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    NEW ANTICOAGULANTS
    51.
    发明申请
    NEW ANTICOAGULANTS 审中-公开
    新抗体

    公开(公告)号：WO1997001568A1

    公开(公告)日：1997-01-16

    申请号：PCT/SE1996000859

    申请日：1996-06-28

    Applicant: PHARMACIA & UPJOHN AB ,  WASHINGTON UNIVERSITY ,  SVAHN, Carl, Magnus ,  WAKSMAN, Gabriel ,  NILSSON, Marianne ,  WESTMAN, Jacob

    Inventor： PHARMACIA & UPJOHN AB ,  WASHINGTON UNIVERSITY

    IPC: C07H03/06

    CPC classification number: C07H3/06

    Abstract: The present invention relates to prevention and treatment of thromboembolic diseases by administration of a therapeutically effective dose of an active trisaccharide comprising an iduronic acid, a glucopyranosyl or glucopyranosylamine unit and a hexuronic acid selected from iduronic acid and glucuronic acid. The specific trisaccharides of the present invention have potent activity towards thrombin and also potentiate the inhibition of FXa, even if the trisaccharides lack sulfate groups. With the present invention, safe and potent anticoagulants with a potentially high oral absorption are achievable, due to the much smaller molecular size and presence of very few, if any, sulfate groups compared to presently available anticoagulants.

    Abstract translation: 本发明涉及通过施用治疗有效剂量的包含艾杜糖醛酸，吡喃葡萄糖基或吡喃葡萄糖胺单元的活性三糖和选自艾杜糖醛酸和葡萄糖醛酸的己糖醛酸的预防和治疗血栓栓塞性疾病。 本发明的具体三糖对凝血酶具有有效的活性，并且即使三糖缺乏硫酸盐基，也增强了FXa的抑制。 利用本发明，与目前可获得的抗凝剂相比，由于与现有抗凝剂相比，分子大小和非常少的（如果有的话）硫酸盐基团的存在，可以实现具有潜在的高口服吸收的安全有效的抗凝剂。

    USE OF ZAPRINAST FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF ACUTE RENAL FAILURE
    53.
    发明申请
    USE OF ZAPRINAST FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF ACUTE RENAL FAILURE 审中-公开
    用于治疗急性肾衰竭药物制剂的ZAPRINAST的应用

    公开(公告)号：WO1996005835A1

    公开(公告)日：1996-02-29

    申请号：PCT/US1995010148

    申请日：1995-08-21

    Applicant: WASHINGTON UNIVERSITY ,  GREENWALD, James, E.

    Inventor： WASHINGTON UNIVERSITY

    IPC: A61K31/505

    CPC classification number: A61K31/519

    Abstract: A method is disclosed for treatment of acute renal failure which comprises administering to a warm-blooded mammal manifesting acute renal failure a small but effective amount of zaprinast sufficient to effect acceleration of recovery from said acute renal failure.

    Abstract translation: 公开了用于治疗急性肾衰竭的方法，其包括对表现急性肾功能衰竭的温血哺乳动物施用足以有效加速从所述急性肾衰竭恢复的小但有效量的zaprinast。

    INDICATOR CELL LINE FOR DETECTING RNA VIRUSES AND METHOD THEREFOR
    54.
    发明申请
    INDICATOR CELL LINE FOR DETECTING RNA VIRUSES AND METHOD THEREFOR 审中-公开
    用于检测RNA病毒的指示剂细胞系及其方法

    公开(公告)号：WO1995017525A1

    公开(公告)日：1995-06-29

    申请号：PCT/US1994014332

    申请日：1994-12-20

    Applicant: WASHINGTON UNIVERSITY

    Inventor： WASHINGTON UNIVERSITY ,  OLIVO, Paul, D. ,  SCHLESINGER, Sondra

    IPC: C12Q01/70

    CPC classification number: C07K14/005 ,  C12N2760/18822 ,  C12Q1/6897 ,  G01N33/56983 ,  G01N2333/085 ,  G01N2333/18 ,  Y10S435/975

