公开(公告)号：US11773357B2

公开(公告)日：2023-10-03

申请号：US17078742

申请日：2020-10-23

Applicant: Cleveland State University

Inventor： Moo-Yeal Lee

IPC: C12M3/00 ,  C12M1/12 ,  C12M1/00 ,  G01N33/50 ,  C12M1/32 ,  C12N5/071

CPC classification number: C12M21/08 ,  C12M23/06 ,  C12M23/12 ,  C12M23/20 ,  C12M23/22 ,  C12M23/58 ,  C12M25/06 ,  C12M29/10 ,  C12N5/0671 ,  G01N33/5014 ,  G01N33/5088

Abstract: A perfusion plate that can be combined with pillar plates containing cell layers is disclosed. The perfusion plate can have an inflow reservoir and an outflow reservoir connected by at least one channel, which fluidly connects the perfusion wells to the reservoirs for the flow of a fluid such as growth media. A perfusion plate can be part of an assembly containing a pillar plate, a lid, and a transparent bottom for visualizing cell growth in the perfusion wells. The perfusion-pillar plate assembly can facilitate perfusion-based tissue culture and tissue communication for high throughput, high-content, drug screening.

公开(公告)号：US11727780B2

公开(公告)日：2023-08-15

申请号：US16278452

申请日：2019-02-18

Applicant: Cleveland State University

Inventor： Wenbing Zhao

IPC: H02G7/06 ,  G08B21/04 ,  G06F3/01 ,  G06T7/246 ,  G06T7/73 ,  G06F1/16 ,  A61B5/00 ,  A61B5/11 ,  G06V40/20

CPC classification number: G08B21/0446 ,  A61B5/11 ,  A61B5/486 ,  G06F1/1694 ,  G06F3/016 ,  G06F3/017 ,  G06T7/246 ,  G06T7/73 ,  G06V40/23 ,  G06V40/28 ,  H02G7/06 ,  A61B5/681 ,  A61B5/7455 ,  G06T2207/10016 ,  G06T2207/30196 ,  G06T2207/30232 ,  G06T2207/30241

Abstract: Systems and methods to perform privacy-aware computer-vision-based human activity monitoring with real-time haptic feedback. The system and method described in this disclosure employing a registration process for consenting human subjects before their activities are monitored. The registration process involves the corroboration of human motion captured in different modalities, i.e., computer-vision-based via the programmable computer-vision-based motion sensor and accelerometer-based via the wearable device. The tracked human activities are assessed in real-time and upon detection of activities that violated predefined rules, haptic feedback is delivered in real-time to the tracked human subject via the wearable device worn by the caregiver.

公开(公告)号：US20230151114A1

公开(公告)日：2023-05-18

申请号：US17987058

申请日：2022-11-15

Applicant: Cleveland State University

Inventor： Merlin Nithya Gnanapragasam ,  Mahesh Ramamoorthy

IPC: C07K16/30 ,  A61K31/7088

CPC classification number: C07K16/3092 ,  A61K31/7088

Abstract: Therapeutic compositions and methods for treating a patient having sickle cell anemia or beta-thalassmia by administering, in therapeutically effective amounts, a composition of an effective amount of an inhibitor of Pumilio-1.

公开(公告)号：US11504311B2

公开(公告)日：2022-11-22

申请号：US17249619

申请日：2021-03-08

Applicant: Cleveland State University

Inventor： Geyou Ao

IPC: A61K8/19 ,  B01F3/08 ,  C01B21/064 ,  A61K8/06 ,  A61K8/73 ,  A61K8/66 ,  A61K8/60 ,  A61Q17/04 ,  B01F23/411 ,  B82Y40/00

Abstract: Compositions contain boron nitride nanomaterials at least partially coated with biomolecules.

公开(公告)号：US11360077B2

公开(公告)日：2022-06-14

申请号：US15918635

申请日：2018-03-12

Applicant: Cleveland State University

Inventor： Michael Kalafatis ,  Katherine Turner

IPC: G01N33/50 ,  G01N33/574 ,  G01N15/14 ,  A61K31/352 ,  A61P35/00 ,  G01N15/10

Abstract: Disclosed are methods and compositions for identifying and treating certain conditions and diseases. In certain instances, the general inventive concepts provide methods for determining rhTRAIL sensitivity of a sample and/or methods and compositions for inducing apoptosis to treat conditions and diseases with rhTRAIL.

公开(公告)号：US11262349B2

公开(公告)日：2022-03-01

申请号：US16157727

申请日：2018-10-11

Applicant: Cleveland State University

Inventor： Moo-Yeal Lee ,  Xue-Long Sun

IPC: G01N33/50 ,  G01N33/543

Abstract: A multiplexed method of monitoring immune-cell responses to different ligands using a micropillar/microwell plate platform is disclosed. The method may include dispensing immune cells onto at least one micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains at least one test compound. The method may also include immobilizing antibodies onto at least one micropillar on a micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains a test compound. The method may also include treating the micropillar chip with at least one reactive polymer.

公开(公告)号：US11207234B2

公开(公告)日：2021-12-28

申请号：US15485962

申请日：2017-04-12

Applicant: Cleveland State University

Inventor： Jerzy T. Sawicki ,  Curt A. Laubscher ,  Ryan J. Farris ,  Steven J-S Etheridge

IPC: H02K11/33 ,  H02K11/20 ,  A61H3/00 ,  F16H19/00 ,  A61H1/02 ,  F16H7/08 ,  F16H7/02

Abstract: An actuating device for orthosis includes a transmission that is operatively connected to a motor such that the motor provides power to the transmission. The transmission includes a first stage, a second stage, and a third stage. Each of these stages includes at least two sprockets and a drive belt tensioned between the two sprockets. The transmission also includes a first shaft and a second shaft. A sprocket of each of the first, second, and third stages of the transmission is attached to the first shaft. An actuating arm is operatively connected to the third stage of the transmission such that the power provided to the transmission by the motor causes the actuating arm to provide an output torque.

公开(公告)号：US11191694B2

公开(公告)日：2021-12-07

申请号：US16398558

申请日：2019-04-30

Applicant: Cleveland State University

Inventor： Antonie J. van den Bogert ,  Daniel Miller ,  Ryan Doris ,  Robert Moody ,  Donald Grimes, Jr.

IPC: A61H3/00 ,  A61H1/02

Abstract: An exoskeleton system is passively powered and pneumatically operated. The system may be a lower-limb system for walking gait restoration. The system may include a first linear actuator located in front of an upper leg section and a second linear actuator located behind a lower leg section.

公开(公告)号：US20210365568A1

公开(公告)日：2021-11-25

申请号：US17326796

申请日：2021-05-21

Applicant: Cleveland State University

Inventor： Hongxing Ye

IPC: G06F21/60 ,  G05B13/04 ,  H02J3/00

Abstract: The present exemplary embodiments relate to a privacy preserving approach to peak load management. It finds example application in conjunction with, for example, power systems, such as smart homes, smart buildings, microgrids, distribution systems and bulk systems, and energy management systems.

公开(公告)号：US20210275412A1

公开(公告)日：2021-09-09

申请号：US17249619

申请日：2021-03-08

Applicant: Cleveland State University

Inventor： Geyou Ao

IPC: A61K8/19 ,  B01F3/08 ,  C01B21/064 ,  A61K8/06 ,  A61K8/73 ,  A61K8/66 ,  A61K8/60 ,  A61Q17/04

Abstract: Compositions contain boron nitride nanomaterials at least partially coated with biomolecules.