公开(公告)号：ES2001594A6

公开(公告)日：1988-06-01

申请号：ES8601384

申请日：1986-08-27

Applicant: HOECHST AG

Inventor： WESS GUNTHER ,  GRANZER ERNOLD ,  BECK GERHARD ,  LAU HANS-HERMANN

IPC: A61K31/365 ,  C07D309/10 ,  C07D309/30 ,  C07F7/18

Abstract: EL PROCEDIMIENTO DESCRITO PREPARA COMPUESTOS DE FORMULA DONDE R1 Y R 5, IGUALES O DIFERENTES, REPRESENTA HIDROGENO O RADICALES ORGANICOS SUSTITUIDOS; R2 Y R4, IGUALES O DIFERENTES, REPRESENTAN HIDROGENO O ALQUILO SUSTITUIDO, HALOGENO O ALCOXI; Y R3 REPRESENTA HIDROGENO, ALQUILO, ALQUENILO, HALOGENO O ALCOXI, HACIENDO REACCIONAR UN FENOL DE FORMULA DONDE R1 A R5 SON COMO ANTES, CON UN YODURO QUIRAL DE FORMULA DONDE R10 SIGNIFICA UN GRUPO PROTECTOR ESTABLE FRENTE A BASES Y ACIDOS DEBILES, CON LO CUAL SE OBTIENEN ETERES DE FORMULA IV QUE SE HIDROLIZAN A SEMIACETALES CORRESPONDIENTES DE FORMULA V, LOS CUALES SE OXIDAN A LACTONAS DE FORMULA VI, QUE POR HIDROLISIS ORIGINAN LOS PRODUCTOS DE FORMULA I. LAS FORMULAS IV, V Y VI SE ILUSTRAN EN LA MEMORIA. LOS PRODUCTOS OBTENIDOS SON UTILES EN MEDICAMENTOS COMO INHIBIDORES DE LA BIOSINTESIS DE LA COLESTERINA.

公开(公告)号：CA2123048C

公开(公告)日：2005-11-29

申请号：CA2123048

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61K31/58 ,  A61K31/675 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J17/00 ,  C07J41/00 ,  C07J43/00

Abstract: Tetrazole-bile acid derivatives of the formula I G1-X-G2 I in which G1, G2 and X have the meanings given and processes for their preparation are described. The compounds have useful pharmacological properties and can therefore be used as medicaments.

公开(公告)号：CA2098256C

公开(公告)日：2004-08-24

申请号：CA2098256

申请日：1993-06-11

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61P1/00 ,  A61P3/00 ,  A61P3/06 ,  A61P7/00 ,  C07H9/00 ,  C07J9/00 ,  C07J41/00 ,  C07J31/00 ,  A61K31/56 ,  A61K31/66

Abstract: Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals. Bile acid derivatives of the formula I Z(X-GS)n in which GS, X, Z and n have the meanings indicated, and a process for the preparation of these compounds are described. The compounds are pharmacologically active and can therefore be used as pharmaceuticals, in particular as a hypolipidemic.

公开(公告)号：CA2123051C

公开(公告)日：2004-01-20

申请号：CA2123051

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61P3/06 ,  A61P9/00 ,  C07J3/00 ,  C07J7/00 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00

Abstract: nor-Bile acid derivatives, processes for their preparation and the use of these compounds as medicaments nor-Bile acid derivatives of the formula I G1 - X - G2 I in which G1, G2 and X have the meanings given, processes for the preparation of these compounds and medicaments are described. On the basis of their pharmacological action, they can be used as an antihyperlipidemic agent.

公开(公告)号：CA2118565C

公开(公告)日：2003-12-02

申请号：CA2118565

申请日：1994-03-08

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: C07J9/00 ,  C07J41/00 ,  C07J43/00 ,  C07J75/00

Abstract: Process for the preparation of 3.beta.-aminocholanic acid derivatives A process for the preparation of 3.beta.-aminocholanic acid derivatives of the formula II wherein R(1), R(2) and R(3) have the meanings given, starting from the corresponding 3.alpha.-hydroxycholanic acid esters, is described.

公开(公告)号：SK280819B6

公开(公告)日：2000-08-14

申请号：SK58593

申请日：1993-06-10

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61P1/00 ,  A61P3/00 ,  A61P3/06 ,  A61P7/00 ,  C07H9/00 ,  C07J9/00 ,  C07J41/00

Abstract: Compounds of the formula (I), in which GS is a residue of the formula (II); X is a bridge group or a covalent bond, GS being bonded via A in the position 3; Z is a central bridge group; n is three or four; and the substituents R1 to R5, E, Y have their meanings specified in the claims. The compounds are pharmacologically active and can, therefore, be used as pharmaceuticals, in particular as a hypolipidemic.

公开(公告)号：AU667009B2

公开(公告)日：1996-02-29

申请号：AU6194894

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： WESS GUNTHER ,  ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER

IPC: A61K31/575 ,  A61P3/06 ,  A61P43/00 ,  C07J9/00 ,  C07J41/00 ,  A61K31/565

公开(公告)号：NZ260470A

公开(公告)日：1995-09-26

申请号：NZ26047094

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： WESS GUNTHER ,  ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER

IPC: A61K31/575 ,  A61P3/06 ,  A61P43/00 ,  C07J9/00 ,  C07J41/00

公开(公告)号：NZ245504A

公开(公告)日：1995-08-28

申请号：NZ24550492

申请日：1992-12-17

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  MULLNER STEFAN ,  WESS GUNTHER

IPC: A61K31/575 ,  A61P1/16 ,  A61P3/06 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  A61K31/58

公开(公告)号：AU6194794A

公开(公告)日：1994-11-10

申请号：AU6194794

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61K31/58 ,  A61K31/675 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J17/00 ,  C07J41/00 ,  C07J43/00 ,  A61K31/565

Abstract: Tetrazole bile acid derivatives of the formula I G1 - X - G2 I in which G1, G2 and X have the stated meanings, and processes for their preparation are described. The compounds have valuable pharmacological properties and can therefore be used as medicines.