公开(公告)号：WO2013106007A1

公开(公告)日：2013-07-18

申请号：PCT/US2012/029587

申请日：2012-03-18

Applicant: PATHWAY GENOMICS ,  BECKER, David ,  PLANTE, James ,  MORENO, Tanya ,  WANG, Cindy

Inventor： BECKER, David ,  PLANTE, James ,  MORENO, Tanya ,  WANG, Cindy

IPC: C12N15/10 ,  B01L3/14 ,  C12M3/08

CPC classification number: B01L3/508 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0006 ,  B01L3/502 ,  B01L3/50825 ,  B01L99/00 ,  B01L2200/185 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/06 ,  B01L2300/0672 ,  C12N15/1006 ,  C12Q1/6806

Abstract: Biological sample collection kits are devised with physical features to enable a high performance collection system which delivers preprocessed biological matter via conventional shipping means to a testing laboratories. In particular, users deposit biological matter such as saliva or blood into a receiving vessel. By sealing the container, the user causes release of a premixed solution containing preservatives and optionally lysis reagents. In addition, a purification agent is arranged to bind to target molecules and facilitate their removal from solution. These time consuming processes occur while the sample is in transit to the testing facility such that when it arrives, it is in a preconditioned state immediately ready for execution of washing steps. Thus, the high performance containers taught herein are useful for collection biological samples and performing initial process steps on received matter - steps which are largely effected during the shipping stage of the transfer process.

Abstract translation: 生物样本收集套件设计有物理特征，以实现高性能收集系统，其通过常规运输方式将预处理的生物物质提供给测试实验室。 特别地，用户将生物物质如唾液或血液沉积到接收容器中。 通过密封容器，使用者引起含有防腐剂和任选裂解试剂的预混溶液的释放。 此外，将净化剂配置成与靶分子结合并促进它们从溶液中的去除。 这些耗时的过程发生在样品转运到测试设备时，使得当其到达时，它处于预处理状态，立即准备好执行洗涤步骤。 因此，本文中教导的高性能容器对于收集生物样品是有用的，并且对接收物质进行初步的处理步骤 - 在转移过程的运输阶段中主要影响的步骤。

公开(公告)号：WO2009075881A2

公开(公告)日：2009-06-18

申请号：PCT/US2008013655

申请日：2008-12-11

Applicant: CODA THERAPEUTICS INC ,  BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

Inventor： BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

IPC: C07K16/18 ,  A61K38/02 ,  C07K2/00

CPC classification number: C07K14/78

Abstract: Methods, compounds, compositions, kits and articles of manufacture comprising one or more gap junction modulating agents for treatment of wounds that do not heal at expected rates, including chronic wounds, delayed healing wounds, incompletely healing wounds, and dehiscent wounds in a subject in need thereof.

Abstract translation: 方法，化合物，组合物，试剂盒和制品，其包含一种或多种间隙连接调节剂，用于治疗以预期速率不愈合的伤口，包括慢性伤口，延迟愈合伤口，不完全愈合的伤口和受试者的开裂伤口 需要。

公开(公告)号：WO2008073479A3

公开(公告)日：2008-08-07

申请号：PCT/US2007025446

申请日：2007-12-11

Applicant: CODA THERAPEUTICS INC ,  BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

Inventor： BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

IPC: A61K31/7105 ,  A61P17/02 ,  C12N15/113

CPC classification number: C12N15/1138 ,  A61K31/7105 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/35

Abstract: Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.

Abstract translation: 用于治疗不按预期速率愈合的伤口的连接蛋白调节剂，包括延迟愈合伤口，不完全愈合的伤口和慢性伤口，以及相关方法，组合物和制品。

公开(公告)号：WO2006134494A3

公开(公告)日：2008-07-03

申请号：PCT/IB2006001961

申请日：2006-02-03

Applicant: CODA THERAPEUTICS LTD ,  GREEN COLIN R ,  BECKER DAVID L

Inventor： GREEN COLIN R ,  BECKER DAVID L

IPC: A61K38/08 ,  A61K31/70 ,  A61K38/10 ,  A61P9/10 ,  A61P17/02 ,  A61P29/00 ,  C12N15/11

CPC classification number: A61K38/177 ,  A61K31/70 ,  A61K38/08 ,  A61K38/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/16 ,  C12N2320/30 ,  Y02P20/582 ,  A61K2300/00

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable.

