公开(公告)号：WO2005093888A3

公开(公告)日：2005-10-06

申请号：PCT/US2004/037151

申请日：2004-11-04

Applicant: ST. LOUIS UNIVERSITY ,  MINTEER, Shelley, D. ,  TOPCAGIC, Sabina ,  TREU, Becky

Inventor： MINTEER, Shelley, D. ,  TOPCAGIC, Sabina ,  TREU, Becky

IPC: H01M8/16 ,  H01M4/90 ,  C12Q1/00

Abstract: Disclosed is an improved biofuel cell having a cathode comprising a dual function membrane, which contains an oxygen oxidoreductase enzyme immobilized within a buffered compartment of the membrane and an electron transport mediator which transfers electrons from an electron conducting electrode to the redox reaction catalyzed by the oxygen oxidoreductase enzyme. The improved biofuel cell also has an anode that contains an oxidoreductase enzyme that uses an organic fuel, such as alcohol, as a substrate. An electric current can flow between the anode and the cathode.

公开(公告)号：WO1989012461A1

公开(公告)日：1989-12-28

申请号：PCT/US1989002404

申请日：1989-06-01

Applicant: ST. LOUIS UNIVERSITY

Inventor： ST. LOUIS UNIVERSITY ,  GREEN, Maurice ,  LOEWENSTEIN, Paul, M.

IPC: A61K39/12

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N2710/10322 ,  C12N2710/20022 ,  C12N2740/16322

Abstract: A method for preparing antagonists of viral transactivating proteins is disclosed. In one aspect the method involves the preparation of antagonists from active domains of the viral transactivating protein. Pharmaceutical compositions comprising the antagonists which compositions are useful in treating an individual suffering from viral infection are also disclosed.

Abstract translation: 公开了一种制备病毒反式激活蛋白质的拮抗剂的方法。 在一个方面，该方法涉及从病毒反式激活蛋白的活性结构域制备拮抗剂。 还公开了包含该组合物可用于治疗患有病毒感染的个体的拮抗剂的药物组合物。

公开(公告)号：WO2012177653A2

公开(公告)日：2012-12-27

申请号：PCT/US2012/043172

申请日：2012-06-19

Applicant: ST. LOUIS UNIVERSITY ,  KAMINSKI, Henry ,  KUSNER, Linda ,  SATIJA, Namita

Inventor： KAMINSKI, Henry ,  KUSNER, Linda ,  SATIJA, Namita

IPC: A61K38/17 ,  C07K19/00 ,  A61K39/44 ,  A61P21/00 ,  A61P21/04

CPC classification number: A61K47/48246 ,  A61K38/00 ,  A61K47/64 ,  A61K47/6849 ,  A61K2039/505 ,  C07K14/005 ,  C07K14/43527 ,  C07K14/46 ,  C07K14/70596 ,  C07K14/78 ,  C07K14/811 ,  C07K16/286 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/30 ,  C07K2319/50 ,  C12N2740/16222 ,  C12N2760/20122 ,  Y02A50/469

Abstract: Compositions and methods for targeting therapeutic agents to neuromuscular junctions are disclosed. Also disclosed are methods for treating diseases and conditions affecting the neuromuscular junction. Compositions include a neuromuscular junction targeting peptide coupled to a therapeutic agent. Compositions may further include a linker peptide. Methods for targeting therapeutic agents to neuromuscular junctions and treating diseases and conditions affecting the neuromuscular junction include administering a composition including a neuromuscular junction targeting peptide coupled to a therapeutic agent.

Abstract translation: 公开了将治疗剂靶向神经肌肉接头的组合物和方法。 还公开了治疗影响神经肌肉接头的疾病和病症的方法。 组合物包括与治疗剂偶联的神经肌肉接头靶向肽。 组合物还可以包括接头肽。 将治疗剂靶向神经肌肉接头并治疗影响神经肌肉接头的疾病和病症的方法包括施用包含与治疗剂偶联的神经肌肉接头靶向肽的组合物。

公开(公告)号：WO2008131431A2

公开(公告)日：2008-10-30

申请号：PCT/US2008/061316

申请日：2008-04-23

Applicant: ST. LOUIS UNIVERSITY

IPC: A61K48/00

CPC classification number: C07K14/705 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/31 ,  C12Y306/03014

Abstract: There are disclosed agents that inhibit Blood Brain Barrier Proteins (BBBP). Such agents are useful in controlling agents entering and exiting the CNS. This allows for drugs to be more effective and/or allowing side effects of the drugs to be lowered.

