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    PROCESS FOR MAKING A LIGHTWEIGHT CELLULAR INORGANIC MATERIAL
    51.
    发明申请
    PROCESS FOR MAKING A LIGHTWEIGHT CELLULAR INORGANIC MATERIAL 审中-公开
    制造轻型细胞无机材料的方法

    公开(公告)号：WO1991004951A1

    公开(公告)日：1991-04-18

    申请号：PCT/US1990005550

    申请日：1990-09-28

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  MESSING, Gary, L. ,  FUJIU, Takamitsu

    IPC: C03C03/00

    CPC classification number: C03C1/006 ,  C03C11/00 ,  C03C14/002 ,  C03C2214/02 ,  C03C2214/06 ,  C03C2214/32

    Abstract: A process for making a cellular inorganic material is disclosed. In this process a sol is formed by dispersing inorganic particles having a size of less than 1000 ANGSTROM in a dispersant liquid. A liquid, immiscible in the dispersant liquid, is added to the sol. A stabilizing effective amount of surfactant is added to the sol prior to, concurrently with or subsequent to the introduction of the immiscible liquid. The stabilized sol is converted into a gel by increasing the viscosity of the sol. The gel is next treated such that the immiscible liquid is dispersed into a plurality of droplets or vaporized into an interconnected gaseous network wherein the gel becomes cellular. The dispersant liquid and the immiscible liquid are removed from the cellular gel followed by removal of the surfactant and sintering to form the cellular inorganic material. The above process may be supplemented by the additional inclusion of an inorganic material selected from the group consisting of inorganic whiskers and inorganic fibers introduced into the dispersant liquid along with the inorganic particles.

    Abstract translation: 公开了一种制备细胞无机材料的方法。 在该方法中，通过将尺寸小于1000的无机颗粒分散在分散剂液体中而形成溶胶。 将分散液中不混溶的液体加入到溶胶中。 在引入不混溶液体之前，同时或之后，将稳定有效量的表面活性剂加入到溶胶中。 通过增加溶胶的粘度将稳定的溶胶转化成凝胶。 接下来处理凝胶，使得不混溶的液体分散成多个液滴或蒸发成互连的气体网络，其中凝胶变成细胞。 从细胞凝胶中除去分散剂液体和不混溶液体，然后除去表面活性剂并烧结以形成细胞无机材料。 上述方法可以通过另外包含选自由无机颗粒组成的组中的无机材料和无机颗粒一起引入分散剂液体中的无机纤维来补充。

    LESION LOCALIZATION DEVICE AND METHOD OF USING
    53.
    发明申请
    LESION LOCALIZATION DEVICE AND METHOD OF USING 审中-公开
    LESION本地化设备及其使用方法

    公开(公告)号：WO1990015576A1

    公开(公告)日：1990-12-27

    申请号：PCT/US1990003244

    申请日：1990-06-07

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  RANK, William, R. ,  NICHOLS, Ronald, Lee ,  SCHOENBERGER, Stephanie, G.

    IPC: A61B10/00

    CPC classification number: A61B17/3403 ,  A61B90/39 ,  A61B2017/06076 ,  A61B2090/3908 ,  A61B2090/3987

    Abstract: A lesion localization marking wire (10) and needle assembly (30) for marking non-palpable lesions within the body. A marking device (10) having a helically wound coil of wire (14) attached to an end of the shaft (12) which is insertable into the body through a needle or cannula (30) for rotatingly anchoring the marking device (10) into a lesion or tumor (54) is provided. The needle or cannula (30) is inserted into the body with the marking device (10) positioned therein so that when the cannula is positioned proximate to a lesion (54) the shaft (12) of the marker is rotated to advance the marker (10) into the lesion to mark it for subsequent surgical procedures. A second helical wire (18) may be provided on the shaft (12) which cooperates with a wire guide device (40) attached to the needle (30) to enable the physician to determine the depth of the marking device (10) as it anchors into the lesion (54). In particular, the device is provided for marking for biopsy lesion of the breast.

    PHOSPHORAMIDES USEFUL AS ANTITUMOR AGENTS
    55.
    发明申请
    PHOSPHORAMIDES USEFUL AS ANTITUMOR AGENTS 审中-公开
    有助于抗肿瘤剂的磷酰胺

    公开(公告)号：WO1989011484A1

    公开(公告)日：1989-11-30

    申请号：PCT/US1989002299

    申请日：1989-05-25

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  BORCH, Richard, F. ,  CANUTE, Gregory, W. ,  VALENTE, Ronald, R.

    IPC: C07F09/24

    CPC classification number: C07F9/2458 ,  C07F9/2429 ,  C07F9/6506

    Abstract: An antitumor compound of formula (I), wherein R1 and R2 may be the same or different and are selected from the group consisting of hydrogen or lower alkyl which is non-substituted with halo, hydroxy or lower alkoxy, provided that the substituent is not on the -carbon; or R1 and R2 taken together with the nitrogen to which they are attached form a morpholion ring. R is a nitro-substituted aryl or nitro-substituted nitrogen, sulfur or oxygen containing heteroaromatic groups R3 and R4 are each independently hydrogen, an electron withdrawing group or lower alkyl which is unsubstituted or mono-substituted with alkyl or an electron withdrawing group.

