公开(公告)号：JP2002226479A

公开(公告)日：2002-08-14

申请号：JP2001384280

申请日：2001-12-18

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON

IPC: C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04

Abstract: PROBLEM TO BE SOLVED: To provide a novel metalloprotease inhibitor that is useful for treating rheumatoid arthritis and the like, a method of producing the same and medicinal composition containing the same. SOLUTION: This invention relates to a novel compound represented by formula (I) [wherein R1 is H or the like; X is O or the like; A represents the compound represented by formula A (wherein Ra is H or the like) or the like], an isomer thereof, an N-oxide thereof and a pharmaceutically acceptable adduct salt.

公开(公告)号：JP2002265448A

公开(公告)日：2002-09-18

申请号：JP2002009645

申请日：2002-01-18

Applicant: SERVIER LAB

Inventor： CASARA PATRICK ,  LE DIGUARHER THIERRY ,  DOREY GILBERT ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON ,  GUILBAUD NICOLAS

IPC: C07C317/00 ,  A61K31/4164 ,  A61K31/417 ,  A61K31/4178 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/454 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P35/00 ,  C07D213/36 ,  C07D213/38 ,  C07D213/57 ,  C07D233/54 ,  C07D233/58 ,  C07D233/61 ,  C07D233/64 ,  C07D401/06

Abstract: PROBLEM TO BE SOLVED: To provide a compound having a specific structure, selectively inhibiting FTase with respect to GGTase and useful for the treatment of diseases relating to the intracellular signal transduction through Ras protein, etc., and the investigation of pathology relating to angiogenetic amplification. SOLUTION: The objective compound is expressed by formula (I) [X is a bond, an alkylene, S(O)n or the like; Y is an aryl, a heteroaryl or the like; R1 to R4 are each independently H, an aryl or the like or together form a bond, a condensed benzene ring or the like; T is CH(R5 ) (R5 is H or the like) or the like; V is H, a substituted aryl or the like; A2 is [C(R6 ) (R'6 )] (R6 and R'6 are each H or the like; and (p) is 0-4); and R7 and R8 are each H or the like]. The invention further relates to its isomer, diastereomer, pharmacologically permissible acid or base and its addition salt.

公开(公告)号：WO2007017585A3

公开(公告)日：2007-04-12

申请号：PCT/FR2006001901

申请日：2006-08-04

Applicant: SERVIER LAB ,  LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE

IPC: C07D491/22 ,  A61K31/4745 ,  A61P35/00 ,  C07D471/14

CPC classification number: C07D471/14

Abstract: Compounds of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 80 , R 90 , R 81 , R 91 , AIk and G are such as defined in the description, can be used for drugs.

Abstract translation: 式（I）化合物，其中R 1，R 2，R 3，R 4，R 4， 80以下，R 80，R 90，R 81，R 91，Alk和 G在描述中定义，可用于药物。

公开(公告)号：WO02057223A3

公开(公告)日：2002-11-28

申请号：PCT/FR0200147

申请日：2002-01-16

Applicant: SERVIER LAB ,  CASARA PATRICK ,  LE DIGUARHER THIERRY ,  DOREY GILBERT ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON ,  GUILBAUD NICOLAS ,  ORTUNO JEAN-CLAUDE ,  FAUCHERE JEAN-LUC

Inventor： CASARA PATRICK ,  LE DIGUARHER THIERRY ,  DOREY GILBERT ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON ,  GUILBAUD NICOLAS ,  ORTUNO JEAN-CLAUDE ,  FAUCHERE JEAN-LUC

IPC: A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  A61K31/415 ,  C07D401/12

CPC classification number: C07D401/14 ,  C07D403/12 ,  C07D413/12

Abstract: A compound having formula (I), wherein X denotes an alkylene group or chain, CO, S(O)n, -S(O)n-A1-, -CO-A1-, -A1-S(O)n-A'1, or A1-CO-A'1-; Y denotes a substituted or non-substituted aryl, heteroaryl, cycloalkyl or heterocyclalkyl group; W denotes a CO or CH2 group; T denotes a N(R1)- or N(R1)CO- group; V denotes a hydrogen atom or a substituted or non-substituted aryl or heteroaryl group; A2 denotes a [C(R2)(R'2)]p group; R1 and R2 are as defined in the description. Medicaments.

Abstract translation: 具有式（I）的化合物，其中X表示亚烷基或链，CO，S（O）n，-S（O）n -A1，-CO-A1-，-A1-S（O） A'1或A1-CO-A'1-; Y表示取代或未取代的芳基，杂芳基，环烷基或杂环烷基; W表示CO或CH 2基团; T表示N（R1） - 或N（R1）CO-基团; V表示氢原子或取代或未取代的芳基或杂芳基; A2表示[C（R2）（R'2）] p基团; R1和R2如说明书中所定义。 药物。

公开(公告)号：WO02094840A2

公开(公告)日：2002-11-28

申请号：PCT/FR0201716

申请日：2002-05-22

Applicant: SERVIER LAB ,  HUSSON HENRI-PHILIPPE ,  GIORGI-RENAULT SYLVIANE ,  DESBENE STEPHANIE ,  HICKMAN JOHN ,  PIERRE ALAIN ,  KRAUS-BERTHIER LAURENCE ,  PFEIFFER BRUNO ,  RENARD PIERRE

