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公开(公告)号：WO0184153A3
公开(公告)日：2002-07-11
申请号：PCT/US0111773
申请日：2001-04-11
Applicant: IDEXX LAB INC
Inventor： CLARK SCOTT M , SUVA ROBERT H , KEPRON MICHAEL R , BARSKI STANISLAW JR , WORKMAN ERWIN F JR
IPC: G01N33/566 , C12M1/00 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/558 , G01N37/00
CPC classification number: G01N33/558 , G01N33/54366 , Y10T436/11 , Y10T436/12 , Y10T436/255
Abstract: Devices and methods for performing assays to determine the presence or quantity of a specific analyte of interest in a fluid sample. In devices according to this invention two separate flow paths are established sequentially in the device with a single user activation step. The first flow path delivers the analyte of interest (if present in the sample) and conjugate soluble binding reagents to the solid phase. If analyte is present, an analyte:conjugate complex is formed and immobilized. The volume of sample delivered by this first path is determined by the absorbent capacity of the solid phase, and not by the amount of sample added to the device, relieving the user from the necessity of measuring the sample. The sample/conjugate mixture is prevented from entering the second flow path because the capillarity and the surface energy of the second flow path prevent it from being wetted by this mixture. The second flow path allows a wash reagent to remove unbound conjugate and sample from the solid phase to the absorbant, and optionally to deliver detection reagents.
Abstract translation: 用于进行测定以确定流体样品中感兴趣的特定分析物的存在或数量的装置和方法。 在根据本发明的设备中，在具有单个用户激活步骤的设备中依次建立两个单独的流路径。 第一流路传送感兴趣的分析物（如果存在于样品中）并将可溶性结合试剂与固相结合。 如果存在分析物，则形成并固定分析物：缀合物。 由该第一路径输送的样品的体积由固相的吸收能力确定，而不是通过添加到装置中的样品的量来确定，从而减轻了用户不必测量样品的量。 由于毛细管力和第二流路的表面能阻止其被该混合物润湿，因此防止样品/共轭物混合物进入第二流动路径。 第二流动路径允许洗涤剂将未结合的结合物和样品从固相除去到吸收剂，并且任选地递送检测试剂。
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公开(公告)号：WO2005058169A3
公开(公告)日：2005-10-27
申请号：PCT/US2004042061
申请日：2004-12-15
Applicant: IDEXX LAB INC , MIKULKA THOMAS LUKE , DJURANOVIC NEVENA NOVKOVIC , BARSKI STANISLAW JR , LIBBY TRACY LYNN HESSEL
Inventor： MIKULKA THOMAS LUKE , DJURANOVIC NEVENA NOVKOVIC , BARSKI STANISLAW JR , LIBBY TRACY LYNN HESSEL
CPC classification number: A61B10/0266 , A61B10/0283 , A61B17/32053 , A61B2090/061 , A61B2090/063 , A61B2090/3937
Abstract: The present disclosure provides for devices for obtaining a sample from inside a body. According to one embodiment, the device includes a tubular body portion (102) defining a chamber (104) for receiving a sample of material therein; a plunger assembly operatively associated with the tubular body portion, the plunger assembly having a stopper (124) slidably disposed within the chamber of the body portion; and feedback elements (140) provided on the tubular body and/or the plunger assembly for providing a user of the sampling device with audible and/or tactile indications regarding an amount of displacement of the plunger assembly relative to the body portion. The stopper is adapted for fluid tight engagement with the body portion. A cutting element (130) is also provided to facilitate sample removal.
Abstract translation: 本公开提供了用于从身体内部获取样品的装置。 根据一个实施例，该装置包括管状主体部分（102），其限定用于在其中容纳材料样本的腔室（104） 柱塞组件，其与所述管状主体部分可操作地相关联，所述柱塞组件具有可滑动地设置在所述主体部分的所述腔室内的止动件（124） 以及设置在管状主体和/或柱塞组件上的反馈元件（140），用于向采样装置的使用者提供关于柱塞组件相对于主体部分的位移量的可听和/或触觉指示。 塞子适于与主体部分流体紧密接合。 还提供切割元件（130）以便于去除样品。
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公开(公告)号：CA2549297C
公开(公告)日：2012-11-27
申请号：CA2549297
申请日：2004-12-15
Applicant: IDEXX LAB INC
Inventor： MIKULKA THOMAS LUKE , DJURANOVIC NEVENA NOVKOVIC , BARSKI STANISLAW JR , LIBBY TRACY LYNN HESSEL
Abstract: The present disclosure provides for devices for obtaining a sample from inside a body. According to one embodiment, the device includes a tubular body portion (102) defining a chamber (104) for receiving a sample of material therein; a plunger assembly operatively associated with the tubular body portion, the plunger assembly having a stopper (124) slidably disposed within the chamber of the body portion; and feedback elements (140) provided on the tubular body and/or the plunger assembly for providing a user of the sampling device with audible and/or tactile indications regarding an amount of displacement of the plunger assembly relative to the body portion. The stopper is adapted for fluid tight engagement with the body portion. A cutting element (130) is also provided to facilitate sample removal.