Abstract translation: 提供了调节连接蛋白活性的方法和组合物，包括例如用于治疗心血管，血管，神经系统，伤口和其他适应症的治疗。 这些化合物和方法可以在治疗上使用，例如降低相关疾病和病症的不良反应的严重性，其中需要直接细胞 - 细胞通信或预防半通道开放的局部破坏。

公开(公告)号：WO2008076903A1

公开(公告)日：2008-06-26

申请号：PCT/US2007/087614

申请日：2007-12-14

Applicant: CATACEL CORP. ,  BECKER, David, A. ,  BARTOS, Randall, J. ,  WHITTENBERGER, William, A.

Inventor： BECKER, David, A. ,  BARTOS, Randall, J. ,  WHITTENBERGER, William, A.

IPC: F28F1/40 ,  F28F1/10

CPC classification number: F23C13/00 ,  B01J10/007 ,  B01J12/007 ,  B01J19/242 ,  B01J19/244 ,  B01J19/2485 ,  B01J2219/00094 ,  B01J2219/2408 ,  B01J2219/2411 ,  B01J2219/2419 ,  B01J2219/2428 ,  B01J2219/2434 ,  B01J2219/2443 ,  B01J2219/2448 ,  F28F1/40 ,  Y10T29/49345 ,  Y10T29/49352 ,  Y10T29/49872 ,  Y10T29/49938

Abstract: A reactor including a monolith having a plurality of fins in an annular arrangement for receiving fluid flow through the reactor. The monolith is disposed within a generally cylindrical outer tube, and around a corrugated inner tube. The reactor includes a device for urging the monolith radially outward, so as to maintain contact between the monolith and the outer tube.

Abstract translation: 一种反应器，包括具有多个翅片的整料件，环形装置用于接收通过反应器的流体流动。 整体件设置在大致圆柱形的外管内，并且围绕波纹内管。 反应器包括用于将整体径向向外推动的装置，以便保持整料和外管之间的接触。

公开(公告)号：WO2008073479A2

公开(公告)日：2008-06-19

申请号：PCT/US2007/025446

申请日：2007-12-11

Applicant: CODA THERAPEUTICS, INC. ,  BECKER, David, L. ,  GREEN, Colin, R. ,  DUFT, Bradford, J.

Inventor： BECKER, David, L. ,  GREEN, Colin, R. ,  DUFT, Bradford, J.

IPC: A61K31/7105 ,  C12N15/11 ,  A61P17/02

CPC classification number: C12N15/1138 ,  A61K31/7105 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/35

Abstract: Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.

Abstract translation: 用于治疗不按预期速率愈合的伤口的连接蛋白调节剂，包括延迟愈合伤口，不完全愈合的伤口和慢性伤口，以及相关方法，组合物和制品。

公开(公告)号：WO2008002614A2

公开(公告)日：2008-01-03

申请号：PCT/US2007/014921

申请日：2007-06-27

Applicant: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES ,  BECKER, David, A. ,  KOLHE, Amolkumar

Inventor： BECKER, David, A. ,  KOLHE, Amolkumar

CPC classification number: C07D221/04 ,  C07D311/94 ,  C07D401/06 ,  C07D417/12

Abstract: Disclosed herein are pseudoazulenyl nitrone compounds and methods of using these compounds to trap free radicals and to treat, prevent, or ameliorate various diseases associated with free radicals.

Abstract translation: 本文公开的是假薁基硝酮化合物和使用这些化合物捕获自由基并治疗，预防或改善与自由基相关的各种疾病的方法。

公开(公告)号：WO2007056342A3

公开(公告)日：2007-08-30

申请号：PCT/US2006043290

申请日：2006-11-07

Applicant: STRYKER CORP ,  BECKER DAVID TERRANCE ,  HOPPER CHRISTOPHER JOHN ,  HAYES MICHAEL JOSEPH ,  SHANKAR VIVEK ,  MAYORAS RICHARD C JR

Inventor： BECKER DAVID TERRANCE ,  HOPPER CHRISTOPHER JOHN ,  HAYES MICHAEL JOSEPH ,  SHANKAR VIVEK ,  MAYORAS RICHARD C JR

