Electrochemical measuring electrode device for simultaneously measuring the partial pressures of two gasses
    61.
    发明公开
    Electrochemical measuring electrode device for simultaneously measuring the partial pressures of two gasses 失效
    对于两种气体的同时分压电化学测量单元。

    公开(公告)号:EP0100463A1

    公开(公告)日:1984-02-15

    申请号:EP83106737.6

    申请日:1983-07-08

    Applicant: RADIOMETER A/S

    CPC classification number: A61B5/14542 A61B5/1477 G01N27/404

    Abstract: An electrochemical electrode device for simultaneously measuring the partial pressures of two gases in a medium of limited gas availability one of which is measured potentiometrically and another one of which is measured polarographically comprises an electrode body (18) constituting a reference electrode relative. to a pH-electrode (19) of a potentiometric electrode system, and a anode relative to a cathode (20) of a polarographic electrode system. Furthermore, the electrode device comprises an electrolyte solution (28) enclosed between the electrode body (18) and a membrane (30). The membrane (30) comprises a basic membrane layer (31), preferably of polytetrafluoroethylene (PTFE) or fluorcethylenepropylene (FEP) of a thickness of about 12 µm, and a covering (32), preferably a polypropylene layer of a thickness of about 15 µm, which covers part of the basic membrane layer so that an uncovered area (34) is constituted in front of the pH-electrode (19). The uncovered area (34) constitutes a first membrane part showing high permeability to the first gas and constitutes together with the potentiometric electrode system and the electrolyte solution a first measuring system for measuring the partial pressure of the first gas. A covered area (32) of the basic membrane layer (30) constitutes together with its covering a second membrane part showing low permeability to the second gas and is arranged In front of the exposed measuring surface of the cathode (20) so as to restrict the diffusion of the second gas to the cathode (20) and together with the polarographic electrode system and the electrolyte solution to constitute a second measuring system for measuring the partial pressure of the second gas. In order to obtain highly accurate and highly responsive measurements of the partial pressures of the two gases in a medium of limited gas availability, the dimension of the exposed measuring surface of the cathode (20), which preferably is a micro-cathode constituted by a 25 µm platinum wire, (22) and the permeability of the second membrane part (32) are adapted to one another so that the response of the polarographic measuring system when measuring in a medium of limited gas availability is substantially identical to the response of the polarographic measuring system when measuring in a medium of unlimited gas availability, and the potentiometric and the polarographic measuring systems have response time characteristics of the same order of magnitude, such as response time constants of the order of 0.5 min.

    Electrochemical electrode device
    62.
    发明公开
    Electrochemical electrode device 失效
    电化学电极阵列。

    公开(公告)号:EP0076464A1

    公开(公告)日:1983-04-13

    申请号:EP82109017.2

    申请日:1982-09-29

    Applicant: RADIOMETER A/S

    CPC classification number: G01N27/30

    Abstract: An electrochemical electrode device comprises a tubular member (11) having a bottom end adapted to be inserted into a liquid sample to be measured, and a top end which is closed by a cap member (12) including electrical conductors (22) by means of which the electrodes of the electrode device are connected to an outer cable (23). In order to facilitate the introduction of liquid or gel (28) into an inner space defined within the tubular member (11) as well as withdrawal of liquid or gel from that space, a longitudinally extending passage (41) is formed within the cap member (12). This passage may be selectively opened and closed by means of a closure member (42) which is received in a cavity extending transversely to and intersecting the longitudinal passage. The closure member is preferably in the form of a swingably mounted slide valve member or a rotatable cock member.

    Electrode device, method for its preparation, and dispersion useful in the method
    63.
    发明公开
    Electrode device, method for its preparation, and dispersion useful in the method 失效
    Elektrodensystem,Verfahren zu dessen Herstellung undfürdieses Verfahren brauchbare Dispersion。

    公开(公告)号:EP0039136A2

    公开(公告)日:1981-11-04

    申请号:EP81301299.4

    申请日:1981-03-26

    Applicant: RADIOMETER A/S

    Inventor: Poulsen, Jorgen

    Abstract: An electrode device for electrochemical measurement of the concentration of the partial pressure of a gas in a liquid or a gas mixture; comprises a measuring surface constituted by or comprising the sensitive part (4) of a measuring electrode and a membrane (6). placed in front of the measuring surface and delimiting a volume of electrolyte solution (5) which is in contact with the measuring electrode. The membrane is permeable to thegas to be determined, and a given distance is obtained and maintained between the measuring surface and the membrane by means of particles (7).
    When assembling the electrode device, a dispersion of the particles in the electrolyte to be incorporated in the electrode device is applied on the measuring surface and/or the membrane in excess, and the electrode device is assembled, whereby excess dispersion is pressed out.
    The dispersion of the particles in the electrolyte is gelled so that it is stable.
    By using particles for obtaining and maintaining the distance between the measuring surface and the membrane, it is possible to obtain very small distances between the measuring surface and the membrane, and the thickness of thin electrolyte layers is easy to control using particles, thus reducing the response time of the electrode. Furthermore, the thickness of the electrolyte layer is adjusted automatically when assembling the electrode device and the membrane between which a dispersion of particles is placed.

