ,  C07D209/14 ,  C07D211/14 ,  C07D213/53 ,  C07D213/80 ,  C07D295/088 ,  C07D303/12 ,  C07D303/36 ,  C07D333/22 ,  C07D409/12 ,  C07D295/12

    Abstract: Compounds of general formula (I) wherein R1 represents a member selected from the group consisting of (a) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms, such groups substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen phenyl, carboxyl, cyano, nitro and hydroxy groups, (b) a 5- to 6-membered heteroaromatic ring wherein the heteroatom is selected from nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms; R3 represents hydrogen, hydroxy or acyloxy; R4 and R5 are the same or different and each represents a member selected from the group consisting of halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and X represents nitrogen or methine and physiologically acceptable acid addition salts thereof and a pharmaceutical composition containing said compounds.

    9.
    发明专利
    未知

    公开(公告)号：DK575277A

    公开(公告)日：1978-06-25

    申请号：DK575277

    申请日：1977-12-22

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  THORWART W ,  KOMAREK J ,  CATHEUSER C ,  POPENDIKER K ,  GREVE H G

    IPC: C07D295/08 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/451 ,  A61K31/455 ,  A61K31/495 ,  A61K31/52 ,  A61K31/522 ,  A61P7/10 ,  A61P9/08 ,  A61P9/12 ,  A61P25/02 ,  A61P25/20 ,  C07D209/14 ,  C07D211/22 ,  C07D213/53 ,  C07D213/80 ,  C07D231/16 ,  C07D231/38 ,  C07D233/54 ,  C07D233/64 ,  C07D295/088 ,  C07D303/12 ,  C07D311/22 ,  C07D317/58 ,  C07D317/62 ,  C07D317/64 ,  C07D333/22 ,  C07D473/12 ,  C07D

    Abstract: Compounds of general formula (I) wherein R1 represents a radical selected from the group consisting of (a) hydrogen, carboxyl; (b) alkyl, alkenyl each having up to 6 carbon atoms and their phenyl substituted derivatives; (c) at most binuclear unsubstituted aryl, at most binuclear aryl substituted by from 1 to 3 substituents selected from the group consisting of alkyl and alkoxy each having up to 6 carbon atoms, benzloxy, haloalkyl having up to 2 carbon atoms, halogen, cyano and nitro; amino, carboxyl and hydroxy; amino, carboxyl and hydroxy each being substituted by alkyl having at most 2 carbon atoms, methylenedioxy groups and O- -hydroximinom ethyl groups; (d) at most bicyclic unsubstituted heteroaromatic group having 1 to 4 heteroatoms selected from the group consisting of nitrogen, one sulphur and one oxygen in the ring system and such a heteroaromatic group being substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy each having up to 2 carbon atoms, phenylalkyl having up to 3 carbon atoms in the alkyl moiety, halogen, methylamino and dimethylamino; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, cycloalkyl having up to 6 carbon atoms and phenyl; and R1 and R2, together with the carbon atom to which they are attached, form a radical selected from the group consisting of fluorene-9-ylidene and a cycloaliphatic group having up to 10 carbon atoms and such a cycloaliphatic group containing a hydrocarbon bridging group; R3 represents a member selected from the group consisting of hydrogen hydroxy and acyloxy; R4 represents a member selected from the group consisting of hydrogen alkyl having up to 3 carbon atoms and phenyl; R5 represents a member selected from the group consisting of halogen, alkoxy having up to 2 carbon atoms and hydroxy; and X represents a member selected from the group consisting of nitrogen and methine and physiologically acceptable acid addition salts thereof; a pharmaceutical composition containing said compounds.

    10.
    发明专利
    未知

    公开(公告)号：DK575077A

    公开(公告)日：1978-06-25

    申请号：DK575077

    申请日：1977-12-22

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  GRANZER E ,  GREVE H G ,  THORWART W

    IPC: C07D295/08 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06 ,  C07D209/14 ,  C07D211/14 ,  C07D213/53 ,  C07D213/80 ,  C07D295/088 ,  C07D303/12 ,  C07D303/36 ,  C07D333/22 ,  C07D409/12 ,  C07D

    Abstract: Compounds of general formula (I) wherein R1 represents a member selected from the group consisting of (a) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms, such groups substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen phenyl, carboxyl, cyano, nitro and hydroxy groups, (b) a 5- to 6-membered heteroaromatic ring wherein the heteroatom is selected from nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms; R3 represents hydrogen, hydroxy or acyloxy; R4 and R5 are the same or different and each represents a member selected from the group consisting of halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and X represents nitrogen or methine and physiologically acceptable acid addition salts thereof and a pharmaceutical composition containing said compounds.

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