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公开(公告)号：AU2004299086A2
公开(公告)日：2005-06-30
申请号：AU2004299086
申请日：2004-12-15
Applicant: IDEXX LAB INC
Inventor： LIBBY TRACY LYNN HESSEL , DJURANOVIC NEVENA NOVKOVIC , MIKULKA THOMAS LUKE , BARSKI STANISLAW JR
Abstract: A device for obtaining a sample from inside a body is disclosed. It comprises a tubular body portion that defines a chamber for receiving a sample of material therein and which has a distal end, a proximal end and defines a longitudinal central axis. The device also comprises a plunger assembly operatively associated with the tubular body portion which has a stopper slidably disposed within the chamber of the tubular body portion that is adapted for fluid tight engagement with the tubular body portion. Feedback elements are provided on at least one of the tubular body portion and the plunger assembly for providing a user of the sampling device with audible and/or tactile indications regarding an amount of displacement of the plunger assembly relative to the tubular body portion. At least one cutting element having a plurality of arms extending radially inwardly from the open distal end of the tubular body portion and angled into the tubular body portion is also provided. Each of the cutting elements have an unsupported free end disposed within the tubular body portion.
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公开(公告)号：AU2001253354B9
公开(公告)日：2005-11-03
申请号：AU2001253354
申请日：2001-04-11
Applicant: IDEXX LAB INC
Inventor： BARSKI STANISLAW JR , KEPRON MICHAEL R , CLARK SCOTT M , WORKMAN ERWIN F JR , SUVA ROBERT H
IPC: G01N33/566 , C12M1/00 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/558 , G01N37/00 , G01N033/543
Abstract: Devices and methods for performing assays to determine the presence or quantity of a specific analyte of interest in a fluid sample. In devices according to this invention two separate flow paths are established sequentially in the device with a single user activation step. The first flow path delivers the analyte of interest (if present in the sample) and conjugate soluble binding reagents to the solid phase. If analyte is present, an analyte:conjugate complex is formed and immobilized. The volume of sample delivered by this first path is determined by the absorbent capacity of the solid phase, and not by the amount of sample added to the device, relieving the user from the necessity of measuring the sample. The sample/conjugate mixture is prevented from entering the second flow path because the capillarity and the surface energy of the second flow path prevent it from being wetted by this mixture. The second flow path allows a wash reagent to remove unbound conjugate and sample from the solid phase to the absorbant, and optionally to deliver detection reagents. The invention may be adapted to many assay formats including, sandwich immunoassays, colloidal gold, or sol particle assays, heterogeneous generic capture assays and competitive assays. In one embodiment, sandwich assays can be performed by immobilizing an analyte binding reagent on the solid phase, and drying a labeled analyte binding reagent in the first flow path. In a competitive assay embodiment, the first flow path would contain labeled analyte that is dissolved by the sample, and the analyte binding reagent is immobilized on the solid phase. In each of these embodiments, the assay can be further modified to run in a "generic capture" format, where the solid phase binding reagent is instead conjugated to a generic ligand such as biotin, and dried in the first flow path (either together or separately from the other assay reagents), and a generic ligand binding reagent (such as avidin) is immobilized on the solid phase. Another aspect of the present invention includes a subassembly for the immunoassay device that is comprised of a plastic housing and a means for delivering fluid and/or wash solution. This subassembly comprises a structure formed from a hydrophobic polymer selectively treated with a water insoluble surface active agent that has been applied as a solution in an organic solvent rendering portions of the surface hydrophilic. When the surface is contacted with an aqueous liquid, it flows only along the treated areas, creating a defined fluid flow path, thereby delivering sample/conjugate solutions to said solid phase.
