公开(公告)号：JP2003113156A

公开(公告)日：2003-04-18

申请号：JP2002203408

申请日：2002-07-12

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  DUBUFFET THIERRY ,  CIMETIERE BERNARD ,  VERBEUREN TONY ,  SIMONET SERGE ,  VAYSSETTES-COURCHAY CHRISTINE

IPC: C07D295/08 ,  A61K31/18 ,  A61K31/195 ,  A61K31/40 ,  A61K31/445 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P25/06 ,  C07B53/00 ,  C07C303/40 ,  C07C311/16 ,  C07C311/17 ,  C07C311/19 ,  C07C311/21 ,  C07D207/08 ,  C07D211/00 ,  C07D261/20 ,  C07D265/30 ,  C07D275/04 ,  C07D275/06 ,  C07D295/088 ,  C07D295/092 ,  C07D413/04 ,  C07D417/04

Abstract: PROBLEM TO BE SOLVED: To provide a medicine useful for treatment of atherothrombotic cardiovascular diseases such as cardiac infarction, stenocardia, cerebrovascular diseases, etc. SOLUTION: This compound is represented by the formula (I) [wherein G is a group represented by the formula (II) (R and R each independently represent hydrogen atom, an alkyl group or the like or R and R form a heterocycloalkyl group together with nitrogen atom) or the like; R represents hydrogen atom, an alkyl group or the like; Ra is hydroxy group, a 1-6C alkoxy group or amino group; Rb and Rc are same or different and each represents hydrogen atom, a halogen atom, an alkyl group or the like; m is an integer of 0-1; n and q are same or different integer of 0-6; p and r are same or different integer of 1-6]. This pharmaceutical composition comprises the compound.

公开(公告)号：JP2002212184A

公开(公告)日：2002-07-31

申请号：JP2001378235

申请日：2001-12-12

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  GLOANEC PHILIPPE ,  VERBEUREN TONY ,  RUPIN ALAIN ,  VALLEZ MARIE ODILE

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/536 ,  A61K38/00 ,  A61P7/02 ,  A61P9/10 ,  A61P43/00 ,  C07D471/04 ,  C07K5/078

Abstract: PROBLEM TO BE SOLVED: To obtain a new inhibitor of serine proteases such as thrombin having improved effects and selectivity. SOLUTION: This compound is represented by formula (I) [wherein, R1 represents hydrogen atom or a linear or a branched 1-6C alkyl group which is optionally substituted; a group represented by formula (II) represents a saturated ring having 4 to 7 ring members that may contain, in addition to nitrogen atom, one or two heteroatoms selected from O, S and N; n represents an integer of 1

公开(公告)号：WO2009066035A3

公开(公告)日：2009-08-27

申请号：PCT/FR2008001261

申请日：2008-09-10

Applicant: SERVIER LAB ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  VALLEZ MARIE-ODILE ,  FRATACCI MARIE-DOMINIQUE ,  LREOND LAURENCE ,  LAVIELLE GILBERT

Inventor： VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  VALLEZ MARIE-ODILE ,  FRATACCI MARIE-DOMINIQUE ,  LREOND LAURENCE ,  LAVIELLE GILBERT

IPC: C07C311/20 ,  A61K31/18 ,  A61K31/404 ,  C07D209/42

CPC classification number: C07D209/42 ,  A61K31/18 ,  A61K31/404 ,  A61K45/06 ,  C07C311/20 ,  A61K2300/00

Abstract: Combination of an anti-atherothrombotic and an angiotensin-converting enzyme inhibitor (ACEI), and also pharmaceutical compositions containing same. Medicaments

Abstract translation: 抗动脉粥样硬化血栓形成和血管紧张素转化酶抑制剂（ACEI）的组合，以及含有其的药物组合物。 药品

公开(公告)号：WO2007144512A3

公开(公告)日：2008-03-20

申请号：PCT/FR2007000989

申请日：2007-06-14

Applicant: SERVIER LAB ,  CORDI ALEXIS ,  HABERKORN LAURE ,  VERBEUREN TONY ,  COURCHAY CHRISTINE ,  SIMONET SERGE

Inventor： CORDI ALEXIS ,  HABERKORN LAURE ,  VERBEUREN TONY ,  COURCHAY CHRISTINE ,  SIMONET SERGE

IPC: C07D257/04 ,  A61K31/41 ,  A61P9/00 ,  A61P9/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14

