公开(公告)号：US11590173B2

公开(公告)日：2023-02-28

申请号：US16841359

申请日：2020-04-06

Applicant: Osiris Therapeutics, Inc.

Inventor： Samson Tom ,  Alla Danilkovitch ,  Dana Yoo ,  Timothy Jansen ,  Jin-Qiang Kuang ,  Jennifer Michelle Marconi

IPC: A61K35/28 ,  A01N1/02 ,  A61K35/50 ,  A61K38/18 ,  A61K38/39 ,  A61K38/57 ,  C12N5/073

Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

公开(公告)号：US20230047934A1

公开(公告)日：2023-02-16

申请号：US17788939

申请日：2021-03-12

Applicant: Osiris Therapeutics, Inc.

Inventor： Steven Michael SINCLAIR ,  Alla DANILKOVITCH ,  Malathi SATHYAMOORTHY ,  Jin-Qiang KUANG ,  Sandeep DHALL ,  Yishan LIU ,  Anthony John MELCHIORRI ,  Matthew Robert MOORMAN ,  Mena Schiano LO MORIELLO ,  Anne Allgood LERCH

IPC: A61K35/50 ,  A61K35/33 ,  A61K35/51 ,  A61K9/19 ,  A61K9/00

Abstract: Disclosed are compositions comprising a minced chorionic matrix, a homogenized amniotic matrix, and a homogenized umbilical cord (UC) matrix, wherein the minced chorionic matrix comprises viable cells, wherein the composition does not comprise trophoblasts. Disclosed are compositions comprising isolated, viable chorionic cells, a homogenized amniotic matrix, and a homogenized UC matrix, wherein the composition does not comprise trophoblasts. Disclosed are compositions comprising a minced chorionic matrix and a homogenized UC matrix, wherein the minced chorionic matrix comprises viable cells, wherein the composition does not comprise trophoblasts or an amniotic matrix. Disclosed are compositions comprising isolated, viable chorionic cells and a homogenized
UC matrix, wherein the composition does not comprise trophoblasts or an amniotic matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.

公开(公告)号：US11464809B2

公开(公告)日：2022-10-11

申请号：US16840554

申请日：2020-04-06

Applicant: Osiris Therapeutics, Inc.

Inventor： Alla Danilkovitch ,  Yi Duan-Arnold ,  Matthew Moorman ,  Anne Lerch ,  Jin-Qiang Kuang

IPC: A61K35/51 ,  A61K35/50 ,  A01N1/02

Abstract: Disclosed are compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are compositions comprising a previously cryopreserved umbilical tissue, wherein after cryopreservation and subsequent thawing the umbilical tissue comprises: a) viable cells native to the umbilical tissue; b) tissue integrity of native umbilical tissue; c) one or more growth factors that are native to the umbilical tissue; and d) depleted amounts of one or more types of functional immunogenic cells. Disclosed are methods of producing compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are methods of treating damaged tissue comprising administering to the site of the damaged tissue compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels.

公开(公告)号：US20220184277A1

公开(公告)日：2022-06-16

申请号：US17681064

申请日：2022-02-25

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： Dana Sue YOO ,  Jin-Qiang KUANG ,  Jaime PADEN ,  Scott A. MAXSON ,  Alla DANILKOVITCH ,  Erasmo LOPEZ ,  Samson TOM

IPC: A61L27/36 ,  A61K35/32 ,  A61L27/24 ,  A61L27/38 ,  A61L27/54 ,  A61K38/01 ,  A61L27/56 ,  A61L27/50

Abstract: This invention provides porated cartilage products and methods of producing porated cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.

公开(公告)号：US20200330520A1

公开(公告)日：2020-10-22

申请号：US16271038

申请日：2019-02-08

Applicant: Osiris Therapeutics, Inc.

Inventor： Samson TOM ,  Alla Danilkovitch ,  Dana You ,  Timothy Jansen ,  Jin-Qiang Kuang ,  Jennifer Michelle Marconi

IPC: A61K35/28 ,  A01N1/02 ,  A61K35/50 ,  A61K38/18 ,  A61K38/39 ,  A61K38/57 ,  C12N5/073

Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

公开(公告)号：US20200230176A1

公开(公告)日：2020-07-23

申请号：US16841359

申请日：2020-04-06

Applicant: Osiris Therapeutics, Inc.

Inventor： Samson Tom ,  Alla Danilkovitch ,  Dana Yoo ,  Timothy Jansen ,  Jin-Qiang Kuang ,  Jennifer Michelle Marconi

IPC: A61K35/28 ,  A01N1/02 ,  A61K35/50 ,  A61K38/18 ,  A61K38/39 ,  A61K38/57 ,  C12N5/073

Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

公开(公告)号：US20200171096A1

公开(公告)日：2020-06-04

申请号：US16694650

申请日：2019-11-25

Applicant: Osiris Therapeutics, Inc.

Inventor： Steven Michael Sinclair ,  Alla Danilkovitch ,  Malathi Sathyamoorthy ,  Jin-Qiang Kuang ,  Sandeep Dhall ,  Anthony John Melchiorri

IPC: A61K35/50 ,  A61K35/36 ,  A61K35/32 ,  A61K9/19 ,  A61K9/16 ,  A61L27/36 ,  A61F13/00 ,  A01N1/02

Abstract: Disclosed are methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are lyophilized tissues prepared using the disclosed methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are methods of treating a wound or tissue defect comprising administering a reconstituted lyophilized tissue to the wound or tissue defect.

公开(公告)号：US10646519B2

公开(公告)日：2020-05-12

申请号：US15949808

申请日：2018-04-10

Applicant: Osiris Therapeutics, Inc.

Inventor： Samson Tom ,  Alla Danilkovitch ,  Dana Yoo ,  Timothy Jansen ,  Jin-Qiang Kuang ,  Jennifer Michelle Marconi

IPC: A61K35/28 ,  A61K35/50 ,  A01N1/02 ,  A61K38/18 ,  A61K38/19 ,  A61K38/57 ,  C12N5/073 ,  A61K38/39

Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

公开(公告)号：US20190276215A1

公开(公告)日：2019-09-12

申请号：US16279413

申请日：2019-02-19

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： YI DUAN-ARNOLD ,  ALLA DANILKOVITCH ,  ALEXANDRA GYURDIEVA ,  JIN-QIANG KUANG ,  STEVEN MICHAEL SINCLAIR

IPC: B65D77/26 ,  A61F15/00 ,  B65B55/22 ,  B65D65/02 ,  A61F2/00 ,  B65B5/04 ,  B65D85/00

Abstract: A support assembly for supporting a biological product (e.g., membrane) in an operative position. The support assembly has a base and a cover. A membrane receiving portion of the base defines a plurality of perforations that extend between top and bottom surfaces of the product receiving portion. The cover is releasably coupled to the base in a product-covering position in which the cover overlies the product receiving portion of the base. In the operative position, the biological product engages the top surface of the product receiving portion and the bottom surface of the cover.

公开(公告)号：US20180360886A1

公开(公告)日：2018-12-20

申请号：US15949808

申请日：2018-04-10

Applicant: Osiris Therapeutics, Inc.

Inventor： Samson Tom ,  Alla Danilkovitch ,  Dana Yoo ,  Timothy Jansen ,  Jin-Qiang Kuang ,  Jennifer Michelle Marconi

IPC: A61K35/28 ,  A61K35/50 ,  A01N1/02 ,  A61K38/18 ,  A61K38/39 ,  A61K38/57 ,  C12N5/073

Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.