    Abstract translation: 用于电化学测量液体或气体混合物中气体分压浓度的电极装置包括由测量电极的敏感部分(4)构成或包括测量电极的测量表面,以及放置在测量电极 测量表面的前面并限定与测量电极接触的电解质溶液(5)的体积。 膜对待测定的气体是可渗透的,并且通过颗粒(7)获得并保持在测量表面和膜之间的给定距离。 当组装电极装置时,将要结合在电极装置中的电解质中的颗粒的分散体过量地施加在测量表面和/或膜上,并且组装电极装置,从而将多余的分散体压出。 颗粒在电解质中的分散体凝胶化,使其稳定。 通过使用用于获得和维持测量表面和膜之间的距离的颗粒,可以在测量表面和膜之间获得非常小的距离,并且薄的电解质层的厚度易于使用颗粒进行控制,从而减少 电极的响应时间。 此外,当组装电极装置和其上放置有颗粒分散体的膜时,自动调节电解质层的厚度。

    REFERENCE ELECTRODE
    64.
    发明公开
    REFERENCE ELECTRODE 有权
    参考电极

    公开(公告)号:EP1084398A1

    公开(公告)日:2001-03-21

    申请号:EP99923405.7

    申请日:1999-05-27

    Applicant: RADIOMETER A/S

    CPC classification number: G01N27/301 G01N27/40

    Abstract: The reference electrode comprises an electrode plug and a chamber (16) closed at the rear containing an electrolyte. The chamber (16) has an aperture (23) covered by a membrane (26) of a material permitting diffusion of ions therethrough, but whose surface is closed for proteins and similar macromolecular substances. A diffusion tight diaphragm element (27) having a through-going orifice (30) located radially within the aperture is situated on the outer side of the ion diffusion membrane (26) relative to the chamber, and the orifice (30) is smaller than the aperture (23).

    CALIBRATION DEVICE FOR USE IN CALIBRATING A SENSOR
    65.
    发明授权
    CALIBRATION DEVICE FOR USE IN CALIBRATING A SENSOR 失效
    校准装置用在传感器校准。

    公开(公告)号:EP0425509B1

    公开(公告)日:1994-06-15

    申请号:EP89906336.6

    申请日:1989-04-20

    Applicant: RADIOMETER A/S

    CPC classification number: G01N27/4163 Y10T436/10

    Abstract: In one embodiment the calibration device (1) comprises a housing (2) which by means of a removable lid (8) and a rupturable barrier layer (3) is divided into a calibration chamber (4) and a second chamber (10). Calibration chamber (4) contains a calibration fluid (5) - e.g. a dry gas - while second chamber (10) contains a second fluid (11) - e.g. a wetting agent. Immediately prior to a calibration process the lid (8) is removed, whereafter the sensor in question with its measuring surface in front is inserted through the second chamber (10) into the housing (2) until abutment against a shoulder (6) in said housing (2). This causes the barrier layer (3) to rupture and the second fluid (11) to contact the calibration fluid (5). Hereafter the calibration process can take place. In another embodiment the device (1) further comprises a membrane (12) which is accommodated in the second chamber (10) and is adapted to be secured to the sensor during the insertion of same into the housing (2). The disclosed device - which is particularly suited for use in calibrating sensors for transcutaneous registering of the contents of CO2 and/or O2 in blood - is self-contained, and can be made of a very compact design, making it very well suited for use in connection with portable equipment. Further the device is suitable for being manufactured in the form of a disposable unit.

    APPARATUS FOR ANALYSIS OF SAMPLES OF FLUIDS
    66.
    发明公开
    APPARATUS FOR ANALYSIS OF SAMPLES OF FLUIDS 失效
    装置用于分析液体样品。

    公开(公告)号:EP0478683A1

    公开(公告)日:1992-04-08

    申请号:EP90910605.0

    申请日:1990-06-13

    Applicant: RADIOMETER A/S

    CPC classification number: G01N35/1002 G01N35/1079 G01N2035/1006

    Abstract: Nouvel appareil servant à mesurer des paramètres tels que le Ph, le pCO2, le PO2 et le contenu en Hb des fluides physiologiques, en particulier le sang. L'appareil comprend de nouveaux moyens servant à suspendre des cuves à réactifs (34, 35, 40, 45, 50) possédant des épaulements (51, 52) et contenant des solutions d'étalonnage, de rinçage, etc., ainsi qu'à suspendre une cuve à déchets liquides (26), en suspendant les cuves entre des tiges (53, 54) pour les amener jusqu'à l'analyseur. Les cuves à réactifs sont munies de couvercles (55, 58) et comprennent un conduit de réactifs liquides descendant de l'orifice de sortie du couvercle jusque dans le liquide. Lorsque la cuve est montée sur l'analyseur, un tuyau d'entrée fixé s'étendant horizontalement et vers l'extérieur à partir de l'analyseur traverse un joint d'étanchéité qui couvre l'orifice de sortie et se raccorde au conduit de réactifs liquides.

