公开(公告)号：DE60000328D1

公开(公告)日：2002-09-19

申请号：DE60000328

申请日：2000-11-09

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  ATASSI GHANEM ,  HICKMAN JOHN ,  CIMETIERE BERNARD

IPC: C07D491/22 ,  A61K31/4375 ,  A61K31/4745 ,  A61P35/00 ,  C07D401/02 ,  C07D471/14

Abstract: Camptothecin analogs (I), their enantiomers, diastereoisomers, and salts with acids and bases are new. Camptothecin analogs of formula (I), their enantiomers, diastereoisomers, and salts are new. n = 0-2; R1-R5 = H, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, 3-11C cycloalkyl, 3-11C cycloalkyl-alkyl, OH, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyloxy, NO2, CN, aminocarbonyl (optionally substituted on the N by one or two alkyl groups), -(CH2)p-NRaRb, or -O-CO- NRaRb; or two adjacent groups of R2-R5 = -O-(CH2)t-O-; p = 0 - 6; Ra, Rb = H, alkyl, 3-11C cycloalkyl, 3-11C cycloalkyl-alkyl, acyl, optionally substituted aryl or optionally substituted arylalkyl; or NRaRb = pyrrolyl, piperidinyl, or piperazinyl each of the cyclic groups being optionally substituted; t = 1-3; R60, R70n, R80, and R90 = H, OH, alkoxy, or -O-CO-X or -O-CO-NXW; X, W = alkyl, alkenyl, alkynyl, 3-11C cycloalkyl, 3-11C cycloalkyl-alkyl, optionally substituted aryl, or optionally substituted aryl alkyl; R61, R71n, R81, and R91 = H, alkyl, alkenyl or alkynyl; or vicinal pairs may together form a bond or an oxirane group; or R60+R61, R70n+R71n, R80+R81n and/or R90+R91 = oxo or -O-(CH2)t1-O-; t1 = 1-3 with the proviso that R60, R70n, R80, R90, R61, R71n, R81, and R91 are not all H. Alkyl, alkoxy and acyl groups have 1-6C; alkenyl have 2-6C and 1-3 double bonds; alkynyl have 2-6C and 1-3 triple bonds; aryl = phenyl or naphthyl; 'substituted' on aryl or aryl alkyl groups means by one or more halogens, alkyl, alkoxy, OH, CN, NO2, amino or mono- or dialkylamino groups; 'substituted' on heterocyclic groups means by one or more alkyl, alkoxy, aryl, aryl alkyl, aryloxy and/or aryloxy alkyl groups. An Independent claim is included for the preparation of (I).

公开(公告)号：AU3017397A

公开(公告)日：1998-02-05

申请号：AU3017397

申请日：1997-07-24

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  ATASSI GHANEM ,  PIERRE ALAIN ,  KRAUS-BERTHIER LAURENCE ,  LEONCE STEPHANE

IPC: C07D221/10 ,  A61K31/435 ,  A61K31/47 ,  A61K31/473 ,  A61K31/55 ,  A61P35/00 ,  C07D209/80 ,  C07D401/12 ,  C07D403/12 ,  C07D519/00 ,  C07D209/58 ,  C07D487/04 ,  A61K31/445

Abstract: Bis-imides of formula (I), their isomers and salts are new. m, n = 0 or 1; X, Y = H, halo, 1-6C alkyl, 1-6C trihaloalkyl, 1-6C alkoxy, OH, CN, NO2, amino, alkylamino, or dialkylamino; Z = 4-12C alkylene chain optionally interrupted by groups NR, O, S, SO, SO2, CONH, or an optionally substituted heterocycle; R = H or 1-6C alkyl; A, with two adjacent C atoms of the phenyl ring to which it is attached, forms one of the following groups, all of which may be substituted: phenyl, naphthyl, tetrahydronaphthyl, 1,4-dioxo-1,2,3,4-tetrahydronaphthyl, or a heterocycle; the ring containing B forms a group of formula (i) or (ii); m1, n1, X1, Y1, and A1 are as defined for m, n, X, Y, and A respectively; and X2 and Y2 are as defined for X and Y.