    Abstract: Cell lines and methods are disclosed for detecting the presence of RNA viruses in a specimen. The cell lines are stably transformed with a DNA molecule that includes a promoter capable of being recognized by the DNA dependent RNA polymerase of the cell capable of directing the transcription of a cDNA of a structurally defective RNA virus genome operably coupled to the promoter. The cDNA contains a structural coding sequence encoding a selected reporter gene product. The RNA molecules transcribed by the DNA dependent RNA polymerase are not capable of causing the translation of the reporter gene in the cell except when an active related virus that provides the necessary trans-acting enzymes to cause the increased replication of the RNA containing the reporter gene which is then translated into the reporter gene product is provided. Methods utilizing the cell lines of this invention to detect RNA viruses in a specimen by incubating the specimen with the cell line and assaying for expression of the reporter gene and a kit containing a supply of the cells and a supply of the reagents necessary for the detection of the reporter gene product are also provided.

    Abstract translation: 公开了用于检测样品中RNA病毒的存在的细胞系和方法。 细胞系被包括能够被能够引导结构有缺陷的RNA病毒基因的cDNA的转录的细胞的DNA依赖性RNA聚合酶识别的启动子的DNA分子稳定转化，所述基因可操作地连接到启动子上。 cDNA含有编码所选报道基因产物的结构编码序列。 由DNA依赖性RNA聚合酶转录的RNA分子不能引起报告基因在细胞中的翻译，除了当提供必需的反式作用酶以引起含有报告基因的RNA的复制增加的活性相关病毒时 然后将其翻译成报告基因产物。 利用本发明的细胞系的方法通过将样品与细胞系一起孵育并测定报告基因的表达和含有细胞供应的试剂盒和检测所必需的试剂的供应来检测标本中的RNA病毒 的报告基因产物也被提供。

    MODIFIED TRUNCATED COMPLEMENT SYSTEM REGULATORS
    55.
    发明申请
    MODIFIED TRUNCATED COMPLEMENT SYSTEM REGULATORS 审中-公开
    改装的截止系统调节器

    公开(公告)号：WO1995008343A1

    公开(公告)日：1995-03-30

    申请号：PCT/US1994010820

    申请日：1994-09-23

    Applicant: WASHINGTON UNIVERSITY

    Inventor： WASHINGTON UNIVERSITY ,  ATKINSON, John, P. ,  HOURCADE, Dennis ,  KRYCH, Malgorzata

    IPC: A61K38/17

    CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K2319/00

    Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which affect the complement inhibitory activities of these proteins, substituting, rearranging or adding SCRs or SCR regions to the proteins, deleting amino acid sequences, and combinations thereof.

    Abstract translation: 描述了具有改变靶C3b和/或C4b的特异性和亲和力的补体激活（RCA）蛋白质的调节剂的类似物。 这些类似物是通过取代影响这些蛋白质的补体抑制活性的氨基酸，取代，重排或添加蛋白质的SCR或SCR区域，缺失氨基酸序列及其组合而获得的。

    INTEGRATED LOW COMPLEXITY BROADBAND MULTI-CHANNEL SWITCH
    57.
    发明申请
    INTEGRATED LOW COMPLEXITY BROADBAND MULTI-CHANNEL SWITCH 审中-公开
    集成低复杂度宽带多通道开关

    公开(公告)号：WO1994024795A1

    公开(公告)日：1994-10-27

    申请号：PCT/US1994004487

    申请日：1994-04-22

    Applicant: WASHINGTON UNIVERSITY

    Inventor： WASHINGTON UNIVERSITY ,  MIN, Paul, Seungkyu ,  SAIDI, Hossein

    IPC: H04L12/56

    CPC classification number: H04L12/5601 ,  H04L49/106 ,  H04L49/1553 ,  H04L49/203 ,  H04L2012/5681 ,  H04Q11/0478

