公开(公告)号：WO1995028878A1

公开(公告)日：1995-11-02

申请号：PCT/US1995004824

申请日：1995-04-24

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  LORD, Peter, C. ,  COLMAN, Fredric, C.

IPC: A61B05/05

CPC classification number: A61B5/6865 ,  A61B5/0002 ,  A61B5/14532 ,  A61M5/1723 ,  G06F19/00

Abstract: An infusion pump system (10) includes a removable in vivo glucose sensor (16) for monitoring glucose concentration level in a patient (12), and for signaling an infusion pump to deliver a selected medication such as insulin to a patient. The glucose sensor (16) comprises a sensor cable (30) for placement through a catheter to position a distal sensor tip (20) at a selected in vivo sensor site. A proximal end of the sensor cable seats within a connector fitting (18) mounted on the catheter (24) at a convenient and accessible subcutaneous position. The connector fitting (18) couples the sensor cable (30) to an implanted control unit (26) which signals the infusion pump (14) to deliver the patient (12) medication. In a preferred system, the infusion pump (14) is also implanted and receives control signals via a direct or telemetric connection. The sensor cable (30) is easily accessed at the connector fitting (18) for periodic sensor removal and replacement, without requiring removal or replacement of other system components.

Abstract translation: 输液泵系统（10）包括用于监测患者（12）中的葡萄糖浓度水平的可移除的体内葡萄糖传感器（16），并且用于发信号通知输液泵将选定的药物例如胰岛素递送给患者。 葡萄糖传感器（16）包括传感器电缆（30），用于通过导管放置以在选定的体内传感器位置定位远端传感器尖端（20）。 传感器电缆的近端位于安装在导管（24）上的方便和可接近的皮下位置的连接器配件（18）内。 连接器配件（18）将传感器电缆（30）耦合到植入的控制单元（26），其传送输液泵（14）以输送患者（12）药物。 在优选的系统中，输注泵（14）也被植入并通过直接或遥测连接接收控制信号。 在连接器配件（18）处容易地访问传感器电缆（30），用于周期性的传感器移除和更换，而不需要拆卸或更换其他系统部件。

公开(公告)号：WO1994003107A1

公开(公告)日：1994-02-17

申请号：PCT/US1993006888

申请日：1993-07-26

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BRIGGS, Richard, W. ,  LIEBIG, Thomas ,  ROS, Pablo ,  BALLINGER, J., Ray

IPC: A61B05/05

CPC classification number: G01R33/5601 ,  A61K49/1806

Abstract: A contrast agent useful for imaging a sample comprising a suspension in a medium acceptable for imaging (a) particles of a contrast agent possessing paramagnetic characteristics and (b) particles of a contrast agent possessing diamagnetic characteristics. Also disclosed is a method of imaging a sample which comprises introducing into the sample the above-described contrast agent and generating a substantially artifact-free image thereof. The combination of diamagnetic barium sulfate and superparamagnetic iron oxide (SPIO) in one suspension produces a macroscopic cancellation of positive and negative magnetic susceptibility components which eliminates susceptibility artifacts even with gradient echo pulse sequences. The relaxation properties which make the SPIO suspension a useful negative contrast agent are retained.

Abstract translation: 用于成像包含在可接受的培养基中的悬浮液的样品的造影剂（a）具有顺磁特性的造影剂颗粒和（b）具有抗磁特性的造影剂颗粒。 还公开了一种对样品成像的方法，其包括向样品中引入上述造影剂并产生其基本上无伪影的图像。 一个悬浮液中的抗磁性硫酸钡和超顺磁性氧化铁（SPIO）的组合产生了正和负磁化率成分的宏观消除，即使使用梯度回波脉冲序列也消除了敏感性伪影。 使SPIO悬浮液成为有用的负造影剂的松弛性能得以保留。

公开(公告)号：WO1993020751A1

公开(公告)日：1993-10-28

申请号：PCT/US1993003476

申请日：1993-04-14

Applicant: BRIGHAM AND WOMEN'S HOSPITAL

Inventor： BRIGHAM AND WOMEN'S HOSPITAL ,  RAYMOND, Stephen, A. ,  STRICHARTZ, Gary, R. ,  PHILIP, James, H. ,  RAEMER, Daniel, B. ,  VICKERS, Martyn, A., Jr.

IPC: A61B05/05

CPC classification number: A61B5/4893 ,  A61B5/05 ,  A61B5/4041 ,  A61B5/7217 ,  A61B17/3401 ,  A61N1/36021

Abstract: The present invention is directed to a method and apparatus for locating and identifying the function of specific peripheral nerves. In one embodiment, the invention takes the form of a nerve stimulator which is used to locate nerves to assist in the administration of regional anesthesia. In another embodiment, the nerve stimulator is used to locate, identify the function of, and guard against the inadvertent cutting of specific nerves during surgical procedures. The apparatus of the invention includes a stimulus delivery means (22), a response-detecting means (14) and a means for automatically modulating the magnitude of the stimulus (16).

