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    METHOD AND DEVICE FOR DETECTING FELINE IMMUNODEFICIENCY VIRUS
    61.
    发明申请
    METHOD AND DEVICE FOR DETECTING FELINE IMMUNODEFICIENCY VIRUS 审中-公开
    用于检测FELINE免疫缺陷病毒的方法和装置

    公开(公告)号：WO2005080939A3

    公开(公告)日：2005-10-06

    申请号：PCT/US2005004924

    申请日：2005-02-16

    Applicant: IDEXX LAB INC ,  GROAT RANDALL G ,  QUENTIN J TONELLI

    Inventor： GROAT RANDALL G ,  QUENTIN J TONELLI

    IPC: A61K39/21 ,  C07K14/15 ,  C07K14/155 ,  C12Q1/70 ,  G01N33/569

    CPC classification number: C07K14/005 ,  C12N2740/15022 ,  C12Q1/702 ,  G01N33/56983 ,  G01N2333/155

    Abstract: A method and device for determining a feline immunodeficiency virus infection or vaccination in an animal. The method includes contacting a biological sample from a felid with various FIV polypeptides and determining the binding of antibodies in the sample to the polypeptides. The determination of whether an animal is infected with FIV or has been vaccinated against FIV can be determined by measuring the animal's immune response to an FIV env polypeptide. A device for detecting FIV antibodies is provided.

    Abstract translation: 用于确定动物的猫免疫缺陷病毒感染或疫苗接种的方法和装置。 该方法包括使来自felid的生物样品与各种FIV多肽接触并确定样品中的抗体与多肽的结合。 通过测量动物对FIV env多肽的免疫应答，可以确定动物是否感染FIV或已经接种FIV疫苗。 提供了一种用于检测FIV抗体的装置。

    DETECTION OF ANALYTES IN FECAL SAMPLES
    62.
    发明申请
    DETECTION OF ANALYTES IN FECAL SAMPLES 审中-公开
    检测FECAL样品中的分析物

    公开(公告)号：WO2004097412A3

    公开(公告)日：2005-02-17

    申请号：PCT/US2004012646

    申请日：2004-04-23

    Applicant: IDEXX LAB INC ,  TONELLI QUENTIN J ,  GROAT RANDALL G ,  MONN MICHAEL P

    Inventor： TONELLI QUENTIN J ,  GROAT RANDALL G ,  MONN MICHAEL P

    IPC: G01N33/53

    CPC classification number: G01N33/5308

    Abstract: A method for detecting a parasitic worm infection of the digestive tract of a mammal. The method includes detecting the binding of a worm antibody to a worm antigen present in the soluble portion of a fecal sample of infected mammals.

    Abstract translation: 一种用于检测哺乳动物的消化道的寄生虫感染的方法。 该方法包括检测蠕虫抗体与存在于受感染哺乳动物的粪便样品的可溶性部分中的蠕虫抗原的结合。

    DIAGNOSTIC DEVICE WITH MULTIPLE INDEPENDENT FLOW PATHS
    65.
    发明申请
    DIAGNOSTIC DEVICE WITH MULTIPLE INDEPENDENT FLOW PATHS 审中-公开
    具有多个独立流程图的诊断装置

    公开(公告)号：WO0184153A3

    公开(公告)日：2002-07-11

    申请号：PCT/US0111773

    申请日：2001-04-11

    Applicant: IDEXX LAB INC

    Inventor： CLARK SCOTT M ,  SUVA ROBERT H ,  KEPRON MICHAEL R ,  BARSKI STANISLAW JR ,  WORKMAN ERWIN F JR

    IPC: G01N33/566 ,  C12M1/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/543 ,  G01N33/558 ,  G01N37/00

    CPC classification number: G01N33/558 ,  G01N33/54366 ,  Y10T436/11 ,  Y10T436/12 ,  Y10T436/255

    Abstract: Devices and methods for performing assays to determine the presence or quantity of a specific analyte of interest in a fluid sample. In devices according to this invention two separate flow paths are established sequentially in the device with a single user activation step. The first flow path delivers the analyte of interest (if present in the sample) and conjugate soluble binding reagents to the solid phase. If analyte is present, an analyte:conjugate complex is formed and immobilized. The volume of sample delivered by this first path is determined by the absorbent capacity of the solid phase, and not by the amount of sample added to the device, relieving the user from the necessity of measuring the sample. The sample/conjugate mixture is prevented from entering the second flow path because the capillarity and the surface energy of the second flow path prevent it from being wetted by this mixture. The second flow path allows a wash reagent to remove unbound conjugate and sample from the solid phase to the absorbant, and optionally to deliver detection reagents.