Inventor： HUSSON HENRI-PHILIPPE ,  GIORGI-RENAULT SYLVIANE ,  DESBENE STEPHANIE ,  HICKMAN JOHN ,  PIERRE ALAIN ,  KRAUS-BERTHIER LAURENCE ,  PFEIFFER BRUNO ,  RENARD PIERRE

IPC: A61K31/4741 ,  A61K31/4743 ,  A61K31/4745 ,  A61K31/661 ,  A61P35/00 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07D497/04 ,  C07F9/60 ,  C07F9/6561

CPC classification number: C07D491/04 ,  C07D491/14 ,  C07F9/6561

Abstract: The invention concerns a compound of formula (I), wherein: (a) represents a single or double bond; (b) represents a cycle selected among (i), (ii), (iii), (iv) and (v); R9a, R9b, R9c, X and Y are such as defined in the description; R1 represents a group selected among hydrogen, aryl, heteroaryl, cycloalkyl, alkyl optionally substituted, and COR11, wherein R11 is such as defined in the description; R2 to R8 represent each a group selected among hydrogen, halogen, hydroxy, polyhalogenoalkyl, nitro, alkyl optionally substituted, amino optionally substituted, alkoxy optionally substituted, -OPO(OH)2 and (II), wherein m represents an integer such that 1

Abstract translation: 本发明涉及式（I）化合物，其中：（a）表示单键或双键; （b）表示选自（i），（ii），（iii），（iv）和（v）中的循环; R9a，R9b，R9c，X和Y如描述中所定义; R 1表示选自氢，芳基，杂芳基，环烷基，任选取代的烷基和COR 11中的基团，其中R 11如说明书中所定义; R 2至R 8表示选自氢，卤素，羟基，多卤代烷基，硝基，任选取代的烷基，任选取代的氨基，任选取代的烷氧基，-OPO（OH）2和（II）中的基团，其中m表示1 R 3或具有R 4的R 3或具有R 5的R 4一起与含有任选含有1或2个杂原子并任选取代的单环或双环基团的碳原子一起形成; R 16表示氢原子或烷基; （c）表示芳基，杂芳基或芳基烷基; 以及其光学异构体，其与药学上可接受的酸或碱的加成盐以及其水合物和溶剂合物。 本发明可用于制备药物。

公开(公告)号：CY1113914T1

公开(公告)日：2016-07-27

申请号：CY131100282

申请日：2013-04-04

Applicant: SERVIER LAB

Inventor： ORTUNO JEAN-CLAUDE ,  CORDI ALEXIS ,  LACOSTE JEAN-MICHEL ,  FEJES IMRE ,  BURBRIDGE MICHAEL ,  HICKMAN JOHN ,  PIERRE ALAIN

IPC: C07D401/12 ,  A61K31/404 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14

Abstract: Ενώσειςτουτύπου (I):

公开(公告)号：AU2010203305B2

公开(公告)日：2015-02-05

申请号：AU2010203305

申请日：2010-07-23

Applicant: SERVIER LAB

Inventor： ORTUNO JEAN-CLAUDE ,  CORDI ALEXIS ,  LACOSTE JEAN-MICHEL ,  FEJES IMRE ,  BURBRIDGE MICHAEL ,  HICKMAN JOHN ,  PIERRE ALAIN

IPC: C07D417/14 ,  A61K31/4045 ,  A61P35/00 ,  C07D403/14 ,  C07D413/14

Abstract: Compounds of formula (I): X R4 N RS I ( ) wherein: * m and n represent 1 or 2, * A represents a pyrrolyl group, * X represents a C(O), S(O) or SO 2 group, + R and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group, + R3 and R4, together with the atoms carrying them, form a heterocyclic group, + R5 represents a hydrogen atom or an alkyl group, + R represents a hydrogen atom or a halogen atom. The compounds are used in pharmaceutical compositions and in the preparation of medicaments for use in the treatment of cancer.

公开(公告)号：ME01491B

公开(公告)日：2014-04-20

申请号：MEP3313

申请日：2010-08-03

Applicant: SERVIER LAB

Inventor： ORTUNO JEAN-CLAUDE ,  LACOSTE JEAN-MICHEL ,  FEJES IMRE ,  BURBRIDGE MICHAEL ,  HICKMAN JOHN ,  PIERRE ALAIN ,  CORDI ALEXIS

IPC: A61K31/404 ,  A61P35/00 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14

公开(公告)号：UA95254C2

公开(公告)日：2011-07-25

申请号：UAA200802669

申请日：2006-08-04

Applicant: SERVIER LAB

Inventor： LAVIELLE GILBERT ,  HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE

IPC: C07D491/22 ,  A61K31/4745 ,  C07D471/14

公开(公告)号：GEP20115229B

公开(公告)日：2011-06-10

申请号：GEAP2006010545

申请日：2006-08-04

Applicant: SERVIER LAB

Inventor： HAUTEFAYE PATRICK ,  PIERRE ALAIN ,  HICKMAN JOHN ,  LEONCE STEPHANE ,  LAVIELLE GILBERT

IPC: C07D491/22 ,  A61K31/4745 ,  C07D471/14

Abstract: Compounds of formula (I), wherein R1, R2, R3, R4, R5, R80, R81, R90, R91, Alk, Alk1, X, X1 and G are such as defined in the description, method for its production, pharmaceutical compositions on its base and use thereof for preparation of medicaments for treating cancer.