CPC classification number: C07D257/04 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14

Abstract: The invention relates to compounds of formula (I): in which: R 1 is an alkanoyl group, R 2 is an alkyl group substituted with a group G, or R 1 and R 2 form, together with the nitrogen atom which bears them, an imidazolyl or benzimidazolyl group, substituted with a group G, and G is a -(CH 2 ) n -A-(CH 2 ) m -(CR 4 R 5 ) P -(CH 2 ) O -R 3 group in which n, m, p, o, R 4 , R 5 and A are as defined in the description, and R 3 is a group of formula (II) or formula (III). The invention also relates to the use of said compounds as angiotensin receptor antagonists and as NO donors, in the fields of hypertension and cardiovascular pathologies.

Abstract translation: 本发明涉及式（I）的化合物：其中：R 1是烷酰基，R 2是被基团G取代的烷基， 与它们的氮原子一起形成与基团G取代的咪唑基或苯并咪唑基，并且G是 - （CH 2）n - 2 ）_{名词 -A-（CH 2 ）米 - （CR 4 - [R}

公开(公告)号：WO2009074733A3

公开(公告)日：2009-08-20

申请号：PCT/FR2008001311

申请日：2008-09-19

Applicant: SERVIER LAB ,  DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  GLOANEC PHILIPPE ,  PARMENTIER JEAN-GILLES ,  BENOIST ALAIN ,  VERBEUREN TONY ,  RUPIN ALAIN ,  COURCHAY CHRISTINE ,  SIMONET SERGE

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  GLOANEC PHILIPPE ,  PARMENTIER JEAN-GILLES ,  BENOIST ALAIN ,  VERBEUREN TONY ,  RUPIN ALAIN ,  COURCHAY CHRISTINE ,  SIMONET SERGE

IPC: C07D207/09 ,  A61K31/385 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4245 ,  A61K31/472 ,  C07D209/42 ,  C07D209/52 ,  C07D217/26 ,  C07D233/36 ,  C07D271/08 ,  C07D495/10

CPC classification number: C07D207/09 ,  C07D209/42 ,  C07D209/52 ,  C07D217/26 ,  C07D233/36 ,  C07D271/08 ,  C07D495/10

Abstract: The invention relates to compounds of the formula (I) in which A is an angiotensine-converting enzyme inhibitor including at least one salifiable basic function, B is a compound including at least one acidic sailifiable function and at least one NO-donor group, m is the number of acidic salified functions of B, and n is the number of basic salified functions of A, provided that the bond(s) between A and B are of the ionic type. The invention can be used in drugs.

Abstract translation: 本发明涉及式（I）化合物，其中A是包含至少一种可成碱性功能的血管紧张素转换酶抑制剂，B是包含至少一个酸性可释放功能的化合物和至少一个NO供体基团，m 是B的酸性盐化函数的数量，n是A的碱性盐化函数的数量，条件是A和B之间的键是离子型。 本发明可用于药物。

公开(公告)号：WO2009004164A9

公开(公告)日：2010-03-18

申请号：PCT/FR2008000731

申请日：2008-05-29

Applicant: SERVIER LAB ,  CORDI ALEXIS ,  HABERKORN LAURE ,  VERBEUREN TONY ,  COURCHAY CHRISTINE ,  SIMONET SERGE

Inventor： CORDI ALEXIS ,  HABERKORN LAURE ,  VERBEUREN TONY ,  COURCHAY CHRISTINE ,  SIMONET SERGE

IPC: C07D403/04 ,  A61K31/4184

CPC classification number: C07D403/04

Abstract: The invention relates to compounds of the general formula (I) G-(CH2)n-A-(CH2)m-(CR1R2)p-(CH2)o-R3 in which: n is 0, 1, 2 or 3; m is 0, 1, 2 or 3; p is 1 or 0; o is 0, 1 or 2; R1 and R2 each represent a hydrogen atom or an alkyl group; one of the groups -CH2- or -CR1R2- can also be replaced with a phenylene, -PhC(O)- or -PhC(O)O- group; A and G are such as defined in the description; and R3 is a group (II) or (III). The invention can be used for drugs.