Abstract translation: 已经公开了抑制血脑屏障蛋白（BBBP）的药剂。 这些试剂可用于控制进入和离开CNS的试剂。 这允许药物更有效和/或允许降低药物的副作用。

公开(公告)号：WO2007056666A2

公开(公告)日：2007-05-18

申请号：PCT/US2006/060487

申请日：2006-11-02

Applicant: ST. LOUIS UNIVERSITY ,  MINTEER, Shelley, D. ,  KLOTZBACH, Tamara, L. ,  DUMA, Rodica

Inventor： MINTEER, Shelley, D. ,  KLOTZBACH, Tamara, L. ,  DUMA, Rodica

IPC: H01M14/00

CPC classification number: H01M8/16 ,  C12N9/0004 ,  H01M4/9008 ,  H01M2004/8684 ,  Y02E60/527

Abstract: Bioanodes, biocathodes, biofuel cells, immobilized enzymes and immobilization materials comprising a micellar hydrophobically modified polysaccharide are disclosed. In particular, the micellar hydrophobically modified polysaccharide can be a hydrophobically modified chitosan or a hydrophobically modified alginate.

Abstract translation: 公开了生物反应器，生物阴极，生物燃料电池，固定化酶和包含胶束疏水改性多糖的固定材料。 特别地，胶束疏水改性多糖可以是疏水改性的壳聚糖或疏水改性的藻酸盐。

公开(公告)号：WO2011143011A1

公开(公告)日：2011-11-17

申请号：PCT/US2011/035009

申请日：2011-05-03

Applicant: ST. LOUIS UNIVERSITY ,  BUCHOLZ, Richard, D.

Inventor： BUCHOLZ, Richard, D.

IPC: A61B17/34

CPC classification number: A61B17/0293 ,  A61B17/3439

Abstract: A surgical distractor for distracting tissue of a patient to access structure underlying the tissue of the patient. The distractor includes a tube having a distal end adapted for insertion in tissue, a proximal end opposite the distal end, an exterior surface adapted for contacting the tissue, and an interior surface opposite the exterior surface defining a hollow interior extending between the distal end and the proximal end for accessing structure underlying the tissue when the distal end is inserted in the tissue. The distractor is adjustable from a reduced configuration, in which the tube has a reduced width sized for inserting the distal end in the tissue, and an expanded configuration, in which the tube has an expanded width greater than the reduced width sized to provide the hollow interior with a size sufficient for accessing the structure underlying the tissue.

Abstract translation: 用于分散患者组织以进入患者组织下方结构的外科牵引器。 牵引器包括管，其具有适于插入组织的远端，与远端相对的近端，适于接触组织的外表面和与外表面相对的内表面，所述内表面限定在远端和 当远端插入组织中时用于进入组织下方的结构的近端。 牵引器可从减小的构型调节，其中管具有尺寸减小的宽度，用于将远端插入组织中，并且扩张构型，其中管具有大于减小的宽度，尺寸被设计成提供中空 具有足以访问组织下方结构的尺寸的内部。

公开(公告)号：WO2004051774A2

公开(公告)日：2004-06-17

申请号：PCT/US2003/037336

申请日：2003-11-21

Applicant: ST. LOUIS UNIVERSITY ,  MINTEER, Shelley, D. ,  AKERS, Niki, L. ,  MOORE, Christine, M.

Inventor： MINTEER, Shelley, D. ,  AKERS, Niki, L. ,  MOORE, Christine, M.