公开(公告)号：AU3855593A

公开(公告)日：1993-11-18

申请号：AU3855593

申请日：1993-05-14

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  LAUBIE MICHEL ,  VERBEUREN TONY

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/16 ,  A61K31/17 ,  A61K31/18 ,  A61K31/19 ,  A61K31/34 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/445 ,  A61P7/02 ,  A61P9/08 ,  A61P43/00 ,  C07C311/19 ,  C07D211/34 ,  C07D211/54 ,  C07D211/58 ,  C07D211/62 ,  C07D211/96 ,  C07D213/42 ,  C07D311/96 ,  C07D333/20 ,  A61K31/20

Abstract: Compounds of formula (I): in which: R1 and R2, which are identical or different, represent a linear or branched (C1-C6)alkyl radical, a substituted or unsubstituted phenyl radical, a pyridyl radical or a thienyl radical, or form, with the carbon atom to which they are attached, a substituted or unsubstituted (C4-C7)cycloalkyl ring, R3 represents - a substituted or unsubstituted phenylsulphonyl radical, - a linear or branched (C1-C6)alkyl radical, - an alkylaminocarbonyl radical, - or a linear or branched (C1-C6)acyl radical, R4 represents any one of the radicals: -CH=CH-(CH2)p-CO2H or -CH2-CH2-(CH2)p-CO2H in which p is equal to 0, 1, 2 or 3, n and m, which are identical or different, represent 0, 1 or 2, their isomers, enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid or base. The compounds described in the present invention possess antithromboxane A2 properties both as antagonists of thromboxane A2 (TxA2) receptors and as inhibitors of the activity of the enzyme responsible for the synthesis of thromboxane A2: thromboxane A2 synthase.

公开(公告)号：MY150497A

公开(公告)日：2014-01-30

申请号：MYPI20063757

申请日：2006-08-03

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STÉPHANE

IPC: C07D491/22

Abstract: COMPOUND OF FORMULA (I): WHEREIN: R?, R?, R?, R?, R?, R??, R??, R??, R??, ALK AND G ARE AS DEFINED IN THE DESCRIPTION. MEDICAMENTS.

公开(公告)号：CA2617957C

公开(公告)日：2011-09-20

申请号：CA2617957

申请日：2006-08-04

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE

IPC: C07D491/22 ,  A61K31/4745 ,  A61P35/00 ,  C07D471/14

Abstract: La présente invention a pour objet les composés de formule (I): (see formula I) dans laquelle : .cndot. R1, R2, R3, R4, R5, R80, R90, R81, R91, Alk et G sont tels que définis dans la description. L'invention vise également le procédé de préparation des composés de formule (I), leur utilisation ainsi que les compositions pharmaceutiques qui les contiennent.

公开(公告)号：UA95253C2

公开(公告)日：2011-07-25

申请号：UAA200802668

申请日：2006-08-04

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE

IPC: C07D471/14 ,  A61P35/00

公开(公告)号：NZ565397A

公开(公告)日：2011-06-30

申请号：NZ56539706

申请日：2006-08-04

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE

IPC: C07D491/22 ,  A61K31/4745 ,  C07D471/14

Abstract: Disclosed herein are camptothecin compounds of formula (I), wherein the substituents are as defined within the specification, process for their preparation, intermediate compound of formula (III'), compositions comprising compounds of formula (I) and the use of said compounds in the treatment of cancer diseases.

公开(公告)号：GEP20115243B

公开(公告)日：2011-06-27

申请号：GEAP2006010531

申请日：2006-08-04

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE

IPC: C07D491/22 ,  A61K31/4745 ,  A61P35/00 ,  C07D471/14

Abstract: A compound of the formula (I) values R1, R2, R3, R4, R5, R80, R81, R90, R91, Alk and G are provided in the description, method for its production, pharmaceutical compositions on its base and use thereof for preparation of medicaments for treatment of cancer diseases.

公开(公告)号：HK1123048A1

公开(公告)日：2009-06-05

申请号：HK09100240

申请日：2009-01-09

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE

IPC: A61K20060101 ,  C07D20060101

Abstract: Compound of formula (I): wherein: R1, R2, R3, R4, R5, R80, R90, R81, R91, Alk, Alk′, X, X′ and G are as defined in the description. Medicinal products containing the same which are useful in the treatment of cancer diseases.

公开(公告)号：MA29648B1

公开(公告)日：2008-07-01

申请号：MA30600

申请日：2008-01-28

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE

IPC: C07D491/22 ,  A61K31/4745 ,  C07D471/14

Abstract: NOUVEAUX COMPOSES ANALOGUES DE LA CAMPTOTHECINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT Composé de formule (I) : dans laquelle : ¿ R1, R2, R3, R4, R5, R80, R90, R81, R91, Alk, Alk', X, X' et G sont tels que définis dans la description. Médicaments.