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    SPECTRAL BIO-IMAGING DATA FOR CELL CLASSIFICATION USING INTERNAL REFERENCE
    62.
    发明专利
    SPECTRAL BIO-IMAGING DATA FOR CELL CLASSIFICATION USING INTERNAL REFERENCE 未知

    公开(公告)号：IL141902D0

    公开(公告)日：2002-03-10

    申请号：IL14190299

    申请日：1999-09-10

    Applicant: APPLIED SPECTRAL IMAGING LTD

    IPC: C12Q1/68 ,  G01B11/06 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01J5/10 ,  G01N1/30 ,  G01N15/14 ,  G01N21/64 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76 ,  G06K

    Abstract: A method of spectral-morphometric analysis of biological samples, the biological samples including substantially constant components and suspected variable components, the method is effected by following the steps of (a) using a spectral data collection device for collecting spectral data of picture elements of the biological samples; (b) defining a spectral vector associated with picture elements representing a constant component of at least one of the biological samples; (c) using the spectral vector for defining a correcting function being selected such that when operated on spectral vectors associated with picture elements representing other constant components, spectral vectors of the other constant components are modified to substantially resemble the spectral vector; (d) operating the correcting function on spectral vectors associated with at least the variable components for obtaining corrected spectral vectors thereof; and (e) classifying the corrected spectral vectors into classification groups.

    64.
    发明专利
    未知

    公开(公告)号：DE29824467U1

    公开(公告)日：2001-03-29

    申请号：DE29824467

    申请日：1998-08-24

    Applicant: APPLIED SPECTRAL IMAGING LTD

    IPC: G01N21/64 ,  G01N15/14 ,  G01N21/78 ,  G01N33/533 ,  G01N33/566 ,  G01N33/58 ,  G02B21/06 ,  G01J3/28 ,  G01J3/443

    Abstract: Classification of pixels into groups of pixels according to their association with a single fluorophore or a combination of fluorophores, comprises: (a) providing a number of wide-band emission filters; (b) for each of the pixels, recording emitted light intensity as retrieved after passing through each one of the emission filters, such that each of the pixels is representable by a vector of a number of dimensions equal to the number of wide-band emission filters; and (c) using an algorithm for evaluating the presence of each of the fluorophores associated with each of the pixels, thus classifying each of the pixels into a group of pixels according to its association with the fluorophores. Each fluorophore has a characterising emission spectrum and a specifying emission peak.

    Method of and composite for fluorescent (in situ) hybridization
    68.
    发明专利
    Method of and composite for fluorescent (in situ) hybridization 未知

    公开(公告)号：AU5123599A

    公开(公告)日：2000-02-21

    申请号：AU5123599

    申请日：1999-07-23

    Applicant: APPLIED SPECTRAL IMAGING LTD

    Inventor： BAR-AM IRIT ,  JANISH CATHY ,  GARINI YUVAL ,  CABIB DARIO ,  BUCKWALD ROBERT A

    IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6841 ,  G01N33/533 ,  G01N33/566 ,  C07H21/04

    Abstract: A fluorescent in situ hybridization method including the steps of (a) obtaining a chromosome spread of a species; (b) preparing a hybridization composite containing a plurality of chromosomal paints each of the plurality of chromosomal paints being labeled with a different fluorophore-or-combination-of-fluorophores, such that an averaged specific activity of highly repetitive sequences in the hybridization composite substantially equals an averaged specific activity of unique sequences in the hybridization composite; (c) denaturing the hybridization composite and subjecting the hybridization composite to conditions for allowing at least a part of the highly repetitive sequences in the hybridization composite to reanneal while at least a part of the unique sequences in the hybridization composite remaining single stranded; (d) contacting under hybridization conditions the hybridization composite with the chromosome spread; (e) washing away excess of the hybridization composite; and (d) analyzing and presenting images of the now hybridized chromosome spread.

    Method for chromosomes classification
    70.
    发明专利
    Method for chromosomes classification 未知

    公开(公告)号：AU6774398A

    公开(公告)日：1998-11-13

    申请号：AU6774398

    申请日：1998-03-27

    Applicant: APPLIED SPECTRAL IMAGING LTD

    Inventor： GARINI YUVAL ,  KATZIR NIR ,  WINE DAVID ,  CABIB DARIO

    IPC: G01N33/48 ,  C12M1/00 ,  C12M3/00 ,  C12N15/09 ,  C12N15/11 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N1/28 ,  G01N21/64 ,  G01N21/75 ,  G01N33/483 ,  G01N33/50 ,  G01N33/52 ,  G01N33/569 ,  G01N33/58 ,  G01N37/00 ,  G02B21/00 ,  G02B21/16 ,  G06K9/00 ,  G06K9/76 ,  G02B21/18

    Abstract: A method for finding L internal reference vectors for classification of L chromosomes or portions of chromosomes of a cell, the L chromosomes or portions of chromosomes being painted with K different fluorophores or combinations thereof, wherein K basic chromosomes or portions of chromosomes of the L chromosomes or portions of chromosomes are each painted with only one of the K different fluorophores, whereas the other L-K of the L chromosomes or portions of chromosomes are each painted with a different combination of the K different fluorophores, the method comprising the steps of (a) using a multi-band collection device for measuring a first vector for each pixel of each of the L chromosomes or portions of chromosomes; (b) identifying pixels belonging to each of the K basic chromosomes or portions of chromosomes and defining the pixels as basic pixels, so as to obtain K basic classes of basic pixels; (c) using at least one basic pixel from each of the K basic classes for obtaining K basic vectors, the K basic vectors being K internal reference vectors; (d) using the K basic vectors for identifying pixels belonging to the other L-K chromosomes or portions of chromosomes; and (e) using the pixels belonging to the other L-K chromosomes or portions of chromosomes for calculating the other L-K internal reference vectors, thereby finding all of the L internal reference vectors. A method for classification of L chromosomes or portions of chromosomes of a cell similarly painted using the above method for finding L internal reference vectors, and using the L reference vectors for classification of each of the pixels into one of L classification classes. And, images presenting color chromosomes.

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