IPC: H01M8/00

CPC classification number: H01M8/1023 ,  C12N11/08 ,  C12Q1/004 ,  C12Q1/32 ,  H01M4/90 ,  H01M8/1039 ,  H01M8/1088 ,  H01M8/16 ,  H01M2300/0082 ,  Y02E60/527 ,  Y02P70/56

Abstract: Disclosed are bioanodes comprising a quaternary ammonium treated Nation® polymer membrane and a dehydrogenase incorporated within the treated Nation® polymer. The dehydrogenase catalyzes the oxidation of an organic fuel and reduces an adenine dinucleotide. The ion conducting polymer membrane lies juxtaposed to a polymethylene green redox polymer membrane, which serves to electro-oxidize the reduced adenine dinucleotide. The bioanode is used in a fuel cell to produce high power densities.

Abstract translation: 公开了包含季铵盐处理的聚合物膜和掺入处理的聚合物中的脱氢酶的生物过程。 脱氢酶催化有机燃料的氧化并且还原腺嘌呤二核苷酸。 离子导电聚合物膜与多亚甲基绿色氧化还原聚合物膜并置，其用于电还原腺嘌呤二核苷酸的电氧化。 生物阳极用于燃料电池中以产生高功率密度。

公开(公告)号：US20240116857A1

公开(公告)日：2024-04-11

申请号：US18348207

申请日：2023-07-06

Applicant: St. Louis University ,  The Board of Regents of the University of Oklahoma

Inventor： John K. WALKER ,  Valentin V. RYBENKOV ,  Ramakumar KINTHADA ,  Hang ZHAO ,  Elena I. ZGURSKAYA ,  Terri BOEHM ,  Zoya PETRUSHENKO

IPC: C07C255/51 ,  A61K45/06 ,  C07C317/40 ,  C07D249/04 ,  C07D295/155 ,  C07D401/12 ,  C07D495/04

CPC classification number: C07C255/51 ,  A61K45/06 ,  C07C317/40 ,  C07D249/04 ,  C07D295/155 ,  C07D401/12 ,  C07D495/04

Abstract: In one aspect, the present disclosure provides compounds such as those with one or more quaternary ammonium ions joined by one or more aromatic rings. These compounds may have a formula:




These compounds may be used in the treatment of a microbial infection such as a bacterial infection including infections of drug resistant strains of bacteria.

公开(公告)号：US20210246127A1

公开(公告)日：2021-08-12

申请号：US17052584

申请日：2019-05-03

Applicant: St. Louis University

Inventor： Christopher Kent ARNATT ,  Chelsea SONDERGARD

IPC: C07D407/04 ,  A61K45/06 ,  C07D333/20 ,  C07D307/52 ,  C07D213/38 ,  G01N33/50

Abstract: In one aspect, the present disclosure provides compounds of the formula (I): In other aspects, the present disclosure provides compositions and methods of targeting GPER for the treatment of cancers, such as breast cancers and leukemias, gallstone disease, cardiovascular disease, and for conferring of neuroprotection on a subject. Also disclosed are high throughput assays for identifying antagonists of GPER.

公开(公告)号：US20190122874A1

公开(公告)日：2019-04-25

申请号：US16167806

申请日：2018-10-23

Applicant: Florida State University Research Foundation, Inc. ,  St. Louis University

Inventor： Michael G. Roper ,  James L. Edwards

IPC: H01J49/00 ,  H01J49/16 ,  H01J49/42 ,  G01N30/72

CPC classification number: H01J49/009 ,  G01N30/7233 ,  G01N30/7266 ,  G01N2030/623 ,  H01J49/0027 ,  H01J49/0036 ,  H01J49/0431 ,  H01J49/165 ,  H01J49/4225 ,  G01N30/32

Abstract: Provided herein are methods for multiplexed sample analysis by mass spectrometry. The methods may be performed without the need for chemical tagging. The methods also may include the analogous use of frequency modulation to multiplex mass spectrometric analysis, which may be referred to as frequency-modulated continuous flow analysis electrospray ionization mass spectrometry (FM-CFA-ESI-MS).