公开(公告)号：WO1993013709A1

公开(公告)日：1993-07-22

申请号：PCT/US1992011247

申请日：1992-12-29

Applicant: INNOVATION ASSOCIATES

Inventor： INNOVATION ASSOCIATES ,  AFROMOWITZ, Martin, A. ,  WOLTHUIS, Roger, A. ,  MITCHELL, Gordon, L.

IPC: A61B05/05

CPC classification number: A61B5/0215

Abstract: A system includes a catheter (10) having a low pressure balloon (42) at one end thereof, a precise, low pressure, low volume fluid infusion means (41) and a pressure sensor (43). The balloon (42) is introduced to a body lumen, such as a blood vessel, and inflated to a pressure at or just above physiologic, typically being below 200 mmHg. From the balloon volume at a particular pressure, the internal cross-sectional area and diameter of the vessel can be calculated. Additional calculations can be made at other pressures below 200 mmHg to determine compliance of the vessel.

公开(公告)号：WO1991019455A1

公开(公告)日：1991-12-26

申请号：PCT/US1991004113

申请日：1991-06-11

Applicant: THE SHIELDING CORPORATION

Inventor： THE SHIELDING CORPORATION ,  MORRIS, Ronald, G. ,  McMILLEN, Charles, E.

IPC: A61B05/05

CPC classification number: H05K9/00 ,  A61B5/055 ,  A61B5/14552 ,  G01R1/18 ,  G01R33/28 ,  G01R33/422

Abstract: A RF shield (10), for use adjacent a portion of a patient's body during a magnetic resonance examination by magnetic resonance examination apparatus, includes an electrically and thermally conductive layer (20) having a pair of opposed surfaces, and a pair of electrically and thermally insulative layers (22 and 24). One of the insulative layers is disposed adjacent one of the opposed surfaces for positioning intermediate the conductive layer and the patient's body portion to insulate the patient's body from the conductive layer, and the other of the insulative layers is disposed adjacent the other of the opposed surfaces for positioning intermediate the conductive layer and the magnetic resonance examination apparatus to insulate the magnetic resonance apparatus from the conductive layer.

公开(公告)号：WO1989009564A1

公开(公告)日：1989-10-19

申请号：PCT/GB1989000363

申请日：1989-04-10

Applicant: THE UNIVERSITY OF SHEFFIELD ,  BROWN, Brian, Hilton ,  BARBER, David, Charles

Inventor： THE UNIVERSITY OF SHEFFIELD

IPC: A61B05/05

CPC classification number: A61B5/0536

Abstract: A method of determining the external shape of a body comprises placing a plurality of electrodes adjacent the surface at spaced intervals round the body, causing currents to flow in the body by applying an electrical potential between pairs of electrodes in turn, measuring potentials between other pairs of electrodes, relating the measured potentials to the distances between the corresponding points of current introduction and of potential measurement, and determining electrode positions consistent with these distances, which electrode positions define the external shape of the body.

公开(公告)号：WO1989004632A1

公开(公告)日：1989-06-01

申请号：PCT/US1988003978

申请日：1988-11-08

Applicant: FLORIDA INTERNATIONAL UNIVERSITY

Inventor： FLORIDA INTERNATIONAL UNIVERSITY ,  HAGMANN, Mark, J. ,  BABIJ, Tadeusz, M.

IPC: A61B05/05

CPC classification number: A61B5/05

Abstract: A detector (14, 15, 22, 60 or 90) for detecting high frequency current (I) includes a high resistivity coil (26) wound around a nonferromagnetic core (34). The ratio of the coil (26) spacing to the cross sectional area of the coil (26) is maintained constant over the length of the coil (26). A high resistivity material shield (36) surrounds and is spaced from the coil (26) and has a gap (38) oriented along an azimuth of the closed loop winding and directed orthogonal to the net current direction of the current induced in the coil (26). The ends of the coil (26) are coupled to a high impedance voltage detector (24) through high resistivity leads (46 and 48) and a resistor (52) is coupled between the leads (46 and 48) to reduce the quality factor. The current detector (14, 15, 22, 60 or 90) may be used to detect current (I) flowing in a human body (10) due to the absorption of high frequency incident radiation as an indication of the specific absorption rate of such radiation.

Abstract translation: 用于检测高频电流（I）的检测器（14,15,22,60或90）包括缠绕在非铁磁芯（34）上的高电阻线圈（26）。 线圈（26）间隔与线圈（26）的横截面积的比率在线圈（26）的长度上保持恒定。 高电阻率材料屏蔽（36）围绕并与线圈（26）隔开并且具有沿着闭环绕组的方位取向的间隙（38），并且与线圈中感应的电流的净电流方向垂直 26）。 线圈（26）的端部通过高电阻率引线（46和48）耦合到高阻抗电压检测器（24），并且电阻器（52）耦合在引线（46和48）之间以降低品质因数。 电流检测器（14,15,22,60或90）可用于检测由于高频入射辐射的吸收而引起的人体（10）中流动的电流（I），作为此类吸收速率的指示 辐射。

公开(公告)号：WO1997024984A1

公开(公告)日：1997-07-17

申请号：PCT/IL1997000001

申请日：1997-01-01

Applicant: N.I. MEDICAL LTD. ,  TSOGLIN, Alexander ,  FRINERMAN, Efim

Inventor： N.I. MEDICAL LTD.

