公开(公告)号：CA2699849A1

公开(公告)日：2009-03-26

申请号：CA2699849

申请日：2008-09-18

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： PONCELET VIRGINIE SOPHIE ,  COUPA SOPHIE ,  STORCK PIERRE-HENRI ,  SCHOENTJES BRUNO

IPC: C07D401/12 ,  A61K31/4045 ,  A61P29/00 ,  A61P35/00 ,  C07D401/14

Abstract: The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds; wherein n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, R20, X, Y, Q and Z have defined meanings.

公开(公告)号：AU2008223793A1

公开(公告)日：2008-09-12

申请号：AU2008223793

申请日：2008-03-07

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： PASQUIER ELISABETH THERESE JEANNE ,  DUFFY JAMES EDWARD STEWART ,  BOURDREZ XAVIER MARC ,  OWENS ANDREW PATE ,  FREYNE EDDY JEAN EDGARD ,  PONCELET VIRGINIE SOPHIE ,  ROUX BRUNO ,  MACRITCHIE JACQUELINE ANNE ,  ANGIBAUD PATRICK RENE ,  MARCONNET-DECRANE LAURENCE FRANCOISE BERNADETTE ,  STORCK PIERRE-HENRI ,  MEYER CHRISTOPHE ,  MEVELLEC LAURENCE ANNE ,  VIALARD JORGE EDUARDO ,  ADELINET CHRISTOPHE DENIS ,  PILATTE ISABELLE NOELLE CONSTANCE

IPC: C07D215/22 ,  A61K31/4704