    Abstract: A multi-channel, multi-casting switch (20) for an ATM network utilizes a particular nonblocking condition of the Flip Network (28), which is exploited to realize a multi-channel switching architecture that supports an arbitrary number of channel groups. Using a single Flip Network (28) recursively, the resulting architecture becomes efficent in the sense that the crosspoint complexity is 0(N log2N) for N inputs. The number of times the Flip Network (28) is used recursively is a function of the number of channel groups only. The architecture is internally nonblocking and bufferless. In multi-channel switching, cells belonging to a single session can traverse over multiple channels and the architecture maintains cells in order by assigning a specific Gray code to each data cell in each group.

    Abstract translation: 用于ATM网络的多信道多播交换机（20）利用翻转网络（28）的特定非阻塞状态，其被利用来实现支持任意数量的信道组的多信道交换架构。 在递归地使用单个翻转网络（28）的情况下，由于N个输入的交叉点复杂度为0（N log2N），所以得到的架构变得有效。 翻转网络（28）递归使用的次数是仅通道组数量的函数。 该架构在内部非阻塞和无缓冲。 在多通道切换中，属于单个会话的单元可以遍历多个通道，并且架构通过为每个组中的每个数据单元分配特定的格雷码来依次维护单元。

    MAGNETIC RECORDING HEAD WITH CONTINUOUSLY MONITORED TRACK FOLLOWING SERVO
    58.
    发明申请
    MAGNETIC RECORDING HEAD WITH CONTINUOUSLY MONITORED TRACK FOLLOWING SERVO 审中-公开
    带有连续监视轨迹的磁记录头

    公开(公告)号：WO1994024669A1

    公开(公告)日：1994-10-27

    申请号：PCT/US1994003721

    申请日：1994-04-05

    Applicant: WASHINGTON UNIVERSITY

    Inventor： WASHINGTON UNIVERSITY ,  INDECK, Ronald, Scott ,  MULLER, Marcel, Wettstein ,  MIAN, Guo

    IPC: G11B21/02

    CPC classification number: G11B21/106 ,  G06F21/10 ,  G06F21/79 ,  G06F2211/007 ,  G06F2221/0744 ,  G06K1/125 ,  G06K7/015 ,  G06K19/12 ,  G07D7/04 ,  G07F7/08 ,  G07F7/086 ,  G11B5/59611 ,  G11B5/59633 ,  G11B20/00086 ,  G11B20/00094 ,  G11B20/00123 ,  G11B23/28

    Abstract: A head assembly and method for maintaining the head assembly on a data encoded track of a magnetic medium is disclosed. The head assembly includes a main head (22) for reading the encoded data, a left track edge auxiliary head (26/42) and a right track edge auxiliary head (26/44). The outputs of each of the three heads are used to create a differential power frequency spectrum which, in excess of a threshold value, indicates misalignment of the head assembly with respect to the track. The disclosed head assembly and method eliminates the requirement for guard bands between adjacent tracks of a magnetic medium, eliminates the encoded burst at the beginning of a track used in the prior art to align a head prior to its sweeping through a track sector, and thereby reduces the overhead or wasted space in a magnetic recording medium.

    Abstract translation: 公开了用于将磁头组件保持在磁性介质的数据编码轨道上的磁头组件和方法。 头组件包括用于读取编码数据的主头（22），左轨道边缘辅助头（26/42）和右轨道边缘辅助头（26/44）。 三个磁头中的每一个的输出用于产生超过阈值的差动功率频谱，其指示磁头组件相对于磁道的不对准。 所公开的头组件和方法消除了对磁介质的相邻轨道之间的保护带的要求，消除了在现有技术中使用的轨道的开始处的编码突发，以在其扫描通过轨道扇区之前使头对准，由此 降低磁记录介质中的开销或浪费的空间。

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