    Abstract translation: 用于进行测定以确定流体样品中感兴趣的特定分析物的存在或数量的装置和方法。 在根据本发明的设备中，在具有单个用户激活步骤的设备中依次建立两个单独的流路径。 第一流路传送感兴趣的分析物（如果存在于样品中）并将可溶性结合试剂与固相结合。 如果存在分析物，则形成并固定分析物：缀合物。 由该第一路径输送的样品的体积由固相的吸收能力确定，而不是通过添加到装置中的样品的量来确定，从而减轻了用户不必测量样品的量。 由于毛细管力和第二流路的表面能阻止其被该混合物润湿，因此防止样品/共轭物混合物进入第二流动路径。 第二流动路径允许洗涤剂将未结合的结合物和样品从固相除去到吸收剂，并且任选地递送检测试剂。

    METHOD AND DEVICE FOR DETECTING ANALYTES IN FLUIDS
    66.
    发明申请
    METHOD AND DEVICE FOR DETECTING ANALYTES IN FLUIDS 审中-公开
    用于检测流体分析仪的方法和装置

    公开(公告)号：WO0058730A8

    公开(公告)日：2001-07-19

    申请号：PCT/US0007965

    申请日：2000-03-24

    Applicant: IDEXX LAB INC ,  CARPENTER CHARLES R

    Inventor： CARPENTER CHARLES R

    IPC: G01N33/543 ,  C12M1/34 ,  C12Q1/25 ,  G01N21/78 ,  G01N33/483 ,  G01N33/533 ,  G01N33/536 ,  G01N33/558 ,  G01N33/577

    CPC classification number: G01N33/558 ,  Y10S435/81 ,  Y10S435/91

    Abstract: A disposable, dry chemistry analytical system is disclosed which is broadly useful for the detection of a variety of analytes present in biological fluids such as whole blood, serum, plasma, urine and cerebral spinal fluid. The invention discloses the use of the reaction interface that forms between two liquids converging from opposite directions within a bibulous material. The discovery comprises a significant improvement over prior art disposable, analytical reagent systems in that the detectable reactant zone is visually distinct and separate from the unreacted reagents allowing for the use of reaction indicators exhibiting only minor changes as well as extremely high concentrations of reactants. In addition, staged, multiple reagents can be incorporated. Whole blood can be used as a sample without the need for separate cell separating materials. Finally, the invention is useful for the detection of analytes in a broad variety of materials such as milk, environmental samples, and other samples containing target analytes.

    Abstract translation: 公开了一次性干燥化学分析系统，其广泛用于检测生物流体如全血，血清，血浆，尿液和脑脊液中存在的各种分析物。 本发明公开了使用在吸水材料内从相反方向汇合的两种液体之间形成的反应界面。 该发现包括对现有技术的一次性分析试剂系统的显着改进，因为可检测的反应物区域在视觉上是不同的并且与未反应试剂分离，允许使用仅显示微小变化的反应指示剂以及极高浓度的反应物。 此外，可以并入分阶段的多种试剂。 全血可用作样品，不需要单独的细胞分离材料。 最后，本发明可用于检测各种材料中的分析物，例如牛奶，环境样品和含有目标分析物的其它样品。

    DEVICE AND METHODS FOR DETERMINATION OF ANALYTE IN A SOLUTION
    68.
    发明申请
    DEVICE AND METHODS FOR DETERMINATION OF ANALYTE IN A SOLUTION 审中-公开
    用于测定溶液中分析物的装置和方法

    公开(公告)号：WO9922017A3

    公开(公告)日：1999-08-05

    申请号：PCT/US9822628

    申请日：1998-10-27

    Applicant: IDEXX LAB INC ,  PIERSON MARK W ,  TOWNSEND DAVID E ,  GU HAOYI ,  NAQUI ALI

    Inventor： PIERSON MARK W ,  TOWNSEND DAVID E ,  GU HAOYI ,  NAQUI ALI

    IPC: C12M1/34 ,  B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  C12Q1/04 ,  G01N33/18 ,  G01N33/48 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569

    CPC classification number: B01L3/0248 ,  B01J19/0046 ,  B01L3/021 ,  B01L3/502 ,  B01L3/5085 ,  B01L3/50853 ,  B01L2300/047 ,  B01L2300/0663 ,  B01L2300/0829 ,  B01L2400/0487 ,  C12M23/12 ,  C12M41/36 ,  G01N33/5304 ,  G01N33/543 ,  G01N33/54366

    Abstract: Method and assay devices for the detection of the presence or amount of biological material, analyte(s), or microorganism(s) in a sample. The method includes the steps of liquefying the sample (if necessary) and distributing the liquefied sample over the surface of the assay device. The device may comprise an incubation plate, a dip stick device, or other devices. The devices have at least one reagent provided within the devices. Some devices have a generally flat horizontal surface which is divided into a plurality of recessed wells. Others have one or more surfaces with reagent island(s) immobilized thereon. Each well or reagent island is adapted to hold an aliquot of liquid. The wells or reagent islands are sized and shaped, and formed of a suitable material, to hold the aliquot within the well or reagent island by surface tension. Any excess liquid from the liquefied sample is drained from the surface of the device. The method then involves incubating the assay device until the presence or amount of the biological material, analyte, or microorganism is determined.

    Abstract translation: 用于检测样品中生物材料，分析物或微生物的存在或量的方法和测定装置。 该方法包括液化样品（如果需要）和将液化样品分布在测定装置表面上的步骤。 该装置可以包括温育板，浸渍棒装置或其他装置。 这些装置具有至少一个设备内提供的试剂。 一些装置具有通常平坦的水平表面，其被分成多个凹陷井。 其他人有一个或多个固定有试剂岛的表面。 每个孔或试剂岛适合于保存一份液体的等分试样。 孔或试剂岛的大小和形状由合适的材料制成，通过表面张力将等分试样保持在孔或试剂岛内。 来自液化样品的任何多余液体从装置表面排出。 该方法然后包括温育测定装置直到确定生物材料，分析物或微生物的存在或量。

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