    CALIBRATION DEVICE FOR USE IN CALIBRATING A SENSOR
    68.
    发明公开
    CALIBRATION DEVICE FOR USE IN CALIBRATING A SENSOR 失效
    校准装置用在传感器校准。

    公开(公告)号:EP0425509A1

    公开(公告)日:1991-05-08

    申请号:EP89906336.0

    申请日:1989-04-20

    Applicant: RADIOMETER A/S

    CPC classification number: G01N27/4163 Y10T436/10

    Abstract: Dans un mode de réalisation le dispositif d'étalonnage (1) comprend un logement (2) divisé au moyen d'un couvercle amovible (8) et d'une couche de barrière cassable (3), en une chambre d'étalonnage (4) et une seconde chambre (10). La chambre d'étalonnage (4) contient un fluide d'étalonnage (5), par exemple un gaz sec, tandis que la seconde chambre (10) contient un second fluide (11), par exemple un agent d'humidification. Immédiatement avant de procéder à un étalonnage on retire le couvercle (8), après quoi on introduit le capteur en question avec sa surface de mesure en avant à travers la seconde chambre (10) jusque dans le logement (2) jusqu'à ce qu'il bute contre un épaulement (6) se trouvant dans ledit logement (2). Cela a pour effet de rompre la couche de barrière (3) et de mettre le second fluide (11) en contact avec le fluide d'étalonnage. Le procédé d'étalonnage peut alors avoir lieu. Dans un autre mode de réalisation, le dispositif (1) comprend en outre une membrane (12) logée dans la seconde chambre (10) et adaptée pour être fixée au capteur pendant son insertion dans ledit logement (2). Le dispositif décrit, particulièrement bien adapté pour une utilisation dans des capteurs d'étalonnage pour l'enregistrement transcutané de la teneur en CO2 et/ou O2 dans le sang, est autonome, et peut être réalisé de manière très compacte, ce qui le rend particulièrement bien adapté pour l'utiliser conjointement avec un équipement portatif. De plus on peut fabriquer ledit dispositif sous la forme d'une unité jetable.

    METHOD FOR DETERMINING THE CONCENTRATION OF OXYGEN
    69.
    发明公开
    METHOD FOR DETERMINING THE CONCENTRATION OF OXYGEN 失效
    程序来确定氧含量。

    公开(公告)号:EP0386072A1

    公开(公告)日:1990-09-12

    申请号:EP88909718.0

    申请日:1988-11-03

    Applicant: RADIOMETER A/S

    CPC classification number: G01N21/62 G01N2021/6482

    Abstract: On détermine la concentration d'oxygène moléculaire dans un échantillon en excitant les molécules d'oxygène de l'échantillon, qui passent de l'état normal électronique à l'état 1DELTAg excité (état de singlet excité), en mesurant une caractéristique de luminescence de 1270-nm des molécules d'oxygène excitées (oxygène de singlet) et en mettant en corrélation la caractéristique de luminescence ainsi mesurée avec la concentration d'oxygène moléculaire dans l'échantillon. Normalement, la caractéristique de luminescence de 1270-nm constitue l'intensité de luminescence de 1270-nm. On excite les molécules d'oxygène de préférence en les soumettant à un contact de diffusion avec un activateur, tel qu'une porphyrine ou un composé associé à la porphyrine, tel qu'un complexe métallique de transition d'une porphyrine. L'activateur est amené dans un état électronique d'excitation d'oxygène par absorption d'un rayonnement électromagnétique, tel qu'un rayonnement lumineux, l'état électronique d'excitation d'oxygène étant éventuellement adapté au système de mesurage utilisé grâce à un inhibiteur constitué par exemple par un polyène substitué. L'activateur peut être présent dans un solvant organique ou un polymère, tel que du chlorure de polyvinyle. L'échantillon contenant l'oxygène est de préférence constitué par un échantillon d'origine biologique, tel qu'un échantillon sanguin.

    SENSOR FOR DETERMINING THE CONCENTRATION OF A BIOCHEMICAL SPECIES
    70.
    发明公开
    SENSOR FOR DETERMINING THE CONCENTRATION OF A BIOCHEMICAL SPECIES 失效
    传感器,用于确定生物物种的浓度。

    公开(公告)号:EP0245396A1

    公开(公告)日:1987-11-19

    申请号:EP86906797.0

    申请日:1986-11-17

    Applicant: RADIOMETER A/S

    Inventor: WEBER, Anders

    CPC classification number: G01N21/7703 G01N33/5438

    Abstract: Le capteur (1) ci-décrit permettant de déterminer la concentration d'une espèce biochimique fonctionne d'après un principe conpétitif et la partie active (2) du capteur donnant la réponse comprend les deux partenaires dans une paire d'affinité immobilisée sur deux parties d'un substrat. L'un de ces partenaires est constitué de l'espèce biochimique ou d'un compétiteur de celle-ci.

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