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Patent Agency Ranking
公开(公告)号：AU2001253354B8
公开(公告)日：2005-09-22
申请号：AU2001253354
申请日：2001-04-11
Applicant: IDEXX LAB INC
Inventor： BARSKI STANISLAW JR , KEPRON MICHAEL R , SUVA ROBERT H , CLARK SCOTT M , WORKMAN ERWIN F JR
IPC: G01N33/566 , C12M1/00 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/558 , G01N37/00 , G01N033/543
Abstract: Devices and methods for performing assays to determine the presence or quantity of a specific analyte of interest in a fluid sample. In devices according to this invention two separate flow paths are established sequentially in the device with a single user activation step. The first flow path delivers the analyte of interest (if present in the sample) and conjugate soluble binding reagents to the solid phase. If analyte is present, an analyte:conjugate complex is formed and immobilized. The volume of sample delivered by this first path is determined by the absorbent capacity of the solid phase, and not by the amount of sample added to the device, relieving the user from the necessity of measuring the sample. The sample/conjugate mixture is prevented from entering the second flow path because the capillarity and the surface energy of the second flow path prevent it from being wetted by this mixture. The second flow path allows a wash reagent to remove unbound conjugate and sample from the solid phase to the absorbant, and optionally to deliver detection reagents. The invention may be adapted to many assay formats including, sandwich immunoassays, colloidal gold, or sol particle assays, heterogeneous generic capture assays and competitive assays. In one embodiment, sandwich assays can be performed by immobilizing an analyte binding reagent on the solid phase, and drying a labeled analyte binding reagent in the first flow path. In a competitive assay embodiment, the first flow path would contain labeled analyte that is dissolved by the sample, and the analyte binding reagent is immobilized on the solid phase. In each of these embodiments, the assay can be further modified to run in a "generic capture" format, where the solid phase binding reagent is instead conjugated to a generic ligand such as biotin, and dried in the first flow path (either together or separately from the other assay reagents), and a generic ligand binding reagent (such as avidin) is immobilized on the solid phase. Another aspect of the present invention includes a subassembly for the immunoassay device that is comprised of a plastic housing and a means for delivering fluid and/or wash solution. This subassembly comprises a structure formed from a hydrophobic polymer selectively treated with a water insoluble surface active agent that has been applied as a solution in an organic solvent rendering portions of the surface hydrophilic. When the surface is contacted with an aqueous liquid, it flows only along the treated areas, creating a defined fluid flow path, thereby delivering sample/conjugate solutions to said solid phase.
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公开(公告)号：AU2001253354B2
公开(公告)日：2005-05-26
申请号：AU2001253354
申请日：2001-04-11
Applicant: IDEXX LAB INC
Inventor： BARSKI STANISLAW JR , KEPRON MICHAEL R , SUVA ROBERT H , CLARK SCOTT M , WORKMAN ERWIN F JR
IPC: G01N33/566 , C12M1/00 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/558 , G01N37/00 , G01N033/543
Abstract: Devices and methods for performing assays to determine the presence or quantity of a specific analyte of interest in a fluid sample. In devices according to this invention two separate flow paths are established sequentially in the device with a single user activation step. The first flow path delivers the analyte of interest (if present in the sample) and conjugate soluble binding reagents to the solid phase. If analyte is present, an analyte:conjugate complex is formed and immobilized. The volume of sample delivered by this first path is determined by the absorbent capacity of the solid phase, and not by the amount of sample added to the device, relieving the user from the necessity of measuring the sample. The sample/conjugate mixture is prevented from entering the second flow path because the capillarity and the surface energy of the second flow path prevent it from being wetted by this mixture. The second flow path allows a wash reagent to remove unbound conjugate and sample from the solid phase to the absorbant, and optionally to deliver detection reagents. The invention may be adapted to many assay formats including, sandwich immunoassays, colloidal gold, or sol particle assays, heterogeneous generic capture assays and competitive assays. In one embodiment, sandwich assays can be performed by immobilizing an analyte binding reagent on the solid phase, and drying a labeled analyte binding reagent in the first flow path. In a competitive assay embodiment, the first flow path would contain labeled analyte that is dissolved by the sample, and the analyte binding reagent is immobilized on the solid phase. In each of these embodiments, the assay can be further modified to run in a "generic capture" format, where the solid phase binding reagent is instead conjugated to a generic ligand such as biotin, and dried in the first flow path (either together or separately from the other assay reagents), and a generic ligand binding reagent (such as avidin) is immobilized on the solid phase. Another aspect of the present invention includes a subassembly for the immunoassay device that is comprised of a plastic housing and a means for delivering fluid and/or wash solution. This subassembly comprises a structure formed from a hydrophobic polymer selectively treated with a water insoluble surface active agent that has been applied as a solution in an organic solvent rendering portions of the surface hydrophilic. When the surface is contacted with an aqueous liquid, it flows only along the treated areas, creating a defined fluid flow path, thereby delivering sample/conjugate solutions to said solid phase.
