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    RANDOM CHEMISTRY FOR THE GENERATION OF NEW COMPOUNDS
    5.
    发明专利
    RANDOM CHEMISTRY FOR THE GENERATION OF NEW COMPOUNDS 未知

    公开(公告)号：CA2160457A1

    公开(公告)日：1994-10-27

    申请号：CA2160457

    申请日：1994-04-19

    Applicant: KAUFFMAN STUART A

    Inventor： KAUFFMAN STUART A ,  REBEK JULIUS JR

    IPC: C07B61/00 ,  C07K1/04 ,  C12N9/00 ,  C12N15/10 ,  C12P1/00 ,  C12P19/34 ,  C12P21/00 ,  C12Q1/68 ,  C12Q1/6811 ,  C07H21/00 ,  C07K1/00

    Abstract: Methods for the generation of new compounds are disclosed. The present invention eliminates the need to know in advance the structure or chemical compounds of a compounds having a desired property. The disclosure of the present invention provides that diversity of unknown compounds may be produced by "random" chemistry, and such a diversity of unknown compounds may be screened for one or more desired properties to detect the presence of suitable compounds. In one aspect, a starting group of organic compounds is caused to undergo a series of chemical reactions to create a diversity of new organic compounds that are screened for the presence of organic compounds having the desired property. In another aspect of the present invention, a diversity of compounds is generated from a group of substrates which are subjected to a group of enzymes representing a diversity of catalytic activities.

    A METHOD AND SYSTEM FOR ROUTING CONTROL IN COMMUNICATION NETWORKS AND FOR SYSTEM CONTROL
    6.
    发明申请
    A METHOD AND SYSTEM FOR ROUTING CONTROL IN COMMUNICATION NETWORKS AND FOR SYSTEM CONTROL 审中-公开
    一种用于在通信网络中进行路由控制和用于系统控制的方法和系统

    公开(公告)号：WO0045584A8

    公开(公告)日：2000-11-02

    申请号：PCT/US0002011

    申请日：2000-01-28

    Applicant: BIOS GROUP LP ,  KAUFFMAN STUART A ,  PLATE TONY A

    Inventor： KAUFFMAN STUART A ,  PLATE TONY A

    IPC: H04L12/701 ,  H04L12/721 ,  H04L12/725 ,  H04M15/00 ,  G06F15/18 ,  H04L12/46

    CPC classification number: H04L45/12 ,  H04L45/00 ,  H04L45/308

    Abstract: The present invention relates generally to a method and system for routing control in communication networks and for system control. More particularly, the present invention performs routing by controlling the components in a network with software agents (102) operating in a reward framework using p, tau, and patches (104) to improve communication performance (106). This invention disclosure includes the combination of reinforcement learning agents in a market-based or performance-based reward framework together with optimization techniques called p, tau, and patches (104) as applied to the problem of topology-and load-based routing in data networks, in order to improve communication performance (106) such as communication latency and bandwidth. The invention also applies to the control of other systems, including operations management, job-shop problems, organizational structure, portfolio management, risk management etc.

    Abstract translation: 本发明一般涉及用于通信网络中的路由控制和系统控制的方法和系统。 更具体地说，本发明通过使用p，tau和补丁（104）在奖励框架中运行的软件代理（102）控制网络中的组件来执行路由，以改善通信性能（106）。 本发明公开内容包括基于市场或基于性能的奖励框架中的强化学习代理的组合以及被应用于数据中的基于拓扑和基于负载的路由问题的被称为p，tau和补丁（104）的优化技术 网络，以便改善诸如通信等待时间和带宽的通信性能（106）。 本发明也适用于其他系统的控制，包括运营管理，作业问题，组织结构，投资组合管理，风险管理等。

    A SYSTEM AND METHOD FOR DETERMINING PRODUCTION PLANS AND FOR PREDICTING INNOVATION
    8.
    发明申请
    A SYSTEM AND METHOD FOR DETERMINING PRODUCTION PLANS AND FOR PREDICTING INNOVATION 审中-公开
    一种用于确定生产计划和预测创新的系统和方法

    公开(公告)号：WO0020983A8

    公开(公告)日：2000-07-20

    申请号：PCT/US9922911

    申请日：1999-10-01

    Applicant: BIOS GROUP LP ,  AUERSWALD PHILIP ,  KAUFFMAN STUART A ,  LOBO JOSE ,  SHELL KARL

    Inventor： AUERSWALD PHILIP ,  KAUFFMAN STUART A ,  LOBO JOSE ,  SHELL KARL

    IPC: G06Q10/00 ,  G06F17/60

    CPC classification number: G06Q10/06

    Abstract: The present invention relates generally to design and evaluation of research and development, technology transfer, and learning-by-doing, and more particularly to the determination of production plans and the prediction of innovation. A preferred embodiment comprises a method for determining a production plan comprising the steps of: defining a plurality of production recipes such that each of said production recipes is a vector of n operations; selecting a current one of the production recipes; evaluating the current production recipe to determine its cost; modifying the current production recipe to create a trial production recipe (130); evaluating the trial production recipe to determine its cost (140, 150); and assigning the trial production recipe to the current production recipe if the cost of the trial production recipe is less than the cost of the current production recipe.