IPC: A61B05/05

CPC classification number: A61B5/0535 ,  A61N1/04

Abstract: Electrodes useful for electric measurements from or injecting current to the human body are disclosed, which are flexible disposable electrodes with a surface area in the range of about 18-36 cm . A particular use of such electrodes is in bioimpedance measurement, particularly such performed by utilizing the same electrodes for passage of current and measurement of potential. Also disclosed are processes for bioimpedance measurement making use of such electrodes.

Abstract translation: 公开了用于对人体进行电测量或向人体注入电流的电极，其为表面积在约18-36cm 2范围内的柔性一次性电极。 这种电极的特定用途是在生物阻抗测量中，特别是通过利用相同的电极通过电流和测量电位来进行。 还公开了使用这种电极的生物阻抗测量的方法。

公开(公告)号：WO1996039932A1

公开(公告)日：1996-12-19

申请号：PCT/US1996008858

申请日：1996-05-31

Applicant: UROMED CORPORATION ,  BRIGHAM AND WOMEN'S HOSPITAL

Inventor： UROMED CORPORATION ,  BRIGHAM AND WOMEN'S HOSPITAL ,  RAYMOND, Stephen, A. ,  COATS, David, E.

IPC: A61B05/05

CPC classification number: A61B5/05 ,  A61B5/4893 ,  A61N1/05 ,  A61N1/08 ,  A61N1/36021 ,  A61N1/36071

Abstract: An apparatus (10) and its method of operation for stimulating andlocating a nerve includes a probe (12) having a plurality of electrodes for applying a stimulus from stimulator (14) and receiving tissue response thereto and a controller (16) for the stimulator (14) and the response detecting means (18). An audible tone module (20) provides a further indication of tissue response to the stimulus from stimulator (14).

Abstract translation: 用于刺激和定位神经的装置（10）及其操作方法包括具有多个电极的探针（12），用于施加来自刺激器（14）的刺激并接收组织响应，以及用于刺激器的控制器（16） 14）和响应检测装置（18）。 可听音模块（20）提供对来自刺激器（14）的刺激的组织响应的进一步指示。

公开(公告)号：WO1996039076A1

公开(公告)日：1996-12-12

申请号：PCT/US1996008876

申请日：1996-06-05

Applicant: VANDERBILT UNIVERSITY

Inventor： VANDERBILT UNIVERSITY ,  RICHARDS, William, O. ,  WIKSWO, John, P., Jr. ,  STATTON, Daniel, J. ,  GOLZARIAN, Javad ,  BRADSHAW, Leonard, A.

IPC: A61B05/05

CPC classification number: A61B5/42 ,  A61B5/04005 ,  A61B5/4255

Abstract: Intestinal ischemia is diagnosed non-invasively by scanning the abdomen (7) externally with a SQUID magnetometer (9) which measures the magnetic field (5) produced by smooth muscle electrical activity. These measurements are processed to determine the basic electrical rhythm (BER) frequency at various locations (43) along the intestine (1). A nominal value for the BER frequency is established at each location (43), and if the measured value falls below the associated nominal value by more than a predetermined margin, ischemia at that location is indicated. Ischemia is further indicated by an internal of arrhythmia in which the BER frequency increases to a range of about 24-180 cpm or at least about twice the nominal value. The BER frequency values are presented on a graphic display (39) which provides an indication of the nominal value at an affected location (43) from the gradient of the measured values at adjacent normal locations. Also, a gradual reduction in the local BER frequency at a particular location is an indication of progressive ischemia, while an absence of BER activity in a section of intestine (1) indicates necrosis.

Abstract translation: 通过用测量由平滑肌电活动产生的磁场（5）的SQUID磁力计（9）向外部扫描腹部（7），非侵入性地诊断肠缺血。 处理这些测量以确定沿着肠（1）的各个位置（43）处的基本电节律（BER）频率。 在每个位置（43）建立BER频率的标称值，如果测量值低于相关联的标称值超过预定的余量，则指示该位置处的缺血。 心律失常的内部进一步表示缺血，其中BER频率增加到约24-180cpm或至少约两倍标称值的范围。 BER频率值呈现在图形显示器（39）上，该图形显示器（39）根据相邻正常位置处的测量值的梯度提供受影响位置（43）处的标称值的指示。 此外，特定位置处的局部BER频率的逐渐降低是进行性缺血的指征，而在肠段（1）中没有BER活性指示坏死。