Abstract translation: 本发明涉及通式（I）G-（CH2）n -A-（CH2）m-（CR1R2）对 - （CH2）o-R3的化合物，其中：n为0,1,2或3; m为0,1,2或3; p为1或0; o为0,1或2; R1和R2各自表示氢原子或烷基; -CH 2 - 或-CR 1 R 2基团之一也可以被亚苯基-PhC（O） - 或-PhC（O）O-基团取代; A和G如描述中所定义; 并且R 3是（II）或（III）基团。 本发明可用于药物。

公开(公告)号：WO2009004164A3

公开(公告)日：2009-04-30

申请号：PCT/FR2008000731

申请日：2008-05-29

Applicant: SERVIER LAB ,  CORDI ALEXIS ,  HABERKORN LAURE ,  VERBEUREN TONY ,  COURCHAY CHRISTINE ,  SIMONET SERGE

Inventor： CORDI ALEXIS ,  HABERKORN LAURE ,  VERBEUREN TONY ,  COURCHAY CHRISTINE ,  SIMONET SERGE

IPC: C07D403/04 ,  A61K31/4184

CPC classification number: C07D403/04

Abstract: The invention relates to compounds of the general formula (I) G-(CH2)n-A-(CH2)m-(CR1R2)p-(CH2)o-R3 in which: n is 0, 1, 2 or 3; m is 0, 1, 2 or 3; p is 1 or 0; o is 0, 1 or 2; R1 and R2 each represent a hydrogen atom or an alkyl group; one of the groups -CH2- or -CR1R2- can also be replaced with a phenylene, -PhC(O)- or -PhC(O)O- group; A and G are such as defined in the description; and R3 is a group (II) or (III). The invention can be used for drugs.

Abstract translation: 本发明涉及通式（I）G-（CH2）n -A-（CH2）m-（CR1R2）对 - （CH2）o-R3的化合物，其中：n为0,1,2或3; m为0,1,2或3; p为1或0; o为0,1或2; R1和R2各自表示氢原子或烷基; -CH 2 - 或-CR 1 R 2基团之一也可以被亚苯基-PhC（O） - 或-PhC（O）O-基团取代; A和G如描述中所定义; 并且R 3是（II）或（III）基团。 本发明可用于药物。

公开(公告)号：BRPI0822066A2

公开(公告)日：2015-09-22

申请号：BRPI0822066

申请日：2008-12-10

Applicant: SERVIER LAB

Inventor： CORDI ALEXIS ,  COURCHAY CHRISTINE ,  HABERKORN LAURE ,  SIMONET SERGE ,  VERBEUREN TONY

IPC: C07D209/08 ,  A61K31/404

公开(公告)号：AU2009201068B2

公开(公告)日：2012-11-22

申请号：AU2009201068

申请日：2009-03-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61P7/02 ,  A61P9/10 ,  C07D407/02 ,  C07D407/12 ,  C07D407/14

Abstract: NEW DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Abstract The invention relates to compounds of formula (1): HC OR3 0 CH 2 wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): 0 (A) The invention also relates to pharmaceutical compositions comprising a compound of 10 formula (1) and methods of treatment comprising administering compounds of formula (1) or a pharmaceutical composition thereof.

公开(公告)号：CY1107157T1

公开(公告)日：2012-10-24

申请号：CY081100096

申请日：2008-01-28

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  GLOANEC PHILLIPPE ,  PARMENTIER JEAN GILLES ,  BENOIST ALAIN ,  RUPIN ALAIN ,  VALLEZ MARIE-ODILE ,  VERBEUREN TONY

IPC: C07D487/04 ,  A61K31/498 ,  A61K31/519 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00

Abstract: Ένωσητουτύπου (Ι):