    Abstract translation: 本发明一般涉及研究开发，技术转让和学习的设计与评估，特别涉及生产计划的确定和创新的预测。 优选实施例包括用于确定生产计划的方法，包括以下步骤：定义多个生产配方，使得每个所述生产配方是n个操作的向量; 选择当前的生产食谱之一; 评估当前的生产配方以确定其成本; 修改当前生产食谱以创建试生产食谱（130）; 评估试生产配方以确定其成本（140,150）; 并且如果试生产配方的成本小于当前生产配方的成本，则将试生产配方分配给当前生产配方。

    CIS ACTING NUCLEIC ACID ELEMENTS AND METHODS OF USE
    9.
    发明申请
    CIS ACTING NUCLEIC ACID ELEMENTS AND METHODS OF USE 审中-公开
    独联体作用的核酸元素和使用方法

    公开(公告)号：WO0004196A2

    公开(公告)日：2000-01-27

    申请号：PCT/US9915860

    申请日：1999-07-13

    Applicant: CISTEM MOLECULAR CORP ,  KAUFFMAN STUART A ,  BALLIVET MARC

    Inventor： KAUFFMAN STUART A ,  BALLIVET MARC

    IPC: C12N15/09 ,  C12N15/10 ,  C12Q1/68

    CPC classification number: C12Q1/6811 ,  C12N15/1034 ,  C12Q1/6804 ,  C12Q1/6809 ,  C12Q2525/179 ,  C12Q2522/101 ,  C12Q2521/507

    Abstract: The invention provides a method of identifying nucleic acid molecules that contain cis acting nucleic acid elements. Also provided is a method of isolating nucleic acid binding factors. The invention also provides methods of identifying compounds that are cis acting nucleic acid element analogs, compounds that are nucleic acid binding factor analogs, compounds that selectively bind cis acting nucleic acid elements and compounds that selectively displace binding between a nucleic acid binding factor and a cis acting nucleic acid element or between nucleic acid binding factors. Also provided is a method of determining a binding state of a nucleic acid. Pluralities of isolated nucleic acid molecules containing cis acting nucleic acid elements, of isolated cis acting nucleic acid elements and of isolated nucleic acid binding factors are also provided. The invention further provides methods of treating pathological conditions using molecules of the invention to alter genetic activites of nucleic acids involved in pathological conditions.

    Abstract translation: 本发明提供了鉴定含有顺式作用核酸元件的核酸分子的方法。 还提供了分离核酸结合因子的方法。 本发明还提供鉴定作为顺式作用核酸元件类似物的化合物，作为核酸结合因子类似物的化合物，选择性结合顺式作用核酸元件的化合物和选择性取代核酸结合因子与顺式 作用核酸元件或核酸结合因子之间。 还提供了确定核酸的结合状态的方法。 还提供了含有顺式作用核酸元件，分离的顺式作用核酸元件和分离的核酸结合因子的多种分离的核酸分子。 本发明还提供使用本发明分子治疗病理状况以改变参与病理状况的核酸的遗传活性的方法。

    AUTOMATIC EVOLUTION OF MIXED ANALOG AND DIGITAL ELECTRONIC CIRCUITS
    10.
    发明申请
    AUTOMATIC EVOLUTION OF MIXED ANALOG AND DIGITAL ELECTRONIC CIRCUITS 审中-公开
    混合模拟和数字电子电路的自动演进

    公开(公告)号：WO0019369A8

    公开(公告)日：2000-07-13

    申请号：PCT/US9922917

    申请日：1999-10-01

    Applicant: BIOS GROUP LP ,  HERRIOT JAMES W ,  KAUFFMAN STUART A

    Inventor： HERRIOT JAMES W ,  KAUFFMAN STUART A

    IPC: G06N3/00 ,  G06F15/00 ,  G06F15/18

    CPC classification number: G06N3/004

    Abstract: A method and system for evolving electronic circuits based on defined rules. A first approach uses a network (50) of nodes (60) having established topological and behavioral relationships amongst themselves. A second approach employs software agents to create signal filters. The software agents are allowed to evolve in signal parameter space so as to match a reference signal (200), subject to established evolutionary rules and parameter space constraints. Narrowband and a low-pass filter can be formed using such agents.

    Abstract translation: 基于定义规则演进电子电路的方法和系统。 第一种方法使用其间具有已建立的拓扑和行为关系的节点（60）的网络（50）。 第二种方法使用软件代理来创建信号过滤器。 允许软件代理在信号参数空间中进化，以便匹配参考信号（200），受制于进化规则和参数空间限制。 可以使用这样的试剂形成窄带和低通滤波器。

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