    Abstract translation: 式（I）的抗肿瘤化合物，其中R 1和R 2可以相同或不同，并且选自氢或未被卤素，羟基或低级烷氧基取代的低级烷基，条件是取代基不是 在碳上 或者R 1和R 2与它们所连接的氮一起形成吗啉环。 R是硝基取代的芳基或硝基取代的氮，含硫或含氧的杂芳基基团R 3和R 4各自独立地为氢，吸电子基团或未被取代或被烷基或吸电子基团单取代的低级烷基。

    FINITE AMPLITUDE DISTORTION-BASED INHOMOGENEOUS PULSE ECHO ULTRASONIC IMAGING
    56.
    发明申请
    FINITE AMPLITUDE DISTORTION-BASED INHOMOGENEOUS PULSE ECHO ULTRASONIC IMAGING 审中-公开
    基于有限幅度失真的异质脉冲超声波超声成像

    公开(公告)号：WO1998020361A1

    公开(公告)日：1998-05-14

    申请号：PCT/US1997020162

    申请日：1997-11-04

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  CHRISTOPHER, Ted

    IPC: G01S07/52

    CPC classification number: G01S7/52046 ,  G01S7/52038 ,  G01S15/895

    Abstract: A method and system for imaging a sample. The method includes the steps of generating an ultrasonic signal, directing the signal into a sample, which signal is distorted and contains a first order and higher order component signals at first and higher frequencies respectively. The received distorted signal is processed, and an image is formed, and then displayed, from one of the higher order component signals of the received distorted signal.

    Abstract translation: 用于对样品成像的方法和系统。 该方法包括以下步骤：产生超声波信号，将信号引入样本，该信号失真，并分别包含第一和更高频率的一阶和高阶分量信号。 处理接收到的失真信号，并从接收到的失真信号的较高阶分量信号之一形成图像，然后显示。

    NANOPARTICLES IMPRINTED WITH RECOGNITION SITES FOR TARGET MOLECULES
    58.
    发明申请
    NANOPARTICLES IMPRINTED WITH RECOGNITION SITES FOR TARGET MOLECULES 审中-公开
    用目标分子识别位点表达的纳米粒子

    公开(公告)号：WO1996041173A1

    公开(公告)日：1996-12-19

    申请号：PCT/US1996007936

    申请日：1996-05-29

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  DARLING, Graham, D. ,  HEISLER, Seymour +di ,  STRANIX, Brent, R. ,  TURKEWITSCH, Petra ,  WANDELT, Barbara

    IPC: G01N33/531

    CPC classification number: G01N33/531 ,  G01N2600/00

    Abstract: The present invention provides solid imprinted particles comprising recognition sites spaced on the surface thereof which selectively bind a preselected template compound (T), wherein said recognition sites are each defined by a shaped polymeric matrix conforming to the shape and size of T, comprising a unit of the formula -B-Det, wherein B is bound to the polymeric matrix and also comprises a functional group which reversibly binds to T, and Det is a moiety capable of generating a detectable signal which changes following binding of B to template compound T.

    Abstract translation: 本发明提供固体印迹颗粒，其包含在其表面上间隔开的选择性结合预选模板化合物（T）的识别位点，其中所述识别位点各自由符合T的形状和尺寸的成形聚合物基质限定，包括单元 式-B-Det，其中B与聚合物基体结合，并且还包含可逆结合T的官能团，并且Det是能够产生在B与模板化合物T结合后发生变化的可检测信号的部分。

    COBALAMINS AS NITRIC OXIDE SEQUESTRANTS
    59.
    发明申请
    COBALAMINS AS NITRIC OXIDE SEQUESTRANTS 审中-公开
    作为氮氧化物序列的化合物

    公开(公告)号：WO1995031204A1

    公开(公告)日：1995-11-23

    申请号：PCT/US1994005650

    申请日：1994-05-17

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC. ,  GREENBERG, Stanley, S. ,  XIE, Jianming ,  MILLER, Mark, J., S. ,  ZATARIAN-KUEBEL, Judy

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC.

    IPC: A61K31/68

    CPC classification number: A61K31/714

    Abstract: The present invention describes a method of sequestering nitric oxide from the bloodstream, endothelium or tissues of mammals by administering a cobalamin to such mammals. A method of treating diseases characterized by elevated nitric oxide levels in the bloodstream, endothelium or tissues is further provided. In particular, a method of treating sepsis by administering a therapeutic dose of hydroxocobalamin is described by the present invention. A method of alleviating systemic hypotension in a septic patient is further described by this invention. A pharmaceutical composition comprising a cobalamin in a concentration ranging from .5 to 50 mg composition/Kg body weight for mammals is also provided.

    Abstract translation: 本发明描述了通过向这些哺乳动物施用钴胺素来从哺乳动物的血液，内皮或组织中螯合一氧化氮的方法。 还提供了治疗以血流，内皮或组织中一氧化氮水平升高为特征的疾病的方法。 特别地，本发明描述了通过施用治疗剂量的羟钴胺素治疗败血症的方法。 通过本发明进一步描述了减轻脓毒症患者的全身性低血压的方法。 还提供了包含浓度为.5至50mg组合物/ Kg体重的钴胺素的药物组合物用于哺乳动物。

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