公开(公告)号：NO972617D0

公开(公告)日：1997-06-06

申请号：NO972617

申请日：1997-06-06

Applicant: RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

Inventor： RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

IPC: A61K39/395 ,  A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K16/00 ,  C07K16/22 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/18 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/536

Abstract: Discoveries are disclosed that show particular aspect or recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as product of antibodies. Means are described fro determining the level of expression of genes for the KGF protein, for example by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.

公开(公告)号：NO972259A

公开(公告)日：1997-05-16

申请号：NO972259

申请日：1997-05-16

Applicant: RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

Inventor： RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

IPC: A61K39/395 ,  A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K16/00 ,  C07K16/22 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/18 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  C12N15/62

CPC classification number: C12Q1/6876 ,  A61K38/00 ,  C07K14/50 ,  C07K14/501 ,  C07K16/22 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/75 ,  C12N15/70 ,  C12N15/79 ,  C12Q2600/158

公开(公告)号：GB9703294D0

公开(公告)日：1997-04-09

申请号：GB9703294

申请日：1997-02-18

Applicant: KAY STUART A ,  KAY ALEXANDER T

IPC: G06F15/02

公开(公告)号：AU7629496A

公开(公告)日：1996-12-30

申请号：AU7629496

申请日：1996-06-07

Applicant: AARONSON STUART A ,  BOTTARO DONALD P ,  CHAN ANDREW M L ,  CIOCE VITTORIA ,  RUBIN JEFFREY S ,  STAHL STEPHEN J ,  WINGFIELD PAUL T

Inventor： CHAN ANDREW M L ,  RUBIN JEFFREY S ,  BOTTARO DONALD P ,  AARONSON STUART A ,  STAHL STEPHEN J ,  WINGFIELD PAUL T ,  CIOCE VITTORIA

IPC: A61K38/00 ,  A61K38/19 ,  C07K14/475 ,  C12N15/12 ,  C12N15/18 ,  C12N15/70 ,  C12N15/85 ,  C12N1/21 ,  C12N5/10 ,  A61K38/18

Abstract: The present invention relates to a novel truncated form of heptocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.

公开(公告)号：LT3472B

公开(公告)日：1995-10-25

申请号：LTIP667

申请日：1993-06-21

Applicant: RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

Inventor： RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

IPC: A61K39/395 ,  A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K16/00 ,  C07K16/22 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/18 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  C07K3/18 ,  C07K13/00 ,  C07K7/06 ,  C07K7/08 ,  C07K7/10 ,  C12N5/00 ,  C12N15/00 ,  G01N33/536

Abstract: Discoveries are disclosed that show particular aspect or recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as product of antibodies. Means are described fro determining the level of expression of genes for the KGF protein, for example by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.

公开(公告)号：LV10284B

公开(公告)日：1995-04-20

申请号：LV920410

申请日：1992-12-23

Applicant: RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

Inventor： RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

IPC: A61K39/395 ,  A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K16/00 ,  C07K16/22 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/18 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/536 ,  C12N15/00 ,  C12N5/00 ,  C07K7/08 ,  C07K7/06

Abstract: Discoveries are disclosed that show particular aspect or recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as product of antibodies. Means are described fro determining the level of expression of genes for the KGF protein, for example by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.

公开(公告)号：LTIP667A

公开(公告)日：1995-01-31

申请号：LTIP667

申请日：1993-06-21

Applicant: RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

Inventor： RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

IPC: A61K39/395 ,  A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K16/00 ,  C07K16/22 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/18 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  C07K3/18 ,  C07K13/00 ,  C07K7/06 ,  C07K7/08 ,  C07K7/10 ,  C12N5/00 ,  C12N15/00 ,  G01N33/536

Abstract: Discoveries are disclosed that show particular aspect or recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as product of antibodies. Means are described fro determining the level of expression of genes for the KGF protein, for example by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.

公开(公告)号：AU6815894A

公开(公告)日：1994-11-08

申请号：AU6815894

申请日：1994-04-19

Applicant: KAUFFMAN STUART A

Inventor： KAUFFMAN STUART A ,  REBEK JULIUS JR

IPC: C07B61/00 ,  C07K1/04 ,  C12N9/00 ,  C12N15/10 ,  C12P1/00 ,  C12P19/34 ,  C12P21/00 ,  C12Q1/68 ,  C12Q1/6811 ,  C12N15/63

公开(公告)号：AU6598694A

公开(公告)日：1994-09-08

申请号：AU6598694

申请日：1994-06-28

Applicant: AARONSON STUART A ,  FINCH PAUL W ,  RUBIN JEFFREY S

Inventor： RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

IPC: A61K39/395 ,  A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K16/00 ,  C07K16/22 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/18 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  C07K13/00 ,  C12N15/19

Abstract: Discoveries are disclosed that show particular aspect or recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as product of antibodies. Means are described fro determining the level of expression of genes for the KGF protein, for example by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.

公开(公告)号：DE3787973D1

公开(公告)日：1993-12-02

申请号：DE3787973

申请日：1987-12-23

Applicant: LARSEN STUART A ,  CHRISTENSEN JUN

Inventor： LARSEN STUART A ,  CHRISTENSEN JUN CHARLES S

IPC: B60P3/08 ,  B65D85/68 ,  B65D88/12 ,  B65D90/00 ,  B60P3/07

Abstract: Method and apparatus to enhance intermodal containers for transport of vehicles wherein multiple longitudinal rails on container walls support movable and removable transverse cargo pallets having foot members which are articulatably connected to the pallets are disclosed. Cargo, preferably an automobile fixed to front and rear pallets is loaded by inserting each pallet's feet onto appropriate rail(s) at door opening, then sliding to stowage spot, the rail selection determining height and tilt. Stowage of any mix of automobiles in intermodal containers is optimized by double-decking, half-decking, double half-decking, mirror-imaging, and envelope intervention. On back haul, pallets serve other cargo as restraints, hangers, pallets, or dunnage deck supports, or they are stowed out of the way. Method and apparatus permit automated load planning and container stuffing, and make containerized shipment of large volumes of automobiles cost competitive with current methods.