IPC: A61B5/00 ,  A61G7/002 ,  G08B21/02

CPC classification number: A61B5/1115 ,  A61B5/002 ,  A61B5/1117 ,  A61B5/6887 ,  A61B5/6891 ,  A61B90/30 ,  A61B2090/309 ,  A61G7/012 ,  A61G7/015 ,  A61G7/018 ,  A61G7/0507 ,  A61G7/0509 ,  A61G7/0514 ,  A61G7/0516 ,  A61G7/0524 ,  A61G2203/42 ,  G08B21/22 ,  Y10S5/905

Abstract: A patient handling device (20) includes a controller (44), with a plurality of sensors (54), control panels (68, 70, 72), and lamps (86, 88, 92) electrically connected to the controller (44). The patient handling device (20) records the normal/desired state of the various components when power is applied. When one of the components goes outside the normal/desired state, the controller (44) issues an alarm. This alarm includes illuminating a plurality of amber alert lamps (86, 88) which can normally be viewed by a user at any position around the outside of the patient handling device (20). The patient handling device (20) also includes a position control (106). This control (106) restricts movement of an upper/fowler portion (32) of the patient handling device (20) in a certain range of angular positions, while permitting movement of the upper portion (32) outside the certain range.

Abstract translation: 患者操作装置（20）包括控制器（44），其具有电连接到控制器（44）的多个传感器（54），控制面板（68,70,72）和灯（86,88,92） 。 患者操作装置（20）在施加电力时记录各种部件的正常/期望状态。 当其中一个部件超出正常/期望状态时，​​控制器（44）发出警报。 该警报包括照亮患者处理装置（20）外部周围的任何位置处的用户可正常看到的多个琥珀色警示灯（86,88）。 患者处理装置（20）还包括位置控制器（106）。 该控制装置（106）限制患者操作装置（20）的上部/捕获器部分（32）在一定角度位置范围内的移动，同时允许上部（32）移动到一定范围之外。

公开(公告)号：WO2007035639A2

公开(公告)日：2007-03-29

申请号：PCT/US2006/036290

申请日：2006-09-18

Applicant: WIZARD INTERNATIONAL, INC. ,  KERR, Stephen, P. ,  BECKER, David, M.

Inventor： KERR, Stephen, P. ,  BECKER, David, M.

IPC: G06Q99/00 ,  G06F17/00 ,  G06G7/00

CPC classification number: G06T11/60 ,  G06Q20/20 ,  G06Q30/0283 ,  G06Q30/06

Abstract: Aspects of the present invention are directed at providing an application program that allows a user to select, model, and visualize components of a framed artwork. In accordance with one embodiment, a method is provided that allows a user to create a digitized representation of a framed artwork. More specifically, the method includes providing a user interface that includes controls for obtaining component selections of the framed artwork. Then, from the user interface, a set of component selections are received. As the component selections are received, the method renders the framed artwork for display.

Abstract translation: 本发明的各方面旨在提供一种应用程序，其允许用户选择，建模和可视化框架艺术品的组件。 根据一个实施例，提供了一种允许用户创建框架艺术品的数字化表示的方法。 更具体地说，该方法包括提供用户界面，该用户界面包括用于获得框架艺术品的组分选择的控件。 然后，从用户界面接收一组组件选择。 当收到组件选择时，该方法呈现框架图稿以供显示。

公开(公告)号：WO2006134494A2

公开(公告)日：2006-12-21

申请号：PCT/IB2006/001961

申请日：2006-02-03

Applicant: CODA THERAPEUTICS LIMITED ,  GREEN, Colin, R. ,  BECKER, David, L.

Inventor： GREEN, Colin, R. ,  BECKER, David, L.

CPC classification number: A61K38/177 ,  A61K31/70 ,  A61K38/08 ,  A61K38/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/16 ,  C12N2320/30 ,  Y02P20/582 ,  A61K2300/00

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication or prevention of hemichannel opening is desirable.

Abstract translation: 提供了调节连接蛋白活性的方法和组合物，包括例如用于治疗心血管，血管，神经系统，伤口和其他适应症的治疗。 这些化合物和方法可以在治疗上使用，例如降低相关疾病和病症的不良反应的严重性，其中需要直接细胞 - 细胞通信或预防半通道开放的局部破坏。