公开(公告)号：US3594110A

公开(公告)日：1971-07-20

申请号：US3594110D

申请日：1968-02-19

Applicant: HOECHST AG

Inventor： HAPPE WILHELM ,  HEITZER ERICH ,  MULLNER STEFAN ,  RINNO HELMUT

IPC: D06P3/00 ,  D06P1/18

CPC classification number: D06P3/00

Abstract: A PROCESS FOR FAST DYEING A SHAPED ARTICLE OF A COPOLYMERIZATE OF (A) STYRENE-ACRYLONITRILE, METHACRYLIC ACID LOWER ALKYL ESTER OR ACRYLONITRILE AND (B) ABOUT 0.1 TO ABOUT 5.0 MOL PERCENT OF A VINYL COMPOUND OF THE FORMULA

R4-C(-R3)=C(-R2)-CO-N(-R1)-PH-A-X

WHEREIN R1 AND R2 EACH IS HYDROGEN OR AN ALKYL OF 1 TO 4 CARBON ATOMS, R3 AND R4 EACH IS HYDROGEN OR A GROUP -COOCH2,-COOC2H5,-COOC3H7 OR-COOC4H5, OR R1 AND R4 FORM A RING WITH A-CO-BRIDGE, PH IS PHENYLENE, ALKOXY-PHENYLENE OR CHLOROPHENYLENE, A IS A GROUP -SO2C2H4- AT THE M OR P POSITION TO THE AMIDO GROUP, AND X IS A GROUP OF -OSO2ME OR -OCOCH3 IN WHICH ME IS AMMONIUM, SODIUM OR POTASSIUM, WHICH COMPRISES TREATING SAID SHAPED ARTICLE WITH AN AQUEOUS SOLUTION OR DISPERSION OF A MONOAZO DYESTUFF HAVING REACTIVE HYDROGEN ATOM AT A TEMPERATURE OF ABOUT 90*C. TO ABOUT 120*C. AT A PH OF ABOUT 5 TO ABOUT 10.

公开(公告)号：AU719576B2

公开(公告)日：2000-05-11

申请号：AU7407696

申请日：1996-12-02

Applicant: HOECHST AG

Inventor： KIRSCHBAUM BERND ,  MULLNER STEFAN ,  BARTLETT ROBERT

IPC: C12N15/09 ,  A61K38/00 ,  C07K14/00 ,  C07K14/47 ,  C12N5/10 ,  C12N9/90 ,  C12N15/55 ,  C12Q1/68 ,  C12Q1/6823 ,  C12Q1/6886 ,  C12N15/64 ,  C12N15/11 ,  C12P21/02

Abstract: Nucleic acid binding protein (I) with helicase activity, the mRNA of which (or its translation products) are strongly expressed in presence of leflunomide (II, i.e. 4-(N-(4-trifluoromethylphenyl)-5-methyl-isoxazole)) or compounds with similar activity is new. Also new are: (1) DNA (III) encoding (I), or parts of it, and sequences that hybridise under stringent conditions with (III); (2) vectors containing (III) or sequences antisense to (III) and (3) host cells containing (III) or the vectors.

公开(公告)号：MX9800757A

公开(公告)日：1998-10-31

申请号：MX9800757

申请日：1998-01-27

Applicant: HOECHST AG

Inventor： MULLNER STEFAN ,  KIRSCHBAUM BERND ,  SCHWAB WILFRIED

IPC: B01J20/281 ,  A61K31/167 ,  A61K31/275 ,  A61K31/42 ,  A61K39/385 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C233/58 ,  C07C235/28 ,  C07C235/74 ,  C07C237/04 ,  C07C255/23 ,  C07C255/30 ,  C07D261/08 ,  C07D261/18 ,  G01N30/88 ,  G01N33/53 ,  G01N33/543 ,  G01N33/558 ,  G01N33/68 ,  G01N33/94 ,  C07D261/14

Abstract: Un compuesto de la formula I (Ver Formula), representando R1 el radical de la formula II o III, (Ver formula); es apropiado para la preparacion de un medicamento para el tratamiento de inflamaciones, enfermedades cancerosas o enfermedades autoinmunes. Un compuesto de la formula IV (Ver Formula) es apropiado para la preparacion de anticuerpos específicos contra un compuesto de la formula I y para descubrir proteínas que se fijen específicamente a partir de extractos celulares, suero, sangre o líquidos sinoviales, para purificar proteínas, para modificar placas de microtitulacion o para preparar un material para cromatografía, especialmente un material para cromatografía de afinidad, y para su empleo en agentes de diagnostico.