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公开(公告)号：AU5335401A
公开(公告)日：2001-11-12
申请号：AU5335401
申请日：2001-04-11
Applicant: IDEXX LAB INC
Inventor： CLARK SCOTT M , SUVA ROBERT H , KEPRON MICHAEL R , BARSKI STANISLAW JR , WORKMAN ERWIN F JR
IPC: G01N33/566 , C12M1/00 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/558 , G01N37/00
Abstract: Devices and methods for performing assays to determine the presence or quantity of a specific analyte of interest in a fluid sample. In devices according to this invention two separate flow paths are established sequentially in the device with a single user activation step. The first flow path delivers the analyte of interest (if present in the sample) and conjugate soluble binding reagents to the solid phase. If analyte is present, an analyte:conjugate complex is formed and immobilized. The volume of sample delivered by this first path is determined by the absorbent capacity of the solid phase, and not by the amount of sample added to the device, relieving the user from the necessity of measuring the sample. The sample/conjugate mixture is prevented from entering the second flow path because the capillarity and the surface energy of the second flow path prevent it from being wetted by this mixture. The second flow path allows a wash reagent to remove unbound conjugate and sample from the solid phase to the absorbant, and optionally to deliver detection reagents. The invention may be adapted to many assay formats including, sandwich immunoassays, colloidal gold, or sol particle assays, heterogeneous generic capture assays and competitive assays. In one embodiment, sandwich assays can be performed by immobilizing an analyte binding reagent on the solid phase, and drying a labeled analyte binding reagent in the first flow path. In a competitive assay embodiment, the first flow path would contain labeled analyte that is dissolved by the sample, and the analyte binding reagent is immobilized on the solid phase. In each of these embodiments, the assay can be further modified to run in a "generic capture" format, where the solid phase binding reagent is instead conjugated to a generic ligand such as biotin, and dried in the first flow path (either together or separately from the other assay reagents), and a generic ligand binding reagent (such as avidin) is immobilized on the solid phase. Another aspect of the present invention includes a subassembly for the immunoassay device that is comprised of a plastic housing and a means for delivering fluid and/or wash solution. This subassembly comprises a structure formed from a hydrophobic polymer selectively treated with a water insoluble surface active agent that has been applied as a solution in an organic solvent rendering portions of the surface hydrophilic. When the surface is contacted with an aqueous liquid, it flows only along the treated areas, creating a defined fluid flow path, thereby delivering sample/conjugate solutions to said solid phase.
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公开(公告)号：AU2004299086B2
公开(公告)日：2011-03-03
申请号：AU2004299086
申请日：2004-12-15
Applicant: IDEXX LAB INC
Inventor： LIBBY TRACY LYNN HESSEL , DJURANOVIC NEVENA NOVKOVIC , MIKULKA THOMAS LUKE , BARSKI STANISLAW JR
Abstract: A device for obtaining a sample from inside a body is disclosed. It comprises a tubular body portion that defines a chamber for receiving a sample of material therein and which has a distal end, a proximal end and defines a longitudinal central axis. The device also comprises a plunger assembly operatively associated with the tubular body portion which has a stopper slidably disposed within the chamber of the tubular body portion that is adapted for fluid tight engagement with the tubular body portion. Feedback elements are provided on at least one of the tubular body portion and the plunger assembly for providing a user of the sampling device with audible and/or tactile indications regarding an amount of displacement of the plunger assembly relative to the tubular body portion. At least one cutting element having a plurality of arms extending radially inwardly from the open distal end of the tubular body portion and angled into the tubular body portion is also provided. Each of the cutting elements have an unsupported free end disposed within the tubular body portion.
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公开(公告)号：AU2004299086A1
公开(公告)日：2005-06-30
申请号：AU2004299086
申请日：2004-12-15
Applicant: IDEXX LAB INC
Inventor： LIBBY TRACY LYNN HESSEL , DJURANOVIC NEVENA NOVKOVIC , MIKULKA THOMAS LUKE , BARSKI STANISLAW JR
Abstract: A device for obtaining a sample from inside a body is disclosed. It comprises a tubular body portion that defines a chamber for receiving a sample of material therein and which has a distal end, a proximal end and defines a longitudinal central axis. The device also comprises a plunger assembly operatively associated with the tubular body portion which has a stopper slidably disposed within the chamber of the tubular body portion that is adapted for fluid tight engagement with the tubular body portion. Feedback elements are provided on at least one of the tubular body portion and the plunger assembly for providing a user of the sampling device with audible and/or tactile indications regarding an amount of displacement of the plunger assembly relative to the tubular body portion. At least one cutting element having a plurality of arms extending radially inwardly from the open distal end of the tubular body portion and angled into the tubular body portion is also provided. Each of the cutting elements have an unsupported free end disposed within the tubular body portion.
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