公开(公告)号：MX9701385A

公开(公告)日：1997-05-31

申请号：MX9701385

申请日：1995-08-07

Applicant: HOECHST AG

Inventor： SCHONHARTING MARTIN ,  MULLNER STEFAN ,  ZABEL PETER

IPC: A61K38/00 ,  A61K31/195 ,  A61K31/44 ,  A61K31/52 ,  A61K31/55 ,  A61K31/70 ,  A61K38/13 ,  A61K45/06 ,  A61P1/16 ,  A61P3/06 ,  A61P3/08 ,  A61P11/00 ,  A61P17/00 ,  A61P27/16 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  A61K31/02

Abstract: Una preparacion de producto combinado que comprende un compuesto que tiene una accion inhibidora de fosfodiesterasa y un compuesto que reduce el contenido de Ca2+ intracelular biologicamente efectivo, es apropiado para el tratamiento de enfermedades inmunologicas.

公开(公告)号：NZ245504A

公开(公告)日：1995-08-28

申请号：NZ24550492

申请日：1992-12-17

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  MULLNER STEFAN ,  WESS GUNTHER

IPC: A61K31/575 ,  A61P1/16 ,  A61P3/06 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  A61K31/58

公开(公告)号：AU643349B2

公开(公告)日：1993-11-11

申请号：AU8982591

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MULLNER STEFAN ,  KONIG WOLFGANG ,  MULLER GUNTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  C07K7/40 ,  A61K37/02

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：PT99850A

公开(公告)日：1992-11-30

申请号：PT9985091

申请日：1991-12-18

Applicant: HOECHST AG

Inventor： MULLNER STEFAN ,  KONIG WOLFGANG ,  MULLER GUNTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  C07K7/40 ,  A61K37/02

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：FI915933A

公开(公告)日：1992-06-20

申请号：FI915933

申请日：1991-12-17

Applicant: HOECHST AG

Inventor： MULLNER STEFAN ,  KOENIG WOLFGANG ,  MULLER GUNTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62 ,  C07K

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：PT95374B

公开(公告)日：1999-04-30

申请号：PT9537490

申请日：1990-09-20

Applicant: HOECHST AG

Inventor： MULLNER STEFAN

IPC: G01N33/53 ,  A61K39/395 ,  C07K14/00 ,  C07K14/62 ,  C07K16/00 ,  C07K16/26 ,  C07K19/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/531 ,  G01N33/577 ,  G01N33/74 ,  C07K4/12

Abstract: The invention relates to antibodies which are obtained by immunisation with a peptide fragment which represents a highly conserved amino-acid sequence of a natural protein. The antibodies according to the invention can be used to produce immunoassays, in particular to produce assays for the determination of genetically engineered products such as insulin, which are produced as sparingly soluble inclusion bodies in microorganisms. The invention particularly relates to a multispecies insulin assay in the form of an RIA.

公开(公告)号：NO179010C

公开(公告)日：1996-07-17

申请号：NO904129

申请日：1990-09-21

Applicant: HOECHST AG

Inventor： MULLNER STEFAN

IPC: G01N33/53 ,  A61K39/395 ,  C07K14/00 ,  C07K14/62 ,  C07K16/00 ,  C07K16/26 ,  C07K19/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/531 ,  G01N33/577 ,  G01N33/74

Abstract: The invention relates to antibodies which are obtained by immunisation with a peptide fragment which represents a highly conserved amino-acid sequence of a natural protein. The antibodies according to the invention can be used to produce immunoassays, in particular to produce assays for the determination of genetically engineered products such as insulin, which are produced as sparingly soluble inclusion bodies in microorganisms. The invention particularly relates to a multispecies insulin assay in the form of an RIA.